scholarly journals Bis(zinc(II)-dipicolylamine)-functionalized sub-2 μm core-shell microspheres for the analysis of N-phosphoproteome

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Yechen Hu ◽  
Bo Jiang ◽  
Yejing Weng ◽  
Zhigang Sui ◽  
Baofeng Zhao ◽  
...  
Keyword(s):  
Critical Role ◽  
Core Shell ◽  
Central Metabolism ◽  
Biological Functions ◽  
Silica Microspheres ◽  
Acidic Conditions ◽  
Neutral Conditions ◽  
Phosphate Groups ◽  
Enrichment Methods

AbstractProtein N-phosphorylation plays a critical role in central metabolism and two/multicomponent signaling of prokaryotes. However, the current enrichment methods for O-phosphopeptides are not preferred for N-phosphopeptides due to the intrinsic lability of P-N bond under acidic conditions. Therefore, the effective N-phosphoproteome analysis remains challenging. Herein, bis(zinc(II)-dipicolylamine)-functionalized sub-2 μm core-shell silica microspheres (SiO2@DpaZn) are tailored for rapid and effective N-phosphopeptides enrichment. Due to the coordination of phosphate groups to Zn(II), N-phosphopeptides can be effectively captured under neutral conditions. Moreover, the method is successfully applied to an E.coli and HeLa N-phosphoproteome study. These results further broaden the range of methods for the discovery of N-phosphoproteins with significant biological functions.

Non-Plasmonic SERS with Silicon: Is It Really Safe? New Insights into Opto-Thermics of Core/Shell Microbeads

2018 ◽  
Author(s):  
Nicolò Bontempi ◽  
Irene Vassalini ◽  
Stefano Danesi ◽  
Matteo Ferroni ◽  
Paolo Colombi ◽  
...  
Keyword(s):  
Critical Role ◽  
Raman Laser ◽  
Core Shell ◽  
Thermal Coupling ◽  
Melting Points ◽  
Experimental Proof ◽  
Weakly Coupled ◽  
Light Management ◽  
Laser Sources ◽  
First Time

<p>Here we investigate for the first time the opto-thermal behavior of SiO<sub>2</sub>/Si core/shell microbeads (Si-rex) irradiated with three common Raman laser sources (lambda=532, 633, 785 nm) under real working conditions. We obtained an experimental proof of the critical role played by bead size and aggregation in heat and light management, demonstrating that in the case of strong opto-thermal coupling the temperature can exceed that of the melting points of both core and shell components. In addition, we also show that weakly coupled beads can be utilized as stable substrates for plasmon-free SERS experiments.</p>

XIST: A Meaningful Long Noncoding RNA in NSCLC Process

2020 ◽  
Vol 26 ◽  
Author(s):  
Yujie Shen ◽  
Yexiang Lin ◽  
Kai Liu ◽  
Jinlan Chen ◽  
Juanjuan Zhong ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Critical Role ◽  
Biological Functions ◽  
Potential Therapeutic Target ◽  
Considerable Evidence ◽  
Lncrna Xist ◽  
Nsclc Patients ◽  
The Relationship

Background: A number of studies have proposed that lncRNA XIST plays a role in the development and chemosensitivity of NSCLC. Besides, XIST may become a potential therapeutic target for NSCLC patients. The aim of this review is to reveal the biological functions and exact mechanisms of XIST in NSCLC. Methods: In this review, relevant researches involving in the relationship between XIST and NSCLC are collected through systematic retrieval of PubMed Results: XIST is an oncogene in NSCLC and is abnormally upregulated in NSCLC tissues. Considerable evidence has shown that XIST exerts a critical role in the proliferation, invasion, migration, apoptosis and chemosensitivity of NSCLC cells. XIST mainly functions as a ceRNA in NSCLC process, while XIST also functions at transcriptional levels. Conclusion: LncRNA XIST has potential to become a novel biomolecular marker of NSCLC and a therapeutic target for NSCLC.

scholarly journals ARMC Subfamily: Structures, Functions, Evolutions, Interactions, and Diseases

2021 ◽  
Vol 8 ◽  
Author(s):  
Yutao Huang ◽  
Zijian Jiang ◽  
Xiangyu Gao ◽  
Peng Luo ◽  
Xiaofan Jiang
Keyword(s):  
Signal Transduction ◽  
Amino Acids ◽  
Cell Adhesion ◽  
Tandem Repeats ◽  
Critical Role ◽  
The Other ◽  
Biological Functions ◽  
Armadillo Repeat ◽  
The One ◽  
Similar Domain

Armadillo repeat-containing proteins (ARMCs) are widely distributed in eukaryotes and have important influences on cell adhesion, signal transduction, mitochondrial function regulation, tumorigenesis, and other processes. These proteins share a similar domain consisting of tandem repeats approximately 42 amino acids in length, and this domain constitutes a substantial platform for the binding between ARMCs and other proteins. An ARMC subfamily, including ARMC1∼10, ARMC12, and ARMCX1∼6, has received increasing attention. These proteins may have many terminal regions and play a critical role in various diseases. On the one hand, based on their similar central domain of tandem repeats, this ARMC subfamily may function similarly to other ARMCs. On the other hand, the unique domains on their terminals may cause these proteins to have different functions. Here, we focus on the ARMC subfamily (ARMC1∼10, ARMC12, and ARMCX1∼6), which is relatively conserved in vertebrates and highly conserved in mammals, particularly primates. We review the structures, biological functions, evolutions, interactions, and related diseases of the ARMC subfamily, which involve more than 30 diseases and 40 bypasses, including interactions and relationships between more than 100 proteins and signaling molecules. We look forward to obtaining a clearer understanding of the ARMC subfamily to facilitate further in-depth research and treatment of related diseases.

Co-Extrusion Technology for Functioned Nature Fiber Reinforced Polymer Composites

2013 ◽  
Vol 773 ◽  
pp. 497-501
Author(s):  
Run Zhou Huang ◽  
Cheng Jun Zhou ◽  
Yang Zhang ◽  
Qing Lin Wu
Keyword(s):  
Polymer Composites ◽  
Shell Structure ◽  
Critical Role ◽  
Core Shell ◽  
Green Composite ◽  
Reinforced Polymer ◽  
Fiber Reinforced Polymer Composites ◽  
Core Shell Structure ◽  
Extrusion Technology ◽  
New Generation

As a new-generation green composite, core-shell structure nature fibers/ polymer composites (NFPC) has been recently developed and used to enhance performance characteristics of composites. The shell layer, made of thermopolymers unfilled or filled with minerals or nature fibers and other additives, plays a critical role in enhancing overall composite properties. The co-extrusion technology for different structural and material combinations are, however, needed to achieve desired processing. In this paper, co-extrusion technology and core-shell structure NFPC have been discussed by systematically studying the effect of structure on properties of NFPC. The result of this paper can help provide a fundamental base for developing new functional applications of core-shell structure NFPCs.

Review of the Synthetic Chemistry Involved in the Production of Core/Shell Semiconductor Nanocrystals

2007 ◽  
Vol 60 (7) ◽  
pp. 457 ◽  
Author(s):  
Joel van Embden ◽  
Jacek Jasieniak ◽  
Daniel E. Gómez ◽  
Paul Mulvaney ◽  
Michael Giersig
Keyword(s):  
Semiconductor Nanocrystals ◽  
Critical Role ◽  
Charge Carriers ◽  
Core Shell ◽  
Synthetic Chemistry ◽  
Shell Material ◽  
Growth Processes ◽  
Passivating Layer ◽  
Spectral Shifts

Passivation of CdSe semiconductor nanocrystals can be achieved by overcoating the particles with a homogeneous shell of a second semiconductor. Shell layers are grown in monolayer steps to ensure homogeneous growth of the shell. The relative band edges of the two materials determine the photoreactiveity of the resultant core-shell nanocrystals. The critical role of ligands in minimizing nucleation of the shell material during the growth of the passivating layer is emphasized. The delocalization of charge carriers into the shell layers can be followed spectroscopically during the growth processes. The relative spectral shifts are directly correlated to the relative energies of the band edges.

Multifunctional core-shell silica microspheres and their performance in self-carrier decomposition, sustained drug release and fluorescent bioimaging

2018 ◽  
Vol 263 ◽  
pp. 148-156 ◽  
Author(s):  
Yamina Ait Mehdi ◽  
Asma Itatahine ◽  
Meriem Fizir ◽  
Deli Xiao ◽  
Pierre Dramou ◽  
...  
Keyword(s):  
Drug Release ◽  
Core Shell ◽  
Silica Microspheres ◽  
Sustained Drug Release

scholarly journals HOTAIR: An Oncogenic Long Non-Coding RNA in Human Cancer

2018 ◽  
Vol 47 (3) ◽  
pp. 893-913 ◽  
Author(s):  
Qing Tang ◽  
Swei Sunny Hann
Keyword(s):  
Drug Resistance ◽  
Human Cancer ◽  
Critical Role ◽  
Stem Cell Differentiation ◽  
Human Diseases ◽  
Biological Functions ◽  
Protein Coding ◽  
Non Coding Rna ◽  
And Function ◽  
Long Non Coding Rna

Long non-coding RNAs (LncRNAs) represent a novel class of noncoding RNAs that are longer than 200 nucleotides without protein-coding potential and function as novel master regulators in various human diseases, including cancer. Accumulating evidence shows that lncRNAs are dysregulated and implicated in various aspects of cellular homeostasis, such as proliferation, apoptosis, mobility, invasion, metastasis, chromatin remodeling, gene transcription, and post-transcriptional processing. However, the mechanisms by which lncRNAs regulate various biological functions in human diseases have yet to be determined. HOX antisense intergenic RNA (HOTAIR) is a recently discovered lncRNA and plays a critical role in various areas of cancer, such as proliferation, survival, migration, drug resistance, and genomic stability. In this review, we briefly introduce the concept, identification, and biological functions of HOTAIR. We then describe the involvement of HOTAIR that has been associated with tumorigenesis, growth, invasion, cancer stem cell differentiation, metastasis, and drug resistance in cancer. We also discuss emerging insights into the role of HOTAIR as potential biomarkers and therapeutic targets for novel treatment paradigms in cancer.

Ferromagnetic–Antiferromagnetic Coupling Core–Shell Nanoparticles with Spin Conservation for Water Oxidation

2021 ◽  
Author(s):  
Jingjie Ge ◽  
Riccardo Ruixi Chen ◽  
Xiao Ren ◽  
Xia Li ◽  
Jiawei Liu ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Electron Transport ◽  
Domain Structure ◽  
Applied Magnetic Field ◽  
Water Oxidation ◽  
Rational Design ◽  
Critical Role ◽  
Antiferromagnetic Coupling ◽  
Core Shell ◽  
Multiple Domain

<p>Rational design of active oxygen evolution reaction (OER) catalysts is critical for the overall efficiency of water electrolysis. OER reactants and products’ differing spin states is one of causes to slow OER kinetics. Thus, spin conservation plays a crucial role in enhancing OER performance. In this work, we design ferromagnetic (FM)–antiferromagnetic (AFM) Fe<sub>3</sub>O<sub>4</sub>@Ni(OH)<sub>2</sub> core–shell catalysts. The interfacial FM–AFM coupling of these catalysts facilitates selective removal of electrons with spin direction opposing the magnetic moment of FM core, improving OER kinetics. The shell thickness is found critical in retaining the coupling effect for OER enhancement. The magnetic domain structure of the FM core also plays a critical role. With a multiple domain core, the applied magnetic field aligns the magnetic domains, optimising the electron transport process. A significant enhancement of OER activity is observed for the multiple domain core catalysts. With a single domain FM core with ordered magnetic dipoles, the spin-selective electron transport with minimal scattering is facilitated even without an applied magnetic field. We therefore draw a magnetism/OER activity model that depends on two main parameters: interfacial spin coupling and domain structure. Our findings provide new design principles for active OER catalysts.</p>

scholarly journals More than Nutrition: Therapeutic Potential of Breast Milk-Derived Exosomes in Cancer

2020 ◽  
Vol 21 (19) ◽  
pp. 7327
Author(s):  
Ki-Uk Kim ◽  
Wan-Hoon Kim ◽  
Chi Hwan Jeong ◽  
Dae Yong Yi ◽  
Hyeyoung Min
Keyword(s):  
Breast Milk ◽  
Therapeutic Potential ◽  
Critical Role ◽  
Drug Carriers ◽  
Enzymatic Digestion ◽  
Lymphocytic Leukemia ◽  
Human Breast Milk ◽  
Exosomal Mirnas ◽  
Acidic Conditions ◽  
Low Prevalence

Human breast milk (HBM) is an irreplaceable source of nutrition for early infant growth and development. Breast-fed children are known to have a low prevalence and reduced risk of various diseases, such as necrotizing enterocolitis, gastroenteritis, acute lymphocytic leukemia, and acute myeloid leukemia. In recent years, HBM has been found to contain a microbiome, extracellular vesicles or exosomes, and microRNAs, as well as nutritional components and non-nutritional proteins, including immunoregulatory proteins, hormones, and growth factors. Especially, the milk-derived exosomes exert various physiological and therapeutic function in cell proliferation, inflammation, immunomodulation, and cancer, which are mainly attributed to their cargo molecules such as proteins and microRNAs. The exosomal miRNAs are protected from enzymatic digestion and acidic conditions, and play a critical role in immune regulation and cancer. In addition, the milk-derived exosomes are developed as drug carriers for delivering small molecules and siRNA to tumor sites. In this review, we examined the various components of HBM and their therapeutic potential, in particular of exosomes and microRNAs, towards cancer.

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