LncRNA DQ786243 contributes to proliferation and metastasis of colorectal cancer both in vitro and in vivo
Keyword(s):
This article aims to find the key long non-coding RNAs (LncRNAs) associated with colorectal cancer (CRC) and to study its biological functions in colorectal cancer progression. Our study has shown that upregulated LncRNA DQ786243 can regulate cell proliferation, cell cycle progression, cell apoptosis, migration, and invasion in CRC cells. Xenograft experiments confirmed that the growth of xenograft tumors formed by CRC cells was suppressed after silencing LncRNA DQ786243 expression. In conclusion, our study suggests that LncRNA DQ786243 is an oncogene that promotes tumor progression and leads us to propose that LncRNAs may serve as key regulatory hubs in CRC progression.
2018 ◽
Vol 26
(3)
◽
pp. 473-481
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2018 ◽
Vol 26
(9)
◽
pp. 1411-1418
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