Mulberry leaf (Morus alba L.): A review of its Potential influences in Mechanisms of Action on Metabolic Diseases

The research has conducted research on the effectiveness of isopropyl myristat as a penetration enhancer on the diffusion rate of whitening cream mulberry leaf extract (Morus alba L) in vitro. This study aims to determine the effect of the use of isopropyl myristat. Mulberry leaf extract cream made with varying concentrations respectively 3%, 4%, 5% Isopropyl myristat as penetration enhancers made into 3 formulas (F1-F4) with the F1 without penetration enhancers. Evaluation of stability before and after accelerated storage includes observation of the organoleptic, emulsion type determination, measurement of pH, and viscosity. The evaluation results indicate four physically stable formula. In vitro diffusion studies conducted by Franz diffusion cells and footage is measured at a wavelength of 367.4 nm. The results of diffusion studies show that formula with the highest diffusion rate of 0.024 µg/minute on F4 (5% isopropyl myristat).

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Anti-Inflammatory Effects of Neochlorogenic Acid Extract from Mulberry Leaf (Morus alba L.) Against LPS-Stimulated Inflammatory Response through Mediating the AMPK/Nrf2 Signaling Pathway in A549 Cells

Molecules ◽

10.3390/molecules25061385 ◽

2020 ◽

Vol 25 (6) ◽

pp. 1385 ◽

Cited By ~ 5

Author(s):

Xiao-han Gao ◽

Sun-dong Zhang ◽

Li-tao Wang ◽

Liang Yu ◽

Xue-lian Zhao ◽

...

Keyword(s):

Inflammatory Response ◽

Signaling Pathway ◽

A549 Cells ◽

Morus Alba ◽

Mulberry Leaf ◽

Tnf Α ◽

Nrf2 Signaling Pathway ◽

Acute Pneumonia ◽

Neochlorogenic Acid ◽

Anti Inflammatory

Neochlorogenic acid (nCGA) is a phenolic compound isolated from mulberry leaf (Morus alba L.), which possesses multiple pharmacological activities containing antioxidant and anti-inflammatory effects. However, the role of nCGA in the treatment of acute pneumonia and the underlying molecular mechanism are still unclear. Hence, the aim of study is to investigate the anti-inflammatory properties of nCGA on LPS-stimulated inflammation in A549 cells. In the present study, results reported that nCGA without cytotoxicity significantly reduced the production of TNF-α, IL-6, and NO, and further suppressed the proteins of iNOS, COX2, TNF-α, IL-6 expression. Furthermore, nCGA also inhibited NF-κB activation and blocked MAPKs signaling pathway phosphorylation. In addition, we found nCGA significantly increased the expression of HO-1 via activating the AMPK/Nrf2 signaling pathway to attenuate the inflammatory response, whereas this protective effect of nCGA was reversed by pre-treatment with compound C (C.C, an AMPK inhibitor). Therefore, all these results indicated that nCGA might act as a natural anti-inflammatory agent for the treatment of acute pneumonia.

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Effect of Mulberry Leaf(Morus alba Linne) Powder Addition on Quality of Yukwa

Journal of the East Asian Society of Dietary Life ◽

10.17495/easdl.2015.8.25.4.643 ◽

2015 ◽

Vol 25 (4) ◽

pp. 643

Author(s):

Jae-Sil Seo

Keyword(s):

Morus Alba ◽

Mulberry Leaf ◽

Powder Addition

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Effect of Morus alba L. Ethanol Leaves Extract on Conjunctivitis Wistar Rats Model by Staphylococcus aureus

Journal of Agromedicine and Medical Sciences ◽

10.19184/ams.v7i1.7299 ◽

2021 ◽

Vol 7 (1) ◽

pp. 1

Author(s):

Gama Wisnu Sanjaya ◽

Cicih Komariah ◽

Dini Agustina

Keyword(s):

Pathogenic Bacteria ◽

Leaf Extract ◽

Clinical Signs ◽

Morus Alba ◽

Control Group ◽

Bacterial Conjunctivitis ◽

Control Group Design ◽

Mulberry Leaf ◽

Mulberry Leaf Extract

Conjunctivitis is inflammation in the conjunctiva, with clinical signs of exudation, cellular infiltration, and vascular dilatation. In adults, Staphylococcus species are the most common pathogenic bacteria resulting in bacterial conjunctivitis. Previous studies in vitro, explaining that mulberry leaf extract can inhibit the growth of S. aureus bacteria. The purpose of this study was to investigate the effect of mulberry leaf ethanol extract (Morus alba L.) on wistar mice conjunctivitis model by S. aureus. This type of research is true experimental with pretest-posttest control group design. The 24-wistar mice were adapted for 7 days. On day 8, a conjunctivitis induction was performed with 1.5 x 108 CFU / ml of S. aureus at 1 drop every 10 minutes for 1 hour (left 3 days) until conjunctivitis . On day 12 until day 19 (7 days), given mulberry leaf extract 45%, 55%, 65% and 75%. The results of TPC S. aureus logarithm on MSA medium of the 11th (pretest) day conjunctival swab and the 17th day (posttest) of rat adaptation were K (-) (5.70 and 4.07); K (+) (5.78 and 3.31); P1 (5.65 and 3.78); P2 (5.63 and 3.82); P3 (5.84 and 3.74); and P4 (5.69 and 3.63), with the posttest group there was improvement in conjunctivitis symptoms rather than the pretest group. The result of One Way Way Anova data analysis showed significant result at pretest p = 0,002 and posttest p = 0,046 (p <0,05) and paired t-test got significant result p = 0,000 (p <0,05). From this study it can be concluded that mulberry leaf extract (Morus alba L.) has the effect of decreasing the number of colonies of S. aureus bacteria and improving symptoms of conjunctivitis. Keywords: mulberry leaf extract, conjunctivitis, S. aureus

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Uji Daya Hambat Formula Gel Ekstrak Etanol Daun Murbei (Morus alba L.) Sebagai Anti Acne Terhadap Bakteri Propionibacterium acne.

Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) ◽

10.22487/j24428744.2019.v5.i2.13663 ◽

2019 ◽

Vol 5 (2) ◽

pp. 206-213

Author(s):

Ahmad Irsyad Aliah ◽

Wahyuni Wahyuni ◽

Nurjannah Bachri

Keyword(s):

Leaf Extract ◽

Ethanol Extract ◽

Bacterial Activity ◽

Morus Alba ◽

Diffusion Method ◽

Clear Zone ◽

Propionibacterium Acne ◽

Mulberry Leaf ◽

Mulberry Leaf Extract ◽

Agar Diffusion Method

A research on the inhibition of formula gel test ethanol extract of leaves of mulberry (Morus alba L.) as an anti-acne against bacteria Propionibacterium acne. This study uses a gel formulation made using mulberry leaf extract (Morus alba L.), which aims to determine the inhibition of antibacterial gel mulberry leaf extract (Morus alba L.) against the bacteria Propionibacterium acne. Gel made three dosage concentrations of 2%, 4% and 6%. Testing inhibition of antibacterial gel agar diffusion method. Test Antibacterial inhibition obtained by looking at the clear zone in the medium and measured using calipers. The results showed that the inhibition of antibacterial gel formulation with a concentration of 2%, 4% and 6% showing that inhibiting bacterial activity.

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Utilization of mulberry leaf meal (Morus alba) as protein supplement in diets for laying hens

Italian Journal of Animal Science ◽

10.4081/ijas.2010.e51 ◽

2010 ◽

Vol 9 (3) ◽

pp. e51 ◽

Cited By ~ 6

Author(s):

Riyadh Al-kirshi ◽

Abdul Razak Alimon ◽

Idrus Zulkifli ◽

Awis Sazili ◽

Mohamed Wan Zahari ◽

...

Keyword(s):

Laying Hens ◽

Morus Alba ◽

Protein Supplement ◽

Leaf Meal ◽

Mulberry Leaf

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KEMAMPUAN DAYA HAMBAT EKSTRAK DAUN MURBEI (Morus alba) TERHADAP PERTUMBUHAN Aspergillus flavus

Jurnal Ilmu dan Teknologi Pangan (ITEPA) ◽

10.24843/itepa.2020.v09.i03.p02 ◽

2020 ◽

Vol 9 (3) ◽

pp. 262

Author(s):

Aditya Yusril Hidayat ◽

Agus Selamet Duniaji ◽

Komang Ayu Nocianitri

Keyword(s):

Aspergillus Flavus ◽

Leaf Extract ◽

Morus Alba ◽

Control Treatment ◽

Strong Inhibition ◽

Extract Concentration ◽

Mulberry Leaf ◽

Mulberry Leaf Extract ◽

Randomized Design ◽

Completely Randomized Design

The aim of this research to determine the ability of mulberry leaf extract (Morus alba) to inhibit the growth of Aspergillus flavus. This research used completely Randomized Design with control treatment (without extract) and treatment of mulberry leaf extract concentration of 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 100%. The experiment were repeated 2 times and resulting in 22 experimental units. The data were presented in descriptive statistic with tables, and figure. The results showed that the extract of mulberry leaf inhibit the growth of Aspergillus flavus with optimal concentration 80% with an average 11.95 mm and strong inhibition categories.

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Effect of Morus alba leaf extract dose on lipid oxidation, microbiological stability, and sensory evaluation of functional liver pâtés during refrigerated storage

PLoS ONE ◽

10.1371/journal.pone.0260030 ◽

2021 ◽

Vol 16 (12) ◽

pp. e0260030

Author(s):

Agnieszka Bilska

Keyword(s):

Leaf Extract ◽

Meat Products ◽

Water Extract ◽

Antioxidant Effect ◽

Morus Alba ◽

Oxidation Products ◽

Mulberry Leaves ◽

Mulberry Leaf ◽

Natural Medicine ◽

Mulberry Leaf Extract

Mulberry (Morus alba L.), and above all the extract from the leaves of this plant, is a natural medicine that has been used in traditional medicine for hundreds of years. Mulberry leaves contains polyphenol compounds: flavonoids, coumarins, numerous phenolic acids, as well as terpenes and steroids. The antioxidant effect of these compounds may be beneficial to the fat fraction of meat products, thereby increasing their functional qualities. The aim of the study was to evaluate the effectiveness of the use of mulberry water leaf extract, as an additive limiting adverse fat changes and affecting the functionality in model liver pâtés. Pork pâtés were prepared by replacing 20% of animal fat with rapeseed oil (RO), and water extract of mulberry leaves was added in the proportion of 0.2%, 0.6% and 1.0%. It has been shown that the addition of mulberry leaf extract delayed the appearance of primary and secondary fat oxidation products. The most effective antioxidant effect during 15-day storage was observed in the sample with the addition of 0.6% and 1.0% water mulberry leaf extract. These samples also showed inhibiting activity against angiotensin-converting enzymes and cholinesterase’s. During storage, the tested pâtés had a high sensory quality with unchanged microbiological quality. Mulberry leaf extract can be an interesting addition to the production of fat meat products, delaying adverse changes in the lipid fraction and increasing the functionality of products.

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