scholarly journals An aetiological study of respiratory infection in children, Edinburgh City Hospital, 1961–1963

1965 ◽  
Vol 63 (2) ◽  
pp. 187-199 ◽  
Author(s):  
G. E. D. Urquhart ◽  
Margaret A. J. Moffat ◽  
Margaret A. Calder ◽  
Gillian M. Cruickshank
Keyword(s):  
Respiratory Infection ◽  
Whooping Cough ◽  
Respiratory Infections ◽  
Serological Response ◽  
City Hospital ◽  
Upper Respiratory Tract ◽  
Respiratory Illnesses ◽  
Number Of Patients ◽  
Homologous Virus ◽  
Upper Respiratory

The findings are described of a combined clinical, bacteriological and virological study which included all children admitted to the City Hospital, Edinburgh, with acute respiratory infection and whooping cough during the winters 1961–62 and 1962–63. During the first winter 131 cases aged 0–12 years and in the second winter 133 aged 0–6 years were examined. The respiratory illnesses were divisible into upper respiratory tract infection, bronchitis, pneumonia, and whooping cough; many of the cases of whooping cough had respiratory complications with bronchitis or pneumonia.Paired sera, a throat swab and a faecal specimen were taken from each child and investigated vircdogically. Over both winters the highest total virus isolation rate was found in the group suffering from upper respiratory disease. Approximately two-thirds of the total number of patients from whom virus was isolated and from whom both acute and convalescent sera were available gave a serological response to the homologous virus; the highest proportion of these patients occurred in the pneumonia and URTI groups. The groups of viruses associated with a fourfold or greater rise in antibodies occurred in the following proportions of the cases: myxovirus 9 %; adeno virus 7 %; entero virus 4 %; herpes simplex 3 %.Bacterial pathogens were isolated from 37 % of patients in 1961–62 and from 49 % in 1962–63,Staph. pyogenesbeing the most common pathogen. Isolation of pneumococci was facilitated during the second year by the examination of a nasal swab. Pre-admission chemotherapy did not significantly alter the bacterial isolation rates. Agglutination studies were carried out on forty clinical cases of whooping cough admitted during the two winters and thirty-two showed significant stable titres toBordetella pertussis; only 9 (18 %) of these cases gave a history of prophylactic immunization.A third of the patients had neither bacterial nor viral pathogens.The findings in this survey illustrate the need for further intensive virological and bacteriological studies of acute respiratory infections in early childhood.

scholarly journals Guide to Leading a Patient with Symptoms of an Acute Respiratory Infection during a Coronavirus Pandemic (COVID-19)

2020 ◽  
Vol 8 (T1) ◽  
pp. 97-102
Author(s):  
Velo Markovski
Keyword(s):  
Respiratory Infection ◽  
Acute Respiratory Infection ◽  
Respiratory Infections ◽  
Diastolic Pressure ◽  
Severe Pneumonia ◽  
High Sensitivity ◽  
Upper Respiratory Tract ◽  
Peripheral Oxygen Saturation ◽  
Radiographic Findings ◽  
Upper Respiratory

BACKGROUND: Over 500 viruses and bacteria primarily cause respiratory infections. During COVID-19 pandemic, these respiratory infections remain; i.e., COVID-19 has no ability to suppress these infections from the circulation. Therefore, it is very important to differentiate respiratory infections from COVID-19. Proving the presence of COVID-19 with polymerase chain reaction (PCR) is not evidence that the disease was caused by this virus. Possible options are: First, a random encounter of the virus in the patient’s upper respiratory tract; second, further possible colonization with a coronavirus (or with COVID-19); the third option is to have an infection; and the fourth possibility is to have a disease or COVID-19 upper respiratory infection. Unfortunately, the method with PCR, although it is with high sensitivity and specificity, does not help us to distinguish which of these four possibilities are in question. AIM: We aimed to present a guide to leading a patient with symptoms of an acute respiratory infection during a coronavirus pandemic (COVID-19). RESULTS: A pandemic of COVID-19 shows that many patients get primary viral pneumonia, but people with normal immune system have no problem recovering. People with reduced immunity die from COVID-19, as opposed to the pandemic influenza virus. It is indirectly concluded that COVID-19 in itself is not very virulent, but it weakens the immunity of those infected who already have some condition and impaired immunity. The available scientific papers show that there is no strong cytokine response, patients have leukopenia and lymphopenia, some patients have a decrease in CD4 T-lymphocytes. From the results of the autopsies available so far, it is clear that there are very few inflammatory cells in the lungs and a lot of fluid domination. Hence, SARS-Cov-2 only somehow speeds up the decline in immunity. The previously published radiographic findings of COVID-19 patients, gave a characteristic findings of the presence of multifocal nodules, described as milky glass, very often localized in the periphery of the lung. Whether it is typical pneumonia, atypical, viral, mixed-type pneumonia, or mycotic pneumonia, it can progress to severe pneumonia. The pneumonia becomes severe when breathing is over 30/min; diastolic pressure below 60 mmHg; low partial oxygen pressure in the blood (PaO2/FiO2 <250 mmHg) (1 mmHg = 0.133 kPa); massive pneumonia, bilateral or multilayered lung X-ray; desorientation; leukopenia; and increased urea. CONCLUSION: Patients with COVID-19 placed in intensive care units should be led by a team of anesthesiologists with an infectious disease specialist or an anesthesiologist with a pulmonologist. Critical respiratory parameters should be peripheral oxygen saturation <90%, PaO2/FiO2 ratio 100 or <100, tachycardia above 110/min.  

scholarly journals The role of the nurse in rational antibioticotherapy

2020 ◽  
pp. 74-74
Author(s):  
V.O. Solodovnik ◽  
A.G. Bashta
Keyword(s):  
Antibiotic Therapy ◽  
Respiratory Infections ◽  
The Elderly ◽  
Route Of Administration ◽  
City Hospital ◽  
Upper Respiratory Tract ◽  
Antimicrobial Drugs ◽  
Rational Therapy ◽  
Upper Respiratory

Objective. A study of the role of the nurse in carrying out rational therapy with the analysis of data of research of treatment of patients on the basis of City Hospital № 21 of Dnipro for 2019. Materials and methods. A study of 50 case histories of patients with infectious diseases of the upper respiratory tract aged 18 to 60 years who required treatment with antibiotics was conducted. Ways and methods of antibiotic therapy were studied. An analysis of the possibilities of the nurse’s influence on antibiotic therapy was performed. Results and discussion. According to the results of the study, it was determined that in 2019 the following drugs were most often used: azithromycin, amoxicillin, ceftriaxone, levofloxacin. The route of administration of antibiotics was distributed according to the following rating: the most commonly used parenteral (intramuscular) route of administration, in second place – oral, in third place – parenteral (intravenous). A stepwise regimen of antibiotics was prescribed in 90 % of cases. The important role of the nurse is determined both in the collection of material for the isolation and study of the pathogen, and in the control and observance of the rules of administration and the algorithm of administration of the antimicrobial drug. Conclusions. The paper covers the role of the nurse in the conduct of rational antibiotic therapy for patients with respiratory infections, noted the features of the appointment of antibiotic therapy in the hospital, ways of drug administration, analysis of treatment results and complications. The issues of rational and safe use of antimicrobial drugs of certain categories of patients – pregnant women, breastfeeding women, the elderly over 60 years – deserve close attention. Particular attention should be paid to the appointment of antibacterial drugs in patients with comorbidities, which should take into account the interaction of various drugs.

scholarly journals HIERARCHIC STRUCTURE OF NASOPHARYNX MICROBIOTIC COMMUNITY IN PATIENTS WITH ACUTE RESPIRATORY INFECTION

2015 ◽  
Author(s):  
S.I. Klymniuk ◽  
L.B. Romaniuk ◽  
O.V. Pokryshko ◽  
M.M. Savchuk ◽  
N.I. Tkachuk ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Respiratory Infection ◽  
Nasal Mucosa ◽  
Acute Respiratory Infection ◽  
Respiratory Infections ◽  
Acute Respiratory Infections ◽  
Upper Respiratory Tract ◽  
Hierarchic Structure ◽  
Upper Respiratory

<p><em>The results of the study of microbiota of nasal mucosa of patients with acute respiratory infections and acute upper respiratory tract pathology are presented. It is revealed that the microbe variety of the nose and nasopharynx forms associations of staphylococci, streptococci, Neisseria, Moraxella, hemophilic bacteria, sometimes Enterobacteriacea and Pseudomonadaceae, mostly of streptococci and staphylococci. Populations of organisms differ in their levels of colonization. The highest values were characteristic for streptococcal community – 7,88 lg CFU/ml. </em></p>

Do Children Who Experience Laryngospasm Have an Increased Risk of Upper Respiratory Tract Infection?

1996 ◽  
Vol 85 (3) ◽  
pp. 475-480. ◽  
Author(s):  
Mark S. Schreiner ◽  
Irene O'Hara ◽  
Dorothea A. Markakis ◽  
George D. Politis
Keyword(s):  
Confidence Interval ◽  
Respiratory Infection ◽  
Odds Ratio ◽  
Signs And Symptoms ◽  
Control Group ◽  
Upper Respiratory Tract ◽  
Upper Respiratory Infection ◽  
Airway Surgery ◽  
Increased Risk ◽  
Upper Respiratory

Background Laryngospasm is the most frequently reported respiratory complication associated with upper respiratory infection and general anesthesia in retrospective studies, but prospective studies have failed to demonstrate any increase in risk. Methods A case-control study was performed to examine whether children with laryngospasm were more likely to have an upper respiratory infection on the day of surgery. The parents of all patients (N = 15,183) who were admitted through the day surgery unit were asked if their child had an active or recent (within 2 weeks of surgery) upper respiratory infection and were questioned about specific signs and symptoms to determine if the child met Tait and Knight's definition of an upper respiratory infection. Control subjects were randomly selected from patients whose surgery had occurred within 1 day of the laryngospasm event. Results Patients who developed laryngospasm (N = 123) were 2.05 times (95% confidence interval 1.21-3.45) more likely to have an active upper respiratory infection as defined by their parents than the 492 patients in the control group (P &lt; or = 0.01). The development of laryngospasm was not related to Tait and Knight's definition for an upper respiratory infection or to recent upper respiratory infection. Children with laryngospasm were more likely to be younger (odds ratio = 0.92, 95% confidence interval 0.87-0.99), to be scheduled for airway surgery (odds ratio = 2.08, 95% confidence interval 1.21-3.59), and to have their anesthesia supervised by a less experienced anesthesiologist (odds ratio = 1.69, 95% confidence interval 1.04-2.7) than children in the control group. Conclusion Laryngospasm was more likely to occur in children with an active upper respiratory infection, children who were younger, children who were undergoing airway surgery, and children whose anesthesia were supervised by less experienced anesthesiologists. Understanding the risk factors and the magnitude of the likely risk should help clinicians make the decision as to whether to anesthetize children with upper respiratory infection.

scholarly journals Viral etiology and epidemiology of pediatric patients hospitalized for acute respiratory tract infections in Macao: a retrospective study from 2014 to 2017

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Cheng Lei ◽  
Lisong Yang ◽  
Cheong Tat Lou ◽  
Fan Yang ◽  
Kin Ian SiTou ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Lower Respiratory Tract ◽  
Respiratory Tract Infections ◽  
Pediatric Patients ◽  
Respiratory Infections ◽  
Upper Respiratory Tract ◽  
Viral Etiology ◽  
Upper Respiratory ◽  
Syncytial Virus ◽  
Tract Infections

Abstract Background Acute respiratory infections (ARIs) are among the leading causes of hospitalization in children. Understanding the local dominant viral etiologies is important to inform infection control practices and clinical management. This study aimed to investigate the viral etiology and epidemiology of respiratory infections among pediatric inpatients in Macao. Methods A retrospective study using electronic health records between 2014 and 2017 at Kiang Wu Hospital was performed. Nasopharyngeal swab specimens were obtained from hospitalized children aged 13 years or younger with respiratory tract diseases. xMAP multiplex assays were employed to detect respiratory agents including 10 respiratory viruses. Data were analyzed to describe the frequency and seasonality. Results Of the 4880 children enrolled in the study, 3767 (77.1%) were positive for at least one of the 13 viral pathogens tested, of which 2707 (55.5%) being male and 2635 (70.0%) under 2 years old. Among the positive results, there were 3091 (82.0%) single infections and 676 (18.0%) multiple infections. The predominant viruses included human rhinovirus/enterovirus (HRV/EV 27.4%), adenovirus (ADV, 15.8%), respiratory syncytial virus B (RSVB, 7.8%) and respiratory syncytial virus A (RSVA, 7.8%). The detection of viral infection was the most prevalent in autumn (960/1176, 81.6%), followed by spring (1095/1406, 77.9%), winter (768/992, 77.4%), and summer (944/1306, 72.3%), with HRV/EV and ADV being most commonly detected throughout the 4 years of study period. The detection rate of viral infection was highest among ARI patients presented with croup (123/141, 87.2%), followed by lower respiratory tract infection (1924/2356, 81.7%) and upper respiratory tract infection (1720/2383, 72.2%). FluA, FluB and ADV were positive factors for upper respiratory tract infections. On the other hand, infection with RSVA, RSVB, PIV3, PIV4, HMPV, and EV/RHV were positively associated with lower respiratory tract infections; and PIV1, PIV2, and PIV3 were positively associated with croup. Conclusions This is the first study in Macao to determine the viral etiology and epidemiology of pediatric patients hospitalized for ARIs. The study findings can contribute to the awareness of pathogen, appropriate preventative measure, accurate diagnosis, and proper clinical management of respiratory viral infections among children in Macao.

Principles of Judicious Use of Antimicrobial Agents for Pediatric Upper Respiratory Tract Infections

PEDIATRICS ◽  
1998 ◽  
Vol 101 (Supplement_1) ◽  
pp. 163-165 ◽  
Author(s):  
Scott F. Dowell ◽  
S. Michael Marcy ◽  
William R. Phillips ◽  
Michael A. Gerber ◽  
Benjamin Schwartz
Keyword(s):  
Respiratory Tract ◽  
Antimicrobial Agents ◽  
Respiratory Infections ◽  
The United States ◽  
Antimicrobial Treatment ◽  
Antimicrobial Use ◽  
Upper Respiratory Tract ◽  
Oral Agents ◽  
Upper Respiratory ◽  
Tract Infections

This article introduces a set of principles to define judicious antimicrobial use for five conditions that account for the majority of outpatient antimicrobial use in the United States. Data from the National Center for Health Statistics indicate that in recent years, approximately three fourths of all outpatient antibiotics have been prescribed for otitis media, sinusitis, bronchitis, pharyngitis, or nonspecific upper respiratory tract infection.1Antimicrobial drug use rates are highest for children1; therefore, the pediatric age group represents the focus for the present guidelines. The evidence-based principles presented here are focused on situations in which antimicrobial therapy could be curtailed without compromising patient care. They are not formulated as comprehensive management strategies. For most upper respiratory infections that require antimicrobial treatment, there are several appropriate oral agents from which to choose. Although the general principles of selecting narrow-spectrum agents with the fewest side effects and lowest cost are important, the principles that follow include few specific antibiotic selection recommendations.

Medical Consultations After Typhoon Haiyan in a Field Hospital in the Philippines

2019 ◽  
Vol 14 (1) ◽  
pp. 34-38
Author(s):  
Julita Gil Cuesta ◽  
Joris Adriaan Frank van Loenhout ◽  
Maria Lourdes de Lara Banquesio ◽  
Masniza Mustaffa ◽  
Debarati Guha-Sapir
Keyword(s):  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
District Hospital ◽  
The Philippines ◽  
Upper Respiratory Tract ◽  
Field Hospital ◽  
Adult Men ◽  
Medical Consultations ◽  
Upper Respiratory ◽  
Tract Infections

ABSTRACTIntroduction and Objectives:Typhoon Haiyan partially destroyed the Ormoc District Hospital in the Philippines. A field hospital was established to replace its outpatient department for 5 weeks. We investigated the reasons for medical consultation in the field hospital.Methods:We described the consultations by sex, age, week, and diagnosis according to the Surveillance in Post-Extreme Emergencies and Disasters system. We compared the number and proportion of upper respiratory tract infections (URTIs) with a control season in 2014.Results:We included 6785 consultations, 55.9% from women. The majority of consultations were communicable diseases (88.2%) followed by noncommunicable (7.1%) and injuries (5.6%). Males suffered more often from injuries than women (66.0% vs 34.0%). Consultations due to injuries decreased from 10.0% in the first to 2.9% in the last week. The most frequent diagnosis over the study period was acute respiratory infections (ARIs) (73.1%), of which 83.0% were children. The number of daily URTIs was higher than in a similar 2014 period.Conclusions:ARI was the most prevalent diagnosis. We recommend ARI treatments being fully accessible after such a disaster. During the first week, injury prevention should focus on adult men. Studies after natural disasters should include control periods to better understand disease distribution, ultimately improving the prioritization in disasters.

Diseases Due to Chlamydiaceae

2013 ◽  
Author(s):  
Walter E Stamm
Keyword(s):  
Sexually Transmitted Diseases ◽  
Respiratory Infections ◽  
Close Contact ◽  
Mammalian Species ◽  
Perinatal Transmission ◽  
Upper Respiratory Tract ◽  
Sexually Transmitted ◽  
Obligate Intracellular ◽  
Upper Respiratory ◽  
Obligate Intracellular Bacteria

The Chlamydiaceae are obligate intracellular bacteria that produce a wide variety of infections in many mammalian and avian species. Three species belonging to two genera of Chlamydiaceae infect humans: Chlamydia trachomatis, Chlamydophila psittaci, and Chlamydophila pneumoniae. C. trachomatis is exclusively a human pathogen and is transmitted from person to person via sexual contact, perinatal transmission, or close contact in households. C. psittaci, in contrast, is more widely distributed in nature, producing genital, conjunctival, intestinal, or respiratory infections in many avian and mammalian species. C. pneumoniae is a fastidious organism that produces upper respiratory tract infection and pneumonitis in both children and adults. This chapter details the epidemiology, pathogenesis, diagnosis, and treatment of chlamydial diseases. Sexually transmitted diseases, perinatal infections, adult inclusion conjunctivitis, trachoma, and psittacosis are covered. The chapter also includes tables outlining comparative features of the three species and treatment of sexually transmitted diseases caused by C. trachomatis, as well as a figure illustrating the life cycle of Chlamydiaceae.  This review contains 1 highly rendered figure, 2 tables, and 87 references.

Bacterial Infections of the Adult Upper Respiratory Tract

2019 ◽  
Author(s):  
Laura K Certain ◽  
Miriam B Barshak
Keyword(s):  
Respiratory Tract ◽  
Bacterial Infections ◽  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
Group A Streptococcus ◽  
The United States ◽  
Controlled Study ◽  
Upper Respiratory Tract ◽  
Upper Respiratory ◽  
Tract Infections

Upper respiratory tract infections are the most common maladies experienced by humankind.1 The majority are caused by respiratory viruses. A Dutch case-controlled study of primary care patients with acute respiratory tract infections found that viruses accounted for 58% of cases; rhinovirus was the most common (24%), followed by influenza virus type A (11%) and corona­viruses (7%). Group A streptococcus (GAS) was responsible for 11%, and 3% of patients had mixed infections. Potential pathogens were detected in 30% of control patients who were free of acute respiratory symptoms; rhinovirus was the most common.2 Given the increasing problem of antibiotic resistance and the increasing awareness of the importance of a healthy microbiome, antibiotic use for upper respiratory infections should be reserved for those patients with clear indications for treatment. A recent study of adult outpatient visits in the United States found that respiratory complaints accounted for 150 antibiotic prescriptions per 1,000 population annually, yet the expected “appropriate” rate would be 45.3 In other words, most antibiotic prescriptions for these complaints are unnecessary. Similarly, a study in the United Kingdom found that general practitioners prescribed antibiotics to about half of all patients presenting with an upper respiratory infection, even though most of these infections are viral.4 This review contains 5 figures, 16 tables, and 82 references. Keywords: infection, airway, sinusitis, otitis media, otitis externa, pharyngitis, epiglottitis, abscess

scholarly journals Serological Response to Pasteurella multocida NanH Sialidase in Persistently Colonized Rabbits

2004 ◽  
Vol 11 (5) ◽  
pp. 825-834 ◽  
Author(s):  
Susan Sanchez ◽  
Shaikh Mizan ◽  
Charlotte Quist ◽  
Patricia Schroder ◽  
Michelle Juneau ◽  
...  
Keyword(s):  
Pasteurella Multocida ◽  
Respiratory Infections ◽  
Clinical Signs ◽  
Circulatory System ◽  
Immunoglobulin M ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serological Response ◽  
Igg Antibody ◽  
Sialidase Activity ◽  
Upper Respiratory

ABSTRACT Pasteurella multocida is a mucosal pathogen that colonizes the upper respiratory system of rabbits. Respiratory infections can result, but the bacteria can also invade the circulatory system, producing abscesses or septicemia. P. multocida produces extracellular sialidase activity, which is believed to augment colonization of the respiratory tract and the production of lesions in an active infection. Previously, it was demonstrated that some isolates of P. multocida contain two unique sialidase genes, nanH and nanB, that encode enzymes with different substrate specificities (S. Mizan, A. D. Henk, A. Stallings, M. Meier, J. J. Maurer, and M. D. Lee, J. Bacteriol. 182:6874-6883, 2000). We developed a recombinant antigen enzyme-linked immunosorbent assay (ELISA) based on the NanH sialidase of P. multocida and demonstrated that rabbits that were experimentally colonized with P. multocida produce detectable anti-NanH immunoglobulin M (IgM) and IgG in serum, although they demonstrated no clinical signs of pasteurellosis. In addition, clinically ill pet rabbits infected with P. multocida possessed IgM and/or IgG antibody against NanH. The NanH ELISA may be useful for the diagnosis of P. multocida infections in sick rabbits as well as for screening for carriers in research rabbit colonies.

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