scholarly journals Similar plasma lipidomic profile in people living with HIV treated with a darunavir-based or an integrase inhibitor-based antiretroviral therapy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Alvaro Mena ◽  
Elvira Clavero ◽  
José Luis Díaz-Díaz ◽  
Angeles Castro
Keyword(s):  
Cardiovascular Disease ◽  
Integrase Inhibitor ◽  
Fold Change ◽  
Mass Spectrometry Data ◽  
Cholesterol Concentration ◽  
P Value ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Living With Hiv ◽  
The Impact

AbstractCardiovascular disease is an important cause of morbidity and mortality in people living with HIV (PLWH), who commonly experience lipid disturbances. The aim of this study was to determine whether the plasma lipidomic profile differs between PLWH receiving a darunavir-based ART and those receiving integrase inhibitor-based ART. This was a cross-sectional study of unselected patients for whom metabolomic analysis was performed using ultra-high-performance liquid chromatography coupled to mass spectrometry. Data for the two subgroups were compared by calculating the log2 of the fold change for each metabolite and then grouping these into the main lipid families. Sixty-two PLWH aged 49.3 ± 8.6 years (82% men) were included: 12 patients (19.4%) had hypertension, 8 (12.9%) had type 2 diabetes, 25 (41.0%) had dyslipidaemia and 9 (14.5%) were taking statins, without significant differences in all these variables between the two groups. Twenty-five (40.3%) received darunavir-based ART and 37 (59.7%) integrase inhibitor-based ART. Although the differences were not statistically significant, patients treated with darunavir-based ART had higher concentrations of total cholesterol (211 mg/dL vs 194 mg/dL), LDL-cholesterol (132 mg/dL vs 117 mg/dL) and triglycerides (155 mg/dL vs 122 mg/dL), and lower HDL-cholesterol concentration (50 mg/dL vs 52 mg/dL). The main lipid families and metabolites differed slightly between groups (log2-fold change; P-value): ceramides (−0.07; 0.49), phosphatidylinositols (−0.05; 0.63), diacylglycerols (0.10; 0.64), phosphatidylethanolamines (0.03; 0.78), triacylglycerols (0.27; 0.18) and lysophosphatidylethanolamines (0.03; 0.83). In the integrase inhibitor-based group, the use of tenofovir alafenamide fumarate significantly increases the majority of lipid fractions, when compared with tenofovir disoproxil fumarate. The lipidomic profile did not differ between PLWH treated with darunavir-based or integrase inhibitor-based ART. This was especially true for ceramides, which are involved in cardiovascular disease. Further studies are needed to study the impact of ART in lipidomic profile.

Quality of Life in People Living With HIV: An Exploratory Cross-Sectional Survey in Belgium

2021 ◽  
Vol 33 (3) ◽  
pp. 249-264
Author(s):  
Gert Scheerder ◽  
Sandra Van den Eynde ◽  
Patrick Reyntiens ◽  
Ria Koeck ◽  
Jessika Deblonde ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Negative Impact ◽  
Sexual Life ◽  
People Living With Hiv ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Related Stigma ◽  
Living With Hiv ◽  
The Impact

This cross-sectional survey explored the quality of life in 505 people living with HIV in Belgium. Several domains of quality of life were impaired: 26% had been diagnosed with depression and 43% had weak social support. HIV-related stigma is still widespread, with 49% believing most people with HIV are rejected and 65% having experienced discrimination due to HIV. The impact of HIV was limited on professional life, but 40% experienced a negative impact on life satisfaction and 41% a negative impact on sexual life. For several domains, people with a recent diagnosis of HIV and long-term survivors had significantly worse scores. This survey also uncovered strengths of people living with HIV, such as positive coping and HIV self-image. Expanding the scope of quality of life in people living with HIV may provide a more complete picture of relevant life domains that may be impacted by living with HIV, but this needs further validation.

scholarly journals Respons Orang Hidup Dengan HIV AIDS (OHIDHA) Dalam Upaya Penanggulangan HIV AIDS di Kabupaten Sukoharjo dan Grobogan

2017 ◽  
Vol 12 (1) ◽  
pp. 92
Author(s):  
Arrum Firda Ayu Maqfiroch ◽  
Zahroh Shaluhiyah
Keyword(s):  
Univariate Analysis ◽  
Hiv And Aids ◽  
P Value ◽  
People Living With Hiv ◽  
Chi Square ◽  
Cross Sectional ◽  
The Status ◽  
Keywords Aids ◽  
Living With Hiv ◽  
Hiv Aids

ABSTRAKPenanggulangan HIV AIDS membutuhkan keterlibatan dari berbagai pihak. Salah satu pihak yang terlibat adalah OHIDHA. OHIDHA merupakan anggota keluarga yang hidup bersama ODHA dan memberikan dukungan kepada ODHA. Stigma di Kabupaten Sukoharjo dan Grobogan masih tinggi. Penelitian ini bertujuan untuk mengetahui faktor-faktor apakah yang menentukan respons OHIDHA dalam upaya penanggulangan HIV AIDS di Kabupaten Sukoharjo dan Grobogan.Penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Teknik pengambilan data kuantitatif melalui wawancara dengan kuesioner. Penelitian ini didukung dengan penelitian kualitatif dengan teknik pengambilan data FGD. Jumlah responden adalah 92 OHIDHA, proporsi 50% dan selang kepercayaan 95%. Analisis data menggunakan analisis univariat dengan distribusi frekuensi, bivariat menggunakan Chi-Square dan multivariat menggunakan regresi logistik.Hasil penelitian menunjukkan bahwa variabel yang berhubungan dengan respons OHIDHA adalah hubungan dengan ODHA (p-value=0,001), lama hidup dengan ODHA (p-value=0,030), lama mengetahui status ODHA (p-value=0,001) dan sikap (p-value=0,005). Hasil analisis multivariat menunjukkan bahwa sikap (p-value=0,006) merupakan variabel yang mempunyai pengaruh paling signifikan dibanding variabel lainnya.Kata Kunci : OHIDHA, respons, Grobogan, Sukoharjo Respons of People Living With HIV AIDS to Control HIV and AIDS in Sukoharjo and Grobogan District; Controlling HIV and AIDS requird the involvement of various sector. One of the sector involved is People Living With HIV AIDS (PLWHA).  PLWHA is a family member who lives with people living with HIV and provide support to people living with HIV. Stigma in Sukoharjo and Grobogan still high. This study aims to determine the factors that determine whether the PLWHA response in control to HIV and AIDS in Sukoharjo Grobogan. This research was a quantitative study with cross sectional approach. Quantitative data collection techniques through interviews with questionnaires . This research was supported by qualitative research with FGD. The number of respondents was 92 PLWHA, the proportion of 50% and 95% confidence interval . Analysis of the data using univariate analysis with frequency distribution, bivariate using Chi-Square and multivariate using logistic regression. The results showed that the variables related to the PLWHA response is a relationship with people living with HIV ( p = 0,001 ) , long life with people living with HIV ( p = 0.030 ) , longer know the status of PLWHA ( 0.001 ) and attitude ( p = 0.005 ). Multivariate analysis showed that the attitude (p value = 0,006) was a variable that has the most significant effect compared to other variables .Keywords : AIDS , response , Grobogan , Sukoharjo

scholarly journals Faktor Personal dan Sikap Teman mengenai Tindakan Pencegahan Dampak Penularan HIV/AIDS dengan Stigma Mahasiswa Terhadap Orang dengan HIV/AIDS (ODHA)

2021 ◽  
Vol 14 (2) ◽  
pp. 184-194
Author(s):  
Rossida Kusuma Dewi ◽  
Tanjung Anitasari Indah Kusumaningrum ◽  
Mayang Widya Saputri ◽  
Dicha Febriyanti ◽  
Sonia Pebrianti
Keyword(s):  
Influential Factor ◽  
P Value ◽  
People Living With Hiv ◽  
Personal Factors ◽  
Chi Square ◽  
Cross Sectional ◽  
Aids Stigma ◽  
The Impact ◽  
Bivariate Test ◽  
Hiv Aids

The prevention program of the impact of HIV / AIDS is a form of handling the existence of the stigma and discrimination of PLWHA. This study aims to analyze the relationship of personal factors consisting of knowledge, perceptions and attitudes of friends about prevention the impact of HIV / AIDS with the stigma of student at the PLWHA, as well as looking for the factors that most influence student stigma against people living with HIV/AIDS. This research is an analytic observational study with a cross sectional approach with a research population of all students of the 2016 and 2017 batches classes of the University in Sukoharjo, totaling 12,457 students with a sample used was 500 students with Proportional Random Sampling. The data collection was using a self administered questionnaire and the data were analyzed using the Chi-Square test in the bivariate test while the logistic regression test was used for multivariate analysis. The results of the bivariate test showed that knowledge (p value = 0,0001), perception (p value = 0,0001), and the attitudes of friends (p value = 0,0001) with stigma of students towards PLWHA with a significant level of a = 0,05. The multivariate test found that the attitude of friends is the most influential factor on student stigma in PLWHA (OR=5,627). It is necessary to provide information to students and the scope of their friendship about HIV/AIDS, as well as HIV prevention programs to reduce stigma in PLWHA.  Keywords : personal factors, friend attitude, HIV/AIDS, stigma, PLWHA

scholarly journals Effect of Snakehead Fish Nugget and Colored Fruit Juice on Immune Response (CD4, TLC, and Leukocytes) in People Living with HIV (PLWHIV)

2021 ◽  
Vol 8 (2) ◽  
pp. 129
Author(s):  
Ginta Siahaan ◽  
Urbanus Sihotang ◽  
Jujuren Sitepu ◽  
Iceratnalela Siregar
Keyword(s):  
Immune Response ◽  
Fruit Juice ◽  
Fruit Juices ◽  
P Value ◽  
People Living With Hiv ◽  
Bioactive Substances ◽  
Food Ingredients ◽  
Post Test ◽  
Living With Hiv ◽  
The Impact

<p>Human Immunodeficiency Virus (HIV) is a virus attacking the body's defense system in people living with HIV (PLHIV), such as Cluster Of Differentiation 4 (CD4), Leukocytes, and Total Lymphocyte Count (TLC). People infected with HIV require adequate macro and micronutrients to improve their quality of life. The content of protein, albumin, zinc, and bioactive substances contained in food ingredients can increase the immune response. Snakehead fish nuggets are rich in Albumin and Zn, while colored fruit juice contains bioactive substances and is high in Vitamin C. This study aimed to determine the impact of snakehead fish nuggets and colored fruit juices on CD4, leukocytes, and TLC in PLHIV in Medan. This research was a Quasi Experiment with a pre and post-test design. The sample represented an entire population of 36 people from all residents of the Rehabilitation Center and was then given the treatment of snakehead fish nuggets and colored fruit juices for 22 days. The data analysis was performed using the T-dependent test after the data were normally distributed. The results showed a treatment impact on CD4, leukocytes, and TLC in PLHIV with a p-value &lt;0.05. </p>

scholarly journals Relationship between Information Skills and Antiretroviral Adherence in People Living With HIV/AIDS

2021 ◽  
Vol 4 (1) ◽  
pp. 23
Author(s):  
Novianti Lailiah ◽  
Nursalam Nursalam ◽  
Ninuk Dian Kurniawati
Keyword(s):  
Rating Scale ◽  
Peer Group ◽  
Sampling Technique ◽  
P Value ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Antiretroviral Adherence ◽  
Information Skills ◽  
Living With Hiv ◽  
Hiv Aids

Introduction: Adherence in ARV therapy is an important mechanism in preventing drug resistance. The level of adherence is influenced by several factors, one of which is the information skills factor. This study aims to analyze the relationship between information skills and ARV adherence in People Living With HIV/AIDS (PLWHA).Method: This was a cross-sectional approach with a sample size of 100 respondents who were selected through simple random sampling technique. The inclusion criteria for respondents were PLWHA who were undergoing ARV therapy, cooperative, aged 20-60 years. The instrument used was information skills questionnaire and Medical Adherence Rating Scale (MARS). The data were analyzed using descriptive analysis and logistic regression test with p value ≤ 0.05.Results: Information skills were  associated with ARV adherence (p = 0.01). Information skills consisting of knowledge about HIV/AIDS and ARV therapy can increase ARV adherence in PLWHA with indicators taking drugs regularly and have medical control on schedule.Conclusions: The information skills factor has an effect on ARV adherence. Increasing information skills can be done through educational activities or peer-group support aimed at gaining insight into disease and treatment, especially for newly diagnosed PLWHA.

scholarly journals ANTIRETROVIRAL SIDE EFFECT ON ADHERENCE IN PEOPLE LIVING WITH HIV AIDS AT DR. KARIADI GENERAL REFFERAL HOSPITAL SEMARANG CENTRAL JAVA

2019 ◽  
Vol 8 (2) ◽  
pp. 79 ◽  
Author(s):  
Gede Arya Bagus Arisudhana ◽  
Muchlis Achsan Udji Sofro ◽  
Untung Sujianto
Keyword(s):  
Health Care ◽  
Side Effects ◽  
Side Effect ◽  
People Living With Hiv ◽  
Drug Adherence ◽  
Cross Sectional ◽  
Central Java ◽  
Living With Hiv ◽  
The Impact ◽  
Hiv Aids

Background: Antiretroviral (ARV) therapy is a lifelong treatment in people living with HIV/AIDS (PLWHA). Adherence is the key to the effectiveness of antiretroviral therapy. ARV have side effects that may affect patient adherence.Purpose: The purpose of this study was to examine the impact of ARV side effects on drug adherence in PLWHA.Methods: This study used cross-sectional approach. Sample size in this study was 78 consist of people who were recruited by purposive sampling. These subjects received ARV therapy in Tropical Disease and Infection Polyclinic at General Hospital of Dr. Kariadi SemarangResult : Result showed that eta2 is 0,525625. It means that ARV side effect has impact on ARV adherence. Most of the side effects reported by the respondents were nausea and dizziness. Some respondents also reported experiencing weakness, difficult to concentrate, and diarrhea. Conclusion : Side effects have impact on patient’s ARV therapy adherence. Therefore health care provider for PLWHA should be able to recognize and concern on ARV side effect management. 

scholarly journals РАСПРОСТРАНЕННОСТЬ КИШЕЧНЫХ ПАРАЗИТОЗОВ У ВИЧ-ПОЗИТИВНЫХ ПАЦИЕНТОВ

2019 ◽  
pp. 16-20
Author(s):  
Шагинян В. Р. ◽  
Данько О. П. ◽  
Антоняк С. Н. ◽  
Казека В. Г. ◽  
Федоренко С. В.
Keyword(s):  
Intestinal Parasites ◽  
Cross Sectional Study ◽  
P Value ◽  
People Living With Hiv ◽  
Hiv Replication ◽  
Cross Sectional ◽  
Hiv Rna ◽  
High Prevalence ◽  
Polymerase Chain ◽  
Living With Hiv

A cross-sectional study among people living with HIV (PLHIV), who are naive and who are on antiretroviral treatment (ART) was conducted in Kyiv, Ukraine from January 2017 to June 2019. In 200 samples of feces from PLHIV were detection intestinal parasites and helminthes. Also in all patients was measure of CD4 T cells by flow cytometry technique and the viral load of HIV (HIV VL) by reverse transcription and polymerase chain reaction, sensitivity of test – 40 copies HIV RNA / ml. The study shows high prevalence of intestinal parasitic in population of PLHIV – 30,0%. The most prevalent parasites were Cryptosporidium (10,5%), Ascaris lumbricoides (1,5%), G. lamblia (0,5%). Opportunistic protozoans (B. Hominis) were found in 15.5% of PLHIV. Among PLHIV with intestinal parasites severe immunosuppression (< 200 CD4 cells/ml) were more common (66.7%) than among PLHIV without intestinal parasites (45.7%); patients with undetectable HIV VL (35.0%), patients receiving ART for more than 6 months (28.3%) were less common (55.7% and 54.3% respectively). In all cases P value was less than 0.05. Our data show that detection even opportunistic intestinal protozoans in PLHIV can be used as a marker of immune suppression and HIV replication activity, and confirms the importance of parasitological surveillance in this group of patients.

scholarly journals Quality of Life People Living with HIV/AIDS and Its Characteristic from a VCT Centre in Indonesia

1970 ◽  
Vol 29 (6) ◽  
Author(s):  
Sri Handayani ◽  
Nita Yunianti Ratnasari ◽  
Putri Halimu Husna ◽  
Marni . ◽  
Tantut Susanto
Keyword(s):  
Quality Of Life ◽  
Support Groups ◽  
Cross Sectional Study ◽  
High Risk Group ◽  
P Value ◽  
People Living With Hiv ◽  
Cross Sectional ◽  
Living With Hiv ◽  
Hiv Aids

BACKGROUND: The quality of life (QoL) construct has also contributed to understanding the comprehension of factors involved in the existence of people infected by the HIV/AIDS. The objective of this study is to assess the quality of life (QoL) of people with HIV/AIDS (PLWHA) in Wonogiri District, Indonesia.METHODS: A cross-sectional study was conducted from September to November 2017. Convenience sampling method was employed to recruit 39 people living with HIV/AIDS (PLWHA) at Voluntary Counselling and Testing (VCT) of Wonogiri, Indonesia. Research data were collected using a self-administered questionnaire of WHOQOL-HIV BREF. The data were further analysed using a ttest and a Chi-square test, while linear regression was used to evaluate factors that correlate with the PLWHAs’ quality of life.RESULTS: The results showed that the gross mean score of social relationships domain is 13.59; psychological domain is 13.31;environment domain is 13.28; spiritual/personal beliefs domainis 13.15; physical domain is 13.10; and level of independence domain is 13.77. The symptom of HIV is associated with quality of life (B =7.611, β = 0.362, t = 2,046, p value = 0.049).CONCLUSION: Healthcare provider should increase providerinitiated testing and counselling (PITC) to contracting group, high risk group, susceptible group, and the community. The PLWHA are recommended to actively participate in peer support groups (PSGs) so that they can improve their quality of life.

scholarly journals A study on the impact of HIV related stigma on adherence to anti-retroviral treatment among people living with HIV/AIDS in central Kerala, India

2020 ◽  
Vol 7 (4) ◽  
pp. 1498
Author(s):  
Priyanka Rajmohan ◽  
Joe Thomas ◽  
Jubina Bency Anthoora Thodi ◽  
Unnikrishnan Uttumadathil Gopinathan
Keyword(s):  
Structured Interview ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Internalized Stigma ◽  
Double Burden ◽  
Cross Sectional ◽  
Related Stigma ◽  
Living With Hiv ◽  
The Impact ◽  
Hiv Aids

Background: In India, an estimated 20,88,638 people are living with HIV/AIDS (prevalence 0.27%). The people living with HIV/AIDS (PLHA) are facing double burden of physical and psychosocial impact of infection. This study is conducted to determine prevalence of HIV related stigma among PLHA and to find the association between stigma and adherence to Anti-Retroviral Therapy (ART) among HIV patients in central Kerala.Methods: A cross-sectional study was done from July to December 2018 among 105 adult HIV positive patients who have enrolled in Thrissur Network of People living with HIV/AIDS (TNP PLUS). After obtaining informed consent, the participants were interviewed using a structured interview schedule consisting of questions on socio-demographic details, stigma and ART adherence.Results: The prevalence of high stigma was found to be 21% and moderate stigma 61%.Out of 105 study subjects,68 (64.8%) were found to have a high adherence to ART (≥95%) and 37 (35.2%) were found to have a low adherence (<95%). Patients who had a moderate/high internalized stigma tend to have a low adherence to ART as compared to patients who had low stigma (OR=3.4 (1.2-12.8) p=0.04). On analyzing the association between the different forms of stigma and adherence to ART, isolation by family members, abandoned by friends and verbal stigma were significantly associated with low ART adherence.Conclusions: HIV related internalized stigma was pervasive among the study subjects. These patients also experience other forms of enacted stigma. The presence of internalized stigma was found to be significantly associated with low adherence to ART.

scholarly journals Does universal health coverage reduce out-of-pocket expenditures for medical consultations for people living with HIV in Senegal? An exploratory cross-sectional study

BMJ Open ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. e046579
Author(s):  
Bernard Taverne ◽  
Gabrièle Laborde-Balen ◽  
Khaly Diaw ◽  
Madjiguene Gueye ◽  
Ndeye-Ngone Have ◽  
...  
Keyword(s):  
National Health ◽  
Cross Sectional Study ◽  
People Living With Hiv ◽  
Health Coverage ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Sex With Men ◽  
Student’S T ◽  
Living With Hiv ◽  
The Impact

ObjectivesIn Senegal, a national health coverage system named Couverture Medicale Universelle (CMU) has been under development since 2013; its impact on out-of-pocket (OOP) expenses for people living with HIV (PLHIV) remains unknown. Our objective was to assess the impact of the national health coverage system on health expenses for PLHIV by measuring the OOP amount for a routine consultation for various categories of PLHIV, in Dakar and different regions in Senegal, viewed from the patients’ perspective.Design, setting and participantsCross-sectional survey in 2018 and 2019 using a face-to-face questionnaire with PLHIV: 344 adults followed up at Fann Regional Centre for research and training in clinical treatment in Dakar; 60 adult men who have sex with men (MSM) in 2 hospitals in Dakar and 7 facilities in the regions; and 130 children and adolescents (0–19 years) in 16 care facilities in the southern regions. We have calculated the total price of the consultation and associated prescriptions along with the patient’s OOP medical and transportation contributions. The average amounts were compared using the Student’s t-test.ResultsAll patients are on antiretroviral treatment with a median duration of 6 years, 5 years and 3 years for adults, MSM and children/adolescents, respectively. The percentage of people who have health coverage is 26%, 18% and 44% for adults, MSM and children. In practice, these systems are rarely used. The OOP amount (health expenses+transportation costs) for a routine consultation is €11 for adults and children, and €32.5 for MSM.ConclusionThe number of PLHIV with coverage is low, and the system’s effectiveness remains limited. Currently, this system has proved ineffective in implementing free healthcare, recommended by WHO since 2005.

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