The underlying mechanism insights into support polydopamine decoration toward ultrathin polyamide membranes for high-performance reverse osmosis

2022 ◽  
pp. 120269
Author(s):  
Qin Shen ◽  
Yuqing Lin ◽  
Takafumi Ueda ◽  
Pengfei Zhang ◽  
Yuandong Jia ◽  
...  
Keyword(s):  
Reverse Osmosis ◽  
High Performance ◽  
Underlying Mechanism ◽  
Polyamide Membranes

scholarly journals Nanostructure-Enhanced Surface Acoustic Waves Biosensor and Its Computational Modeling

2009 ◽  
Vol 2009 ◽  
pp. 1-11 ◽  
Author(s):  
Guigen Zhang
Keyword(s):  
Acoustic Waves ◽  
High Performance ◽  
Surface Acoustic Waves ◽  
Active Surface ◽  
Underlying Mechanism ◽  
Saw Sensor ◽  
Saw Devices ◽  
Operational Capabilities ◽  
Sensing Platform ◽  
Enhanced Surface

Surface acoustic wave (SAW) devices are considered to be very promising in providing a high-performance sensing platform with wireless and remote operational capabilities. In this review, the basic principles of SAW devices and Love-mode SAW-based biosensors are discussed first to illustrate the need for surface enhancement for the active area of a SAW sensor. Then some of the recent efforts made to incorporate nanostructures into SAW sensors are summarized. After that, a computational approach to elucidate the underlying mechanism for the operations of a Love-mode SAW biosensor with nanostructured active surface is discussed. Finally, a modeling example for a Love-mode SAW sensor with skyscraper nanopillars added to in its active surface along with some selected results is presented.

Flexible silicon nanowires sensor for acetone detection on plastic substrates

2021 ◽  
Author(s):  
Kuibo Lan ◽  
Zhi Wang ◽  
Xiaodong Yang ◽  
Junqing Wei ◽  
Yuxiang Qin ◽  
...  
Keyword(s):  
Silicon Nanowires ◽  
High Performance ◽  
Underlying Mechanism ◽  
Environmental Safety ◽  
Cmos Process ◽  
Plastic Substrates ◽  
Irregular Shapes ◽  
Good Potential ◽  
Mechanical Bending ◽  
Acetone Detection

Abstract Acetone commonly exists in daily life and is harmful to human health, therefore the convenient and sensitive monitoring of acetone is highly desired. In addition, flexible sensors have the advantages of light-weight, conformal attachable to irregular shapes, etc. In this study, we fabricated high performance flexible silicon nanowires (SiNWs) sensor for acetone detection by transferring the monocrystalline Si film and metal-assisted chemical etching method on polyethylene terephthalate (PET). The SiNWs sensor enabled detection of gaseous acetone with a concentration as low as 0.1 parts per million (ppm) at flat and bending states. The flexible SiNWs sensor was compatible with the CMOS process and exhibited good sensitivity, selectivity and repeatability for acetone detection at room temperature. The flexible sensor showed performance improvement under mechanical bending condition and the underlying mechanism was discussed. The results demonstrated the good potential of the flexible SiNWs sensor for the applications of wearable devices in environmental safety, food quality, and healthcare.

scholarly journals Untargeted Metabolomics Reveals the Protective Effect of a Traditional Chinese Herbal Decoction on Cisplatin-Induced Acute Kidney Injury

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Yuyan Li ◽  
Xinhui Liu ◽  
Siqi Liu ◽  
Jiandong Lu ◽  
Jianping Chen ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Mouse Model ◽  
High Performance ◽  
Kidney Injury ◽  
Underlying Mechanism ◽  
Lysine Biosynthesis ◽  
Chinese Herbal ◽  
Flight Mass Spectrometry ◽  
Herbal Decoction ◽  
Group A

Our previous studies have demonstrated that Jian-Pi-Yi-Shen formula (JPYSF), a traditional Chinese herbal decoction, has a renoprotective effect in 5/6 nephrectomy-induced chronic kidney injury. However, the role and potential mechanisms of JPYSF in the treatment of acute kidney injury (AKI) remain unknown. This study was designed to test the beneficial effect of JPYSF in an AKI mouse model and to investigate the underlying mechanism by using metabolomics analysis. The AKI mouse model was induced by a single intraperitoneal injection of cisplatin at a dose of 20 mg/kg. The mice in the treatment group were pretreated orally with JPYSF (18.35 g/kg/d) for 5 days before cisplatin injection. Seventy-two hours after cisplatin injection, serum and kidney samples were collected for biochemical and histological examination. Ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UHPLC-QTOF/MS) was applied to analyze metabolic profiling variations in the kidney. The results showed that pretreatment with JPYSF obviously reduced the levels of serum creatinine and blood urea nitrogen and alleviated renal pathological injury in AKI mice. Orthogonal partial least-squares discriminant analysis (OPLS-DA) score plot revealed a clear separation between the AKI and AKI + JPYSF group. A total of 68 and 87 significantly differentially expressed metabolites were identified in the kidney of AKI mice responding to JPYSF treatment in negative and positive ion mode, respectively. The pivotal pathways affected by JPYSF included vitamin B6 metabolism, alanine, aspartate and glutamate metabolism, lysine biosynthesis, and butanoate metabolism. In conclusion, JPYSF can protect the kidney from cisplatin-induced AKI, which may be associated with regulating renal metabolic disorders.

scholarly journals Toxicity Reduction of Euphorbia kansui Stir-Fried with Vinegar Based on Conversion of 3-O-(2′E,4′Z-Decadi-enoyl)-20-O-acetylingenol

Molecules ◽  
2019 ◽  
Vol 24 (20) ◽  
pp. 3806 ◽  
Author(s):  
Qiao Zhang ◽  
Yi Zhang ◽  
Shi-Kang Zhou ◽  
Kan Wang ◽  
Min Zhang ◽  
...  
Keyword(s):  
High Performance ◽  
Developmental Toxicity ◽  
Underlying Mechanism ◽  
Severe Toxicity ◽  
Sod Activity ◽  
Mechanisms Of Toxicity ◽  
Toxicity Reduction ◽  
Euphorbia Kansui ◽  
The Difference ◽  
Underlying Mechanisms

The dried roots of Euphorbia kansui S.L.Liou ex S.B.Ho have long been used to treat edema in China. However, the severe toxicity caused by Euphorbia kansui (EK) has seriously restricted its clinical application. Although EK was processed with vinegar to reduce its toxicity, the detailed mechanisms of attenuation in toxicity of EK stir-fried with vinegar (VEK) have not been well delineated. Diterpenoids are the main toxic ingredients of EK, and changes in these after processing may be the underlying mechanism of toxicity attenuation of VEK. 3-O-(2′E,4′Z-decadienoyl)-20-O-acetylingenol (3-O-EZ) is one of the diterpenoids derived from EK, and the content of 3-O-EZ was significantly reduced after processing. This study aims to explore the underlying mechanisms of toxicity reduction of VEK based on the change of 3-O-EZ after processing with vinegar. Based on the chemical structure of 3-O-EZ and the method of processing with vinegar, simulation experiments were carried out to confirm the presence of the product both in EK and VEK and to enrich the product. Then, the difference of peak area of 3-O-EZ and its hydrolysate in EK and VEK were detected by ultra-high-performance liquid chromatography (UPLC). Furthermore, the toxicity effect of 3-O-EZ and its hydrolysate, as well as the underlying mechanism, on zebrafish embryos were investigated. The findings showed that the diterpenoids (3-O-EZ) in EK can convert into less toxic ingenol in VEK after processing with vinegar; meanwhile, the content of ingenol in VEK was higher than that of EK. More interestingly, the ingenol exhibited less toxicity (acute toxicity, developmental toxicity and organic toxicity) than that of 3-O-EZ, and 3-O-EZ could increase malondialdehyde (MDA) content and reduce glutathione (GSH) content; cause embryo oxidative damage by inhibition of the succinate dehydrogenase (SDH) and superoxide dismutase (SOD) activity; and induce inflammation and apoptosis by elevation of IL-2 and IL-8 contents and activation of the caspase-3 and caspase-9 activity. Thus, this study contributes to our understanding of the mechanism of attenuation in toxicity of VEK, and provides the possibility of safe and rational use of EK in clinics.

scholarly journals The Aqueous Extract from Ceratonia siliqua Leaves Protects against 6-Hydroxydopamine in Zebrafish: Understanding the Underlying Mechanism

Antioxidants ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 304 ◽  
Author(s):  
Sara Abidar ◽  
Razvan Boiangiu ◽  
Gabriela Dumitru ◽  
Elena Todirascu-Ciornea ◽  
Amina Amakran ◽  
...  
Keyword(s):  
Aqueous Extract ◽  
High Performance ◽  
Antioxidant Activities ◽  
Memory Performance ◽  
Underlying Mechanism ◽  
Ceratonia Siliqua ◽  
Ceratonia Siliqua L ◽  
6 Hydroxydopamine

Ceratonia siliqua L. is a Mediterranean medicinal plant traditionally cultivated for its ethnopharmacological benefits, such as antidiarrheal, antidiabetic, enhance acetylcholine, antioxidant, antiatherosclerotic, and for its possible anti-neurodegenerative potential. The aim of the present study was to evaluate the chemical composition, as well as the cognitive-enhancing, anxiolytic, and antioxidant activities of the aqueous extract from C. siliqua (CsAE) leaves against 6-hydroxydopamine (6-OHDA) zebrafish Parkinson’s disease (PD) model. CsAE (0.1, 0.3, and 1 mg/L) was administered by immersion to zebrafish (Danio rerio) for eight consecutive days and one hour before each behavioral test of each day, while 6-OHDA (250 µM) treatment was supplied one day before the novel tank diving test (NTT). Qualitative and quantitative analyses were performed by the ultra-high-performance liquid chromatography (UHPLC) analysis. The memory performance was evaluated through the NTT and Y-maze tests. Additionally, the in vitro and in vivo antioxidant status and acetylcholinesterase (AChE) activity was also assessed. Our finds demonstrated that CsAE presented positive antioxidant and anti-AChE activities, which contributed to the improvement of cognitive function in the 6-OHDA zebrafish PD model.

scholarly journals Ionization behavior of nanoporous polyamide membranes

2020 ◽  
Vol 117 (48) ◽  
pp. 30191-30200
Author(s):  
Cody L. Ritt ◽  
Jay R. Werber ◽  
Mengyi Wang ◽  
Zhongyue Yang ◽  
Yumeng Zhao ◽  
...  
Keyword(s):  
High Performance ◽  
Interfacial Polymerization ◽  
Carboxyl Groups ◽  
Structure Property ◽  
Nanoconfined Water ◽  
Fundamental Understanding ◽  
Ionization Behavior ◽  
Water Salt ◽  
Low Permittivity ◽  
Polyamide Membranes

Escalating global water scarcity necessitates high-performance desalination membranes, for which fundamental understanding of structure–property–performance relationships is required. In this study, we comprehensively assess the ionization behavior of nanoporous polyamide selective layers in state-of-the-art nanofiltration (NF) membranes. In these films, residual carboxylic acids and amines influence permeability and selectivity by imparting hydrophilicity and ionizable moieties that can exclude coions. We utilize layered interfacial polymerization to prepare physically and chemically similar selective layers of controlled thickness. We then demonstrate location-dependent ionization of carboxyl groups in NF polyamide films. Specifically, only surface carboxyl groups ionize under neutral pH, whereas interior carboxyl ionization requires pH >9. Conversely, amine ionization behaves invariably across the film. First-principles simulations reveal that the low permittivity of nanoconfined water drives the anomalous carboxyl ionization behavior. Furthermore, we report that interior carboxyl ionization could improve the water–salt permselectivity of NF membranes over fourfold, suggesting that interior charge density could be an important tool to enhance the selectivity of polyamide membranes. Our findings highlight the influence of nanoconfinement on membrane transport properties and provide enhanced fundamental understanding of ionization that could enable novel membrane design.

scholarly journals Recycling of Reverse Osmosis Concentrates to the Membrane Bioreactor in the MBR-RO Process for Water Reuse: effect on mbr performances

2017 ◽  
Vol 30 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Thi Thu Nga Vu ◽  
Manon Montaner ◽  
Christelle Guigui
Keyword(s):  
Organic Matter ◽  
Reverse Osmosis ◽  
Membrane Fouling ◽  
Water Reuse ◽  
High Performance ◽  
Membrane Bioreactor ◽  
Membrane System ◽  
Size Exclusion ◽  
Ro Concentrate ◽  
The Impact

Wastewater effluents can be treated by an integrated membrane system combining membrane bioreactor (MBR) and reverse osmosis (RO) for effective removal of micropollutants in the field of high-quality water reuse. However, discharging the RO concentrate waste stream directly into the natural environment could lead to serious problems due to the toxic components contained in the concentrates (micropollutants, salts, organic matter). A possible solution could be the recirculation of RO concentrate waste to the MBR. However, such an operation should be studied in detail since the recirculation of non-biodegradable organic matter or high concentrations of salts and micropollutants could directly or indirectly contribute to MBR membrane fouling and modification of the biodegradation activity. In this context, the work reported here focused on the recirculation of such concentrates in an MBR, paying specific attention to MBR membrane fouling. Lab-scale experiments were performed on a continuous MBR-RO treatment line with RO concentrate recirculation. The main goal was to determine the recovery of the RO unit and of the global process that maintained good process performance in terms of biodegradation and MBR fouling. The results demonstrate that the impact of the toxic flow on activated sludge depends on the recovery of the RO step but the same trends were observed regardless of the organic matter and salt contents of the concentrates: the concentration of proteins increased slightly. Size-exclusion high performance liquid chromatography (HPLC-SEC) was employed to study the effects of RO concentrate on the production of protein-like soluble microbial products (SMPs) and demonstrated a significant peak of protein-like substances corresponding to 10-100 kDa and 100-1 000 kDa molecules in the supernatant. Thus a significant increase in the propensity for sludge fouling was observed, which could be attributed to the increased quantity of protein-like substances. Finally, the effect of the concentrate on sludge activity was studied and no significant effect was observed on biodegradation, indicating that the return of the concentrate to the MBR could be a good alternative.

Critical Review of Early Age Cycling Effects on the Capacity of Pile to Sleeve Grouted Connections As Treated in ISO 19902

2019 ◽  
Author(s):  
Andi Merxhani ◽  
Jacob Fisker Jensen ◽  
Joao Caetano ◽  
Casper Klintø Christiansen
Keyword(s):  
Compressive Strength ◽  
Experimental Evidence ◽  
Structural Design ◽  
High Performance ◽  
Underlying Mechanism ◽  
Early Age ◽  
Design Code ◽  
Concrete Members ◽  
Jacket Structures ◽  
Shearing Mechanism

Abstract The treatment of early age cyclic loading (EAC) on pile-sleeve grouted connections is one of the challenging problems encountered in the design of offshore jacket structures. ISO 19902 appears to be the only offshore structural design code that quantifies the strength de-rating due to EAC. However, the mechanism of EAC considered in the ISO standard is little understood. Main provision is that the strength reduction due to EAC is considered to be linearly proportional to the compressive strength of the grout. This provision is conservatively applicable for medium strength grouts. However, it is over-conservative when modern high-performance grouts are used, and it can be further argued that it actually loses its physical meaning. Thus, a further investigation into the mechanics of the problem is deemed beneficial in order to understand better its underlying mechanism. Using existing experimental evidence and a simple mechanical model, it is shown that the EAC mechanism considered in ISO 19902 triggers the grout matrix failure mechanism of the grouted connections. This behavior is characteristic of segregating grout materials. The benefit of the approach followed is that it links the interpretation of EAC to the grout material properties. The phenomenon is then understood using methods and experimental results that are well established in concrete mechanics. After a comparison with existing experimental evidence on grouted connections and concrete members, it is suggested that the strength drop for the specific shearing mechanism is independent of the uniaxial compressive strength of the grout material.

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