Trends and influencing factors of plasma folate levels in Chinese women at mid-pregnancy, late pregnancy and lactation periods

2020 ◽  
pp. 1-7
Author(s):  
Yu-Bo Zhou ◽  
Ke-Yi Si ◽  
Hong-Tian Li ◽  
Xiu-Cui Li ◽  
Ying Meng ◽  
...  
Keyword(s):  
Late Pregnancy ◽  
Geographic Region ◽  
Northern Region ◽  
Cross Sectional ◽  
Lactating Women ◽  
Folate Concentration ◽  
Folate Status ◽  
Plasma Folate ◽  
South Central ◽  
Pregnancy And Lactation

Abstract Folate status for women during early pregnancy has been investigated, but data for women during mid-pregnancy, late pregnancy or lactation are sparse or lacking. Between May and July 2014, we conducted a cross-sectional study in 1211 pregnant and lactating women from three representative regions in China. Approximately 135 women were enrolled in each stratum by physiological periods (mid-pregnancy, late pregnancy or lactation) and regions (south, central or north). Plasma folate concentrations were measured by microbiological assay. The adjusted medians of folate concentration decreased from 28·8 (interquartile range (IQR) 19·9, 38·2) nmol/l in mid-pregnancy to 18·6 (IQR 13·2, 26·4) nmol/l in late pregnancy, and to 17·0 (IQR 12·3, 22·5) nmol/l in lactation (Pfor trend < 0·001). Overall, lower folate concentrations were more likely to be observed in women residing in the northern region, with younger age, higher pre-pregnancy BMI, lower education or multiparity, and in lactating women who had undergone a Caesarean delivery or who were breastfeeding exclusively. In total, 380 (31·4 %) women had a suboptimal folate status (folate concentration <13·5 nmol/l). Women in late pregnancy and lactating, residing in the northern region, having multiparity and low education level had a higher risk of suboptimal folate status, while those with older age had a lower risk. In conclusion, maternal plasma folate concentrations decreased as pregnancy progressed, and were influenced by geographic region and maternal socio-demographic characteristics. Future studies are warranted to assess the necessity of folic acid supplementation during later pregnancy and lactation especially for women at a higher risk of folate depletion.

scholarly journals CARDIORESPIRATORY AND NEUROMUSCULAR FITNESS OF FEDERAL HIGHWAY POLICE OFFICERS

2018 ◽  
Vol 24 (6) ◽  
pp. 426-431
Author(s):  
Eduardo Frio Marins ◽  
Rodrigo Wiltgen Ferreira ◽  
Fabrício Boscolo Del Vecchio
Keyword(s):  
Upper Limb ◽  
Police Officers ◽  
Geographic Region ◽  
Northern Region ◽  
Patrol Officers ◽  
Level Of Evidence ◽  
Cross Sectional ◽  
Independent Variables ◽  
Federal Highway ◽  
Highway Patrol

ABSTRACT Introduction: Higher levels of physical fitness are associated with better quality of life and indicators of health and performance in police forces. Objective: This study aims to describe and evaluate the level of cardiorespiratory and neuromuscular fitness of a national sample of federal highway patrol officers. Methods: Cross-sectional study with data from 6212 agents of the Federal Highway Police. Endpoints were as follows: abdominal resistance (AR); upper limb muscular resistance (ULMR); upper limb muscle strength (ULMS) and cardiorespiratory fitness (CF). The following independent variables were included: sex; age; geographic region of posting and participation in the Institutional Physical Education Program (IPEP). The linear regression model was used to test the association between endpoints and independent variables. Results: The highest proportion of police officers obtained an excellent score for neuromuscular endpoints (AR: 63.9% men, 69.6% women, ULMR: 68.8% men, 61.8% women, ULMS: 22.2% men, 40% women). In CF, the highest percentage of scores was average and good (respectively, 30.6% and 43.0% for men, 39.1% and 39.2% for women). Male officers were fitter than female officers, except for the ULMS endpoint. There was a decrease in fitness levels for all endpoints according to age. Police officers from the northern region were fitter than in the other regions. Police officers who were not registered in the IPEP were fitter than those registered. Conclusion: Federal Highway Patrol officers have good levels of fitness, which declines with age. Level of Evidence III; Study of nonconsecutive patients; without consistently applied "gold" reference standard.

scholarly journals Folate Deficiency and Anemia Among Women of Reproductive Age (15-49 Years) in Senegal: Results of a National Cross-Sectional Survey

2017 ◽  
Vol 39 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Ndèye Fatou Ndiaye ◽  
Nicole Idohou-Dossou ◽  
Adama Diouf ◽  
Amadou Tidiane Guiro ◽  
Salimata Wade
Keyword(s):  
Rural Women ◽  
Folate Deficiency ◽  
Reproductive Age ◽  
Cluster Sampling ◽  
Protein Markers ◽  
Women Of Reproductive Age ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Folate Concentration ◽  
Plasma Folate

Background: Widely spread throughout the world, folate and iron deficiencies are risk factors for many diseases. However, contrary to iron deficiency and anemia, which have been documented in depth, the prevalence of folate deficiency among women has not been well-studied. Objective: The aim of this study is to determine the prevalence of folate deficiency and anemia and their association among Senegalese women of reproductive age. Methods: A national cross-sectional survey using a stratified 2-stage cluster sampling was conducted. Data were collected from 1012 women (aged 15-49 years). Plasma folate and hemoglobin (Hb), as well as protein markers of subclinical infections, were equally measured. Results: The mean folate concentration was 8.50 nmol/L (8.16-8.85 nmol/L), and 54.8% of the women were folate deficient (<10 nmol/L). Plasma folate concentration of rural women (7.27 nmol/L [6.89-7.68 nmol/L]) and urban women (10.45 nmol/L [9.88-11.05 nmol/L]) was significantly different ( P < .0001), the highest concentration being observed in women living in Dakar, the capital of Senegal. The breastfeeding women showed lower plasma folate concentration compared to nonbreastfeeding ones: 6.97 nmol/L (6.37-7.63 nmol/L) versus 9.03 nmol/L (8.61-9.46 nmol/L). Overall, 27% of the women were suffering from inflammation/infections. Mean Hb concentration was 116.86 (1.18) g/L, and 47.63% of the women involved in the study were anemic (pregnant women Hb <110 g/L; nonpregnant Hb <120 g/L). Also, a positive and significant correlation was found between plasma folate and Hb concentrations ( r = .07; P = .0167). Conclusions: This study showed a high prevalence of folate deficiency and anemia among Senegalese women (15-49 years), particularly those living in rural settings and breastfeeding women.

scholarly journals Dietary pattern and nutritional status among lactating women in North Karnataka

2020 ◽  
Vol 7 (5) ◽  
pp. 1875
Author(s):  
Antoney Unni Xavier ◽  
Amgiasvasanth A. M.
Keyword(s):  
Nutritional Status ◽  
Low Income ◽  
Cross Sectional Study ◽  
Dietary Intakes ◽  
Cross Sectional ◽  
Socioeconomic Condition ◽  
Lactating Women ◽  
Low Socioeconomic ◽  
Lactating Mothers ◽  
Pregnancy And Lactation

Background: Women from low-income settings are considered as nutritionally vulnerable. This risk is augmented during pregnancy and lactation as food nutrient requirement increases. Lactating mothers are subjected to nutritional stresses which are further exaggerated by frequent pregnancies resulting in high maternal mortality and health risk for children. Attainment of millennium development goals (MDG) by our country is largely dependent on the health of mothers and children, which in turn is influenced by diet. Objective of this study was to assess the nutritional status and associated factors of lactating women. To assess diet pattern of lactating womenMethods: Cross-sectional study carried out for a period of three month by house to house visit in the urban field practice area of SDMCMSH, Dharwad. Taking prevalence of malnutrition among lactating mothers (15-49 years) as 50, sample size was calculated to be 100 using n=4pq/d×d. Data analysed using the IBMSPSS 20.0.Results: Majority of mothers were housewives and in the age group of 20-25 year. >80% of the participants did not take additional meals during lactation. >60% of women from low socioeconomic state were malnourished and >55% of women from high socioeconomic state but working is malnourished.Conclusions: Dietary intakes of the lactating women are insufficient compared to national recommendations. Low socioeconomic condition and working status of mother are important predictors of malnourishment. Effective nutritional education of families and communities is recommended to improve dietary practices and result in adequate nutrition. 

scholarly journals Serum folate status among blood donors in south-central China

2021 ◽  
Author(s):  
Yan Ma ◽  
Huan Deng ◽  
Mingdi He ◽  
Ru Yang ◽  
Gang Shen
Keyword(s):  
Alcohol Consumption ◽  
Blood Donors ◽  
Vegetable Consumption ◽  
Fruit And Vegetable Consumption ◽  
Central China ◽  
Serum Folate ◽  
Fruit And Vegetable ◽  
Folate Concentration ◽  
Folate Status ◽  
South Central

Folate deficiency has been confirmed to be related to various diseases. Unfortunately, there are few reports on the folate status of Chinese adults. This study aims to evaluate the serum folate status of blood donors in south-central China. In this study, 248 blood donors were included. The information on subjects was collected by a brief questionnaire concerning alcohol consumption habits, smoking habits, fruit and vegetable consumption and physical activity. The serum folate concentration was measured by electrochemiluminescence immunoassay. The geometric mean serum folate concentration was 13.4[Formula: see text]nmol[Formula: see text]l[Formula: see text] (95% CI, 12.7–14.1). The prevalence of serum folate concentrations below 6.8[Formula: see text]nmol[Formula: see text]l[Formula: see text] was 5.2% (95% CI, 2.5–8.0). There were significant differences in serum folate concentrations with respect to sex ([Formula: see text]-values [Formula: see text] 0.05), age ([Formula: see text]-values [Formula: see text] 0.05), fruit and vegetable consumption ([Formula: see text]-values [Formula: see text] 0.05), and alcohol consumption habits ([Formula: see text]-values [Formula: see text] 0.05). The concentration of serum folate increased with age ([Formula: see text]-values [Formula: see text] 0.05) and fruit and vegetable consumption ([Formula: see text]-values [Formula: see text] 0.05). Individuals with an age of 30 years or younger were nearly 3.5 times as likely as those aged over 30 years to have an insufficient level of serum folate (OR = 3.48; 95% CI: 1.01–11.99). An age of 30 years or younger was a risk factor for folate deficiency. Most blood donors had sufficient serum folate concentrations in south-central China. National surveys of folate status should be implemented in China.

scholarly journals Medication Use During Pregnancy and Lactation in a Dutch Population

2018 ◽  
Vol 35 (1) ◽  
pp. 154-164 ◽  
Author(s):  
Marita de Waard ◽  
Birgit S. Blomjous ◽  
Marinka L. F. Hol ◽  
Sintha D. Sie ◽  
Willemijn E. Corpeleijn ◽  
...  
Keyword(s):  
Healthcare Providers ◽  
Medication Use ◽  
Information Service ◽  
Structured Interview ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Lactating Women ◽  
Unknown Risk ◽  
Tertiary Center ◽  
Pregnancy And Lactation

Background: Medication use during pregnancy and lactation can be unavoidable, but knowledge on safety for the fetus or breastfed infant is limited among patients and healthcare providers. Research aim: This study aimed to determine (a) the prevalence of medication use in pregnant and lactating women in a tertiary academic center, (b) the types and safety of these medicines, and (c) the influence of medication use on initiation of breastfeeding. Methods: This study used a cross-sectional survey among women ( N = 292) who underwent high-risk or low-risk deliveries. Data about their use of prescribed, over-the-counter, and homeopathic medication during pregnancy were obtained through a structured interview, followed by a questionnaire during lactation. Safety was classified according to the risk classification system from the Dutch Teratological Information Service. Results: Overall, 95.5% of participants used medication. One third of participants used at least one medicine with an unknown risk for the fetus. Teratogenic medication was used by 6.5% of participants, whereas 29.5% used medication with a (suspected) pharmacological effect on the fetus. Lactation was initiated by 258 (88.7%) participants, of which 84.2% used medication while breastfeeding. In 3.8% of participants, this medication was classified unsafe, but none used medication with an unknown risk. One-third of the nonlactating participants decided not to initiate breastfeeding because of medication use. In 70% of participants, this decision was appropriate. Conclusion: The prevalence of overall use of medication in Dutch pregnant and lactating women admitted to a tertiary center was high. There is an urgent need for pharmacometric studies for determination of the safe use of the most frequently used medicines during pregnancy or lactation.

scholarly journals Folate Intake and Markers of Folate Status in Women of Reproductive Age, Pregnant and Lactating Women: A Meta-Analysis

2012 ◽  
Vol 2012 ◽  
pp. 1-13 ◽  
Author(s):  
Cristiana Berti ◽  
Katalin Fekete ◽  
Carla Dullemeijer ◽  
Monica Trovato ◽  
Olga W. Souverein ◽  
...  
Keyword(s):  
Blood Cell ◽  
Dose Response ◽  
Red Blood Cell ◽  
Meta Analysis ◽  
Plasma Homocysteine ◽  
Folate Intake ◽  
Childbearing Age ◽  
Lactating Women ◽  
Folate Status ◽  
Plasma Folate

Background. Pregnant and breastfeeding women are at risk for folate deficiency. Folate supplementation has been shown to be associated with enhanced markers of folate status. However, dose-response analyses for adult women are still lacking.Objective. To assess the dose-response relationship between total folate intake (folic acidplusdietary folate) and markers of folate status (plasma/serum folate, red blood cell folate, and plasma homocysteine); to evaluate potential differences between women in childbearing age, pregnant and lactating women.Methods. Electronic literature searches were carried out on three databases until February 2010. The overall pooled regression coefficient (β) and SE(β) were calculated using meta-analysis on a double-log scale.Results. The majority of data was based on nonpregnant, nonlactating women in childbearingage. The pooled estimate of the relationship between folate intake and serum/plasma folate was 0.56 (95% CI = 0.40–0.72,P<0.00001); that is, the doubling of folate intake increases the folate level in serum/plasma by 47%. For red blood cell folate, the pooled-effect estimate was 0.30 (95% CI = 0.22–0.38,P<0.00001), that is, +23% for doubling intake. For plasma-homocysteine it was –0.10 (95% = –0.17 to –0.04,P=0.001), that is, –7% for doubling the intake. Associations tended to be weaker in pregnant and lactating women.Conclusion. Significant relationships between folate intake and serum/plasma folate, red blood cell folate, and plasma homocysteine were quantified. This dose-response methodology may be applied for setting requirements for women in childbearing age, as well as for pregnant and lactating women.

Association between tea drinking and plasma folate concentration among women aged 18–30 years in China

2020 ◽  
pp. 1-8
Author(s):  
Xiaoqian Jia ◽  
Mengyuan Ren ◽  
Yali Zhang ◽  
Rongwei Ye ◽  
Le Zhang ◽  
...  
Keyword(s):  
Multiple Linear Regression Model ◽  
Positive Association ◽  
Folate Intake ◽  
Tea Consumption ◽  
Cross Sectional ◽  
Folate Concentration ◽  
Plasma Folate ◽  
Han Ethnicity ◽  
Tea Drinking ◽  
The Relationship

Abstract Objective: Association was found between tea and neural tube defects. However, few studies investigated the relationship between tea consumption and blood folate levels. We aimed to investigate the association between tea consumption and plasma folate concentrations among women aged 18–30 years in different ethnicities of China. Design: Data were obtained from a national cross-sectional study conducted from 2005 to 2006 of women aged 18–30 years in China. Socio-demographic characteristics and lifestyle were obtained from a questionnaire. Dietary folate intake was determined by 24-h dietary recall. Plasma folate concentrations were measured by a microbiological assay. Multiple linear regression model was used to calculate partial regression coefficients after adjusting for confounding factors. Setting: Nine provinces or autonomous regions in China. Participants: A total of 2932 women aged 18–30 years in China. Results: After stratifying by ethnicity and tea type, tea consumption was significantly positively associated with plasma folate levels in Han women who drank unfermented tea weekly (β = 0·067, and P = 0·037) or daily (β = 0·119, and P = 0·031) and in Uighur women who drank fermented tea weekly (β = 0·325, and P = 0·028). For women who drank unfermented tea in Han ethnicity, weekly and daily tea drinkers had 6·77 % (95 % CI: 6·36 %, 7·21 %) and 7·13 % (95 % CI: 6·40 %, 7·96 %) increase in plasma folate concentration compared with no tea drinkers. Conclusions: There is a suggestion of possible positive association between unfermented tea drinking in Han ethnicity and plasma folate concentrations, for Chinese women aged 18–30 years. The relationship between tea drinking in other ethnic groups and plasma folate still needs to be further explored.

scholarly journals Community pharmacists’ services for women during pregnancy and breast feeding in Kuwait: a cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (1) ◽  
pp. e018980 ◽  
Author(s):  
Abdullah Albassam ◽  
Abdelmoneim Awad
Keyword(s):  
Breast Feeding ◽  
Self Care ◽  
Community Pharmacists ◽  
Continuing Professional Development ◽  
Education Programme ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Lactating Women ◽  
Pregnancy And Lactation ◽  
In Pregnancy

ObjectivesThis study was designed to identify the services provided by community pharmacists in Kuwait and their views regarding self-care in pregnancy and lactation. In addition, it determined the pharmacists’ recommendations for treatment of pregnancy-related and breast feeding-related ailments.DesignCross-sectional questionnaire-based survey.SettingCommunity pharmacies in Kuwait.Participants207 pharmacies were randomly selected from the Ministry of Health database. One registered pharmacist was approached from each pharmacy. One hundred and ninety-two (92.8%) pharmacists agreed to participate and completed a self-administered questionnaire.OutcomesThe proportions of pharmacists offering particular advice for health conditions in pregnancy and lactation, pharmacists’ recommendations for common and specific ailments during pregnancy and breast feeding, and pharmacists’ views about self-care in pregnancy and breast feeding.ResultsThe top services provided to pregnant and lactating women were recommending vitamins and food supplements (89.8%) and contraception advice (83.4%), respectively. More than half of participants indicated that they would recommend medications for headache, constipation, cough, runny nose, sore throat, nausea/vomiting, indigestion, sore or cracked nipple and insufficient milk. Diarrhoea, haemorrhoids, insomnia, varicose vein, swelling of the feet and legs, vaginal itching, back pain, fever, mastitis and engorgement were frequently referred to the physician. Recommendations on medication use were occasionally inappropriate in terms of unneeded drug therapy, off-label use and safety. In relation to offering advice and solving medication and health problems of pregnant and lactating women, more than half of pharmacists indicated that they have sufficient knowledge (61.5%; 50.5%) and confidence (58.3%; 53.1%), respectively. Most of the respondents (88.5%) agreed that a continuing education programme on this topic would be of value for their practice.ConclusionThe present findings show that respondents had different recommendations for treatment of pregnancy-related and lactation-related ailments; and also highlight the need for interventions, including continuing professional development and revision of the undergraduate pharmacy curriculum.

Nitrogen and phosphorus in the Vistula River, Poland -- changes from source to mouth

1994 ◽  
Vol 30 (5) ◽  
pp. 177-186 ◽  
Author(s):  
Karin Sundblad ◽  
Andrzej Tonderski ◽  
Jacek Rulewski
Keyword(s):  
Central Region ◽  
Northern Region ◽  
Point Sources ◽  
Nutrient Loss ◽  
Phosphorus Concentration ◽  
Nitrogen And Phosphorus ◽  
Concentration Data ◽  
Diffuse Sources ◽  
Vistula River ◽  
South Central

Nitrogen and phosphorus concentration data representing samples collected once a month for nine months at 13 locations along the Vistula River are considered in a preliminary discussion of the sources of the nutrients transported to the Baltic Sea. Concentrations in relation to flow data indicated substantial differences between subbasins. Based on those differences, on the area-specific nutrient loss for a six-month period and on the wastewater discharge in each subbasin, four regions could be recognized in the river basin: i) the southern region with a large impact of point sources, ii) the south central region, where diffuse sources seemed to be of major importance, iii) the north central region with a combined effect of point and diffuse sources, and retention in two reservoirs, iv) the northern region where point sources seemed to be the dominating source, at least for phosphorus. Our results illustrate the importance of differences in phosphorus retention between the basins. Long-term retention along the course of the river, particularly in the two reservoirs, must be estimated to allow proper source apportionment in the Vistula basin. Concentration decreases in the Wloclawek Reservoir varied between 44 and 68% for P, and 11 to 37% for N, in the months with significant retention. In some months, however, concentrations increased, indicating a release of nutrients.

Folate Nutritional Status among Psoriasis Patients not Exposed to Antifolate Drug

2020 ◽  
Vol 16 (4) ◽  
pp. 543-553
Author(s):  
Luciana Y. Tomita ◽  
Andréia C. da Costa ◽  
Solange Andreoni ◽  
Luiza K.M. Oyafuso ◽  
Vânia D’Almeida ◽  
...  
Keyword(s):  
Folic Acid ◽  
Linear Regression ◽  
Multiple Linear Regression Model ◽  
Folate Intake ◽  
Serum Folate ◽  
Linear Regression Models ◽  
Cross Sectional ◽  
Folic Acid Fortification ◽  
Plasma Folate ◽  
Psoriasis Severity

Background: Folic acid fortification program has been established to prevent tube defects. However, concern has been raised among patients using anti-folate drug, i.e. psoriatic patients, a common, chronic, autoimmune inflammatory skin disease associated with obesity and smoking. Objective: To investigate dietary and circulating folate, vitamin B12 (B12) and homocysteine (hcy) in psoriatic subjects exposed to the national mandatory folic acid fortification program. Methods: Cross-sectional study using the Food Frequency Questionnaire, plasma folate, B12, hcy and psoriasis severity using the Psoriasis Area and Severity Index score. Median, interquartile ranges (IQRs) and linear regression models were conducted to investigate factors associated with plasma folate, B12 and hcy. Results: 82 (73%) mild psoriasis, 18 (16%) moderate and 12 (11%) severe psoriasis. 58% female, 61% non-white, 31% former smokers, and 20% current smokers. Median (IQRs) were 51 (40, 60) years. Only 32% reached the Estimated Average Requirement of folate intake. Folate and B12 deficiencies were observed in 9% and 6% of the blood sample respectively, but hyperhomocysteinaemia in 21%. Severity of psoriasis was negatively correlated with folate and B12 concentrations. In a multiple linear regression model, folate intake contributed positively to 14% of serum folate, and negative predictors were psoriasis severity, smoking habits and saturated fatty acid explaining 29% of circulating folate. Conclusion: Only one third reached dietary intake of folate, but deficiencies of folate and B12 were low. Psoriasis severity was negatively correlated with circulating folate and B12. Stopping smoking and a folate rich diet may be important targets for managing psoriasis.

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