Plant sources, techniques of production and uses of tar: A review

Background: Coronavirus Disease-2019 belongs to the family of viruses which cause a serious pneumonia along with fever, breathing issues and infection of lungs for the first time in China and later spread worldwide. Objective: Several studies and clinical trials have been conducted to identify potential drugs and vaccines for Coronavirus Disease-2019. The present study listed natural secondary metabolites identified from plant sources with antiviral properties and could be safer and tolerable treatment for Coronavirus Disease-2019. Methods: A comprehensive search on the reported studies was conducted using different search engine such as Google scholar, SciFinder, Sciencedirect, Medline PubMed, and Scopus for the collection of research articles based on plantderived secondary metabolites, herbal extracts, and traditional medicine for coronavirus infections. Results: Status of COVID-19 worldwide and information of important molecular targets involved in COVID-19 is described and through literature search, is highlighted that numerous plant species and their extracts possess antiviral properties and studied with respect to Coronavirus treatments. Chemical information, plant source, test system type with mechanism of action for each secondary metabolite is also mentioned in this review paper. Conclusion: The present review has listed plants that have presented antiviral potential in the previous coronavirus pandemics and their secondary metabolites which could be significant for the development of novel and a safer drug which could prevent and cure coronavirus infection worldwide.

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Nano Phytomedicine Based Delivery System for CNS Disease

Current Drug Metabolism ◽

10.2174/1389200221666200523161003 ◽

2020 ◽

Vol 21 (9) ◽

pp. 661-673 ◽

Cited By ~ 1

Author(s):

Mohammed Asadullah Jahangir ◽

Chettupalli Anand ◽

Abdul Muheem ◽

Sadaf Jamal Gilani ◽

Mohamad Taleuzzaman ◽

...

Keyword(s):

Herbal Medicine ◽

Low Cost ◽

Herbal Medicines ◽

Herbal Drugs ◽

Widespread Acceptance ◽

The Central Nervous System ◽

Low Toxicity ◽

Ancient Times ◽

Plant Sources ◽

Herbal Formulations

Herbal medicines are being used since ancient times and are an important part of the alternative and traditional medicinal system. In recent decades, scientists are embracing herbal medicines based on the fact that a number of drugs that are currently in use are derived directly or indirectly from plant sources. Moreover, herbal drugs have lesser side effects, albeit are potentially strong therapeutic agents. The herbal medicine market is estimated to be around US $62 billion globally. Herbal medicine has gained widespread acceptance due to its low toxicity, low cost, ease of accessibility and efficacy in treating difficult diseases. Safety and efficacy are another important factors in the commercialization process of herbal medicines. Nanotechnology has been shown to be potentially effective in improving the bioactivity and bioavailability of herbal medicines. Development of nano-phytomedicines (or by reducing the size of phytomedicine), attaching polymers with phytomedicines and modifying the surface properties of herbal drugs, have increased the solubility, permeability and eventually the bioavailability of herbal formulations. Novel formulations such as niosomes, liposomes, nanospheres, phytosomes etc., can be exploited in this area. This article reviews herbal medicines, which have prominent activity in the Central Nervous System (CNS) disorders and reported nano-phytomedicines based delivery systems.

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Phyto-fabrication of Iron Nanoparticles: Characterization and Antibacterial Capacity

Current Nanoscience ◽

10.2174/1573413716999200817105934 ◽

2020 ◽

Vol 16 ◽

Author(s):

Asma S. Algebaly ◽

Afrah E. Mohammed ◽

Mudawi M. Elobeid

Keyword(s):

Electron Microscopy ◽

Plant Extracts ◽

Large Scale ◽

Iron Nanoparticles ◽

Ethanolic Extract ◽

Green Technology ◽

Resistant Bacteria ◽

Scale Production ◽

Bacterial Strains ◽

Plant Sources

Introduction: Fabrication of iron nanoparticles (FeNPs) has recently gained a great concern for their varied applications in remediation technologies of the environment. Objective: The current study aimed to fabricate iron nanoparticles by green technology approach using different plant sources, Azadirachta indica leaf and Calligonum comosum root following two extraction methods. Methods: Currently, a mixture of FeCl2 and FeCl3 was used to react with the plant extracts which are considered as reducing and stabilizing agents for the generation of FeNPs in one step. Different techniques were used for FeNPs identification. Results: Immediately after mixing of the two reaction components, the color changed to dark brown as an indication of safe conversion of Fe ions to FeNPs, that later confirmed by zeta sizer, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). FeNPs fabricated by C. comosum showed smaller size when compared by those fabricated by A. indica. Using both plant sources, FeNPs fabricated by the aqueous extract had smaller size in relation to those fabricated by ethanolic extract. Furthermore, antibacterial ability against two bacterial strains was approved. Conclusion: The current results indicated that, at room temperature plant extracts fabricated Fe ion to Fe nanoparticles, suggesting its probable usage for large scale production as well as its suitability against bacteria. It could also be recommended for antibiotic resistant bacteria.

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Comparison of extraction efficiency of various methods to extract L-DOPA from Mucuna pruriens (L.) DC.

International Journal of Bioassays ◽

10.21746/ijbio.2017.04.003 ◽

2017 ◽

Vol 6 (04) ◽

pp. 5343

Author(s):

Ragni Vora ◽

Ambika N. Joshi* ◽

Nitesh C. Joshi

Keyword(s):

Extraction Efficiency ◽

Soxhlet Extraction ◽

Extraction Methods ◽

Mucuna Pruriens ◽

Water Mixture ◽

Uv Detector ◽

Pharmacological Activities ◽

Hplc Mobile Phase ◽

Plant Sources ◽

Seed Extracts

Mucuna pruriens seeds are noted to be a natural source of L-DOPA and are also used as a substitute for the synthetic L-DOPA. In the present study; attempts are made to develop suitable method(s) for extraction of L-DOPA from the powdered seeds of Mucuna pruriens using different solvents and conditions. The Seed powder was subjected to 7 different extraction methods and Method 1 was subjected to various solvent concentrations. Some methods used de-fatting procedure, either the method was cold maceration or in high temperature. Soxhlet extraction was also used in one of the extraction methods. All the extracts were analyzed using RP-HPLC. Mobile Phase used was Water: Methanol: AcetoNitrile (100:60:40) (v/v) containing 0.2% Triethylamine, pH = 3.3 and monitored at 280 nm with variable wavelength UV detector. The extraction was best with Methanol Water mixture in a cold maceration technique and overall gives good extraction efficiency of 13.36 % L-DOPA and id the best method giving highest extraction efficiency. The De-fatting method was the 2nd best methods giving approximately 8.8% L-DOPA and Method 5 viz, heat reflux method gives 8.7% L-DOPA making it the 3rd best method. There are not many studies done for optimization of extraction technique for L-DOPA despite an extensive work is reported for isolation, identification and pharmacological activities of L-DOPA from various plant sources. Keeping this in view, present investigation was done to study the extraction efficiency of various extraction methods of L-DOPA content in seed extracts of Mucuna pruriens and compare it.

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Uncovering Prospective Role and Applications of Existing and New Nutraceuticals from Bacterial, Fungal, Algal and Cyanobacterial, and Plant Sources

Sustainability ◽

10.3390/su13073671 ◽

2021 ◽

Vol 13 (7) ◽

pp. 3671

Author(s):

Jameel R. Al-Obaidi ◽

Khalid H. Alobaidi ◽

Bilal Salim Al-Taie ◽

David Hong-Sheng Wee ◽

Hasnain Hussain ◽

...

Keyword(s):

Human Health ◽

Well Being ◽

Vital Role ◽

Biologically Active ◽

Future Perspective ◽

The Public ◽

Biological Sources ◽

Pharmaceutical Properties ◽

Plant Sources ◽

Health And Well Being

Nutraceuticals are a category of products more often associated with food but having pharmaceuticals property and characteristics. However, there is still no internationally accepted concept of these food-pharmaceutical properties, and their interpretation can differ from country to country. Nutraceuticals are used as part of dietary supplements in most countries. They can be phytochemicals which are biologically active and have health benefits. These can be supplied as a supplement and/or as a functional food to the customer. For human health and longevity, these materials are likely to play a vital role. Consumption of these items is typical without a therapeutic prescription and/or supervision by the vast majority of the public. The development of nutraceuticals can be achieved through many bioresources and organisms. This review article will discuss the current research on nutraceuticals from different biological sources and their potential use as an agent for improving human health and well-being, as well as the gaps and future perspective of research related to nutraceutical development.

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Development of active and smart packaging films based on starch, polyvinyl alcohol and betacyanins from different plant sources

International Journal of Biological Macromolecules ◽

10.1016/j.ijbiomac.2021.04.152 ◽

2021 ◽

Vol 183 ◽

pp. 358-368

Author(s):

Xiyu Yao ◽

Yan Qin ◽

Man Zhang ◽

Jixian Zhang ◽

Chunlu Qian ◽

...

Keyword(s):

Polyvinyl Alcohol ◽

Packaging Films ◽

Smart Packaging ◽

Plant Sources

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Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

Nutrients ◽

10.3390/nu11102288 ◽

2019 ◽

Vol 11 (10) ◽

pp. 2288 ◽

Cited By ~ 41

Author(s):

Wijdan M. Dabeek ◽

Melissa Ventura Marra

Keyword(s):

Blood Pressure ◽

Cardiovascular Disease ◽

Vegetable Intake ◽

Cardiovascular Effects ◽

Fruit And Vegetable Intake ◽

Food Sources ◽

Free Form ◽

Kaempferol Glycoside ◽

Plant Sources ◽

Reduced Risk

Fruit and vegetable intake has been associated with a reduced risk of cardiovascular disease. Quercetin and kaempferol are among the most ubiquitous polyphenols in fruit and vegetables. Most of the quercetin and kaempferol in plants is attached to sugar moieties rather than in the free form. The types and attachments of sugars impact bioavailability, and thus bioactivity. This article aims to review the current literature on the bioavailability of quercetin and kaempferol from food sources and evaluate the potential cardiovascular effects in humans. Foods with the highest concentrations of quercetin and kaempferol in plants are not necessarily the most bioavailable sources. Glucoside conjugates which are found in onions appear to have the highest bioavailability in humans. The absorbed quercetin and kaempferol are rapidly metabolized in the liver and circulate as methyl, glucuronide, and sulfate metabolites. These metabolites can be measured in the blood and urine to assess bioactivity in human trials. The optimal effective dose of quercetin reported to have beneficial effect of lowering blood pressure and inflammation is 500 mg of the aglycone form. Few clinical studies have examined the potential cardiovascular effects of high intakes of quercetin- and kaempferol-rich plants. However, it is possible that a lower dosage from plant sources could be effective due to of its higher bioavailability compared to the aglycone form. Studies are needed to evaluate the potential cardiovascular benefits of plants rich in quercetin and kaempferol glycoside conjugates.

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THE EFFECT OF BACTERIAL CELL LYSIS AND OF PLANT EXTRACTS ON CELLULOSE PRODUCTION BY ACETOBACTER XYLINUM

Canadian Journal of Biochemistry and Physiology ◽

10.1139/y63-193 ◽

1963 ◽

Vol 41 (1) ◽

pp. 1691-1702 ◽

Cited By ~ 2

Author(s):

T. E. Webb ◽

J. Ross Colvin

Keyword(s):

Bacterial Cell ◽

Cell Envelope ◽

Acetobacter Xylinum ◽

Cellulose Synthesis ◽

Additive Effects ◽

Cellulose Production ◽

Whole Cells ◽

Negative Results ◽

Heat Stable ◽

Plant Sources

The production of cellulose by lysozyme lysates of Acetobacter xylinum is similar to that of a suspension of whole cells, in contrast to the negative results obtained with previous "cell-free" preparations. The results of differential centrifugation of these lysates suggests that most of the enzymes required for cellulose synthesis from glucose normally are held by the cell envelope and are not located in the cytoplasm. However, a heat-stable cofactor(s) is present in the supernatant derived from the cell contents which may stimulate cellulose synthesis by the cell envelopes.The addition of extracts from a number of plant sources increased cellulose synthesis by whole cells of A. xylinum. In particular, the supernatant prepared by centrifugation of an homogenate of tomatoes increased bacterial cellulose production at pH 6 by a factor of 3. Both dialyzable and non-dialyzable substances in the extract are responsible. Fractionation of the non-dialyzable portion of the extract by column chromatography suggests that the overall increase is due to additive effects of several compounds. Here also the compounds appear to act upon the bacterial cell envelope.

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