scholarly journals Correction of energometabolic disorders atsignificant iodine deficiency in calves

2021 ◽  
Vol 37 ◽  
pp. 00019
Author(s):  
Alexei Evglevskiy ◽  
Olga Shvets ◽  
Tatyana Mikhaleva
Keyword(s):  
Energy Metabolism ◽  
Iodine Deficiency ◽  
Sodium Succinate ◽  
Metabolic Effect ◽  
The Body ◽  
Pharmacological Properties ◽  
Similar Concentration ◽  
Energy Effect ◽  
Biochemical Processes ◽  
Clinical Recovery

The paper is devoted to the development and use of theiodomethaboliccomplex based on iodine-iodide with polyvinyl alcohol (iodinol) and succinic acid.It was found that the inclusion of succinic acid or sodium succinate in a similar concentration in the composition of iodinol allowed not only qualitatively improving the pharmacological properties of iodinol, but also obtaining an energometabolic composition suitable for parenteral administration.The results of using the iodomethabolic compositionrevealed that with the parenteral administration to calves with clinically pronounced iodine deficiency, it provides effective normalization of pathological biochemical processes in the body of calves (metabolic effect) and pronounced activation of energy metabolism (energy effect), and in general, an energometabolic effect that ensures clinical recovery of animals from iodine deficiency.

Effect of Methylprednisolone and Reduced Glutathione on Survival in Mice and Hepatic Energy Metabolism in Rats with Endotoxin Shock

1985 ◽  
Vol 1 (3) ◽  
pp. 249-251
Author(s):  
I. Kosugi ◽  
K. Tajimi ◽  
K. Okada
Keyword(s):  
Energy Metabolism ◽  
Sodium Succinate ◽  
Endotoxin Shock ◽  
Free Radical Scavenger ◽  
The Body ◽  
Radical Scavenger ◽  
Beneficial Effects ◽  
Methylprednisolone Sodium Succinate ◽  
Hepatic Energy Metabolism

Reduced glytathione (GSH) is the tripeptide of glycine, cysteine and glutamic acid and is widely distributed in the body. FSH has been reported to comprise at least 90% of the nonprotein sulfhydryl (NPSH). Although the role of GSH in the tissue has not been clearly established, it is known to be a cofactor for enzymes, a substrate in detoxifications, and a free radical scavenger.Several investigators have reported that the level of NPSH, mainly GSH, in the tissue was decreased in several types of shock and that exogenous administration of GSH has beneficial effects on shock (1,2). This study was designed to evaluate the effects of GSH on the survival rate in mice and the hepatic energy metabolism in rats after administration of endotoxin. These results were compared with those of methylprednisolone sodium succinate (MP), since many investigators have reported that the large doses of glucocorticoid have beneficial effects in several types of shock in experimental animals and in man (3,4).

scholarly journals Relationships between dietary macronutrients and adult neurogenesis in the regulation of energy metabolism – CORRIGENDUM

2013 ◽  
Vol 111 (4) ◽  
pp. 755-755
Author(s):  
Marianne A. Yon ◽  
Suzanna L. Mauger ◽  
Lucy C. Pickavance
Keyword(s):  
Body Weight ◽  
Energy Metabolism ◽  
Adult Neurogenesis ◽  
Brain Regions ◽  
The Body ◽  
Adult Brain ◽  
Metabolic Dysfunction ◽  
Neurogenic Niche ◽  
Normal Limits ◽  
Simple Carbohydrates

Of the environmental factors which have an impact on body weight, nutrients are most influential. Within normal limits, hypothalamic and related neuronal populations correct perturbations in energy metabolism, to return the body to its nutritional set-point, either through direct response to nutrients or indirectly via peripheral appetite signals. Excessive intake of certain macronutrients, such as simple carbohydrates and SFA, can lead to obesity and attendant metabolic dysfunction, also reflected in alterations in structural plasticity, and, intriguingly, neurogenesis, in some of these brain regions. Neurogenesis, previously thought to occur only in the embryo, is now known to take place in the adult brain, dependent on numerous stimulating and inhibiting factors, including dietary components. Because of classic associations between neurogenesis and the hippocampus, in learning and cognition, this brain region has also been the focus of attention in the study of links between diet and neurogenesis. Recently, however, a more complete picture of this relationship has been building: not only has the hypothalamus been shown to satisfy the criteria for a neurogenic niche, but appetite-related mediators, including circulating hormones, such as leptin and ghrelin, pro-inflammatory cytokines and the endocannabinoid intracellular messengers, are also being examined for their potential role in mediating neurogenic responses to macronutrients. The present review draws together these observations and investigates whether n-3 PUFA may exert their attenuating effects on body weight through the stimulation of adult neurogenesis. Exploration of the effects of nutraceuticals on neurogenic brain regions may encourage the development of new rational therapies in the fight against obesity.

scholarly journals Perspectives on Sustainable Development in the Context of Public Health Issues

2015 ◽  
Vol 7 (1) ◽  
pp. 37-39
Author(s):  
Ioana-Codruta Racz
Keyword(s):  
Public Health ◽  
Sustainable Development ◽  
Iodine Deficiency ◽  
Central Africa ◽  
Public Health Problem ◽  
The Body ◽  
Human Consumption ◽  
Main Role ◽  
Northern Asia ◽  
Good Nutrition

Abstract Health is an integral part of sustainable development, a process that can’t be materialized if there is a high prevalence of diseases, a high percentage of those is due to environmental factors. An important component of health is the healthy nutrition, especially of children and pregnant women. Iodine is an essential micronutrient for a good nutrition that covers the physiological needs of the body, iodine deficiency having important consequences for mother and fetus, then for children, especially in the first years of life. The main role of iodine in the body is due to his importance for synthesis of thyroid hormones involved in growth and development of psychic and somatic body, starting with intrauterine life. Iodine deficiency was, and still is, a public health problem, globally the most affected countries are in Central Africa, central South America and northern Asia. Europe iodine deficiency is relatively lower. Multiple interventions were made to improve and even eradicate iodine deficiency disorders, in particular through the universal iodization of salt for human consumption, but must be supported in continuing efforts because this issue is not fully resolved to this day.

scholarly journals Energy metabolism in the body of bulls receiving cavitated concentrated feed in the diet

2019 ◽  
Vol 102 (4) ◽  
pp. 218-226
Author(s):  
Nadezhda M Shirnina ◽  
◽  
Bulat Kh Galiev ◽  
Ivan S Miroshnikov ◽  
Ilmira A Rakhimzhanova ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
The Body

scholarly journals Myocardial Damage by SARS-CoV-2: Emerging Mechanisms and Therapies

Viruses ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1880
Author(s):  
Huyen Tran Ho ◽  
Stefan Peischard ◽  
Nathalie Strutz-Seebohm ◽  
Karin Klingel ◽  
Guiscard Seebohm
Keyword(s):  
Immune Response ◽  
Cell Death ◽  
Energy Metabolism ◽  
Programmed Cell Death ◽  
Viral Replication ◽  
Ion Homeostasis ◽  
Membrane Vesicles ◽  
Cardiac Cells ◽  
The Body ◽  
Double Membrane

Evidence is emerging that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can infect various organs of the body, including cardiomyocytes and cardiac endothelial cells in the heart. This review focuses on the effects of SARS-CoV-2 in the heart after direct infection that can lead to myocarditis and an outline of potential treatment options. The main points are: (1) Viral entry: SARS-CoV-2 uses specific receptors and proteases for docking and priming in cardiac cells. Thus, different receptors or protease inhibitors might be effective in SARS-CoV-2-infected cardiac cells. (2) Viral replication: SARS-CoV-2 uses RNA-dependent RNA polymerase for replication. Drugs acting against ssRNA(+) viral replication for cardiac cells can be effective. (3) Autophagy and double-membrane vesicles: SARS-CoV-2 manipulates autophagy to inhibit viral clearance and promote SARS-CoV-2 replication by creating double-membrane vesicles as replication sites. (4) Immune response: Host immune response is manipulated to evade host cell attacks against SARS-CoV-2 and increased inflammation by dysregulating immune cells. Efficiency of immunosuppressive therapy must be elucidated. (5) Programmed cell death: SARS-CoV-2 inhibits programmed cell death in early stages and induces apoptosis, necroptosis, and pyroptosis in later stages. (6) Energy metabolism: SARS-CoV-2 infection leads to disturbed energy metabolism that in turn leads to a decrease in ATP production and ROS production. (7) Viroporins: SARS-CoV-2 creates viroporins that lead to an imbalance of ion homeostasis. This causes apoptosis, altered action potential, and arrhythmia.

In silico platform for xenobiotics ADME-T pharmacological properties modeling and prediction. Part II: the body in a Hilbertian space

2009 ◽  
Vol 14 (7-8) ◽  
pp. 406-412 ◽  
Author(s):  
Alexandre Jacob ◽  
Jaturong Pratuangdejkul ◽  
Sébastien Buffet ◽  
Jean-Marie Launay ◽  
Philippe Manivet
Keyword(s):  
In Silico ◽  
The Body ◽  
Pharmacological Properties ◽  
Modeling And Prediction

Title- Role of herbal products in curing Vitiligo

2021 ◽  
Vol 2 (3) ◽  
pp. 68-73
Author(s):  
Pratik Talukder ◽  
Tiasha Majumdar
Keyword(s):  
Oxidative Stress ◽  
Secondary Metabolites ◽  
Skin Disorder ◽  
The Body ◽  
Pharmacological Properties ◽  
Herbal Products ◽  
Health Disorders ◽  
Destruction Of Melanocytes

Plants produce a wide diversity of secondary metabolites which serve them as defence compounds against herbivores, and other plants and microbes, but also as signal compounds. In general, secondary metabolites exhibit a wide array of biological and pharmacological properties. Because of this, some plants or products isolated from them have been and are still used to treat infections, health disorders or diseases. Vitiligo is a skin disorder that is caused due to oxidative stress in the body resulting in the destruction of melanocytes, which are the cells responsible for the pigmentation of the skin. On their destruction the skin gets depigmented resulting in patches of skin losing their colour. In this review we focus on how plant based herbal products help in curing vitiligo.

Digestibility of nutrients and energy metabolism in lactating cows when sapropel is included in the ration

2021 ◽  
pp. 22-27
Author(s):  
L. P. Yarmots ◽  
G. A. Yarmots ◽  
A. E. Belenkaya ◽  
M. O. Smyshlyaeva
Keyword(s):  
Energy Metabolism ◽  
Milk Fat ◽  
Animal Husbandry ◽  
Feed Additives ◽  
The Body ◽  
Biologically Active ◽  
Main Trend ◽  
Control Group ◽  
Lactating Cows ◽  
Positive Effect

Unbalanced mineral and vitamin nutrition of lactating cows can be a critical factor in the realization of their productive potential. The development and introduction into production of inexpensive, but effective feed additives is the main trend of improving the feeding of modern animal husbandry. Under the conditions of the Tyumen region such natural raw materials can be sapropels, which successfully combine a variety of biologically active substances. The purpose of the research was to study the digestibility of nutrients and energy metabolism in lactating cows when sapropel is included in the ration. Scientifi c and economic experiment in the study of the effectiveness of feeding sapropel lake Nepryak has been carried out in the training and experimental farm of the State Northern Trans-Urals Agrarian University. The animals of the control group have been fed the main diet. Cows of the 1st and 2nd experimental groups have been fed 300 and 500 g of sapropel per head/day, respectively, in addition to the main ration. It has been found as a result of research that the introduction of sapropel into the ration of cows has a positive effect on the digestibility of nutrients. The digestibility coefficients were higher in the animals of the 1st and 2nd experimental groups compared with the cows of the control group. Cows from the experimental groups digested all the organic substances of the ration better. During the experiment period cows of the 1st and 2nd experimental groups in contrast to the control group had higher milk yield by 11,31 and 10,38 %, respectively, milk protein yield by 10,56 and 5,95 %, milk fat yield by 17,18 and 12,99 %. It has been established that the introduction of sapropel into the ration of cows has the positive effect on the digestibility of nutrients, contributes to the increase of milk productivity, normalizes the metabolism in the body.

Sire effects on growth ano carcase characteristics of friesian steers slaughtered at 500, 550 or 600 kg liveweight

1991 ◽  
Vol 1991 ◽  
pp. 26-26
Author(s):  
K J McCracken ◽  
C A Moore ◽  
E F Unsworth ◽  
F J Gordon ◽  
R W J Steen ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Metabolism ◽  
Growth Performance ◽  
Gene Pool ◽  
The Body ◽  
Slaughter Weight ◽  
Nutritional Studies

Whilst it is well recognised that there is considerable within-breed variation in growth performance and body composition of cattle it is unusual for sire origin to be taken into account when designing nutritional studies. In planning an experiment on the effects of plane of nutrition and slaughter weight on the body composition and energy metabolism of Friesian steers it was recognised that the increased incidence of the Holstein gene pool in many AI bulls could have serious implications for interpretation of the results. Hence AI bulls of low Holstein content were identified and an attempt was made to obtain calves from a small number of bulls of uniform conformation.

scholarly journals The Association between Excess Body Mass and Disturbances in Somatic Mineral Levels

2020 ◽  
Vol 21 (19) ◽  
pp. 7306
Author(s):  
Weronika Banach ◽  
Karolina Nitschke ◽  
Natalia Krajewska ◽  
Wojciech Mongiałło ◽  
Oskar Matuszak ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass ◽  
Iodine Deficiency ◽  
Calcium Sensitivity ◽  
The Body ◽  
Excess Body Weight ◽  
Iron Level ◽  
Obese Women ◽  
Study Results ◽  
Mineral Levels

Background: Obesity and excess body weight are significant epidemiological issues, not only because they are costly to treat, but also because they are among the leading causes of death worldwide. In 2016, an estimated 40% of the global population was overweight, reflecting the importance of the issue. Obesity is linked to metabolism malfunction and concomitantly with altered mineral levels in the body. In this paper, we review alterations in somatic levels of iron, calcium, magnesium, copper, iodine, chromium, selenium, and zinc in relation to excess body mass. Methodology: An electronic literature search was performed using PubMed. Our search covered original English research articles published over the past five years, culminating in 63 papers included for study. Results: The reviewed papers presented correlation between obesity and hypomagnesemia and hypozincemia. They also indicated that patients with excess body mass present increased body copper levels. Studies have similarly indicated that obesity appears to be associated with lower selenium levels in both blood and urine, which may be correlated with the decline and weakening of defenses against oxidative stress. It has been found that decreased level of chromium is connected with metabolic syndrome. Chromium supplementation influences body mass, but the effect of the supplementation depends on the chemical form of the chromium. It is hypothesized that obesity poses a risk of iodine deficiency and iodine absorption may be disrupted by increased fat intake in obese women. A range of studies have suggested that obesity is correlated with iron deficiency. On the other hand, some reports have indicated that excess body mass may coexist with iron excess. The relation between obesity and body iron level requires further investigation. Calcium signaling seems to be disturbed in obesity, due to the increased production of reactive oxygen species and low level of fast troponin isoform responsible for mediating calcium sensitivity of muscle relaxation. Correlation between excess body mass and calcium levels needs further research. Conclusions: Excess body mass is associated with alterations in mineral levels in the body, in particular hypomagnesemia and decreased selenium (Se) and zinc (Zn) levels. Chromium (Cr) deficiency is associated with metabolic syndrome. Obese patients are at risk of iodine deficiency. Excess body mass is associated with elevated levels of copper (Cu). Data on the association between obesity and iron (Fe) levels are contradictory. Obesity coexists with disturbed calcium (Ca) signaling pathways. The association between obesity and body Ca levels has not been investigated in detail.

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