Impulsivity and neural correlates of response inhibition in schizophrenia

2010 ◽  
Vol 41 (2) ◽  
pp. 291-299 ◽  
Author(s):  
A. Kaladjian ◽  
R. Jeanningros ◽  
J.-M. Azorin ◽  
J.-L. Anton ◽  
P. Mazzola-Pomietto
Keyword(s):  
Response Inhibition ◽  
Healthy Subjects ◽  
Neural Correlates ◽  
Brain Network ◽  
Cerebral Activation ◽  
Neural Processes ◽  
Psychometric Measures ◽  
The Right ◽  
The Relationship ◽  
The Brain

BackgroundThe clinical picture of schizophrenia is frequently worsened by manifestations of impulsivity. However, the neural correlates of impulsivity in this disorder are poorly known. Although impulsivity has been related to disturbances of the neural processes underlying response inhibition, no studies have yet examined the relationship between these processes and psychometric measures of impulsivity in schizophrenia. This was the aim of the current investigation.MethodEvent-related functional magnetic resonance imaging in conjunction with a Go/NoGo task was employed to probe the neural activity associated with response inhibition in 26 patients with schizophrenia and 30 healthy comparison subjects. All participants also completed the Barratt Impulsiveness Scale – version 11 (BIS-11). Voxel-wise regression analyses were used to examine the relationship between the BIS-11 score and brain activation during response inhibition in each group.ResultsPatients with schizophrenia were more impulsive than healthy subjects, as indicated by higher BIS-11 scores. Patients, but not healthy subjects, were found to display a positive correlation between these scores and cerebral activation associated with response inhibition. This correlation involves a unique cluster localized within the right ventrolateral prefrontal cortex (VLPFC), a key node of the brain network subserving response inhibition.ConclusionsWe evidenced in patients with schizophrenia that greater BIS-11 scores are associated with greater activation within the right VLPFC during response inhibition. This finding suggests that the efficiency of this brain region to process inhibitory control is reduced in the more impulsive patients.

Is Transient Global Amnesia a Network Disease?

2018 ◽  
Vol 80 (5-6) ◽  
pp. 345-354 ◽  
Author(s):  
Kang Min Park ◽  
Byung In Lee ◽  
Sung Eun Kim
Keyword(s):  
White Matter ◽  
Healthy Subjects ◽  
Transient Global Amnesia ◽  
Brain Network ◽  
Network Measures ◽  
Postcentral Gyrus ◽  
Frontal Operculum ◽  
Global Amnesia ◽  
The Right ◽  
The Brain

Background: We evaluated a brain network using graph theoretical analysis and microstructural abnormalities of the white matter in patients with transient global amnesia (TGA). Methods: Twenty patients with TGA and healthy control subjects were recruited, and they underwent diffusion tensor imaging (DTI) scans. Graph theory was applied to obtain network measures based on DTI data. We investigated the network measures and microstructural abnormalities of white matter using tract-based spatial statistics (TBSS) analysis in the patients with TGA. Results: Measures of global topology were not different between the patients with TGA and healthy subjects. However, there were significant differences of hubs organization; the strength of the right superior and inferior orbitofrontal, the right inferior frontal operculum, the left superior parietal, and left postcentral gyrus, the cluster coefficient of the right middle orbitofrontal and left inferior parietal gyrus, the betweenness centrality of the left angular gyrus, and the pagerank centrality of the right superior and inferior orbitofrontal, right inferior frontal operculum, left superior parietal, and left postcentral gyrus in the patients with TGA were significantly lower than those in healthy subjects. Regarding the analysis of the white matter microstructure with TBSS, there were no differences in the fractional anisotropy and mean diffusivity values between the 2 groups. Conclusions: We newly identify a reorganization of network hubs of the brain network in patients with TGA, especially in the regions of the default-mode network. These alterations of the brain network may play a role in the pathophysiologic mechanism underlying TGA and suggest that TGA is a network disease.

scholarly journals Sex differences in neural and behavioral signatures of cooperation revealed by fNIRS hyperscanning

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Joseph M. Baker ◽  
Ning Liu ◽  
Xu Cui ◽  
Pascal Vrticka ◽  
Manish Saggar ◽  
...  
Keyword(s):  
Sex Differences ◽  
Temporal Cortex ◽  
Neural Correlates ◽  
Behavioral Signatures ◽  
Computer Based ◽  
Males And Females ◽  
Brain And Behavior ◽  
The Right ◽  
And Behavior ◽  
The Brain

Abstract Researchers from multiple fields have sought to understand how sex moderates human social behavior. While over 50 years of research has revealed differences in cooperation behavior of males and females, the underlying neural correlates of these sex differences have not been explained. A missing and fundamental element of this puzzle is an understanding of how the sex composition of an interacting dyad influences the brain and behavior during cooperation. Using fNIRS-based hyperscanning in 111 same- and mixed-sex dyads, we identified significant behavioral and neural sex-related differences in association with a computer-based cooperation task. Dyads containing at least one male demonstrated significantly higher behavioral performance than female/female dyads. Individual males and females showed significant activation in the right frontopolar and right inferior prefrontal cortices, although this activation was greater in females compared to males. Female/female dyad’s exhibited significant inter-brain coherence within the right temporal cortex, while significant coherence in male/male dyads occurred in the right inferior prefrontal cortex. Significant coherence was not observed in mixed-sex dyads. Finally, for same-sex dyads only, task-related inter-brain coherence was positively correlated with cooperation task performance. Our results highlight multiple important and previously undetected influences of sex on concurrent neural and behavioral signatures of cooperation.

scholarly journals Possible Effect of Headphone Usage on Working Memory Among Students in Faculty of Medicine, Ahmadu Bello University, Zaria‒Nigeria

2019 ◽  
pp. 1-4
Author(s):  
Yushau Yusuf ◽  
Muhammad U.A ◽  
Isah F.A
Keyword(s):  
Working Memory ◽  
Signal Processing ◽  
Cognitive Abilities ◽  
Healthy Subjects ◽  
Significant Difference ◽  
Stored Information ◽  
Age Range ◽  
The Relationship ◽  
The Brain ◽  
Back Task

Working memory is a system that is responsible for transient holding and processing of new and already stored information. It also involves processing for reasoning, comprehension, learning and memory updating. Headphones are a pair of small loudspeakers that are designed to be held in place close to a user’s ear. They are electroacoustic transducers which convert electrical signals to a corresponding sound in the user’s ear. Several studies have recently shown a link between cognitive abilities and response to hearing aid and signal processing in the brain. Therefore, the relationship between headphone usage among healthy subjects become pertinent. This study is aimed at evaluating the effect of headphone on working memory using N-back task. One hundred (100) participants (55 headphone users and 45 non-headphone user’s) within the age range of 18-31 years were assessed. Participants were instructed to keep in memory, a series of letters and say “target” whenever there was a repetition of letter with exactly one intervening letter and to remain silent when any other letter appeared. The results of this study showed that there was no statistically significant difference in working memory between headphone and non-headphone users with p>0.05. In conclusion, this study revealed headphone use has no effect on working memory of the participants subjected to N–back test.

The neural correlates of inhibitory control in 10-month-old infants: a functional near-infrared spectroscopy study

2021 ◽  
Author(s):  
Abigail Fiske ◽  
Carina de Klerk ◽  
Katie Y. K. Lui ◽  
Liam H Collins-Jones ◽  
Alexandra Hendry ◽  
...  
Keyword(s):  
Infrared Spectroscopy ◽  
Inhibitory Control ◽  
Near Infrared Spectroscopy ◽  
Response Inhibition ◽  
Near Infrared ◽  
Neural Correlates ◽  
Older Children ◽  
Functional Near Infrared Spectroscopy ◽  
Inhibition Performance ◽  
The Right

Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response inhibition, this study aimed to uncover the neural underpinnings of inhibitory control in 10-month-old infants (N = 135). We found that when inhibition is required, the right prefrontal and parietal cortices were more activated than when there is no inhibitory demand. Further, activation in right prefrontal areas was associated with individual differences in response inhibition performance. This demonstrates that inhibitory control in infants as young as 10 months of age is supported by similar brain areas as in older children and adults. With this study we have lowered the age-boundary for localising the neural substrates of response inhibition to the first year of life.

Neural Responses to Human Voice and Hemisphere Dominance for Lexical-semantic Processing

2007 ◽  
Vol 46 (02) ◽  
pp. 247-250 ◽  
Author(s):  
H. Takahashi ◽  
N. Yahata ◽  
M. Matsuura ◽  
K. Asai ◽  
Y. Okubo ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Semantic Processing ◽  
Hemispheric Dominance ◽  
Cerebral Activation ◽  
Voice Perception ◽  
Lexical Semantic ◽  
Human Voice ◽  
Fmri Study ◽  
The Right ◽  
Parietal Cortices

Summary Objectives : In our previous functional magnetic resonance imaging (fMRI) study, we determined that there was distinct left hemispheric dominance for lexical- semantic processing without the influence of human voice perception in right-handed healthy subjects. However, the degree of right-handedness in the right-handed subjects ranged from 52 to 100 according to the Edinburgh Handedness Inventory (EHI) score. In the present study, we aimed to clarify the correlation between the degree of right-handedness and language dominance in the fronto-temporo-parietal cortices by examining cerebral activation for lexical-semantic processing. Methods : Twenty-seven normal right-handed healthy subjects were scanned by fMRI while listening to sentences (SEN), reverse sentences (rSEN), and identifiable non-vocal sounds (SND). Fronto-temporo-parietal activation was observed in the left hemisphere under the SEN - rSEN contrast, which included lexical- semantic processing without the influence of human voice perception. Laterality Indexwas calculated as LI = (L - R)/(L + R) X 100, L: left, R: right. Results : Laterality Index in the fronto-temporo-parietal cortices did not correlate with the degree of right-handedness in EHI score. Conclusions : The present study indicated that the degree of right-handedness from 52 to 100 in EHI score had no effect on the degree of left hemispheric dominance for lexical-semantic processing in right-handed healthy subjects.

scholarly journals Mindfulness Meditation Is Related to Long-Lasting Changes in Hippocampal Functional Topology during Resting State: A Magnetoencephalography Study

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Anna Lardone ◽  
Marianna Liparoti ◽  
Pierpaolo Sorrentino ◽  
Rosaria Rucco ◽  
Francesca Jacini ◽  
...  
Keyword(s):  
Resting State ◽  
Mindfulness Meditation ◽  
Brain Connectivity ◽  
Brain Networks ◽  
Brain Network ◽  
Long Term Effects ◽  
Age Related ◽  
Functional Topology ◽  
The Right ◽  
The Brain

It has been suggested that the practice of meditation is associated to neuroplasticity phenomena, reducing age-related brain degeneration and improving cognitive functions. Neuroimaging studies have shown that the brain connectivity changes in meditators. In the present work, we aim to describe the possible long-term effects of meditation on the brain networks. To this aim, we used magnetoencephalography to study functional resting-state brain networks in Vipassana meditators. We observed topological modifications in the brain network in meditators compared to controls. More specifically, in the theta band, the meditators showed statistically significant (p corrected = 0.009) higher degree (a centrality index that represents the number of connections incident upon a given node) in the right hippocampus as compared to controls. Taking into account the role of the hippocampus in memory processes, and in the pathophysiology of Alzheimer’s disease, meditation might have a potential role in a panel of preventive strategies.

scholarly journals 4327 Structural Neural Correlates of Social Functioning in First Episode Psychosis and Malleability in Response to Targeted Cognitive Training

2020 ◽  
Vol 4 (s1) ◽  
pp. 37-38
Author(s):  
Kathleen Miley ◽  
Fang Yu ◽  
Ian Ramsay ◽  
Sophia Vinogradov
Keyword(s):  
Social Functioning ◽  
Cognitive Training ◽  
Gray Matter Volume ◽  
Neural Correlates ◽  
Parahippocampal Gyrus ◽  
First Episode ◽  
Posterior Cingulate ◽  
Episode Psychosis ◽  
The Right ◽  
The Relationship

OBJECTIVES/GOALS: Development of interventions that improve social functioning (SF) in first episode psychosis (FEP) is hindered by a poor understanding of the neural mechanisms underlying SF deficits. This research aims to identify neural correlates of social functioning in FEP, and to evaluate whether this substrate is malleable in response to cognitive training. METHODS/STUDY POPULATION: This is a secondary data-analysis of participants in an ongoing randomized clinical trial investigating whether 12 weeks of targeted cognitive training is neuroprotective in FEP, versus treatment as usual. Baseline and post-training assessments include a brain MRI, three measures of SF, and a neurocognitive battery. Healthy controls complete MRI only. Differences in cortical thickness (CTh) and gray matter volume (GMV) in regions of interest between FEP and controls will be determined with ANCOVA. Multiple linear regression will be used to determine the relationship between neural substrate and SF in FEP. Linear mixed models will be used to examine the relationship between change in CTh and GMV and change in SF. Data collection is ongoing for this study. RESULTS/ANTICIPATED RESULTS: In preliminary data including 12 FEP and 9 healthy controls, FEP demonstrated cortical loss in the right superior frontal cortex and the right isthmus-posterior cingulate. Greater cortical thickness in the posterior cingulate cortex was associated with better social functioning across multiple measures when controlling for global cognition. Gray matter volume in the parahippocampal gyrus was also associated with better social functioning. Preliminary results evaluating whether targeted cognitive training is neuroprotective in these regions of interest in a manner that is associated with improved social functioning will also be presented. DISCUSSION/SIGNIFICANCE OF IMPACT: Preliminary results link the posterior cingulate and parahippocampal gyrus to SF in FEP. Further research will investigate the contribution of changes in these brain regions to improved SF. The identification of biological treatment targets for SF may lead to development and optimization of novel interventions to alleviate SF deficits in FEP.

scholarly journals Association Between Trait Empathy and Resting Brain Activity in Women With Primary Dysmenorrhea During the Pain and Pain-Free Phases

2020 ◽  
Vol 11 ◽  
Author(s):  
Wanghuan Dun ◽  
Tongtong Fan ◽  
Qiming Wang ◽  
Ke Wang ◽  
Jing Yang ◽  
...  
Keyword(s):  
Brain Activity ◽  
Inferior Frontal Gyrus ◽  
Brain Network ◽  
Primary Dysmenorrhea ◽  
Pain Experience ◽  
Current State ◽  
The Neural Network ◽  
The Right ◽  
The Brain

Empathy refers to the ability to understand someone else's emotions and fluctuates with the current state in healthy individuals. However, little is known about the neural network of empathy in clinical populations at different pain states. The current study aimed to examine the effects of long-term pain on empathy-related networks and whether empathy varied at different pain states by studying primary dysmenorrhea (PDM) patients. Multivariate partial least squares was employed in 46 PDM women and 46 healthy controls (HC) during periovulatory, luteal, and menstruation phases. We identified neural networks associated with different aspects of empathy in both groups. Part of the obtained empathy-related network in PDM exhibited a similar activity compared with HC, including the right anterior insula and other regions, whereas others have an opposite activity in PDM, including the inferior frontal gyrus and right inferior parietal lobule. These results indicated an abnormal regulation to empathy in PDM. Furthermore, there was no difference in empathy association patterns in PDM between the pain and pain-free states. This study suggested that long-term pain experience may lead to an abnormal function of the brain network for empathy processing that did not vary with the pain or pain-free state across the menstrual cycle.

IQ DISCREPANCIES AMONG IMPULSIVE AND NON-IMPULSIVE INMATES

1992 ◽  
Vol 20 (3) ◽  
pp. 213-217 ◽  
Author(s):  
Shirley N. Myers ◽  
Jon B. Ellis
Keyword(s):  
Future Research ◽  
Criminal Behaviour ◽  
Verbal Scale ◽  
The Right ◽  
The Relationship ◽  
The Brain ◽  
Performance Scale

The intention of this study was to examine the relationship between the right and left hemispheres of the brain and criminal behaviour. It was predicted that prisoners scoring higher on the Verbal scale than the Performance scale of the WAIS-R would tend to commit more analytical thought-out crimes. Those scoring higher on the Performance scale may be more impulsive type criminals and tend to commit crimes less thought out. A total of 51 inmates were tested with the WAIS-R. Inmates who scored lower on the Verbal scale than the Performance scale tended to be more impulsive. Due to the overlap in crimes committed by both types of criminals, it was recommended that future research in this area may include a third category of both impulsive-non-impulsive along with the separation of the two categories.

scholarly journals Abnormal EEG Complexity and Functional Connectivity of Brain in Patients with Acute Thalamic Ischemic Stroke

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Shuang Liu ◽  
Jie Guo ◽  
Jiayuan Meng ◽  
Zhijun Wang ◽  
Yang Yao ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Functional Connectivity ◽  
Healthy Subjects ◽  
Brain Network ◽  
Control Group ◽  
Stroke Patients ◽  
Cerebral Disease ◽  
Essential Information ◽  
Stroke Group ◽  
The Brain

Ischemic thalamus stroke has become a serious cardiovascular and cerebral disease in recent years. To date the existing researches mostly concentrated on the power spectral density (PSD) in several frequency bands. In this paper, we investigated the nonlinear features of EEG and brain functional connectivity in patients with acute thalamic ischemic stroke and healthy subjects. Electroencephalography (EEG) in resting condition with eyes closed was recorded for 12 stroke patients and 11 healthy subjects as control group. Lempel-Ziv complexity (LZC), Sample Entropy (SampEn), and brain network using partial directed coherence (PDC) were calculated for feature extraction. Results showed that patients had increased mean LZC and SampEn than the controls, which implied the stroke group has higher EEG complexity. For the brain network, the stroke group displayed a trend of weaker cortical connectivity, which suggests a functional impairment of information transmission in cortical connections in stroke patients. These findings suggest that nonlinear analysis and brain network could provide essential information for better understanding the brain dysfunction in the stroke and assisting monitoring or prognostication of stroke evolution.

Sign in / Sign up

Export Citation Format

Share Document