scholarly journals Food nanoparticles from rice vinegar: isolation, characterization, and antioxidant activities

2022 ◽  
Vol 6 (1) ◽  
Author(s):  
Zhaoshuo Yu ◽  
Ying Tan ◽  
Sihao Luo ◽  
Jingru Zhou ◽  
Tianhao Xu ◽  
...  
Keyword(s):  
Dry Matter ◽  
Antioxidant Activities ◽  
Peritoneal Macrophages ◽  
Mineral Elements ◽  
Cellular Growth ◽  
Hydrodynamic Diameter ◽  
Gel Chromatography ◽  
Rice Vinegar ◽  
Average Hydrodynamic Diameter ◽  
Spherical Microparticles

AbstractAbundant nanostructures have been constantly found in various foods, like vinegar, tea, coffee, and milk. However, these structures largely remain unexplored and even been eliminated for stability reasons in food industry. Here we report the isolation, characterization, and antioxidant activities of food nanoparticles (NPs) carrying polyphenols from Chinese rice vinegar. Using a gel-chromatography-based isolation protocol, the vinegar was separated into three major fractions. They were identified as spherical NPs (P1), lollipop-like NPs (P2) and spherical microparticles (P3) with average hydrodynamic diameter of 210, 245,1643 nm, separately. The former two fractions accounted for the major parts of dry matter in the vinegar. The P1-NPs fraction was composed of proteins, carbohydrates, and a high number of polyphenols (15 wt%), demonstrated potent antioxidant activity as determined by ABTS and ORAC assays. Moreover, they effectively quenched peroxyl free radicals in peritoneal macrophages and promoted cellular growth. The P2 fraction contained majority of organic acids, esters and mineral elements of the vinegar. It demonstrated the NPs are bioactive units of the rice vinegar, inspiring the development of novel functional nanomaterials with nutraceutical and pharmaceutical applications.

Trypsinolysis of Polyurethane Particles Based on Сyclodextrin with Encapsulated Moxifloxacin

2021 ◽  
Vol 37 (5) ◽  
pp. 72-79
Author(s):  
L.R. Yakupova ◽  
А.А. Skuredina ◽  
Е.V. Kudryashova
Keyword(s):  
Enzymatic Degradation ◽  
Dosage Forms ◽  
Oral Dosage ◽  
Hydrodynamic Diameter ◽  
Prolonged Action ◽  
Cyclodextrin Complexes ◽  
Acidic Media ◽  
Drug Molecules ◽  
Oral Dosage Forms ◽  
Average Hydrodynamic Diameter

Abstract-Moxifloxacin encapsulation in polymer cyclodextrin-based particles with an average hydrodynamic diameter of 150--200 nm has led to the formation of potential delivery systems with a degree of moxifloxacin inclusion of more than 80%. Cross-linking of the moxifloxacin-cyclodextrin complexes caused a pronounced slowdown in the release of the drug molecules in acidic media to less than 10% per day. In the presence of trypsin, the drug release was accelerated by 15--20% within 90 min. It was shown by Fourier-transform infrared spectroscopy that this acceleration was due to the partial enzymatic degradation of the urethane bonds of the polymer matrix near the surface of the particles. The results obtained are important for the development of highly effective oral dosage forms of prolonged action. Key words: fluoroquinolones, cyclodextrins, FTIR spectroscopy, trypsin

scholarly journals A simple and sensitive sensor for silver ions based on unmodified gold nanoparticles by using dynamic light scattering techniques

2017 ◽  
Vol 95 (12) ◽  
pp. 1267-1272 ◽  
Author(s):  
Zhiyou Xiao ◽  
Anjiang Tang ◽  
Hongsheng Huang ◽  
Ze Wang
Keyword(s):  
Gold Nanoparticles ◽  
Light Scattering ◽  
Dynamic Light Scattering ◽  
High Sensitivity ◽  
Silver Ions ◽  
Hydrodynamic Diameter ◽  
Optimum Conditions ◽  
Sensitivity And Selectivity ◽  
Sensitive Sensor ◽  
Average Hydrodynamic Diameter

A simple and sensitive assay for Ag+ was developed with unmodified gold nanoparticles (AuNPs) by using dynamic light scattering techniques. Ag+ could induce the oligonucleotide (5′-ATC ACT ATA TCA TAT ACT CAT-3′) to change from a single-stranded structure to a double-stranded structure and desorb from the surface of AuNPs, which triggered the aggregation of AuNPs in the salt solution. The average hydrodynamic diameter of aggregated AuNPs could be detected by using dynamic light scattering techniques. Under the optimum conditions, the average hydrodynamic diameter of AuNPs is proportional to the concentration of Ag+ within the range of 13.3–100.0 nmol/L, with a detection limit of 3.2 nmol/L. The method is easy to operate and has low sample consumption, high sensitivity and selectivity.

scholarly journals Comparative Studies of the Phytochemical and Antioxidant activities of the leaves, stems, roots, and seeds extracts of Mitracarpus scaber Zucc (Rubiaceae)

2020 ◽  
Vol 10 (7) ◽  
pp. 668
Author(s):  
Wacothon Karime Coulibaly
Keyword(s):  
Ascorbic Acid ◽  
Phenolic Compounds ◽  
Dry Matter ◽  
Antioxidant Activities ◽  
Phytochemical Screening ◽  
Average Value ◽  
Mitracarpus Scaber ◽  
Layer Chromatography ◽  
Gallic Acid Equivalent ◽  
Ethyl Acetate Extracts

Extracts of the leaves, stem, roots, and seeds of <em>Mitracarpus scaber</em> plants have been thoroughly investigated in an attempt to determine their phytochemical and antioxidant activities.<em> </em>Phytochemical screening carried out by thin-layer chromatography (TLC) revealed the presence of several secondary metabolites in all the selective extracts of the plant. The levels of phenolic compounds showed that the leaves of <em>M. Scaber</em> are the richest in polyphenols with an average value of 488.291 ± 1.205 μg GAE/g (microgram of gallic acid equivalent per gram of the dry matter of the powdered plant). The total flavonoid assay revealed a high content in the leaves (1.624 ± 0.032 %). Also, studies of the antioxidant activities by DPPH<sup>● </sup>(2,2-diphenyl-1'-picrylhydrazyl) method showed a significant effect compared to vitamin C (96.62 %). The percentages of inhibition are respectively 89.82 % and 82.3 % for ethyl acetate extracts of the leaves and seeds. Furthermore, the inhibitory percentages of n-butanol in the leaves and seeds are 90.57 % and 83.67 %, respectively. Calculated IC<sub>50</sub> showed that the n-butanol fraction of the seeds exhibited the highest activity with an IC<sub>50</sub> of 0.293 mg/mL less than ascorbic acid with an IC<sub>50</sub> of 0.387 mg/mL.

scholarly journals HPLC Fingerprint of Bioactive Compounds and Antioxidant Activities of Viscum album from Different Host Trees

2011 ◽  
Vol 39 (1) ◽  
pp. 48 ◽  
Author(s):  
Simona Ioana VICAŞ ◽  
Olivia Dumitrita RUGINA ◽  
Loredana LEOPOLD ◽  
Adela PINTEA ◽  
Carmen SOCACIU
Keyword(s):  
Antioxidant Activity ◽  
Bioactive Compounds ◽  
Malus Domestica ◽  
Dry Matter ◽  
Total Phenolics ◽  
Antioxidant Activities ◽  
Viscum Album ◽  
Fraxinus Excelsior ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Host Trees

Viscum album L. is a medicinal plants used for many years as a remedy in the traditional medicine and in complementary cancer therapies. We investigated the influence of some host trees: Acer campestre (VAA), Fraxinus excelsior (VAF), Populus nigra (VAP), Malus domestica (VAM), and Robinia pseudoacacia (VAR), on the chemical composition and antioxidant activity of leaves and stems from V. album, as well the influence of the solvent (water and ethanol) used for extraction on biological activity. HPLC with photodiode array detector analysis of bioactive compounds from leaves and stems of mistletoes (V. album) hosted by five differents trees was performed. Antioxidant activities, determined by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), Oxygen Radical Absorbance Capacity (ORAC), (Trolox-equivalent antioxidant capacity (TEAC) methods were compared with the quantification of total phenolics using the Folin -Ciocalteu reagent. V. album hosted by Fraxinus excelsior (VAF), recorded the highest level of total phenolic acids (108.64 μg/g dry matter) while the mistletoe hosted by Malus domestica (VAM) had the lowest level of total polyphenols (39.37 μg/g dry matter). In general, higher antioxidant activity was detected in the alcoholic than in the aqueous extracts. The values obtained for total phenolics in both, aqueous and ethanol extracts, decreased in the order: VAR > VAF > VAP > VAA > VAM. The mistletoe stem extracts contained lower levels of phenolics, as compared to leaves, in both solvents. Our results suggest that mistletoe extracts possess significant antioxidant activities that may be due to their bioactive compounds content, suggesting that this plant may be an important source of natural products with chemopreventive and chemotherapeutic activities.

scholarly journals Review about Non-Lipid Components and Minor Fat-Soluble Bioactive Compounds of Almond Kernel

Foods ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1646
Author(s):  
José M. Roncero ◽  
Manuel Álvarez-Ortí ◽  
Arturo Pardo-Giménez ◽  
Adrián Rabadán ◽  
José E. Pardo
Keyword(s):  
Antioxidant Activities ◽  
Protein Profile ◽  
Soluble Sugars ◽  
Mineral Elements ◽  
Protein Food ◽  
Iron Copper ◽  
Mineral Fraction ◽  
Copper Manganese ◽  
Phytochemical Compounds ◽  
Lipid Components

This work presents a bibliographic review about almond kernel non-lipid components, in particular about the protein fraction, the carbohydrates and the mineral fraction. In addition, other fat-soluble phytochemicals which are present in minor concentrations but show important antioxidant activities are reviewed. Almond kernel is a rich protein food (8.4–35.1%), in which the globulin–albumin fraction dominates, followed by glutelins and prolamins. Within the almond kernel protein profile, amandine dominates. Free amino acids represent a small amount of the total nitrogen quantity, highlighting the presence of glutamic acid and aspartic acid, followed by arginine. Carbohydrates that appear in almond kernels (14–28%) are soluble sugars (mainly sucrose), starch and other polysaccharides such as cellulose and non-digestible hemicelluloses. Regarding the mineral elements, potassium is the most common, followed by phosphorus; both macronutrients represent more than 70% of the total mineral fraction, without taking into account nitrogen. Microminerals include sodium, iron, copper, manganese and zinc. Within the phytochemical compounds, tocopherols, squalene, phytosterols, stanols, sphingolipids, phospholipids, chlorophylls, carotenoids, phenols and volatile compounds can be found.

Statistical research on the fate of dietary mineral elements in dry and lactating cows IV. Chloride

1969 ◽  
Vol 73 (2) ◽  
pp. 223-229 ◽  
Author(s):  
R. Paquay ◽  
F. Lomba ◽  
A. Lousse ◽  
V. Bienfet
Keyword(s):  
Milk Production ◽  
Dry Matter ◽  
Mineral Elements ◽  
Statistical Research ◽  
Lactating Cows ◽  
Chloride Excretion ◽  
Daily Milk Production ◽  
Very High ◽  
Matter Energy ◽  
Daily Milk

SUMMARYStatistical analyses were carried out on the data obtained under very strict conditions in metabolism stalls with 41 different rations fed to 127 adult non-pregnant dry cows, and with 14 other different rations fed to 35 adult non-pregnant lactating cows that had calved 2–6 months earlier and whose daily milk production ranged from 11 to 20 kg.The authors have calculated and studied the correlations between faecal and urinary losses of chloride, chloride excretion with the milk, digestible chloride and chloride balance and many other nutritive factors which were analysed for each of the 55 above mentioned experimental diets.The results show that the digestion and utilization of chloride is not influenced by the amount of ingested chloride at the time of the trial. The digestion is generally very high, negatively correlated with dry matter, energy, and pentosans intakes, and positively with nitrogen and potassium intakes. But the most important factor in the fate of dietary chloride seems to be the necessity for the cow to eliminate most of the time high amounts of potassium in the urines.

scholarly journals Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies

2016 ◽  
Vol 2016 ◽  
pp. 1-17 ◽  
Author(s):  
Anna Maria Mileo ◽  
Stefania Miccadei
Keyword(s):  
Oxidative Stress ◽  
Genome Instability ◽  
Antioxidant Activities ◽  
Therapeutic Strategies ◽  
Cellular Growth ◽  
Cancer Therapies ◽  
Cancer Disease ◽  
Antioxidant Agents ◽  
Cytotoxic Treatment ◽  
Therapeutic Tools

Cancer onset and progression have been linked to oxidative stress by increasing DNA mutations or inducing DNA damage, genome instability, and cell proliferation and therefore antioxidant agents could interfere with carcinogenesis. It is well known that conventional radio-/chemotherapies influence tumour outcome through ROS modulation. Since these antitumour treatments have important side effects, the challenge is to develop new anticancer therapeutic strategies more effective and less toxic for patients. To this purpose, many natural polyphenols have emerged as very promising anticancer bioactive compounds. Beside their well-known antioxidant activities, several polyphenols target epigenetic processes involved in cancer development through the modulation of oxidative stress. An alternative strategy to the cytotoxic treatment is an approach leading to cytostasis through the induction of therapy-induced senescence. Many anticancer polyphenols cause cellular growth arrest through the induction of a ROS-dependent premature senescence and are considered promising antitumour therapeutic tools. Furthermore, one of the most innovative and interesting topics is the evaluation of efficacy of prooxidant therapies on cancer stem cells (CSCs). Several ROS inducers-polyphenols can impact CSCs metabolisms and self-renewal related pathways. Natural polyphenol roles, mainly in chemoprevention and cancer therapies, are described and discussed in the light of the current literature data.

Responses of intensively grazed dairy pastures to applications of fertiliser nitrogen in south-western Australia

2007 ◽  
Vol 47 (8) ◽  
pp. 927 ◽  
Author(s):  
M. D. A. Bolland ◽  
I. F. Guthridge
Keyword(s):  
Western Australia ◽  
Dry Matter ◽  
Maximum Yield ◽  
Subterranean Clover ◽  
Trifolium Subterraneum ◽  
Growing Season ◽  
Mineral Elements ◽  
Italian Ryegrass ◽  
Total N ◽  
Dry Matter Digestibility

For the first time, we quantified pasture dry matter (DM) responses to applied fertiliser nitrogen (N) for intensively grazed, rain-fed, dairy pastures on sandy soils common in the Mediterranean-type climate of south-western Australia. The pastures are composed of subterranean clover (Trifolium subterraneum L.) and annual and Italian ryegrass (Lolium rigidum Gaud. and L. multiflorum Lam.). Six rates of N, as urea (46% N), were applied to 15 m by 15 m plots four times during 2002 and after each of the first 5–7 grazings in 2003 and 2004, throughout the typical April–October growing season. Total rates of N applied in the first year of the experiments were 0, 60, 120, 160, 200 and 320 kg N/ha, which were adjusted in subsequent years as detailed in the ‘Materials and methods’ section of this paper. The pastures in the experiments were rotationally grazed, by starting grazing when ryegrass plants had 2–3 leaves per tiller. The amount of pasture DM on each plot was measured before and after each grazing and was then used to estimate the amount of pasture DM consumed by the cows at each grazing for different times during the growing season. Linear increases (responses) of pasture DM to applied N occurred throughout the whole growing season when a total of up to 320 kg N/ha was applied in each year. No maximum yield plateaus were defined. Across all three experiments and years, on average in each year, a total of ~5 t/ha consumed DM was produced when no N was applied and ~7.5 t/ha was produced when a total of 200 kg N/ha was applied, giving ~2.5 t/ha increase in DM consumed and an N response efficiency of ~12.5 kg DM N/kg applied. As more fertiliser N was applied, the proportion of ryegrass in the pasture consistently increased, whereas clover content decreased. Concentrations of nitrate-N in the DM consistently increased as more N was applied, whereas concentrations of total N, and, therefore, concentration of crude protein in the DM, either increased or were unaffected by applied N. Application of N had no effect on concentrations of other mineral elements in DM and on dry matter digestibility and metabolisable energy of the DM. The results were generally consistent with findings of previous pasture N studies for perennial and annual temperate and subtropical pastures. We have shown that when pasture use for milk production has been maximised in the region, it is profitable to apply fertiliser N to grow extra DM consumed by dairy cows; conversely, it is a waste of money to apply N to undergrazed pastures to produce more unused DM.

INFLUENCE DES CULTIVARS ET DES STADES DE CROISSANCE SUR LE RENDEMENT EN MATIERE SECHE ET LA COMPOSITION CHIMIQUE DE FOURRAGES D’AVOINE IMMATURE

1984 ◽  
Vol 64 (4) ◽  
pp. 935-943 ◽  
Author(s):  
PAUL GERVAIS
Keyword(s):  
Chemical Composition ◽  
Dry Matter ◽  
Mineral Elements ◽  
Vegetative Stage ◽  
Composition Chimique ◽  
Stages Of Growth ◽  
Nitrogen Free Extract ◽  
Significant Difference ◽  
Dough Stage ◽  
Detailed Chemical

The forage yields and the detailed chemical composition of six cultivars of oats harvested at the vegetative stage (three cuttings during the growing season to simulate grazing) and at the heading and dough stages (one cutting for silage) were established over a period of 3 yr. No significant difference in the dry matter yields of the cultivars was found within any of the three stages of growth. Highly significant increases in the yields, however, were recorded with advance in maturity from 4210 kg/ha at the vegetative stage to 6754 kg at heading and 9219 kg at dough stage. Likewise, the percent dry matter increased progressively from 12% to 19% to 33% for the same stages. In general, the organic and mineral compositions of the cultivars did not vary significantly within any stage of growth, but were influenced by the age of the tissues. The total digestible nutrient, the crude protein, the cell contents and the mineral elements Ca, P, K, Mg, Na, Zn and Fe decreased while the nitrogen-free extract, the cell walls, the lignin and the hemicellulose increased from the vegetative to the dough stage. The other constituents exhibited a less defined pattern or remained relatively stable from one stage to another.Key words: Yields, chemical composition, stages of growth, cultivars, forage oats

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