scholarly journals Maternal depressive symptoms during pregnancy, placental expression of genes regulating glucocorticoid and serotonin function and infant regulatory behaviors

2015 ◽  
Vol 45 (15) ◽  
pp. 3217-3226 ◽  
Author(s):  
K. Räikkönen ◽  
A.-K. Pesonen ◽  
J. R. O'Reilly ◽  
S. Tuovinen ◽  
M. Lahti ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Animal Studies ◽  
Depression Scale ◽  
Fetal Brain ◽  
Epidemiologic Studies ◽  
Mrna Levels ◽  
Maternal Depressive Symptoms ◽  
Behavioral Challenges ◽  
Expression Of Genes ◽  
Unit Increase

Background.Glucocorticoids and serotonin may mediate the link between maternal environment, fetal brain development and ‘programming’ of offspring behaviors. The placenta regulates fetal exposure to maternal hormonal signals in animal studies, but few data address this in humans. We measured prospectively maternal depressive symptoms during pregnancy and mRNAs encoding key gene products determining glucocorticoid and serotonin function in term human placenta and explored associations with infant regulatory behaviors.Method.Bi-weekly self-ratings of the Center for Epidemiologic Studies Depression Scale from 12th to 13th gestational week onwards and term placental mRNAs of 11beta-hydroxysteroid dehydrogenase type 2 (HSD2B11), type 1 (HSD1B11), glucocorticoid (NR3C1), mineralocorticoid receptors (NR3C2) and serotonin transporter (SLC6A4) were obtained from 54 healthy mothers aged 32.2 ± 5.3 years with singleton pregnancies and without pregnancy complications. Infant regulatory behaviors (crying, feeding, spitting, elimination, sleeping and predictability) were mother-rated at 15.6 ± 4.2 days.Results.Higher placental mRNA levels of HSD2B11 [0.41 standard deviation (s.d.) unit increase per s.d. unit increase; 95% confidence interval (CI) 0.13–0.69, p = 0.005], HSD1B11 (0.30, 0.03–0.57, p = 0.03), NR3C1 (0.44, 0.19–0.68, p = 0.001) and SLC6A4 (0.26, 0.00–0.53, p = 0.05) were associated with more regulatory behavioral challenges of the infant. Higher placental NR3C1 mRNA partly mediated the association between maternal depressive symptoms during pregnancy and infant regulatory behaviors (p < 0.05).Conclusions.Higher placental expression of genes regulating feto-placental glucocorticoid and serotonin exposure is characteristic of infants with more regulatory behavioral challenges. Maternal depression acts, at least partly, via altering glucocorticoid action in the placenta to impact on offspring regulatory behaviors.

Maternal depressive symptoms throughout pregnancy are associated with increased placental glucocorticoid sensitivity

2015 ◽  
Vol 45 (10) ◽  
pp. 2023-2030 ◽  
Author(s):  
R. M. Reynolds ◽  
A.-K. Pesonen ◽  
J. R. O'Reilly ◽  
S. Tuovinen ◽  
M. Lahti ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Effect Size ◽  
Post Partum ◽  
Mrna Levels ◽  
Maternal Depressive Symptoms ◽  
Placental Function ◽  
Messenger Ribonucleic Acid ◽  
Expression Of Genes ◽  
Prediction And Prevention ◽  
Mr Effect

BackgroundMaternal prenatal depression predicts post-partum depression and increases risk of prematurity and low birth weight. These effects may be mediated by altered placental function. We hypothesized that placental function would be influenced by the gestational week of experiencing depressive symptoms and aimed to examine associations between maternal depressive symptoms during pregnancy and placental expression of genes involved in glucocorticoid and serotonin transfer between mother and fetus.MethodWe studied women participating in a prospective pregnancy cohort: the Prediction and Prevention of Preeclampsia (PREDO) Study, Helsinki, Finland. Maternal depressive symptoms were assessed at 2-week intervals throughout pregnancy in 56 healthy women with singleton, term pregnancies. Messenger ribonucleic acid (mRNA) levels of glucocorticoid (GR) and mineralocorticoid (MR) receptors and serotonin transporter (SLC6A4), 11β-hydroxysteroid dehydrogenase type 1 (HSD1) and 2 (HSD2) were quantified in placental biopsies.ResultsIn adjusted analyses women who reported higher depressive symptoms across the whole pregnancy had higher mRNA levels of GR [effect size 0.31 s.d. units, 95% confidence interval (CI) 0.01–0.60, p = 0.042] and MR (effect size 0.34 s.d. units, 95% CI 0.01–0.68, p = 0.047). These effects were significant for symptoms experienced in the third trimester of pregnancy for GR; findings for MR were also significant for symptoms experienced in the second trimester. GR and MR mRNA levels increased linearly by having the trimester-specific depressive symptoms scores 0, 1 or 2–3 times above the clinical cut-off for depression (p = 0.003, p = 0.049, respectively, and p = 0.004, p = 0.15 in adjusted analyses).ConclusionsOur findings offer potential gestational-age-specific mechanisms linking maternal depressive symptoms during pregnancy via placental biology. Future studies will test whether these also link with adverse offspring outcomes.

scholarly journals Association between maternal depressive symptoms with child malnutrition or child excess weight

2017 ◽  
Vol 17 (3) ◽  
pp. 591-601 ◽  
Author(s):  
Thais Feres Moreira Lima ◽  
Warles Melo Maciel ◽  
Monyk Neves de Alencar ◽  
Joana Athayde da Silva Cruz ◽  
Carolina Abreu de Carvalho ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Postnatal Depression ◽  
Directed Acyclic Graph ◽  
Edinburgh Postnatal Depression Scale ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Excess Weight ◽  
Child Malnutrition ◽  
Maternal Depressive Symptoms ◽  
Z Score

Abstract Objectives: to verify associations between maternal depressive symptoms with child malnutrition or child excess weight. Methods: prospective study with data from the BRISA prenatal cohort in São Luís, Brazil, obtained from the 22nd to the 25th week of gestation (in 2009 and 2010) and, later, when children were aged 12 to 32 months (in 2010 and 2012). Maternal depressive symptoms were identified using the Center for Epidemiologic Studies Depression Scale (CES-D) and the Edinburgh Postnatal Depression Scale (EPDS). For the excess weight evaluation, BMI z-score for age > +2 was used. For measuring child malnutrition, height z-score for age < -2 was used. The confounding factors were identified using a directed acyclic graph in DAGitty software. Results: we did not find associations between maternal depressive symptoms with child malnutrition or child excess weight. The prevalence of maternal depressive symptoms was 27.6% during gestation and 19.8% in the second or third year of the child's life. The malnutrition rate was 6% and the excess weight rate was 10.9%. Conclusions: no associations between maternal depressive symptoms in prenatal or in the second or third year of the child's life and child malnutrition or excess weight were detected.

scholarly journals The mediating role of adolescents’ loneliness and social withdrawal in the association between maternal depressive symptoms and suicidality in adolescence: A 20-year population-based study

2021 ◽  
pp. 1-9
Author(s):  
Lamprini Psychogiou ◽  
Marilyn N. Ahun ◽  
Michel Boivin ◽  
Richard E. Tremblay ◽  
Massimiliano Orri ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Indirect Effect ◽  
Social Withdrawal ◽  
Depression Scale ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Maternal Depressive Symptoms ◽  
Mediating Role ◽  
Increased Risk ◽  
Development Data

Abstract We examined whether adolescents’ loneliness and social withdrawal mediated the association between maternal depressive symptoms and adolescent suicidality. Secondary analyses on the Québec Longitudinal Study of Child Development data were conducted (n = 1,623). Each mother completed the Centre for Epidemiologic Studies Depression Scale (at child ages 5 months, 1.5, 3.5, 5, and 7 years). Adolescent's social withdrawal (adolescent, father, and teacher reported at 10, 12, and 13 years) and loneliness (adolescent reported at 10, 12, and 13 years), were assessed using items from the Social Behavior Questionnaire and the Loneliness and Social Satisfaction Questionnaire, respectively. Adolescents completed self-reports to assess suicidal thoughts and attempts at 13, 15, 17, and 20 years. Children of mothers with higher levels of maternal depressive symptoms had an increased risk for suicidality (OR = 1.15, 95% CI: 1.03–1.28). Loneliness explained 16% of the total effect of maternal depressive symptoms on adolescent suicidality (indirect effect OR = 1.02, 95% CI: 1.00–1.04). There was no indirect effect of maternal depressive symptoms on adolescent suicidal outcomes via social withdrawal (indirect effect OR = 1.00, 95% CI: 0.99–1.02). Interventions that target loneliness may be beneficial for decreasing the risk for suicidality among adolescents of mothers with depressive symptoms.

scholarly journals Validation of the Japanese Version of the Center for Epidemiologic Studies Depression Scale—Revised: A Preliminary Analysis

2021 ◽  
Vol 11 (8) ◽  
pp. 107
Author(s):  
Hirohito Tsuboi ◽  
Yui Takakura ◽  
Hiromasa Tsujiguchi ◽  
Sakae Miyagi ◽  
Keita Suzuki ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Depressive Symptoms ◽  
Native Speakers ◽  
Depression Scale ◽  
Japanese Version ◽  
Population Based ◽  
Epidemiologic Studies ◽  
Community Dwelling ◽  
Two Factors ◽  
Study Population

To make the Japanese version of the CESD-R—a revised version of the Center for Epidemiologic Studies depression scale (CES-D)—in the assessment of depressive symptoms in a general population. The English version of CESD-R was translated into Japanese, and back-translated into English by three native speakers of Japanese and English; then, we selected the version most completely consistent with the original items. The CESD-R was applied to 398 community-dwelling people (191 men: 48.0%, and 207 women: 52.0%) who were over 40 years old. The Japanese version of the CES-D was also carried out in the same population. Factor analysis was performed. Additionally, the correlations between the CESD-R and CES-D results were identified. The CESD-R scores showed a significantly positive correlation with CES-D scores (r = 0.74, p < 0.0005). Analysis of the CESD-R yielded a Cronbach’s alpha result of 0.90. Factor analysis revealed one principal factor in the CESD-R, whereas the original CES-D had two factors because of reversed items. The Japanese version of the CESD-R appears to have the reliability to be applicable for assessing depressive symptoms in population-based samples. However, because the Japanese expressions for some items might be unusual, our study population was also limited; further studies on other populations and on incorporating improved Japanese terminology will be needed.

scholarly journals Trajectories of maternal depressive symptoms and offspring’s risk behavior in early adolescence: data from the 2004 Pelotas birth cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ana Beatriz Bozzini ◽  
Jessica Mayumi Maruyama ◽  
Tiago N. Munhoz ◽  
Aluísio J. D. Barros ◽  
Fernando C. Barros ◽  
...  
Keyword(s):  
Cohort Study ◽  
Depressive Symptoms ◽  
Alcohol Use ◽  
Maternal Depression ◽  
Risk Behavior ◽  
Birth Cohort ◽  
Depression Scale ◽  
Self Report ◽  
Birth Cohort Study ◽  
Maternal Depressive Symptoms

Abstract Background This longitudinal study explored the relationship between trajectories of maternal depressive symptoms and offspring’s risk behavior in adolescence contributing to an extremely scarce literature about the impacts of maternal depression trajectories on offspring risk behaviors. Methods We included 3437 11-year-old adolescents from the 2004 Pelotas Birth Cohort Study. Trajectories of maternal depressive symptoms were constructed using Edinburgh Postnatal Depression Scale (EDPS) from age 3 months to 11 years. We identified five trajectories of maternal depressive symptoms: “low” “moderate low”, “increasing”, “decreasing”, and “chronic high”. The following adolescent outcomes were identified via self-report questionnaire and analyzed as binary outcome –yes/no: involvement in fights and alcohol use at age 11. We used logistic regression models to examine the effects of trajectories of maternal depressive symptoms on offspring’s risk behavior adjusting for potential confounding variable. Results Alcohol use and/or abuse as well as involvement in fights during adolescence, were not significantly associated with any specific trajectory of maternal depressive symptoms neither in the crude nor in the adjusted analyses. Conclusion Alcohol use and involvement in fights at age 11 were not associated with any specific trajectory of maternal depression.

scholarly journals Effects of social support, hope and resilience on depressive symptoms within 18 months after diagnosis of prostate cancer

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Xinxin Zhao ◽  
Ming Sun ◽  
Ye Yang
Keyword(s):  
Prostate Cancer ◽  
Social Support ◽  
Depressive Symptoms ◽  
Perceived Social Support ◽  
Depression Scale ◽  
Psychosocial Interventions ◽  
Epidemiologic Studies ◽  
Depression Symptoms ◽  
Cross Sectional ◽  
Modifiable Factors

Abstract Background The prevalence of depression symptoms and related modifiable factors in prostate cancer (PCa) are not well evaluated. We aimed to assess the effects of perceived social support, hope and resilience on depressive symptoms within 18 months after diagnosis of PCa, and to evaluate the role of hope and resilience as mediators of that relationship. Method A cross-sectional study was analyzed in consecutive inpatients with PCa during the months of January 2018 and August 2019. A total of 667 patients eligible for this study completed questionnaires on demographic and clinic variables, Center for Epidemiologic Studies Depression Scale, Multidimensional Scale of Perceived Social Support, Adult Hope Scale, and Resilience Scale (14 items). All registered patients were all volunteers and anonymous. Depressive symptoms, perceived social support, hope and resilience were measured anonymously. Out of 667 patients, a total of 564 effective respondents (< 30% missing data) became our subjects. Hierarchical linear regression was used to identify the factors associated with depressive symptoms. Asymptotic and resampling strategies were used to conduct the mediating effects of hope and resilience. Results The prevalence of depressive symptoms was 65.9% in PCa patients. Hierarchical regression analyses indicated that perceived social support, hope, and resilience together accounted for 27.5% variance of depressive symptoms. Support from family, hope, and resilience significantly associated with depressive symptoms, respectively. Hope (a*b = − 0.0783, BCa95% CI: − 0.134 to − 0.0319, p < 0.05), and resilience (a*b = − 0.1315, BCa95% CI: − 0.1894 to − 0.0783, p < 0.05) significantly mediated the association between perceived social support and depressive symptoms. Conclusions The high prevalence of depressive symptoms among PCa patients should receive more attention. Perceived social support, hope and resilience could be positive resources for combating depressive symptoms, and hope and resilience mediated the association between perceived social support and depressive symptoms. Enhancing social support, particularly the support form family, and improving patients’ outlook and resilience may be potential targets for future psychosocial interventions aimed at reducing depressive symptoms.

scholarly journals Association between depressive symptoms and psychosocial factors and perception of maternal self-efficacy in teenage mothers

Salud Mental ◽  
2017 ◽  
Vol 40 (5) ◽  
pp. 201-208
Author(s):  
Ma Asunción Lara ◽  
◽  
Pamela Patiño ◽  
Laura Navarrete ◽  
Zaira Hernández ◽  
...  
Keyword(s):  
Social Support ◽  
Depressive Symptoms ◽  
Adolescent Mothers ◽  
Self Efficacy ◽  
Teenage Pregnancy ◽  
Post Partum ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Bivariate Analysis ◽  
Cross Sectional

Introduction. Teenage pregnancy is a national health priority. Having to deal with pregnancy during adolescence can cause the mother, at an already vulnerable age, to doubt her maternal capacity to cope with a challenge of this magnitude. The teenage mother’s assessment of her maternal self-efficacy is associated with her performance, in other words, the way she relates and responds to the needs of her infant, which has major implications for the latter’s development. Objective. To study the association between personal (depressive symptoms, self-esteem) and environmental characteristics (social support, partner satisfaction) and those of the infant (problems with infant care, the infants’s temperament) and the perception of maternal self-efficacy (PME) in adolescent mothers. Method. Cross-sectional study. The following instruments were applied: Center for Epidemiologic Studies Depression Scale (CES-D), Post-partum Depression Predictors Inventory-Revised (PDPI-R), and Maternal Efficacy Questionnaire to 120 mothers under 20 during the first six months postpartum. Bivariate lineal regression and hierarchical linear regression analyses were used for the data analysis. Results. When adjusting for other variables, symptoms of depression and difficult infant temperament were associated with lower PME. Social support was only associated with increased PME in the bivariate analysis. Discussion and conclusion. These findings contribute to the limited literature on the subject and provide elements for designing strategies to improve adolescent mothers’ PME to encourage behaviors that are more relevant and sensitive to infants’ physical and emotional needs.

scholarly journals Depressive Symptoms and Resilience among Pregnant Adolescents: A Case-Control Study

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Danny Salazar-Pousada ◽  
Dalton Arroyo ◽  
Luis Hidalgo ◽  
Faustino R. Pérez-López ◽  
Peter Chedraui
Keyword(s):  
Depressive Symptoms ◽  
Depressed Mood ◽  
Depression Scale ◽  
Case Control ◽  
Epidemiologic Studies ◽  
Pregnant Adolescents ◽  
Control Approach ◽  
Resilience Scale ◽  
Study Programs ◽  
Adolescents And Adults

Background. Data regarding depression and resilience among adolescents is still lacking.Objective. To assess depressive symptoms and resilience among pregnant adolescents.Method. Depressive symptoms and resilience were assessed using two validated inventories, the 10-item Center for Epidemiologic Studies Short Depression Scale (CESD-10) and the 14-item Wagnild and Young Resilience Scale (RS), respectively. A case-control approach was used to compare differences between adolescents and adults.Results. A total of 302 pregnant women were enrolled in the study, 151 assigned to each group. Overall, 56.6% of gravids presented total CESD-10 scores 10 or more indicating depressed mood. Despite this, total CESD-10 scores and depressed mood rate did not differ among studied groups. Adolescents did however display lower resilience reflected by lower total RS scores and a higher rate of scores below the calculated median (P<.05). Logistic regression analysis could not establish any risk factor for depressed mood among studied subjects; however, having an adolescent partner (OR, 2.0 CI 95% 1.06–4.0,P=.03) and a preterm delivery (OR, 3.0 CI 95% 1.43–6.55,P=.004) related to a higher risk for lower resilience.Conclusion. In light of the findings of the present study, programs oriented at giving adolescents support before, during, and after pregnancy should be encouraged.

Abstract MP60: Depressive Symptoms and Risk of Incident Atrial Fibrillation: The Multi-Ethnic Study of Atherosclerosis

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Parveen K Garg ◽  
Wesley T O'Neal ◽  
Ana V Diez Roux ◽  
Alvaro Alonso ◽  
Elsayed Soliman ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Depressive Symptoms ◽  
Proportional Hazards ◽  
Depression Scale ◽  
Epidemiologic Studies ◽  
Cox Proportional Hazards ◽  
Fee For Service ◽  
Score Distribution ◽  
Ethnic Study ◽  
Increased Risk

Background: Depression has been suggested as a potential risk factor for atrial fibrillation (AF) through effects on the autonomic nervous system and hypothalamus-pituitary-adrenal axis. Current literature examining the prospective relationship between depression and AF is inconsistent and limited to studies performed in predominantly white populations. We determined the relationship of both depressive symptoms and anti-depressant use with incident AF in a multi-ethnic cohort. Methods: The Multi-Ethnic Study of Atherosclerosis is a prospective study of 6,814 individuals without clinical cardiovascular disease. Depressive symptoms were assessed at baseline by the 20-item Center for Epidemiologic Studies Depression Scale (CES-D) and use of anti-depressant medications. Five CES-D groups were created based on the score distribution in approximate quartiles, and the top quartile split in 2 such that the top group represented persons with a score ≥16, a value commonly used to identify clinically relevant symptoms. Incident AF was identified from study ECGs verified for AF, ICD-9 hospital discharge diagnoses consistent with AF, and, for participants enrolled in fee-for-service Medicare, inpatient and outpatient AF claims data. Results: 6,644 participants (mean age=62; 53% women; 38% white; 28% black; 22% Hispanic; 12% Chinese-American) were included and followed for a median of 13 years. In separate adjusted Cox proportional hazards analyses, a CES-D≥16 (referent=CES-D<2) and anti-depressant use were each associated with higher incidence of AF (Table). Associations did not differ by race or gender (interaction p-values of 0.18 and 0.17 respectively). Similar results were obtained using time-updated measures of depression. Conclusions: Depressive symptoms are associated with an increased risk of incident AF. Further study into whether improving depressive symptoms reduces AF incidence is important.

scholarly journals Masculine Traits and Depressive Symptoms in Older and Younger Men and Women

2015 ◽  
Vol 12 (1) ◽  
pp. 19-29 ◽  
Author(s):  
Elizabeth C. Price ◽  
Jeffrey J. Gregg ◽  
Merideth D. Smith ◽  
Amy Fiske
Keyword(s):  
Depressive Symptoms ◽  
Internalizing Symptoms ◽  
Depression Scale ◽  
Externalizing Symptoms ◽  
Epidemiologic Studies ◽  
Assessment Tools ◽  
Age Group ◽  
Men And Women ◽  
Younger Men ◽  
And Gender

Evidence suggests that men who strongly endorse masculine traits display an atypical presentation of depression, including more externalizing symptoms (e.g., anger or substance use), but fewer typical, internalizing symptoms (e.g., depressed mood or crying). This phenomenon has not been adequately explored in older adults or women. The current study used the externalizing subscale of the Masculine Depression Scale in older and younger men and women to detect atypical symptoms. It was predicted that individuals who more strongly endorsed masculine traits would have higher scores on the measure of externalizing symptoms relative to a measure of typical depressive symptoms Center for Epidemiologic Studies–Depression Scale. It was anticipated that results would differ by age-group but not by gender. Multigroup path analysis was used to test the hypothesis. The hypothesized path model, in which endorsement of masculine traits was associated with lower scores on the Center for Epidemiologic Studies–Depression Scale and with scores on the externalizing, but not internalizing, factor of the Masculine Depression Scale, fit the data well. Results differed significantly by age-group and gender. Masculine individuals reported lower levels of typical depressive symptoms relative to externalizing symptoms, but further research is needed within age- and gender groups. Results are consistent with the gendered responding framework and suggest that current assessment tools, which tend to focus on internalizing symptoms of depression, may not detect depression in individuals who endorse masculine traits.

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