Agents for the Treatment of Pseudomonas aeruginosa Infections

1987 ◽  
Vol 8 (9) ◽  
pp. 380-383
Author(s):  
Mark Eggleston
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Mortality Rate ◽  
High Mortality ◽  
Antimicrobial Agents ◽  
The Past ◽  
Common Pathogen ◽  
Enhanced Activity

Pseudomonas aeruginosa is the most common pathogen of Pseudomonas species. One of the most virulent organisms pathogenic to man, P aeruginosa can cause a variety of infections in humans. Despite the introduction of many new antimicrobial agents with enhanced activity against P aeruginosa, the high mortality rate associated with the organism over the past two decades continues.

Treatment of Tetanus Neonatorum

PEDIATRICS ◽  
1967 ◽  
Vol 40 (2) ◽  
pp. 307-308
Author(s):  
MANZOOR ANZARI
Keyword(s):  
Mortality Rate ◽  
High Mortality ◽  
Successful Treatment ◽  
Primary Factor ◽  
Supportive Treatment ◽  
The Past ◽  
A Current

The successful treatment of newborn tetanus has continued to be a challenge. An appreciable drop in the mortality rate for this disease from a high percentage of some 80% to a current 36% has occurred only within the past 10 years. In a retrospective appraisal of treatment, it would seem that antitoxin serum has not been specific in the treatment of tetanus or in a decrease of the mortality rate; whereas heretofore, neglected supportive treatment was the primary factor contributing to a high mortality rate.

Penicillins With Antipseudomonal Activity

1985 ◽  
Vol 6 (4) ◽  
pp. 165-168
Author(s):  
Sandra M. Norris
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Antibiotic Resistance ◽  
Mortality Rate ◽  
High Mortality ◽  
Multiple Antibiotic Resistance ◽  
Nosocomial Pathogen

The escalating role of Pseudomonas aeruginosa as a nosocomial pathogen, the relatively high mortality rate associated with pseudomonal infections, the intrinsic antibiotic resistance of this versatile, ubiquitous organism, and the growing number of reports of multiple antibiotic resistance developing during therapy of Pseudomonas infections prompt a review of currently available penicillins with antipseudomonal activity. Ticarcillin, piperacillin, mezlocillin and azlocillin have upstaged carbenicillin, the first antipseudomonal, β-lactam agent clinically used, with other products “in the wings.”

scholarly journals Generation of Distinct Differentially Culturable Forms of Burkholderia following Starvation at Low Temperature

2022 ◽  
Author(s):  
Joss M. Auty ◽  
Christopher H. Jenkins ◽  
Jennifer Hincks ◽  
Anna A. Straatman-Iwanowska ◽  
Natalie Allcock ◽  
...  
Keyword(s):  
Mortality Rate ◽  
Low Temperature ◽  
High Mortality ◽  
Antimicrobial Agents ◽  
Bacterial Pathogens ◽  
High Abundance ◽  
Infected Host ◽  
Content Type

Bacterial pathogens exhibit physiologically distinct forms that enable their survival in an infected host, the environment and following exposure to antimicrobial agents. B. pseudomallei causes the disease melioidosis, which has a high mortality rate and is difficult to treat with antibiotics. The bacterium is endemic to several countries and detected in high abundance in the environment.

scholarly journals Alternative Screening Approaches for Discovery of Middle East Respiratory Syndrome Coronavirus Inhibitors

2014 ◽  
Vol 58 (8) ◽  
pp. 4251-4252 ◽  
Author(s):  
Robert L. LaFemina
Keyword(s):  
Middle East ◽  
Severe Acute Respiratory Syndrome ◽  
Respiratory Disease ◽  
High Mortality ◽  
Antimicrobial Agents ◽  
Mortality Rates ◽  
Middle East Respiratory Syndrome ◽  
Lead Compounds ◽  
The Past ◽  
Screening Approaches

ABSTRACTTwo coronaviruses causing severe respiratory disease and high mortality rates emerging within the past dozen years reinforces the need for clinically efficacious antivirals targeting coronaviruses. Alternative screening approaches for antivirals against the recently emergent Middle East respiratory syndrome coronavirus (MERS-CoV) may provide lead compounds to address this need. TwoAntimicrobial Agents and Chemotherapy(AAC) papers screened libraries of approved compounds that may potentially be repurposed as MERS-CoV antivirals. A third AAC paper showed that a previously described severe acute respiratory syndrome coronavirus (SARS-CoV) helicase inhibitor also has activity against MERS-CoV.

scholarly journals Ecthyma gangrenosum in a neonate

2017 ◽  
Vol 4 (2) ◽  
pp. 663
Author(s):  
Vindhiya K. ◽  
Lakshmi Charan C. ◽  
Aishwarya D. ◽  
Sindhu M.
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Mortality Rate ◽  
Critically Ill ◽  
High Mortality ◽  
Critically Ill Patients ◽  
Skin Infection ◽  
Rapid Progression ◽  
Healthy Children ◽  
Proper Treatment ◽  
Ecthyma Gangrenosum

Ecthyma gangrenosum (EG) is a rare skin infection caused by pseudomonas aeruginosa. It typically occurs in immunocompromised and critically ill patients but can occur rarely in healthy children. 28 days old neonate presented with widespread vesiculobullous lesions which ruptured to form punched out gangrenous ulcers with black eschar. Blood and pus culture grew Pseudomonas aeruginosa and diagnosis of EG due to pseudomonas was made. Despite appropriate measures, baby succumbed to the illness. Rapid progression of the lesions and high mortality rate emphasize the importance of early suspicion and proper treatment. 

Emamectin benzoate is a safe and effective anthelmintic against coelomic nematode Philometra rubra in striped bass Morone saxatilis

2020 ◽  
Vol 142 ◽  
pp. 47-53
Author(s):  
K Béland ◽  
G Séguin ◽  
S Lair
Keyword(s):  
Mortality Rate ◽  
Striped Bass ◽  
High Mortality ◽  
Morone Saxatilis ◽  
Treatment Results ◽  
Emamectin Benzoate ◽  
Once Daily ◽  
Fish Hatchery ◽  
Parasitic Burden

An unusually high mortality rate due to verminous (Philometra rubra) coelomitis was documented in wild-hatched striped bass Morone saxatilis raised in a fish hatchery as part of a stock restoration program. To decrease the parasitic burden and therefore potentially minimize mortality, the effectiveness of 2 different anthelmintics was evaluated. Two trials were conducted on wild-collected fingerlings naturally infected by P. rubra. In 2006, 144 yearling fish were randomly assigned to 4 experimental groups: (1) levamisole (Levasol®) at 2 mg l-1 via immersion for 8 h once weekly for 3 wk; (2) levamisole at a dose of 2.5 mg kg-1 biomass via feed once daily for 7 d; (3) emamectin benzoate (Slice®) at a dose of 0.05 mg kg-1 biomass via feed once daily for 7 d; and (4) control. Emamectin successfully eliminated live nematodes in 84.9% of the fish, whereas the administration of levamisole, either via immersion or feed, was not successful in significantly reducing the number of live P. rubra. In 2007, the administration of the same dosage of emamectin to approximately 1000 naturally infected yearling striped bass was associated with a 100% mortality rate of P. rubra in the 30 fish randomly examined 5 wk after the beginning of the treatment. Results of these trials indicate that, at the dosage used, the administration of emamectin at the end of the summer is safe for striped bass yearlings and considerably reduces the prevalence and intensity of the infection by this parasite.

Inovasi Teknologi Pembuatan Pakan Udang dengan Penambahan Tepung Kopasanda (Chromolaena odorata L.) di Desa Tamangapa Kecamatan Ma’rang Kab. Pangkep

2019 ◽  
Vol 3 (2) ◽  
pp. 140
Author(s):  
Harlina Harlina ◽  
Hadijah Hadijah ◽  
Kamaruddin Kamaruddin ◽  
Ernaningsih Ernaningsih
Keyword(s):  
Mortality Rate ◽  
Community Service ◽  
High Mortality ◽  
Raw Materials ◽  
Development Program ◽  
Chromolaena Odorata ◽  
Farmed Fish ◽  
Counseling Training ◽  
Shrimp Feed ◽  
Simple Technology

Tamangapa village, Ma’rang district is part of the community development program conducted by Universitas Muslim Indonesia in Pangkajene Kepulauan regency. The local shrimp farmers of Tamangapa village have been facing major issue due to expensive artificial feed and high mortality rate. In order to solve the needs of feed and high mortality rate for farmed fish or shrimp, the source of the natural ingredients using kopasanda leaves Chromolaena odorata L is required. The use of a natural ingredient is also used to prevent the vibriosis using simple technology such as the utilization of local raw materials which is affordable and locally available. The present community service aimed to provide the proper knowledge and skills to members of the fish/shrimp farmer’s group through counseling, training and mentoring. This community service program encouraged the local farmers to be able to utilize the local raw materials as a source of shrimp feed, use the feed pellet machine, and packaging leading to independent feed production. The participatory training method, lectures, forum group discussions, and practices of making shrimp feed and packaging were applied. The Implementation of the Community Partnership Program of Shrimp and Fish Cultivation Groups is independently able to produce organic fish or shrimp feed for farmer’s group leading to higher productivity of aquaculture.

Brain-eating Amoebae Infection: Challenges and Opportunities in Chemotherapy

2019 ◽  
Vol 19 (12) ◽  
pp. 980-987 ◽  
Author(s):  
Mohammad Ridwane Mungroo ◽  
Ayaz Anwar ◽  
Naveed Ahmed Khan ◽  
Ruqaiyyah Siddiqui
Keyword(s):  
Mortality Rate ◽  
Free Living ◽  
Outdoor Activities ◽  
The Past ◽  
Free Living Amoeba ◽  
Challenges And Opportunities ◽  
Life Threatening ◽  
The Central Nervous System ◽  
Living Nature ◽  
Treatment And Diagnosis

Pathogenic free-living amoeba are known to cause a devastating infection of the central nervous system and are often referred to as “brain-eating amoebae”. The mortality rate of more than 90% and free-living nature of these amoebae is a cause for concern. It is distressing that the mortality rate has remained the same over the past few decades, highlighting the lack of interest by the pharmaceutical industry. With the threat of global warming and increased outdoor activities of public, there is a need for renewed interest in identifying potential anti-amoebic compounds for successful prognosis. Here, we discuss the available chemotherapeutic options and opportunities for potential strategies in the treatment and diagnosis of these life-threatening infections.

Candida albicans endocarditis involving a normal native aortic valve in an immunocompetent patient

2020 ◽  
Vol 13 (11) ◽  
pp. e236902
Author(s):  
Taha Sheikh ◽  
Jeremy C Tomcho ◽  
Mohammed T Awad ◽  
Syeda Ramsha Zaidi
Keyword(s):  
Candida Albicans ◽  
Mortality Rate ◽  
Aortic Valve ◽  
High Mortality ◽  
Treatment Options ◽  
Immunocompetent Patient ◽  
Fungal Endocarditis ◽  
Appropriate Treatment ◽  
Mechanical Valves ◽  
Serious Infection

Fungal endocarditis, specifically from Candida species, is a rare but serious infection with a high mortality rate. Most cases occur in bioprosthetic or mechanical valves and are uncommon in native, structurally normal valves. When Candida endocarditis is detected and appropriate treatment is initiated earlier, there is an improvement in mortality. While the recommendation is usually to treat with a combination of surgery and antifungal medications, patient comorbidities may limit treatment options.

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