Younger women fare better than older women with ovarian cancer

ObjectiveThe aim of this study is to compare the clinicopathological features and survival of young women with endometrial cancer (aged <50 years) with those of older women with endometrial cancer (aged ≥50 years).MethodsWe conducted a retrospective cohort study of patients with histologically confirmed endometrial cancer treated at the Taipei Veterans General Hospital from 2001 to 2010.ResultsOne hundred forty-six patients (28.5%) were aged younger than 50 years at diagnosis. The median follow-up was 36.5 months (range, 0.9–121.7 months). Low body mass index (P< 0.001), nulliparity (P< 0.001), less medical illness (P< 0.001), synchronous primary ovarian cancer (P= 0.001), endometrioid type (P= 0.005), low tumor grade (P< 0.001), no para-aortic lymph node involvement (P< 0.047), less myometrial invasion (P< 0.001), and no vascular space invasion (P= 0.001) were common among the younger women compared with the older women. There were significant differences in the disease-free survival (P= 0.006) and overall survival (P= 0.004) between the 2 groups. In the multivariate Cox model, advanced stage had an effect on both disease-free survival (P= 0.004) and overall survival (P= 0.050).ConclusionsNulliparity, body mass index less than or equal to 23 kg/m2, endometrioid type, low-grade tumor, synchronous primary ovarian cancer, and favorable survival were common among the younger women.

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Under-Treatment of Older Patients with Newly Diagnosed Epithelial Ovarian Cancer Remains an Issue

Cancers ◽

10.3390/cancers13050952 ◽

2021 ◽

Vol 13 (5) ◽

pp. 952

Author(s):

Lucy Dumas ◽

Rebecca Bowen ◽

John Butler ◽

Susana Banerjee

Keyword(s):

Ovarian Cancer ◽

Older Women ◽

Older Patients ◽

Single Agent ◽

Eastern Cooperative Oncology Group ◽

Standard Of Care ◽

First Line ◽

Care Treatment ◽

Platinum Based Chemotherapy ◽

Standard Of Care Treatment

Older women with ovarian cancer have disproportionately poorer survival outcomes than their younger counterparts and receive less treatment. In order to understand where the gaps lie in the treatment of older patients, studies incorporating more detailed assessment of baseline characteristics and treatment delivery beyond the scope of most cancer registries are required. We aimed to assess the proportion of women over the age of 65 who are offered and receive standard of care for first-line ovarian cancer at two UK NHS Cancer Centres over a 5-year period (December 2009 to August 2015). Standard of care treatment was defined as a combination of cytoreductive surgery and if indicated platinum-based chemotherapy (combination or single-agent). Sixty-five percent of patients aged 65 and above received standard of care treatment. Increasing age was associated with lower rates of receiving standard of care (35% > 80 years old versus 78% of 65–69-year-olds, p = 0.000). Older women were less likely to complete the planned chemotherapy course (p = 0.034). The oldest women continue to receive lower rates of standard care compared to younger women. Once adjusted for Federation of Gynaecology and Obstetrics (FIGO) stage, Eastern Cooperative Oncology Group (ECOG) performance status and first-line treatment received, age was no longer an independent risk factor for poorer overall survival. Optimisation of vulnerable patients utilising a comprehensive geriatric assessment and directed interventions to facilitate the delivery of standard of care treatment could help narrow the survival discrepancy between the oldest patients and their younger counterparts.

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Taking the next step in PARP-inhibitor clinical trials in older women with ovarian cancer – Staging the aging

Gynecologic Oncology Reports ◽

10.1016/j.gore.2021.100710 ◽

2021 ◽

Vol 35 ◽

pp. 100710

Author(s):

G. Liposits ◽

S.M. Lichtman

Keyword(s):

Ovarian Cancer ◽

Clinical Trials ◽

Older Women ◽

Parp Inhibitor ◽

Cancer Staging

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Utilization of preimplantation genetic testing in the USA

Journal of Assisted Reproduction and Genetics ◽

10.1007/s10815-021-02078-4 ◽

2021 ◽

Author(s):

Kaitlyn Roche ◽

Catherine Racowsky ◽

Joyce Harper

Keyword(s):

Genetic Testing ◽

Older Women ◽

State Level ◽

Oocyte Retrieval ◽

Preimplantation Genetic Testing ◽

Annual Increase ◽

Younger Women ◽

Live Birth Rates ◽

Significant Difference ◽

The Usa

Abstract Purpose To evaluate the use of preimplantation genetic testing (PGT) and live birth rates (LBR) in the USA from 2014 to 2017 and to understand how PGT is being used at a clinic and state level. Methods This study accessed SART data for 2014 to 2017 to determine LBR and the CDC for years 2016 and 2017 to identify PGT usage. Primary cycles included only the first embryo transfer within 1 year of an oocyte retrieval; subsequent cycles included transfers occurring after the first transfer or beyond 1 year of oocyte retrieval. Results In the SART data, the number of primary PGT cycles showed a significant monotonic annual increase from 18,805 in 2014 to 54,442 in 2017 (P = 0.042) and subsequent PGT cycles in these years increased from 2946 to 14,361 (P = 0.01). There was a significant difference in primary PGT cycle use by age, where younger women had a greater percentage of PGT treatment cycles than older women. In both PGT and non-PGT cycles, the LBR per oocyte retrieval decreased significantly from 2014 to 2017 (P<0001) and younger women had a significantly higher LBR per oocyte retrieval compared to older women (P < 0.001). The CDC data revealed that in 2016, just 53 (11.4%) clinics used PGT for more than 50% of their cycles, which increased to 99 (21.4%) clinics in 2017 (P< 0.001). Conclusions A growing number of US clinics are offering PGT to their patients. These findings support re-evaluation of the application for PGT.

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An improved YOLOv3 model for detecting location information of ovarian cancer from CT images

Intelligent Data Analysis ◽

10.3233/ida-205542 ◽

2021 ◽

Vol 25 (6) ◽

pp. 1565-1578

Author(s):

Xun Wang ◽

Hanlin Li ◽

Lisheng Wang ◽

Yongzhi Yu ◽

Hao Zhou ◽

...

Keyword(s):

Ovarian Cancer ◽

Cancer Cells ◽

Ovarian Cancer Cells ◽

Location Information ◽

Learning Technology ◽

Medical College ◽

Geometric Deformation ◽

Women's Lives ◽

Aided Diagnosis ◽

Better Than

Ovarian cancer is a malignant tumor that poses a serious threat to women’s lives. Computer-aided diagnosis (CAD) systems can classify the type of ovarian tumors, but few of them can provide exactly the location information of ovarian cancer cells. Recently, deep learning technology becomes hot for automatic detection of cancer cells, particularly for detecting their locations. In this work, we propose a novel end-to-end network YOLO-OC (Ovarian cancer) model, which can extract the characteristics of ovarian cancer more efficiently. In our method, deformable convolution is used to enhance the model’s ability to learn geometric deformation in space. Squeeze-and-Excitation (SE) module is proposed to automatically learn the importance of different channel features. Data experiments are conducted on datasets collected from The Affiliated Hospital of Qingdao University Medical College, China. Experimental results show that our YOLO-OC model achieves 91.83%, 85.66% and 73.82% on mean average precision [email protected], [email protected] and mAP@[.5,.95], respectively, which performs better than Faster R-CNN, SSD and RetinaNet on both accuracy and efficiency.

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What's the Risk? Older Women Report Fewer Symptoms for Suspected Acute Coronary Syndrome than Younger Women

BioResearch Open Access ◽

10.1089/biores.2018.0020 ◽

2018 ◽

Vol 7 (1) ◽

pp. 131-138 ◽

Cited By ~ 5

Author(s):

Holli A. DeVon ◽

Karen Vuckovic ◽

Larisa A. Burke ◽

Sahereh Mirzaei ◽

Katherine Breen ◽

...

Keyword(s):

Acute Coronary Syndrome ◽

Older Women ◽

Younger Women ◽

Coronary Syndrome

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Reported Intimacy and Dominance Gestures by Women in a Corporate Setting

Psychological Reports ◽

10.2466/pr0.1983.52.3.1007 ◽

1983 ◽

Vol 52 (3) ◽

pp. 1007-1010

Author(s):

Aghop Der-Karabetian ◽

Eric Rico

Keyword(s):

Marital Status ◽

Older Women ◽

Sexual Intimacy ◽

Younger Women ◽

Relationship Of ◽

The Relationship ◽

Effect Of Age

The study tested the relationship of reported intimacy and dominance gestures by women in a corporate setting. The effect of age and marital status was also examined. The reported frequencies of the two types of gestures were uncorrelated ( r = .28). However, dominance was reported more frequently ( M = 9.85, SD = 1.8) than sexual intimacy ( M = 5.76, SD = 3.1). The 34 younger women reported more dominance and less sexual intimacy than the 48 older women. Single persons reported being targets of more dominance gestures than the married, but the younger women reported less sexual intimacy. Possible explanations for the findings are discussed.

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Maori fertility in a period of transition

Journal of Biosocial Science ◽

10.1017/s0021932000010208 ◽

1975 ◽

Vol 7 (3) ◽

pp. 345-352 ◽

Cited By ~ 5

Author(s):

A. V Zodgekar

Keyword(s):

Older Women ◽

Fertility Decline ◽

Birth Rate ◽

Crude Birth Rate ◽

Rapid Urbanization ◽

Younger Women ◽

Low Level ◽

Child Bearing ◽

Age Patterns ◽

Substantial Decline

SummaryAn analysis of Maori fertility shows that a transition from a high to a low level has begun. The crude birth rate has declined by nearly 28% during the period 1961–72; only a small part of this decline can be attributed to changes in the age–sex and marital status composition.A substantial decline in the fertility of older women has been observed and there are indications of the beginning of a major decline in the fertility of younger women. Since women aged 30–49 still account for 30% of total fertility there is enough potential for a further fertility decline in the later child-bearing years.Age patterns of fertility decline suggest that inter-marriage between Pakehas and Maoris is not a prime cause of the recent fertility decline. The factors which are thought to be responsible for this change in Maori fertility are rapid urbanization, a low level of infant mortality and an increase in the overall level of education.A further decline in Maori fertility will depend on the continuation of the tendency in fertility among the younger women.

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CERVICAL CANCER AMONG 39 YEARS OR YOUNGER FEMALES IN SOUTH INDIA; A RETROSPECTIVE STUDY

10.36106/ijsr/0700673 ◽

2021 ◽

pp. 15-17

Author(s):

B Ramkumar ◽

Srigopal Mohanty ◽

Kiranmayee Narapaneni ◽

Amit Saklani ◽

J Kannan

Keyword(s):

Cervical Cancer ◽

Retrospective Study ◽

Older Women ◽

Young Women ◽

Clinicopathological Characteristics ◽

Categorical Variables ◽

Chi Square ◽

Younger Women ◽

Ciency Virus ◽

Chi Square Test

Background: Cervical cancer in young women is rare and disparity exists in its characteristics in the available reports. The study aimed to determine the disease burden and to compare its clinicopathological characteristics with older women. Materials and methods: Retrospective study was performed by retrieving data from the cancer registry for consecutive 843 cervical cancer patients treated in the center between 2017 and 2020. Patients were divided into younger (<40 years) and older (≥ 40 years) age. Statistical analysis was performed using SPSS software version 23 for windows. Chi square test was used for analyzing the categorical variables and P < 0.05 was considered signicant. Results: Cervical cancer in young women constituted 9.4%, with majority (96.2%) belonged to 30-39 years age. Higher prevalence of human immunodeciency virus (HIV) was found among younger compared to older women (P = 0.000). Younger women commonly presented late compared to older women (patients presented after 4 months are 49.4% vs. 18.8% respectively, P=0.000). Squamous cell carcinoma was commonest histology in both the groups and no difference in histology pattern between the two groups. Younger women had higher rate of bulky tumor (>4cm) compared to older (62.2% vs. 44.4%, P = 0.023). Conclusion: Delayed and advanced stage of presentation of cervical cancer in younger women in this region of India warrants promotion of health education, knowledge translation, regular cervical cancer screening for its prevention and early detection

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