Application of FOS and CPP in intestinal health of Weaned Piglets

The present experiment was conducted to study the effects of different levels of oligosaccharide(FOS) and complex CPP preparation(CPP) in diets on growth performance and serum biochemical parameters for weaned piglets. 240 crossbred DLY( Duroc× Landrace× Yorkshire) 21-day-old weaning piglets, about 7.2 kg in initial body weight were selected and randomly divided into 6 groups, with 2 repeats for each group, 20 each repeat(half male and half female.). Group 1, as the control group, fed base diet(BD) , group 2 fed BD adding 0.10% aureomycin, group 3, 4, 5, 6, respectively, fed BD adding 0.05% CPP, 0.05% FOS, 0.20% FOS and 0.10% FOS + 0.05% of CPP. Feeding trial was conducted for 35 days.Results: (1) Intestinal pH: Compared with the control group, the pH values of jejunum, ileum, cecum and colon in the 3, 4, 5 and 6 groups were significantly lower (P < 0.05), while there was no significant difference between the antibiotic group and the control group (P > 0.05).(2) Small intestinal villus morphology: Duodenal segment, villus length of 6 groups was significantly increased compared with the control group (P < 0.05), villus height to recess depth ratio (V/C) was significantly increased (P < 0.05). There was no significant difference in villus length between groups in jejunal segment (P > 0.05). Groups five V/C was significantly higher than that in the control group (P < 0.05). Compared with the control group and the antibiotic group, the ileal segment in the six groups significantly increased V/C (P < 0.05).(3) Intestinal flora Adding FOS, CPP and their combination could reduce the number of E. coli and Salmonella in different intestinal segments, and increase the number of Lactobacillus and Bifidobacteria. Among them, the effect of joint addition is the most obvious. Conclusion: Adding FOS and C PP to the diet of weaned piglets could effectively reduce the intestinal pH value of piglets, increase the length of intestinal villi and V/C, reduce the number of harmful bacteria and increase the number of beneficial bacteria. It is beneficial to maintain the balance of intestinal morphology and microflora and improve the intestinal health of piglets. Among them, the combination of 0.10% FOS and 0.05% CPP is the best, followed by 0.20% FOS.

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Effects of Yucca Shidigera Extract and Candida Utilis on Growth Performance and Intestinal Health of Weaned Piglets

10.21203/rs.3.rs-112917/v1 ◽

2020 ◽

Author(s):

Zhenguo Yang ◽

Yao Wang ◽

Tianle He ◽

Ziema Bumbie Gifty ◽

Zhihong Sun ◽

...

Keyword(s):

Growth Performance ◽

Candida Utilis ◽

Average Daily Gain ◽

Intestinal Flora ◽

Animal Husbandry ◽

Good Effect ◽

Control Group ◽

Intestinal Health ◽

Weaned Piglets ◽

Cecal Microflora

Abstract BackgroundEconomic benefit is an important goal pursued by animal husbandry industry. The emergence of antibiotics has promoted the development of animal husbandry, but many problems caused by the abuse of antibiotics have caused concerns about the use of antibiotics from all walks of life. Therefore, it is imperative to find alternatives to antibiotics. A large number of studies have shown that plant extracts and probiotics have certain potential in improving animal growth performance, antioxidant capacity and immune function. The purpose of this study was to explore the effects of Yucca Shidigera Extract (YSE) and Candida Utilis (CU) on weaned piglets. We compared and evaluated the effects of YSE and CU on weaned piglets from the aspects of growth performance, immunity, antioxidant function, ileal morphology and microflora changes. Forty 28-day-old healthy weaned piglets (Rongchang pig×Landrace×Large white) were randomly divided into 4 treatments: (1) control group (CON); (2) CU; (3) YSE; (4) CU+YSE. ResultsOur results showed that YSE and CU improved the growth performance by significantly increasing final weight, average daily gain (ADG) (P < 0.05), and there is decreasing trend of feed/gain ratio (P=0.087). The effect of adding YSE or CU alone on growth performance had little difference, and the effect of oral CU was slightly better than that of adding YSE. At the same time, the combination of YSE and CU had a good effect on reducing the diarrhea rate. In addition, both YSE and CU increased the diversity of cecal microflora, and CU increased the diversity more significantly, but did not change the dominant microflora of cecum. We also found that the addition of YSE and CU could maintain the structural integrity of intestinal tissue and regulate intestinal pH, to maintain the level of intestinal-associated immune proteins. At the same time, YSE and CU have certain benefits in regulating intestinal flora. ConclusionYSE and CU can improve the growth performance, reduce the diarrhea rate, improve intestinal health, and increase the diversity and abundance of cecal microflora in weaned piglets. Therefore, they are expected to be used as probiotics in the production of weaned piglets.

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Dietary supplementation with Bacillus mixture promotes the gut health of weaned piglets

10.21203/rs.2.19700/v1 ◽

2019 ◽

Author(s):

Xiaodan Wang ◽

Zhilong Tian ◽

Yue Zhao ◽

Wenming Zhang ◽

Zhanbin Wang ◽

...

Keyword(s):

Gut Microbiota ◽

Dietary Supplementation ◽

Intestinal Morphology ◽

Control Group ◽

Gut Health ◽

Intestinal Health ◽

Weaned Piglets ◽

Villus Height ◽

Crypt Depth ◽

Relative Abundances

Abstract This study was conducted to investigate the effects of dietary supplementation with a mixture of Bacillus on the intestinal health of weaned piglets. We randomly assigned 120 piglets to three groups; a control group (basal diet), a probiotics group (supplemented with 4 × 109 CFU/g Bacillus licheniformis-B. subtilis mixture; BLS mix), and an antibiotics group (supplemented with 0.04 kg/t virginiamycin, 0.2 kg/t colistin, and 3000 mg/kg zinc oxide). All groups had five replicates with eight piglets per replicate. On days 7, 21, and 42 of the trial, intestine and digesta samples were collected to determine the intestinal morphology, gut microbiota and metabolites, and the expression of genes related to gut health. The results showed that the BLS mix decreased the jejunum crypt depth, increased the ileum villus height, and increased the jejunum and ileum villus height to crypt depth ratio. The BLS mix also increased the expression levels of E-cadherin and Occludin in the colon and pro-inflammatory cytokines and TLR4 in ileum and colon. The BLS mix also increased Simpson’s diversity index in the gut microbiota and the relative abundances of o_Bacteroidetes and f_Ruminococcaceae, but it decreased the relative abundances of Blautia, and Clostridium. Collectively, these findings suggested that dietary BLS mix supplementation efficaciously promotes intestinal health through the modulation of gut microbiota in weaned piglets.

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Effects of Dietary FOS and CPP on growth performance and serum biochemical parameters for weaned piglets

E3S Web of Conferences ◽

10.1051/e3sconf/201913101078 ◽

2019 ◽

Vol 131 ◽

pp. 01078

Author(s):

Feng Zhao ◽

Zhongsheng Xia

Keyword(s):

Growth Performance ◽

Biochemical Parameters ◽

Control Group ◽

Female Group ◽

Apparent Digestibility ◽

Serum Biochemical Parameters ◽

Weaned Piglets ◽

Significant Difference ◽

Serum Biochemical ◽

Group 2

The present experiment was conducted to study the effects of different levels of oligosaccharide(FOS) and complex CPP preparation(CPP) in diets on growth performance and serum biochemical parameters for weaned piglets. 240 crossbred DLY( Duroc× Landrace× Yorkshire) 21-day-old weaning piglets, about 7.2 kg in initial body weight were selected and randomly divided into 6 groups, with 2 repeats for each group, 20 each repeat(half male and half female.). Group 1, as the control group, was fed base diet(BD), group 2 was fed BD adding 0.10% aureomycin, group 3, 4, 5, 6, respectively, was fed BD adding 0.05% CPP, 0.05% FOS, 0.20% FOS and 0.10% FOS + 0.05% of CPP. Feeding trial was conducted for 35 days. Results: (1) The combination of 0.10%FOS and 0.05%CPP(group 6) were added, the average daily gain of weaned pigs increased by 13.71 % (P < 0.05) and the feed conversion ratio was reduced by 7.41 % (P < 0.05) compared with control. The diarrhea rate of piglets decreased by 94.63 % (P < 0.01) compared with the control (p < 0.05), and decreased by 62.86 % (P <0.05) compared with group 2.(2)There was no significant difference in the apparent digestibility of nutrient, such as ether extract and crude protein, by adding FOS and CPP individually or jointly in diet of weaned piglets, but apparent digestibility of crude fiber increased , to acertain extent, and there was no significant difference with diet adding 0.10 % of antibiotics (group 2)(P >0.05).(3) There was no significant difference in serum biochemical indexes, such as serum total protein, albumin, urea nitrogen, cholesterol, triglycerides, alanine aminotransferase, aspartate aminotransferase and sugar by adding FOS and CPP individually or jointly in diet of weaned piglets (P > 0.05);there was no significant effect in serum immunoglobulin IgG and IgM (P> 0.05), but the serum IgE content was increased in different degrees. Conclusion: Adding FOS and CPP in diet for weaned piglets can improve the growth performance, reduce diarrhea rate of piglets, and promote digestion and absorption of feed nutrients, without significant difference between them and diet adding antibiotics. Among them, the effect of adding 0.10%FOS+0.05%CPP was the best.

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Effects of different doses of probiotic yeast Saccharomyces cerevisiae on the duodenal mucosa in rabbits

Indian Journal of Animal Research ◽

10.18805/ijar.5570 ◽

2015 ◽

Author(s):

Nilay Seyidoglu ◽

Sabire Peker

Keyword(s):

Saccharomyces Cerevisiae ◽

Basal Diet ◽

Morphological Properties ◽

Control Group ◽

Yeast Culture ◽

Total Thickness ◽

Intestinal Health ◽

Yeast Saccharomyces Cerevisiae ◽

Significant Difference ◽

Different Doses

Probiotics and their components have been used to improve growth performance and immunity, as well as intestinal health. This study evaluated the effect of different doses of Saccharomyces cerevisiae on the morphological properties of duodenums of rabbits. Twenty 6-7 weeks old male New Zealand White Rabbits were randomly allocated into three groups for 90 days. The first group (control group) received the basal diet, the second group received basal diet supplemented with S.cerevisiae at a level of 2g/kg of feed, and the third group was fed with S.cerevisiae live yeast culture added at 4.0 g/kg. At the end of the experiment duodenum segments were taken, fixed in 10% neutral buffered formalin and processed for histological examination. In this study, the total thickness of the mucosa, the height of the villi and depth of the crypts and depth of the glands of the duodenum were found to be longer with the increased yeast doses. However, there was no significant difference among the villus crypt ratio of the groups. In conclusion, the total thickness of the mucosa, villus heights, crypt depths and gland depths were increased significantly in both of the yeast groups of rabbits. Therefore, it may be proposed that administration of S.cerevisiae in either low or high doses may be used for intestinal health.

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Dietary Supplementation With Bacillus subtilis Promotes Growth and Gut Health of Weaned Piglets

Frontiers in Veterinary Science ◽

10.3389/fvets.2020.600772 ◽

2021 ◽

Vol 7 ◽

Author(s):

Zhilong Tian ◽

Xiaodan Wang ◽

Yehui Duan ◽

Yue Zhao ◽

Wenming Zhang ◽

...

Keyword(s):

Bacillus Subtilis ◽

Dietary Supplementation ◽

Basal Diet ◽

Intestinal Morphology ◽

Control Group ◽

Gut Health ◽

Weaned Piglets ◽

Villus Height ◽

Expression Of Genes ◽

Group A

This study was conducted to investigate the effects of dietary supplementation with different types of Bacillus subtilis (B. subtilis) on the growth and gut health of weaned piglets. A total of 160 piglets were randomly assigned into four groups: control group (a basal diet), BS-A group (a basal diet supplemented with B. subtilis A at 1 × 106 CFU/g feed), BS-B group (a basal diet supplemented with B. subtilis B at 1 × 106 CFU/g feed), and BS-C group (a basal diet supplemented with B. subtilis C at 1 × 106 CFU/g feed). All groups had five replicates with eight piglets per replicate. On days 7, 21, and 42 of the trial, blood plasma and intestinal tissues and digesta samples were collected to determine plasma cytokine concentrations, intestinal morphology, gut microbiota community and metabolic activity, and the expression of genes related to gut physiology and metabolism. The results showed that dietary B. subtilis supplementation improved (P < 0.05) the body weight and average daily gain (in BS-B and BS-C groups) of weaned piglets and decreased (P < 0.05) the diarrhea rates (in BS-A, BS-B, and BS-C groups). In the intestinal morphology analysis, B. subtilis supplementation improved (P < 0.05) the size of villus height and villus height to crypt depth ratio in the ileum of weaned piglets. Firmicutes, Bacteroidetes, and Tenericutes were the most dominant microflora in piglets' colon whatever the trial group and time of analysis. Dietary BS-C supplementation increased (P < 0.05) the relative abundances of Anaerovibrio and Bulleidia and decreased (P < 0.05) the relative abundances of Clostridium and Coprococcus compared with the control group. In addition, dietary B. subtilis supplementation increased (P < 0.05) the indicators of intestinal health, including plasma levels of interleukin (IL)-2 and IL-10, as well as the colonic levels of short-chain fatty acids. Furthermore, dietary B. subtilis supplementation also up-regulated (P < 0.05) the expression of genes involved in metabolic pathways related to intestinal microbiota maturation. In conclusion, these findings suggest that a diet containing BS-B or BS-C can efficiently promote growth performance, decrease diarrhea incidence, and ameliorate several indicators of intestinal health through the modulation of gut microbiota composition and metabolic activity in weaned piglets.

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Drinking water supplemented with wood vinegar on growth performance, intestinal morphology, and gut microbial of broiler chickens

Veterinary World ◽

10.14202/vetworld.2021.92-96 ◽

2021 ◽

Vol 14 (1) ◽

pp. 92-96

Author(s):

Kornkamon Hanchai ◽

Tassanee Trairatapiwan ◽

Rachakris Lertpatarakomol

Keyword(s):

Drinking Water ◽

Growth Performance ◽

Broiler Chickens ◽

Body Weight Gain ◽

Intestinal Morphology ◽

Control Group ◽

Broiler Chicks ◽

Plant Materials ◽

Wood Vinegar ◽

Significant Difference

Background and Aim: Wood vinegar is a product generated from the combustion and distillation of wood and other plant materials. It has been shown to suppress bacteria, resulting in healthier livestock and increased yields. This study aimed to determine the efficacy of drinking water supplemented with wood vinegar on growth performance, intestinal health, and gut microbial of broilers. Materials and Methods: A total of 120 Ross 308 1-day-old male broiler chicks were randomly distributed in a completely randomized experimental design. The study consisted of three treatments containing four replicates, with 10 birds in each. Treatments were given 0.5% and 1.0% (V/V) wood vinegar supplemented in drinking water, while no supplementation was given to the control group. The animals were raised in an open-house system. All groups were provided with a commercial diet and drinking water ad libitum. Analysis of variance was conducted using the general linear model procedure to compare the levels of wood vinegar supplementation in drinking water on growth performance, intestinal morphology, and gut microbial. Results: No significant differences (p>0.05) were found for body weight gain, feed intake, feed conversion ratio, and water consumption between groups during the starter (1-21 days old), grower (22-35 days old), and whole (1-35 days old) growth periods. Moreover, no significant differences in villi height and crypt depth (p>0.05) at 21 and 35 days of age were found. In addition, no significant difference in terms of lactic acid bacteria and Escherichia coli was found between the different treatments. Conclusion: Drinking water supplemented with wood vinegar was not found to have an effect on the growth performance and gut microbial of broiler chickens in the present study. However, the supplementation of wood vinegar in drinking water could improve intestinal morphology.

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Electroacupuncture for Gastrointestinal Function Recovery after Gynecological Surgery: A Systematic Review and Meta-Analysis

Evidence-based Complementary and Alternative Medicine ◽

10.1155/2021/8329366 ◽

2021 ◽

Vol 2021 ◽

pp. 1-16

Author(s):

Xiang Gao ◽

Yuzhuo Zhang ◽

Yizhe Zhang ◽

YuTzu Ku ◽

Yi Guo

Keyword(s):

Large Scale ◽

Ph Value ◽

Meta Analysis ◽

Control Group ◽

Controlled Trials ◽

Gastrointestinal Function ◽

Cochrane Central Register ◽

Gynecological Surgery ◽

Function Recovery ◽

Significant Difference

Background. Evidence for the efficacy and safety of electroacupuncture (EA) on gastrointestinal function recovery after gynecological surgery is unclear. Objective. This meta-analysis aimed to evaluate the effects of EA on recovery of postoperative gastrointestinal function for patients receiving gynecological surgery. Data sources: PubMed, Cochrane Central Register of Controlled Trials (CINAHL), Embase, China National Knowledge Infrastructure (CNKI), Weipu (CQVIP), and Wanfang databases were systematically searched from the inception dates to May 30, 2020, for relevant randomized controlled trials (RCTs). Study selection: RCTs that evaluated EA for postoperative gastrointestinal function directly related to gynecological surgery in adults aged 18 years or over. Data extraction and synthesis: paired reviewer independently extracted the data and assessed study quality. Standardized mean differences (SMD) were calculated as the effect measure from a random effects model. Main outcomes and measures: time to first flatus (TFF), time to bowel sounds recovery (TBS), and time to first defecation (TFD) were recorded as primary outcomes; postoperative nausea and vomiting (PONV), motilin (MTL), gastrin (GAS), pH value of gastric mucosa (pHi), gastric mucosal partial pressure of carbon dioxide (PgCO2), vasoactive intestinal peptide (VIP), and adverse event were reported as secondary outcomes. Results. We included eighteen RCTs (1117 participants). Our findings suggested that compared to the control group (CG), electroacupuncture group (EG) showed significant effects on TFF (SMD = −0.98, 95% CI: [−1.28, −0.68], P < 0.00001 , I2 = 69%), TBS (SMD = −0.98, 95% CI: [−1.84, −0.12], P = 0.03 , I2 = 92%), and TFD (SMD = −1.23, 95% CI: [−1.59, −0.88], P < 0.0001 , I2 = 0%). Moreover, the incidence of PONV at postoperative 6 h (OR = 0.42, 95% CI: [0.27, 0.64], P < 0.0001 , I2 = 0%) and 24 h (OR = 0.46, 95% CI: [0.32, 0.68], P < 0.0001 , I2 = 0%) was lower in the EG than that in the CG, whereas no significant difference in ratio of PONV at postoperative 48 h (OR = 0.55, 95% CI: [0.20, 1.51], P = 0.25 , I2 = 0%) was detected between the two groups. Meanwhile, there was a significant effect in favor of EA on the level of MTL at postoperative 6 h (SMD = −0.93, 95% CI: [−1.36, −0.61], P < 0.0001 , I2 = 21%), while no significant effect was observed at postoperative 24 h (SMD = −0.43, 95% CI: [−0.89, 0.02], P = 0.06 , I2 = 69%) in the EG when compared to the CG. Additionally, a large significant effect on decreasing PgCO2 was found in the EG in comparison to the CG, but no significant effect in favor of EA on GAS, VIP, or pHi was observed. It was reported that there was one participant with pain at the needling sites and bruising, and three participants withdrew because they were not intolerant to EA. Conclusions. EA could be a promising strategy for the prevention and treatment of gastrointestinal dysfunction after gynecological surgery, including shortening TFF and TFD, TBS, regulating MTL, and decreasing the ratio of PONV within postoperative 24h. The effects on MTL and PONV varied with different intervention points, and EA used at 30 min prior to surgery might be recommended. However, the evidence quality ranged from low to very low, and large-scale and high-quality RCTs were warranted.

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The Effects of Different Levels of Citric Acid on Growth Performance, Nutrient Digestibility and Gastrointestinal pH of Weaned Piglets

Indian Journal of Animal Research ◽

10.18805/ijar.bf-1432 ◽

2022 ◽

Author(s):

Shi Wenying ◽

Lu Chunlian ◽

Li Shang ◽

Song Jiachun ◽

Cao Hongzhan

Keyword(s):

Citric Acid ◽

Growth Performance ◽

Average Daily Gain ◽

Nutrient Digestibility ◽

Control Treatment ◽

Control Group ◽

Weaned Piglets ◽

Gastrointestinal Ph ◽

Significant Difference ◽

Different Levels

Background: This study was conducted to evaluate the effects of different levels of citric acid (CA) on the growth performance, nutrient digestibility and gastrointestinal pH of weaned piglets. Methods: A total of 120 weaned piglets with an initial BW of 7.15±0.01 kg, were randomly divided into four groups including control treatment each with three replicates of 10 piglets each. Each group was supplemented with 0.5% (control group), 1%, 1.5% and 2% CA in the basal diet, respectively. Result: The results showed that the average daily feed intake (ADFI) and average daily gain (ADG) of added 1% CA group were significantly higher than that of 0.5% group (P less than 0.05). Dietary CA significantly improved the utilization rates of crude protein, calcium and phosphorus (P less than 0.05), while there was no significant difference between adding 1% and 1.5% CA (P greater than 0.05). Compared with the control group, adding CA effectively reduced the pH of the stomach, duodenum jejunum and ileum contents and adding 2% CA were significantly lower than those in other groups (P less than 0.05). Therefore, the addition of 1.0% CA in the diets of weaned piglets is suitable.

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Effects of Xylo-Oligosaccharides on Growth and Gut Microbiota as Potential Replacements for Antibiotic in Weaning Piglets

Frontiers in Microbiology ◽

10.3389/fmicb.2021.641172 ◽

2021 ◽

Vol 12 ◽

Author(s):

Yuxia Chen ◽

Yining Xie ◽

Ruqing Zhong ◽

Lei Liu ◽

Changguang Lin ◽

...

Keyword(s):

Gut Microbiota ◽

Basal Diet ◽

Intestinal Morphology ◽

Short Chain ◽

Control Group ◽

Rrna Gene ◽

Weaned Piglets ◽

Villus Height ◽

Crypt Depth ◽

Weaning Piglets

Xylo-oligosaccharides (XOS) is a well-known kind of oligosaccharide and extensively applied as a prebiotic. The objective of this study was to investigate the effect of XOS supplementation substituting chlortetracycline (CTC) on growth, gut morphology, gut microbiota, and hindgut short chain fatty acid (SCFA) contents of weaning piglets. A total of 180 weaned piglets were randomly allocated to three treatments for 28 days, as follows: control group (basal diet, CON), basal diet with 500 mg/kg (XOS500) XOS, and positive control (basal diet with 100 mg/kg CTC). Compared with the CON group, the piglets in the XOS500 group improved body weight (BW) on days 28, average daily gain (ADG) and reduced feed: gain ratio during days 1–28 (P < 0.05). The XOS500 supplementation increased Villus height and Villus height: Crypt depth ratio in the ileum (P < 0.05). Villus Height: Crypt Depth of the ileum was also increased in the CTC treatment group (P < 0.05). Meanwhile, the XOS500 supplementation increased significantly the numbers of goblet cells in the crypt of the cecum. High-throughput 16S rRNA gene sequencing revealed distinct differences in microbial compositions between the ileum and cecum. XOS500 supplementation significantly increased the bacterial diversity. However, CTC treatment markedly reduced the microbial diversity (P < 0.05). Meanwhile, XOS500 supplementation in the diet significantly increased the abundance of Lactobacillus genus compared to the CON and CTC group in the ileum and cecum (P < 0.01), whereas the level of Clostridium_sensu_stricto_1, Escherichia-Shigella, and Terrisporobacter genus in the XOS500 group were markedly lower than the CON and CTC group (P < 0.05). In addition, dietary supplementation with XOS500 significantly increased the total short-chain fatty acids, propionate and butyrate concentrations and decreased the acetate concentration compared to the CON group in the cecum (P < 0.05). In summary, dietary supplemented with XOS500 could enhance specific beneficial microbiota abundance and decrease harmful microbiota abundance to maintain the structure of the intestinal morphology and improve growth performance of weaned piglets. Thus, XOS may potentially function as an alternative to in-feed antibiotics in weaned piglets in modern husbandry.

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Influence of Bacterial Organic Selenium on Blood Parameters, Immune Response, Selenium Retention and Intestinal Morphology of Broiler Chickens

10.21203/rs.2.23476/v2 ◽

2020 ◽

Author(s):

A. M. Dalia ◽

T. C. Loh ◽

A. Q. Sazili ◽

Anjas Asmara Samsudin

Keyword(s):

Broiler Chickens ◽

Hematological Parameters ◽

Basal Diet ◽

Blood Parameters ◽

Intestinal Morphology ◽

Control Group ◽

Villus Height ◽

Organic Selenium ◽

Significant Difference ◽

Immunity Response

Abstract Background: Several studies indicated that dietary organic selenium (Se) usually absorbed better than an inorganic source, with high retention and bioavailability. Dietary Se as an antioxidant element affects the immune system and hematological status in animals. Therefore, the aim of this study was to evaluate the effect of dietary supplementation of bacterial selenium as an organic source on hematology, immunity response, selenium retention, and gut morphology in broiler chickens. Results: The present results revealed that supplementation of inorganic Se was associated with the lowest level of RBC, HB, and PCV with significant difference than ADS18-Se. In the starter stage, both T2 and T5 were associated with the significantly highest IgG level compared to the basal diet, while all supplemented groups showed higher IgM levels compared to the control group. In the finisher phase, all Se supplemented groups showed significant (P ˂ 0.05) increases in IgG, IgA, and IgM levels compared to T1. Birds fed bacterial-Se showed high intestinal villus height and better Se retention more than sodium selenite. The organic selenium of ADS18 had a superior action in improving Se retention compared to ADS1 and ADS2 bacterial Se. Conclusion: Bacterial organic Se had a beneficial effect on the villus height of small intestine led to high Se absorption and retention. Thus, it caused a better effect of Se on hematological parameters and immunity response.

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