Use of soluble glass boluses containing Cu, Co and Se in the prevention of trace-element deficiencies in goats

1988 ◽  
Vol 110 (1) ◽  
pp. 155-158 ◽  
Author(s):  
G. P. Zervas
Keyword(s):  
Trace Elements ◽  
Vitamin B12 ◽  
Trace Element ◽  
Serum Vitamin ◽  
Experimental Period ◽  
The Other ◽  
Blood Samples ◽  
The Third ◽  
Soluble Glass ◽  
Plasma Copper

SummaryTwo experiments were carried out to examine the value of copper, cobalt and selenium contained in soluble glass boluses as a means of providing supplementary trace elements to goats.In the first experiment 36 purebred Toggenburg goats were used and divided into two groups. One group was treated with soluble glass boluses while the other was left as control.In the second experiment 46 Saanen half-bred goats were used, divided into three groups. The first group was treated with soluble glass boluses, the second was treated with selenium injectable compound and the third was left as control.Blood samples were collected on four occasions, during an experimental period of almost 12 months and plasma copper, serum vitamin B12 and blood selenium concentrations were determined. All those measurements showed significant increases for about a year, and were due to treatment. The advantages of glass boluses were not shared by the selenium injectable compound.

Marginal deficiencies of cobalt and selenium in weaner sheep: response to supplementation

1990 ◽  
Vol 30 (3) ◽  
pp. 337 ◽  
Author(s):  
DG Masters ◽  
DW Peter
Keyword(s):  
Trace Elements ◽  
Vitamin B12 ◽  
Treatment Effects ◽  
Experimental Period ◽  
Single Element ◽  
Selenium Status ◽  
Significant Treatment ◽  
Wool Growth ◽  
Soluble Glass ◽  
Grazing Sheep

Five groups of 30 weaner wethers were given (i) no treatment, or a supplement of either (ii) copper (injection), (iii) cobalt (intraruminal pellet), (iv) selenium (intraruminal pellet) or (v) copper, cobalt plus selenium (intraruminal, soluble glass bolus). Liveweight, wool growth and indicators of copper, cobalt and selenium status were measured over a 54-week experimental period. The provision of all 3 elements resulted in a 180 g increase (P<0.05) in clean wool growth relative to controls. With selenium or cobalt alone there was a trend towards increases in clean wool, whereas wool growth of copper treated sheep was identical to the controls. There were no persistent or significant treatment effects on liveweight. The results indicate that both wool and liveweight changes should be used to assess responses to trace elements and show that combined deficiencies, not detectable in experiments using single element supplements, may depress productivity in grazing sheep. Glass boluses were an effective method of providing selenium and raised selenium in liver and plasma for 54 weeks. Selenium pellets resulted in smaller, less persistent increases in these tissues. Glass boluses were less effective than cobalt pellets in providing cobalt and resulted in only a small increase in vitamin B12 at 26 weeks (P=0.1), compared with increases due to cobalt pellets at both 26 and 54 weeks (P<0.05).

The effect of a zinc, cobalt and selenium soluble glass bolus on the trace element status of extensively grazed sheep over winter

2001 ◽  
Vol 73 (1) ◽  
pp. 163-169 ◽  
Author(s):  
N. R. Kendall ◽  
D. W. Jackson ◽  
A. M. Mackenzie ◽  
D. V. Illingworth ◽  
I. M. Gill ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Glutathione Peroxidase ◽  
Trace Element ◽  
Serum Vitamin ◽  
Vitamin B ◽  
Ewe Lambs ◽  
Copper Status ◽  
Soluble Glass ◽  
Erythrocyte Superoxide Dismutase ◽  
Plasma Copper

AbstractThe effects of trace element deficiencies in lambs, particularly zinc, copper, cobalt and selenium, include decreased growth rates and increased mortality. However, trace element supplementation of sheep reared under extensive conditions has several logistical problems.Two trials were designed to investigate the effect of a zinc, cobalt and selenium soluble glass bolus on the trace element status of out-wintered ewe lambs. In trial 1 600 8-month-old ewe lambs (500 Scottish Blackface and 100 North Country Cheviots) were allocated to two treatment groups; 300 were treated with a zinc, cobalt and selenium soluble glass bolus (zinc) and 300 were untreated (control). In trial 2, 315 8-month-old Scottish Blackface ewe lambs were allocated to three treatments: 105 were treated with the zinc, cobalt and selenium soluble glass bolus (zinc), 105 were treated with a copper, cobalt and selenium soluble glass bolus (copper) and the remaining 105 were untreated (control). Blood samples were collected immediately prior to giving boluses and again after approximately 4 months. These were assessed for zinc (plasma zinc concentration), cobalt (serum vitamin B12concentration), selenium (erythrocyte glutathione peroxidase activity) and copper status (plasma copper concentration, caeruloplasmin, amine oxidase and superoxide dismutase activity and calculation of the ratio between the caeruloplasmin and plasma copper).The zinc bolus in both trials significantly increased the plasma zinc concentrations (P< 0·001 andP< 0·01 respectively), erythrocyte glutathione peroxidase activities (P< 0·001) and serum vitamin B12concentrations (P< 0·001). The copper bolus also significantly increased the erythrocyte glutathione peroxidase activities (P< 0·001) and serum vitamin B12concentrations (P< 0·001) when compared with the controls but were not significantly different from the zinc group. The copper bolus significantly increased all of the copper status indicators (P< 0·01) when compared with the control and zinc groups. However, in trial 1 when only the zinc and control groups were compared, the zinc bolus significantly increased the ratio (P< 0·001) and serum caeruloplasmin (P< 0·001) and erythrocyte superoxide dismutase (P< 0·01) activities. These responses were not observed in trial 2 with the erythrocyte superoxide dismutase being significantly reduced in the zinc group when compared with the control group (P< 0·001).The zinc, cobalt and selenium soluble glass bolus increased the status of all three trace elements consistently for a period of at least 100 days. The increases of cobalt and selenium status were similar to those achieved using the copper, cobalt and selenium bolus, which also increased the copper status of the sheep.

Effect of suckling during early lactation and changeover to machine milking on plasma oxytocin and cortisol levels and milking characteristics in Holstein cows

1995 ◽  
Vol 62 (2) ◽  
pp. 249-256 ◽  
Author(s):  
Vladimír Tančin ◽  
L'Ubomír Harcek ◽  
Ján Brouček ◽  
Michal Uhrinčať ◽  
Štefan Mihina
Keyword(s):  
Milk Yield ◽  
Flow Rate ◽  
Plasma Concentrations ◽  
The Other ◽  
Early Lactation ◽  
Flow Rates ◽  
Blood Samples ◽  
Machine Milking ◽  
The Third ◽  
Oxytocin Release

SUMMARYPlasma concentrations of oxytocin and cortisol, and milk yield and flow rates, were compared in three primiparous cows and two cows in their second lactation during suckling and subsequent machine milking. After calving, cows suckled their calves for 3–4 weeks and then the experiment was carried out over 4 d. Blood samples were taken prior to, during and after suckling or evening machine milking (EMM) on day 1 of the experiment (the last day of suckling), day 2 (first EMM) and day 4 (third EMM). After weaning and rehousing, cows were machine milked twice daily. During the first EMM, average milk yield and flow rate in the second minute of milking were significantly lower (P < 0·05) than corresponding values for the other 2 d. Plasma oxytocin concentrations were lower during the first than during the third EMM (P < 0·001) and suckling (P < 0·001), and more oxytocin was released during the third EMM than during suckling (P < 0·01). Cortisol concentrations were higher during and after the first EMM than during the third EMM. Thus in cows sucked for several weeks after calving and then separated from their calves and rehoused we found a transient decrease in oxytocin release, milk yield and flow rates during the first machine milking.

scholarly journals Cobalamin (vitamin B12) and B12 binding proteins in hypereosinophilic syndromes and secondary eosinophilia

Blood ◽  
1984 ◽  
Vol 63 (4) ◽  
pp. 779-783
Author(s):  
J Zittoun ◽  
JP Farcet ◽  
J Marquet ◽  
C Sultan ◽  
R Zittoun
Keyword(s):  
Vitamin B12 ◽  
Binding Proteins ◽  
Binding Capacity ◽  
Hypereosinophilic Syndrome ◽  
Elevated Serum ◽  
Serum Vitamin ◽  
Myeloproliferative Disorders ◽  
The Other ◽  
Intracellular Content ◽  
Eosinophil Counts

Serum cobalamin (vitamin B12) and unsaturated B12 binding capacity (UBBC) have been measured in 24 cases of hypereosinophilia: 16 were cases of hypereosinophilic syndrome (HES) and 8 of secondary eosinophilia. The two groups were similar with respect to absolute eosinophil counts. Serum cobalamin and UBBC were found to be markedly increased in most cases of HES and normal in secondary eosinophilia. This elevation of UBBC was mainly related to the increase of R binders (transcobalamins I and III). The elevated serum cobalamin and R binders in HES were due neither to a higher intracellular content of R binders nor to an increased release of these binders from eosinophils of HES. Pure fractions of eosinophils obtained from HES and secondary eosinophilia did not exhibit any difference in vitamin B12 binders. On the other hand, neutrophil-rich fractions from the same patients showed a higher content of intracellular B12 binding proteins than pure eosinophil fractions, irrespective of the cause of eosinophilia. These findings suggest that the increased serum vitamin B12 and UBBC could reflect an expanded pool of both eosinophils and neutrophils in HES and, thus, provide an additional argument for the inclusion of this syndrome in the group of myeloproliferative disorders.

scholarly journals Effect of cobalt supplementation on lamb growth rates in the face of cobalt deficiency

2020 ◽  
Vol 8 (2) ◽  
pp. e001099
Author(s):  
Kim Hamer ◽  
Hannah Mylin ◽  
Donald Barrie ◽  
Valentina Busin ◽  
Katharine Denholm
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Blood Sample ◽  
Growth Rates ◽  
Selenium Deficiency ◽  
Blood Samples ◽  
The Face ◽  
Cobalt Deficiency ◽  
Lamb Growth

A hill farm in eastern Scotland had noted poor lamb growth rates since 2014. Cobalt, selenium and copper deficiencies were reported from historical blood sample results, and trace element supplementation had been administered to the ewes, but not the lambs. A supplementation trial was undertaken in 2018 to compare the daily liveweight gain (DLWG) between lambs supplemented with trace elements and unsupplemented lambs. The trace element supplements used were intraruminal boluses containing 51-mg cobalt, 10-mg selenium and 60-mg iodine (Downland Essential Lamb bolus, Downland). Blood samples taken two months postsupplementation showed that unsupplemented lambs had cobalt-deficient status, but not selenium deficiency. Lambs supplemented with the trace element boluses had an increase in DLWG of 49 g/day compared with unsupplemented lambs. This case confirms that cobalt supplementation on deficient farms can be associated with a significant improvement in growth rates of growing lambs on Scottish hill farms.

scholarly journals Trace Metal Distribution in Sulfide Minerals from Ultramafic-Hosted Hydrothermal Systems: Examples from the Kairei Vent Field, Central Indian Ridge

Minerals ◽  
2018 ◽  
Vol 8 (11) ◽  
pp. 526 ◽  
Author(s):  
Yejian Wang ◽  
Xiqiu Han ◽  
Sven Petersen ◽  
Matthias Frische ◽  
Zhongyan Qiu ◽  
...  
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
Massive Sulfide ◽  
Sulfide Minerals ◽  
Hydrothermal Systems ◽  
The Other ◽  
Central Indian Ridge ◽  
Sulfide Deposits ◽  
High Concentrations ◽  
Seafloor Massive Sulfide

The ultramafic-hosted Kairei vent field is located at 25°19′ S, 70°02′ E, towards the Northern end of segment 1 of the Central Indian Ridge (CIR-S1) at a water depth of ~2450 m. This study aims to investigate the distribution of trace elements among sulfide minerals of differing textures and to examine the possible factors controlling the trace element distribution in those minerals using LA-ICP-MS spot and line scan analyses. Our results show that there are distinct systematic differences in trace element distributions throughout the different minerals, as follows: (1) pyrite is divided into three types at Kairei, including early-stage euhedral pyrite (py-I), sub-euhedral pyrite (py-II), and colloform pyrite (py-III). Pyrite is generally enriched with Mo, Au, As, Tl, Mn, and U. Pyrite-I has high contents of Se, Te, Bi, and Ni when compared to the other types; py-II is enriched in Au relative to py-I and py-III, but poor in Ni; py-III is enriched in Mo, Pb, and U but is poor in Se, Te, Bi, and Au relative to py-I and py-II. Variations in the concentrations of Se, Te, and Bi in pyrite are most likely governed by the strong temperature gradient. There is generally a lower concentration of nickel than Co in pyrite, indicating that our samples precipitated at high temperatures, whereas the extreme Co enrichment is likely from a magmatic heat source combined with an influence of serpentinization reactions. (2) Chalcopyrite is characterized by high concentrations of Co, Se, and Te. The abundance of Se and Te in chalcopyrite over the other minerals is interpreted to have been caused by the high solubilities of Se and Te in the chalcopyrite lattice at high temperatures. The concentrations of Sb, As, and Au are relatively low in chalcopyrite from the Kairei vent field. (3) Sphalerite from Zn-rich chimneys is characterized by high concentrations of Sn, Co, Ga, Ge, Ag, Pb, Sb, As, and Cd, but is depleted in Se, Te, Bi, Mo, Au, Ni, Tl, Mn, Ba, V, and U in comparison with the other minerals. The high concentrations of Cd and Co are likely caused by the substitution of Cd2+ and Co2+ for Zn2+ in sphalerite. A high concentration of Pb accompanied by a high Ag concentration in sphalerite indicates that Ag occurs as Pb–Ag sulfosalts. Gold is generally low in sphalerite and strongly correlates with Pb, suggesting its presence in microinclusions of galena. The strong correlation of As with Ge in sphalerite from Kairei suggests that they might precipitate at medium temperatures and under moderately reduced conditions. (4) Bornite–digenite has very low concentrations of most trace elements, except for Co, Se, and Bi. Serpentinization in ultramafic-hosted hydrothermal systems might play an important role in Au enrichment in pyrite with low As contents. Compared to felsic-hosted seafloor massive sulfide deposits, sulfide minerals from ultramafic-hosted deposits show higher concentrations of Se and Te, but lower As, Sb, and Au concentrations, the latter often attributed to the contribution of magmatic volatiles. As with typical ultramafic-hosted seafloor massive sulfide deposits, Se enrichment in chalcopyrite from Kairei indicates that the primary factor that controls the Se enrichment is temperature-controlled mobility in vent fluids.

scholarly journals Measurement of Nutritional and Inflammatory Biomarkers in Dry Plasma Spots (DPS) (P10-097-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Neal Craft ◽  
Francisco Arredondo ◽  
Matthew Fleshman ◽  
Eleanor Brindle ◽  
Lorraine Lillis ◽  
...  
Keyword(s):  
Vitamin B12 ◽  
Storage Temperature ◽  
Nutritional Assessment ◽  
Serum Vitamin ◽  
Temperature Stability ◽  
Retinol Binding Protein ◽  
Blood Samples ◽  
Reactive Protein ◽  
Funding Sources ◽  
Gates Foundation

Abstract Objectives Conduct time and temperature stability experiments on Nutritional Biomarkers (NBs) and inflammation markers extracted from ViveBio Dry Plasma Spots (DPS). Methods Blood samples of 3 hematocrits (20, 30 and 45%) were created by combining purchased red blood cells (RBC) and sera. Blood samples of 35 µL were loaded onto ViveBio plasma separators. The underlying pads with plasma were stored at 45°, 23°, 4°, -20° and -70°C. Samples were tested on days 0, 1, 3, 7, 14, 28, 84 and 168. Ferritin, Retinol Binding Protein (RBP4), soluble Transferrin Receptors (sTfR), Thyroglobulin (Tg), α-acid Glycoprotein (AGP), and C-Reactive Protein (CRP) were measured using the Quansys Biosciences, Q-Plex Micronutrient Array (Q-Plex). Values measured in the liquid sera were used as reference values for the DPS. Red blood cell (RBC) folates and serum vitamin B12 were measured using a 96 well plate microbiological assay (ALPCO-Immundiagnostik AG). 25OH-Vitamin D3, Retinol, Methylmalonic acid (MMA) and Homocysteine (HCY) were measured using LC-MS/MS. The Q-Plex was compared at 3 independent laboratories using a group of 80 whole blood samples, non-spiked and spiked with AGP, CRP, HRP2 and sTfR. Liquid plasma and extracted plasma from ViveBio pads were generated and stored at -80°C four weeks prior to assay. Results Overall, the measured values for Ferritin, RBP4, Tg, AGP, CRP, 25OH-D, Retinol and MMA decrease with increasing storage temperature and length of storage. Ferritin and Tg exhibited the best stability at 16.8% and 8.0% over a 6 month period. Vitamin B12 exhibited very poor stability declining to below the LOQ within day 3. Most of the NBs at 1 month correlated well with liquid plasma values (r2 = 0.42 to 0.99) (AGP at 23°C, r2 = 0.428; at -70°C r2 = 0.990 Ferritin stored at 23°C, r2 = 0.854; at -70°C r2 = 0.992; Thyroglobulin at 23°C, r2 = 0.916; at -70°C r2 = 0.830). Conclusions We have demonstrated that NBs can be analyzed in low volumes of DPS generated by the ViveBio plasma separator. The Q-Plex performed reproducibly on split samples among 3 labs. These tools offer great potential to improve nutritional assessment in population studies. Funding Sources Funding provided by the Bill and Melinda Gates foundation.

The effect of a copper, cobalt and selenium bolus on fertility and trace element status of dairy cattle.

2001 ◽  
Vol 26 (2) ◽  
pp. 423-427
Author(s):  
A.M. Mackenzie ◽  
M.M Moeini ◽  
S.B. Telfer
Keyword(s):  
Dairy Cattle ◽  
Trace Element ◽  
Slow Release ◽  
Calving Interval ◽  
Normal Range ◽  
Treatment Groups ◽  
Soluble Glass ◽  
Holstein Friesian ◽  
Trace Element Status ◽  
Plasma Copper

AbstractInfertility is one of the manifestations of clinical copper deficiency in dairy cattle that results from high dietary molybdenum intakes. This trial investigated the effects of slow release glass copper, cobalt and selenium boluses (Cosecure) on the number of inseminations required for confirmed pregnancy, calving interval and trace element status in dairy cattle. Sixty Holstein Friesian dairy cattle were allocated to one of two treatment groups, 30 cattle were treated with two soluble glass trace element boluses (Cosecure®,Telsol Ltd.) on day 0 and 169 while the remaining 30 cattle were left untreated (Controls). The cattle were grazed at pasture (day 0 to 165) which has been shown to contain high levels of molybdenum (range from 2.3 to 3.1 mg/kg DM). Blood samples were taken between days 0 and 280 to measure copper and selenium status and the number of inseminations and calving intervals were recorded. The control cattle required significantly more inseminations to confirmed pregnancy compared with the Cosecure treated cattle (2.5 v 1.7 SEmean 0.16, p<0.01) and had a significantly longer calving interval (397 v 372 days, SEmean 9.2, p<0.05). Plasma copper concentrations were significantly higher in the Cosecure treated cattle on days 30, 78 and 135 (p<0.01) compared with the controls, although the controls were all in the normal range (> 12 μmol/l). Cosecure treated cattle had significantly higher glutathione peroxidase (GSHPx) activities on day 246 (P.0.05). However, on all sample dates, the GSHPx activities were in the normal range for both treatment groups (>40units/ml PCV). The dietary cobalt intakes of the cows were measured (1.5 to 2.1 mg/kg DM in grass and 2.1 to 2.7 mg/Kg DM in compound) and found to be well in excess of the requirement of 0.2 mg/Kg DM. It was concluded that treatment with slow release glass copper, cobalt and selenium boluses (Cosecure) reduced the number of inseminations required for conception in the dairy cows due to the slowly released copper.

Trace element and vitamin B12 status of sheep given an oral dose of one, two or four soluble glass pellets containing copper, selenium and cobalt

1988 ◽  
Vol 28 (3) ◽  
pp. 299 ◽  
Author(s):  
GJ Judson ◽  
TH Brown ◽  
BR Kempe ◽  
RK Turnbull
Keyword(s):  
Oral Dose ◽  
Vitamin B12 ◽  
Trace Element ◽  
Copper Toxicity ◽  
Human Consumption ◽  
Retention Period ◽  
Mean Values ◽  
Liver Copper ◽  
Soluble Glass ◽  
The Mean

We investigated the effect of an oral dose of 1, 2 or 4 soluble glass pellets containing cobalt, selenium and copper on the trace element and vitamin B12 status of sheep at pasture. Although the effective life of the pellet was intended to be 1 year, the retention of the pellet in the rumen was sometimes less than 6 months. Despite the apparently short retention period, an oral dose of 1 pellet was sufficient to provide physiologically significant quantities of copper, selenium and vitamin B12 to the animal for at least 45, 32 and 16 weeks respectively. The mean values for untreated sheep and sheep given 1 pellet were respectively 0.49 and 3.11 mmol copper/kg liver (dry matter) at week 45, 1.03 and 1.51 �mol selenium/L blood at week 32, and 1.15 and 1.82 nmol vitamin B12/L plasma at week 16. Sheep of normal copper and selenium status may be at risk of copper toxicity if given an oral dose of 2 or more pellets and of selenium toxicity if given 4 or more pellets at the same time. In sheep dosed with 4 pellets, mean liver copper and selenium concentrations exceeded, for 16 and 8 weeks respectively, the concentrations acceptable for human consumption.

scholarly journals The effects of trace element supplements on blood levels of horses

1980 ◽  
Vol 52 (5) ◽  
pp. 468-476
Author(s):  
Esa Kääntee ◽  
Paavo Kurkela
Keyword(s):  
Trace Elements ◽  
Trace Element ◽  
The Other ◽  
Blood Levels ◽  
Horse Blood

This study concerns the effects of Se, Cu, Co, Mn and Zn supplements on blood levels of Finnish warm-blooded trotters. The results revealed that the blood Se content corresponding to the feed Se content of 0.1 mg/kg is 0.17 ± 0.03 mg/kg in the horse. Blood Se level was directly related to the feed Se content and the other feed trace elements had a similar effect on blood levels.

Sign in / Sign up

Export Citation Format

Share Document