Australasian Huperzia as potential sources of Huperzine A and B

Planta Medica ◽  
2009 ◽  
Vol 75 (09) ◽  
Author(s):  
WH Lim ◽  
JQG Goodger ◽  
AR Field ◽  
JAM Holtum ◽  
IE Woodrow
Keyword(s):  
Huperzine A ◽  
Potential Sources

PHENOLIC METABOLITES OF DL-NORGESTREL: A METHOD FOR THE REMOVAL OF 1-HYDROXYLATED METABOLITES, POTENTIAL SOURCES OF PHENOLIC ARTIFACTS

1974 ◽  
Vol 76 (4) ◽  
pp. 789-800 ◽  
Author(s):  
Samuel F. Sisenwine ◽  
Ann L. Liu ◽  
Hazel B. Kimmel ◽  
Hans W. Ruelius
Keyword(s):  
Urinary Metabolites ◽  
Ion Exchange Resin ◽  
Gas Chromatography Mass Spectrometry ◽  
Phenolic Metabolites ◽  
Hydroxylated Metabolites ◽  
Analytical Work ◽  
Potential Sources ◽  
Alkaline Conditions ◽  
Artifact Formation ◽  
Work Up

ABSTRACT The identification of 1β-hydroxynorgestrel among the urinary metabolites of dl-norgestrel and the facile transformation of this compound under mild alkaline conditions to a potentially oestrogenic phenol provide an experimental basis for the conclusion advanced by others that the oestrogens present in the urine of subjects treated with synthetic progestens are artifacts formed during analytical work-up. A method has been devised which eliminates 1-hydroxylated metabolites as potential sources of phenolic artifacts. This method is based on the reduction by NaBH4 of the 1-hydroxy-4-en-3-one grouping in the A ring thereby excluding the possibility of aromatization during later fractionation on a basic ion exchange resin that separates neutral from phenolic metabolites. In the urines of women treated with 14C-dl-nogestrel, only 0.17–0.27% of the dose is found to have phenolic properties when this method is used. Two of the phenolic metabolites, 18-homoethynyloestradiol and 16β-hydroxy-18-homoethynyloestradiol, are present in amounts smaller than 0.01 % of the dose. Without the reduction steps the percentages are noticeably higher, indicating artifact formation under alkaline conditions. Similar results were obtained with urines from African Green Monkeys (Cercopithecus Aethiops) that had been dosed with 14C-dl-norgestrel. Radiolabelled 18-homoethynyloestradiol and 16β-hydroxy-18-homoethynyloestradiol were isolated from monkey urine and their identity confirmed by gas chromatography-mass spectrometry.

The Improvement of Paclitaxel Cytotoxicity using Nanocellulose based Nature Resources

2019 ◽  
Vol 1 (1) ◽  
pp. 7
Author(s):  
R Nahrowi ◽  
A Setiawan ◽  
Noviany Noviany ◽  
I Sukmana ◽  
S D Yuwono
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Natural Resources ◽  
Cell Viability ◽  
Cancer Cells ◽  
Drug Delivery System ◽  
Target Cell ◽  
Mitotic Cycle ◽  
Potential Sources ◽  
Local Accumulation

Paclitaxel is one of the cancer drugs that often used. These drug kills cancer cells byinhibiting mitotic cycle. The efficiency of paclitaxel is increased by the use ofnanomaterials as a carrier of paclitaxel. Nanomaterials can enhance encapsulationefficiency, improve the drug release to the target cell following nanomaterialdegradation, and improve local accumulation of drug in the cell through endocytosisreceptor. Nanomaterial that often used forencapsulation of paclitaxel is a polymerderived from natural resources such as cellulose. The advantages of cellulose as acarrier of paclitaxel are nontoxic, biodegradable, and very abundant from varioussources. One of the potential sources of cellulose for drug delivery system is cassavabaggase.Keywords: Paclitaxel, encapsulation, cell viability, nanocellulose

Model Statistika Prediksi Energi Surya Dengan Menggunakan Autoregresif Integrated Moving Average (ARIMA)

Jurnal MIPA ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 181
Author(s):  
Imriani Moroki ◽  
Alfrets Septy Wauran
Keyword(s):  
Renewable Energy ◽  
Solar Energy ◽  
Moving Average ◽  
Arima Model ◽  
Solar Irradiation ◽  
Energy Sources ◽  
Energy Potential ◽  
Good Design ◽  
Potential Sources ◽  
The Common

Energi terbarukan adalah salah satu masalah energi paling terkenal saat ini. Ada beberapa sumber potensial energi terbarukan. Salah satu energi terbarukan yang umum dan sederhana adalah energi matahari. Masalah besar ketersediaan energi saat ini adalah terbatasnya sumber energi konvensional seperti bahan bakar. Ini semua sumber energi memiliki banyak masalah karena memiliki jumlah energi yang terbatas. Penting untuk membuat model dan analisis berdasarkan ketersediaan sumber energi. Energi matahari adalah energi terbarukan yang paling disukai di negara-negara khatulistiwa saat ini. Tergantung pada produksi energi surya di daerah tertentu untuk memiliki desain dan analisis energi matahari yang baik. Untuk memiliki analisis yang baik tentang itu, dalam makalah ini kami membuat model prediksi energi surya berdasarkan data iradiasi matahari. Kami membuat model energi surya dan angin dengan menggunakan Metode Autoregresif Integrated Moving Average (ARIMA). Model ini diimplementasikan oleh R Studio yang kuat dari statistik. Sebagai hasil akhir, kami mendapatkan model statistik solar yang dibandingkan dengan data aktualRenewable energy is one of the most fomous issues of energy today. There are some renewable energy potential sources. One of the common n simple renewable energy is solar energy. The big problem of the availability of energy today is the limeted sources of conventional enery like fuel. This all energy sources have a lot of problem because it has a limited number of energy. It is important to make a model and analysis based on the availability of the energy sources. Solar energy is the most prefered renewable energy in equator countries today. It depends on the production of solar energy in certain area to have a good design and analysis of  the solar energy. To have a good analysis of it, in this paper we make a prediction model of solar energy based on the data of solar irradiation. We make the solar and wind enery model by using Autoregresif Integrated Moving Average (ARIMA) Method. This model is implemented by R Studio that is a powerfull of statistical. As the final result, we got the statistical model of solar comparing with the actual data

Huperzine A: Behavioral and Pharmacological Evaluation in Rhesus Monkeys

2008 ◽  
Author(s):  
Todd M. Myers ◽  
Wei Sun ◽  
Ashima Saxena ◽  
Bhupendra P. Doctor ◽  
Andrew J. Bonvillain ◽  
...  
Keyword(s):  
Rhesus Monkeys ◽  
Huperzine A ◽  
Pharmacological Evaluation

Natural Anti-inflammatory compounds as Drug candidates in Alzheimer’s disease

2020 ◽  
Vol 27 ◽  
Author(s):  
Reyaz Hassan Mir ◽  
Abdul Jalil Shah ◽  
Roohi Mohi-ud-din ◽  
Faheem Hyder Potoo ◽  
Mohd. Akbar Dar ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Natural Products ◽  
Protective Action ◽  
New Drugs ◽  
Huperzine A ◽  
Brain Disorder ◽  
Anti Inflammatory

: Alzheimer's disease (AD) is a chronic neurodegenerative brain disorder characterized by memory impairment, dementia, oxidative stress in elderly people. Currently, only a few drugs are available in the market with various adverse effects. So to develop new drugs with protective action against the disease, research is turning to the identification of plant products as a remedy. Natural compounds with anti-inflammatory activity could be good candidates for developing effective therapeutic strategies. Phytochemicals including Curcumin, Resveratrol, Quercetin, Huperzine-A, Rosmarinic acid, genistein, obovatol, and Oxyresvertarol were reported molecules for the treatment of AD. Several alkaloids such as galantamine, oridonin, glaucocalyxin B, tetrandrine, berberine, anatabine have been shown anti-inflammatory effects in AD models in vitro as well as in-vivo. In conclusion, natural products from plants represent interesting candidates for the treatment of AD. This review highlights the potential of specific compounds from natural products along with their synthetic derivatives to counteract AD in the CNS.

Nutraceuticals from Marine Bionetworks

2019 ◽  
Vol 15 (4) ◽  
pp. 338-344
Author(s):  
Abhitav Tiwari ◽  
Shambhawi Pritam ◽  
Keerti Mishra ◽  
Mehshara Khan ◽  
Neeraj Upmanyu ◽  
...  
Keyword(s):  
Dietary Supplements ◽  
Bioactive Compounds ◽  
Daily Basis ◽  
Marine Organisms ◽  
Bioactive Molecules ◽  
Natural Sources ◽  
Nutraceutical Compounds ◽  
Potential Sources ◽  
Immense Potential ◽  
Potential Use

“Nutrition” and “Pharmaceutical” together build up the perception of “Nutraceuticals” that refer to the food or dietary supplements that help to incorporate additional health benefits to the fundamental sustenance accomplished on daily basis. Each nutraceutical contains one or more bioactive molecules that are usually obtained by chemical and/ or biotechnological synthesis or by extraction from natural sources. Among the natural sources, marine bionetwork possess immense potential for the presence of bioactive compounds. Some of these bioactive compounds as isolated from marine sources, have potential use as nutraceuticals. This mini review provides a brief overview of nutraceutical compounds from marine sources that are currently under research and/or have been commercialized. A detailed discussion on the biochemical categories of compounds and the marine organisms that play as potential sources of these bioactive nutraceutical compounds have been included.

Studies on mosquito density in urban Kano: a study to calculate larval indices in municipal area of Gwale, Kano, Nigeria

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
A.B. Umar ◽  
A.H. Dankaka ◽  
M. Manjur Shah
Keyword(s):  
Local Government ◽  
Critical Level ◽  
Cross Sectional Study ◽  
Local Government Area ◽  
Mosquito Density ◽  
Sectional Study ◽  
Cross Sectional ◽  
Potential Sources ◽  
Mosquito Breeding ◽  
Water Holding

The study is carried out to standardize larval indices namely House Index, Container Index and Breteau Index and also to identify the major breeding sources of mosquitoes in the residential environment in and around the Gwale Local government area of  Kano, Nigeria. A cross-sectional study by selecting 50 houses randomly from the 6 wards of Municipality was employed. Every water holding container indoors and outdoors were counted and searched for larval presence and noted on a pretested format. In this study, 300 houses were surveyed in 21 days out of which 94.33% (283 houses) were found to have potential sources for mosquito breeding. All the entomological indices were found to be above the critical level. House Index = 28.67%; Container Index = 12.14%; Breteau Index = 64.00% showing high chances for outbreaks of mosquito borne diseases. The area is prone to mosquito borne disease like malaria and therefore warrants interventions from the competent.

Inference

2018 ◽  
Author(s):  
Mark Sainsbury
Keyword(s):  
Common Basis ◽  
Plausible Reasoning ◽  
Potential Sources ◽  
Semantic Properties

Display theory predicts that no inferential relations among attitude attributions are based on the logical or semantic properties of the expressions in attribution complements. This chapter shows various ways in which there may be an illusion that such relations obtain. One common basis for the illusion is that we implicitly appeal to psychological facts. Since there is no reason to think these are necessary, the inferences are not truth preserving of necessity, even if they generally have true conclusions when they have true premises. They are examples of “plausible reasoning”. Wanting and fearing are discussed in detail as potential sources of the apparently inferential phenomena.

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