scholarly journals OSiRIS: A Distributed Storage and Networking Project Update

2020 ◽  
Vol 245 ◽  
pp. 04012
Author(s):  
Shawn McKee ◽  
Benjeman Meekhof ◽  
Ezra Kissel ◽  
Andrew Keen ◽  
Kenneth M. Merz ◽  
...  

We report on the status of the OSiRIS project (NSF Award #1541335, UM, IU, MSU and WSU) after its fourth year. OSiRIS is delivering a distributed Ceph storage infrastructure coupled together with software-defined networking to support multiple science domains across Michigan’s three largest research universities as well as the Van Andel Institute. The project’s goal is to provide a single scalable, distributed storage infrastructure that allows researchers at each campus to work collaboratively with other researchers across campus or across institutions. The NSF CC*DNI DIBBs program which funded OSiRIS is seeking solutions to the challenges of multi-institutional collaborations involving large amounts of data and we are exploring the creative use of Ceph and networking to address those challenges. We will present details on the current status of the project and its various science domain users and use-cases. In the presentation we will cover the various design choices, configuration and the tuning and operational challenges we have encountered in providing a multiinstitutional Ceph deployment interconnected by a monitored, programmable network fabric. We will conclude with our plans for the final year of the project and its longer term outlook.

Author(s):  
Florian A. Huber ◽  
Roman Guggenberger

AbstractRecent investigations have focused on the clinical application of artificial intelligence (AI) for tasks specifically addressing the musculoskeletal imaging routine. Several AI applications have been dedicated to optimizing the radiology value chain in spine imaging, independent from modality or specific application. This review aims to summarize the status quo and future perspective regarding utilization of AI for spine imaging. First, the basics of AI concepts are clarified. Second, the different tasks and use cases for AI applications in spine imaging are discussed and illustrated by examples. Finally, the authors of this review present their personal perception of AI in daily imaging and discuss future chances and challenges that come along with AI-based solutions.


Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4423
Author(s):  
Marco A. Castro-Rojas ◽  
Yadira I. Vega-Cantu ◽  
Geoffrey A. Cordell ◽  
Aida Rodriguez-Garcia

Glass ionomer cements and resin-based composites are promising materials in restorative dentistry. However, their limited mechanical properties and the risk of bulk/marginal fracture compromise their lifespan. Intensive research has been conducted to understand and develop new materials that can mimic the functional behavior of the oral cavity. Nanotechnological approaches have emerged to treat oral infections and become a part of scaffolds for tissue regeneration. Carbon nanotubes are promising materials to create multifunctional platforms for dental applications. This review provides a comprehensive survey of and information on the status of this state-of-the-art technology and describes the development of glass ionomers reinforced with carbon nanotubes possessing improved mechanical properties. The applications of carbon nanotubes in drug delivery and tissue engineering for healing infections and lesions of the oral cavity are also described. The review concludes with a summary of the current status and presents a vision of future applications of carbon nanotubes in the practice of dentistry.


2021 ◽  
pp. 026666692110154
Author(s):  
Usman Ahmed Adam ◽  
Kiran Kaur

Institutional repositories are powerful tools to facilitate global access to intellectual output by members of the institution, particularly in assisting them to preserve and maximize access to their research output globally. This exploratory study of the status of institutional repositories implementation in African countries using the global Directory of Open Access Repositories (OpenDOAR) and Transparent Ranking: All Repositories by Google Scholar, reports on the operational status and the performance of repositories. Factor analysis and cluster analysis are used to analyze the operational level of institutional repositories in African countries. The analysis showed that the typical performance of institutional repositories remains below average. The possibility of global open access to research results through institutional repositories in South Africa, Kenya, Nigeria, Algeria, Sudan, and Egypt appeared to be relatively more feasible than other African countries. This study concludes that many organizations, institutions, and societies spend great efforts in support of open access implementation in Africa, however, the widespread implementation of institutional repositories is still very slow paced, and the performance of the implemented repositories was below expectation. Suggestions for regaining the intended direction of African institutional repositories are given based on the current status.


2013 ◽  
Vol 116 (1) ◽  
pp. 125-141 ◽  
Author(s):  
Manoj Dora ◽  
Dirk Van Goubergen ◽  
Maneesh Kumar ◽  
Adrienn Molnar ◽  
Xavier Gellynck

Purpose – Recent literature emphasizes the application of lean manufacturing practices to food processing industries in order to improve operational efficiency and productivity. Only a very limited number of studies have focused on the implementation of lean manufacturing practices within small and medium-sized enterprises (SMEs) operating in the food sector. The majority of these studies used the case study method and concentrated on individual lean manufacturing techniques geared towards resolving efficiency issues. This paper aims to analyze the status of the lean manufacturing practices and their benefits and barriers among European food processing SMEs. Design/methodology/approach – A structured questionnaire was developed to collect data. A total of 35 SMEs' representatives, mostly CEOs and operations managers, participated in the survey. The study investigated the role of two control variables in lean implementation: size of the company and country of origin. Findings – The findings show that lean manufacturing practice deployment in food processing SMEs is generally low and still evolving. However, some lean manufacturing practices are more prevalent than others; e.g. flow, pull and statistical process control are not widely used by the food processing SMEs, whereas total productive maintenance, employee involvement, and customer association are more widespread. The key barriers encountered by food SMEs in the implementation of lean manufacturing practices result from the special characteristics of the food sector, such as highly perishable products, complicated processing, extremely variable raw materials, recipes and unpredictable demand. In addition, lack of knowledge and resources makes it difficult for food processing SMEs to embark on the lean journey. Originality/value – The gap in the literature regarding the application of lean manufacturing in the food sector is identified and addressed in this study. The originality of this paper lies in analyzing the current status of the use of lean manufacturing practices among food SMEs in Europe and identifying potential barriers.


2005 ◽  
Vol 16 (07) ◽  
pp. 410-418 ◽  
Author(s):  
Dennis Van Vliet

The members of the profession of audiology often express concern that the services and products that have been developed to provide benefit to the hearing impaired are not sought after or delivered to the majority of those diagnosed with hearing loss. A critical look at the status quo of hearing care delivery in the United States is needed to verify this assumption and to develop strategies to improve the situation. A key concern is the lack of a comprehensive high-quality scientific database upon which to build continuous improvements in the effectiveness of the services and products that are provided to the hearing impaired.


MedChemComm ◽  
2015 ◽  
Vol 6 (1) ◽  
pp. 13-23 ◽  
Author(s):  
Inés González-Gil ◽  
Debora Zian ◽  
Henar Vázquez-Villa ◽  
Silvia Ortega-Gutiérrez ◽  
María L. López-Rodríguez

The current status of the LPA1receptor and its ligands in the drug development pipeline is reviewed.


Author(s):  
ELENA SIMONCHUK

The article examines the dynamics of social status self-evaluations of the Ukrainians based on two waves (2009 and 2019) of the Social Inequality module of International Social Survey Programme. Three types of social status self-evaluation in different biographical situations were noted: the current one (at the time of the survey), the retrospective one (of the parents’ family status) and the perspective one (status of oneself in 10 years’ time). They were measured through the respondents’ self-determination of their appropriate status on an imaginary 10-step social ladder. The noticeable changes for the better in the current social status self-evaluations of the Ukrainians are stated, which is visualized in changing the diagram of their distribution from pyramidal shape (where the lower-middle and the lowest positions are the basic ones) to the close to rhombus shape (where the majority is concentrated on the middle levels). The retrospective self-evaluations still demonstrate negative situation: the respondents mostly perceive the social status of parents’ families as higher than their current status. At the same time, the perspective self-evaluations of the Ukrainians are rather optimistic: majority of them hope to significantly increase their own status in the social hierarchy in the next decade. A connection between the class positions (both objectively and subjectively determined) and the status self-evaluations of three kinds was also studied. It is recorded that in both years of the survey this connection remains quite significant and expected in nature. Regarding EGP-classes: representatives of service classes and small owners had significantly higher current, retrospective and prospective self-evaluations than working-class people, primarily unskilled workers and farm labours. Regarding the subjective classes defined by nominal categories (upper middle, middle, lower middle, working, lower class): the higher the subjective class position a person has, the higher he/she evaluates his/her social status.


2013 ◽  
Vol 40 (1) ◽  
pp. 77 ◽  
Author(s):  
Mitchell B. East ◽  
J. Daren Riedle ◽  
Day B. Ligon

Context Monitoring populations of long-lived species requires continuous long-term efforts. This is especially applicable for species that have experienced declines range-wide. Aims Our study assessed the current status of a population of wild Macrochelys temminckii and compared the present results to those from a survey conducted nearly a decade ago. Methods Trapping in 2010–2011 was conducted on two creeks within the refuge, during the months of May–July. Capture data were compared with data collected by similar methods in 1997–2001. Key results The population structure of M. temminckii was dominated by juveniles, with few large adults or small juveniles detected and a missing size class was evident. Retrospective analysis of 1997–2001 data revealed that the population was likely to be in decline even then, despite high capture rates. Conclusions The M. temminckii population showed significant declines that indicated that the population had experienced stressors of unknown origin. The status of M. temminckii at the refuge is concerning, given the protection afforded this remnant population. Implications Short-term data from 1997–2001 indicated a healthy M. temminckii population, whereas longer-term data showed that the population has declined, resulting in significant demographic changes. Continued monitoring will be necessary to develop management recommendations and track the impact of implemented management practices. Longer-term monitoring of long-lived vertebrates is required to identify population trends.


2009 ◽  
Vol 4 (3) ◽  
pp. 60
Author(s):  
Kate Kelly

Bolin, Mary K. “Librarian Status at U.S. Research Universities: Extending the Typology.” Journal of Academic Librarianship 34.5 (August 2008): 416-24. Objective – To describe and categorize the status of librarians at 119 American research libraries using a typology of librarian status first developed for 50 U.S. land grant universities. Design – Survey. Setting – U.S. research universities. Subjects – 119 American research universities. Included are those universities whose library is a member of the Association of Research Libraries (ARL), in addition to land grant universities who are not also ARL members, and any flagship state universities who are neither ARL nor land grant universities. All subjects are classified as either “research – very high” or “research – high” in the Carnegie Classification of Institutions of Higher Education. The 119 institutions represent a total census of the selected population. Methods – The websites of the 119 institutions were surveyed and data on institutional characteristics such as governance, size and geography collected. Additionally, data describing librarian status characteristics such as administrator title, rank systems and tenure status was gathered from sources such as promotion and tenure documentation, faculty handbooks, and policy manuals available on websites. Data was compiled on a spreadsheet and imported into SPSS which was used to create frequencies and cross tabulations. Data was categorised and cross-tabulated using a typology of status originally applied to 50 land grant universities in a previous study. The typology comprises four possible status types for librarians: Type 1 – Faculty: Professorial ranks. Type 2 – Faculty: Other ranks with tenure. Type 3 – Faculty: Other ranks without tenure. Type 4 – Non-faculty: Professional or academic staff. Main Results – In the 119 institutions surveyed, librarians held faculty status at 74 (62%) institutions, of which 63 (51%) provided tenure track positions. At the remaining 45 (38%) institutions, librarians were considered non-faculty. Of the 50 “land grant” institutions in the population, 40 (80%) had librarians with faculty status and 35 (70%) provided tenure track. Ten universities (20%) considered librarians non-faculty. Of the 97 ARL libraries in the population, 55 (57%) had librarians with faculty status and 44 (45%) provided tenure track. Non-faculty librarians were found at 42 (43%) of these institutions. Of the 90 public institutions in the population, 68 (76%) had librarians who were faculty, 57 (64%) provided tenure track, and 22 (24%) had non-faculty librarians. Among the 29 private institutions the status ratios were reversed with only 4 (13%) institutions having librarians ranked as tenure track faculty (type 1 or type 2) and 23 (80%) having non-faculty librarians. In the total population (119) type 3 “Faculty: Other ranks without tenure” was the least common category, 48% (57) of libraries were headed by a dean, 67% (80) of institutions had librarian representation on faculty senate and as the size of an institution increased the likelihood of librarians having faculty rank decreased. “Dean” was the most popular administrator title in the population; it correlated with professorial rank and was strongly associated with tenure. Having tenure was, in turn, strongly associated with faculty senate representation. In the Northeast census region type 4, non-faculty staff predominated while type 1 was rare; in the Midwest there was an almost even split between type 1 and type 4; in the South there was a fairly even spread across all four types, and in the West a fairly even spread across types 1, 2 and 4. Finally, the data showed that as the size of an institution increased, the likelihood of librarians having faculty rank decreased. Conclusion – The typology created for land grant universities can be extended and applied to a wider population. It is valid and reliable both for organizing information about librarian status and for comparing institutions and population segments.


2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Hong Ding ◽  
Juan Xu ◽  
Zhimei Lin ◽  
Jingcao Huang ◽  
Fangfang Wang ◽  
...  

AbstractMultiple myeloma (MM) is a treatable plasma cell cancer with no cure. Clinical evidence shows that the status of minimal residual disease (MRD) after treatment is an independent prognostic factor of MM. MRD indicates the depth of post-therapeutic remission. In this review article, we outlined the major clinical trials that have determined the prognostic value of MRD in MM. We also reviewed different methods that were used for MM MRD assessment. Most important, we reviewed our current understanding of MM MRD biology. MRD studies strongly indicate that MRD is not a uniform declination of whole MM tumor population. Rather, MM MRD exhibits unique signatures of cytogenetic aberration and gene expression profiles, unlike those of MM cells before therapy. Diagnostic high-risk MM and low-risk MM exhibited a diversity of MRD features. Clonal evaluation may occur at the MRD stage in MM. The dynamics from the diagnostic MM to MRD correlate with the disease prognosis. Lastly, on the aspect of omics, we performed data-based analysis to address the biological features underlying the course of diagnostic-to-MRD MM. To summarize, the MRD stage of disease represents a critical step in MM pathogenesis and progression. Demonstration of MM MRD biology should help us to deal with the curative difficulties.


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