Intensity Of Therapeutic Range And Mean Anticoagulant Dosage Prescribed: An International Study

1981 ◽  
Author(s):  
L Poller ◽  
D A Taberner

It has been suggested that anticoagulant dosage requirements vary in different parts of the world. An international survey on anticoagulant dosage involving over 500 laboratories was performed employing a questionnaire on the mean daily anticoagulant dosage of 20 stabilised patients. Replies received show a considerable variation in dosage between countries.In order to further investigate the influence of the intensity of the therapeutic range on local dosage differences, participants were asked to assess a lyophilised human coumarin plasma sample. Most agreed that the plasma was adequately anticoagulated. However, laboratories finding the plasma overdosed were prescribing a lower mean anticoagulant dosage than those laboratories finding the plasma underdosed. This suggests that some of the differences in dosage between laboratories may be accounted for by the varying intensities of the therapeutic ranges used in the different countries.

1869 ◽  
Vol 25 (2) ◽  
pp. 575-637 ◽  
Author(s):  
Alexander Buchan

Charts, showing by Isobaric Lines the mean pressure of the atmosphere over the globe during the months of the year, may be justly regarded as furnishing the key to all questions of meteorological inquiry; for without the information conveyed by such charts it is impossible to discuss satisfactorily those questions which relate to prevailing winds, the varying temperature, and the rainfall throughout the year in the different countries of the world. It is to meet this desideratum that the Charts of Mean Atmospheric Pressure of the globe which are given with this paper are offered as the first approximate solution of this great physical problem.Since Part I. was read in March 1868, valuable additional information has been obtained from Australia, New Zealand, Tasmania, Africa, South America, the west coast of North America, Iceland, Norway, and Sweden, and from several isolated stations in different parts of Europe and Asia. The period for the British Islands and a large portion of Europe has been extended so as to include the eleven years from 1857 to 1867.


2018 ◽  
Vol 10 (3) ◽  
pp. 504-523 ◽  
Author(s):  
Dong-Ik Kim ◽  
Dawei Han

Abstract Long term climate data are vitally important in reliably assessing water resources and water related hazards, but in-situ observations are generally sparse in space and limited in time. Although there are several global datasets available as substitutes, there is a lack of comparative studies about their suitability in different parts of the world. In this study, to find out the reliable century-long climate dataset in South Korea, we first evaluate multi-decadal reanalyses (ERA-20 cm, ERA-20c, ERA-40 and NOAA 20th century reanalysis (20CR)) and gridded observations (CRUv3.23 and GPCCv7) for monthly mean precipitation and temperature. In the temporal and statistical comparisons, CRUv3.23 and GPCCv7 for precipitation and ERA-40 for temperature perform the best, and ERA-20c and 20CR also indicate meaningful agreements. For ERA-20 cm, it has only a statistical agreement, but the mean has the difficulty in representing its ensemble. This paper also shows that the applicability of each dataset may vary by region and all products should be locally adjusted before being applied in climate impact assessments. These findings not only help to fill in the knowledge gaps about these datasets in South Korea but also provide a useful guideline for the applicability of the global datasets in different parts of the world.


1874 ◽  
Vol 22 (148-155) ◽  
pp. 254-258

The first observations which seemed to show that the mean position of the declination-needle followed an annual law were those of Cassini, made, more than eighty years ago, in the hall of the Paris Observatory and in the caves below it (90 feet under ground). It cannot be said, however, that Cassini’s result has been confirmed by subsequent observations, either as regards the direction or amounts of movement from month to month. The extensive series of observations made in different parts of the world in modern times have given results so different that we must conclude either that the magnetic needle obeys different annual laws at each place, or that the differences are due to instrumental errors. The consequence has been that, after long, laborious, and expensive researches, it is still a question whether the magnetic needle obeys an annual law or not.


2020 ◽  
Vol 9 (2) ◽  
pp. e000791
Author(s):  
Romulo Negrini ◽  
Raquel Domingues da Silva Ferreira ◽  
Renata Silva Albino ◽  
Carol Amaral Tavares Daltro

BackgroundCaesarean rates increased in different parts of the world, rising from 20% to 33% in the USA and from 40% to 55% in Brazil between 1996 and 2011; however, there was no reduction in morbimortality rates. Several factors have been suggested as responsible for this increase, such as health judicialisation, fear of the painful process on the patients’ part and reduction of medical training in vaginal delivery and labour complications. It is urgent to reverse this process and, therefore, a model of actions was created with the intention of engaging the team in order to reduce caesarean rates in a Brazilian hospital.MethodologyThe model was based on the following actions: encouragement of labour analgesia; execution of written reports of any cardiotocographic examination; plan-do-study-act cycles for nursing orientations about the positions that favour pregnant women during labour; creation of a birth induction form; monthly feedback with physicians and nurses on caesarean rates achieved; verification of the caesarean rate by medical staff with individual feedback; daily round of medical coordination for case discussions; disclosure of caesarean rates on hospital posters; and constant dissemination of literature with strategies to reduce caesarean delivery. This plan of action started in January 2016. The mean caesarean section rate in the 31 months preceding the interventions (period A) was then compared with the 31 subsequent months (period B).ResultsBoth periods presented caesarean rates with normal distribution. The mean caesarean rate was 29.24% (range: 38.69%–23.89%, SD 3.24%) vs 25.84% (range: 17.96%–34.97%, SD 3.92%, p<0.05), respectively, for periods A and B.ConclusionAfter the implementation of the plan of action, there was a reduction in caesarean rates in this hospital.


1993 ◽  
Vol 39 (1) ◽  
pp. 72-75 ◽  
Author(s):  
M M Reidenberg ◽  
Z P Gu ◽  
B Lorenzo ◽  
E Coutinho ◽  
C Athayde ◽  
...  

Abstract Hypokalemia has been associated with the taking of gossypol, a potential oral antifertility drug for men. Because the frequency of this response differed in different parts of the world, this study was done to learn if "normal" serum [K+] also differed. [K+] was measured by flame photometry in serum from apparently normal men from Austria (n = 30), China (53), Brazil (100), the Dominican Republic (38), and the US (103), and in plasma from Nigerian men (82). The mean (SD) for [K+] in Chinese men, 3.82 (0.27) mmol/L, was lower than that in Brazilians [4.06 (0.29) mmol/L], Austrians [4.14 (0.44) mmol/L], Dominicans [4.37 (0.33) mmol/L], or Americans [4.38 (0.37) mmol/L]. Apparently there are regional differences in average serum [K+], with men in China having lower serum [K+] than men elsewhere. This may predispose them to hypokalemia.


2017 ◽  
Vol 4 (2) ◽  
pp. 14
Author(s):  
Putri Megasari

Hepatitis has become a health problem in the world. The hepatitis virus infected many people. According to the teacher of MTsN 02 Bondowoso more than 20 students have hepatitis A viral infection. The purpose of this research was to know the differences of students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study used pre-experimental (pre-post test design). This study used stratified random sampling technique, 127 students from 270 sample involved this research,and 143 students was excluded. We used questionnaires to collect data. The results showed that the mean value of the students 'knowledge about hepatitis A before counseling in MTsN 02 Bondowoso 2015 was 83.96 with the lowest value of 37.5 and the highest value was 100. The mean value of the students' knowledge about hepatitis A after counseling in MTsN 02 Bondowoso 2015 was 93.21 with the lowest value waf 62.5 and the highest value was 100. Paired t test showed that t (-9.07) > t table (1.98), the null hypothesis (H0) was rejected. There was a difference between students' knowledge about hepatitis A before and after counseling in MTsN 02 Bondowoso 2015. This study showed that routine counseling by healthcare provider was important to prevent hepatitis A infection.; Keywords: counseling, knowledge of students, hepatitis


1963 ◽  
Vol 42 (2) ◽  
pp. 214-224
Author(s):  
Raymond C. Mellinger ◽  
Jalileh A. Mansour ◽  
Richmond W. Smith

ABSTRACT A reference standard is widely sought for use in the quantitative bioassay of pituitary gonadotrophin recovered from urine. The biologic similarity of pooled urinary extracts obtained from large numbers of subjects, utilizing groups of different age and sex, preparing and assaying the materials by varying techniques in different parts of the world, has lead to a general acceptance of such preparations as international gonadotrophin reference standards. In the present study, however, the extract of pooled urine from a small number of young women is shown to produce a significantly different bioassay response from that of the reference materials. Gonadotrophins of individual subjects likewise varied from the multiple subject standards in many instances. The cause of these differences is thought to be due to the modifying influence of non-hormonal substances extracted from urine with the gonadotrophin and not necessarily to variations in the gonadotrophins themselves. Such modifying factors might have similar effects in a comparative assay of pooled extracts contributed by many subjects, but produce significant variations when material from individual subjects is compared. It is concluded that the expression of potency of a gonadotrophic extract in terms of pooled reference material to which it is not essentially similar may diminish rather than enhance the validity of the assay.


Author(s):  
Brian Stanley

This book charts the transformation of one of the world's great religions during an age marked by world wars, genocide, nationalism, decolonization, and powerful ideological currents, many of them hostile to Christianity. The book traces how Christianity evolved from a religion defined by the culture and politics of Europe to the expanding polycentric and multicultural faith it is today—one whose growing popular support is strongest in sub-Saharan Africa, Latin America, China, and other parts of Asia. The book sheds critical light on themes of central importance for understanding the global contours of modern Christianity, illustrating each one with contrasting case studies, usually taken from different parts of the world. Unlike other books on world Christianity, this one is not a regional survey or chronological narrative, nor does it focus on theology or ecclesiastical institutions. The book provides a history of Christianity as a popular faith experienced and lived by its adherents, telling a compelling and multifaceted story of Christendom's fortunes in Europe, North America, and across the rest of the globe. It demonstrates how Christianity has had less to fear from the onslaughts of secularism than from the readiness of Christians themselves to accommodate their faith to ideologies that privilege racial identity or radical individualism.


2020 ◽  
Vol 7 (2) ◽  
pp. 199-204
Author(s):  
Shrikant Verma ◽  
Mohammad Abbas ◽  
Sushma Verma ◽  
Syed Tasleem Raza ◽  
Farzana Mahdi

A novel spillover coronavirus (nCoV), with its epicenter in Wuhan, China's People's Republic, has emerged as an international public health emergency. This began as an outbreak in December 2019, and till November eighth, 2020, there have been 8.5 million affirmed instances of novel Covid disease2019 (COVID-19) in India, with 1,26,611 deaths, resulting in an overall case fatality rate of 1.48 percent. Coronavirus clinical signs are fundamentally the same as those of other respiratory infections. In different parts of the world, the quantity of research center affirmed cases and related passings are rising consistently. The COVID- 19 is an arising pandemic-responsible viral infection. Coronavirus has influenced huge parts of the total populace, which has prompted a global general wellbeing crisis, setting all health associations on high attentive. This review sums up the overall landmass, virology, pathogenesis, the study of disease transmission, clinical introduction, determination, treatment, and control of COVID-19 with the reference to India.


2019 ◽  
pp. 81-88
Author(s):  
Ozoem Martha ◽  
Chibuike Victoria C. ◽  
Ugwunwoti Emeka P.

This study was carried out to determine the modern office technology competencies expected of office technology and management (OTM) graduate workers by supervisors in Delta State. The study was guided by two research questions and two hypotheses tested at 0.05 level of significance. The respondents consisted of 142 supervisors, made up of 74 heads of department and directors of government establishments, and 68 managers and directors of private establishments in the study area. Descriptive survey research design was used to conduct the study and 28 – items questionnaire were used to collect data from respondents. The instrument was validated by three experts and had a Cronbach Alpha reliability coefficient of 0.77. Means with standard deviations were used to answer the research questions, while t-test was used to test the null hypotheses. The extent of supervisor‟s expectations of information processing competencies did not differ significantly based on the mean ratings of male and female supervisors of OTM graduates in government and private establishments. The findings also revealed that supervisors expect much information processing and communication competencies from the OTM graduate workers. Based on the findings and the implications, it was recommended among others that, curriculum planners, business and OTM education lecturers should ensure that the competencies required for modern office technologies are entrenched and taught in the institutions to prepare the OTM graduates for the world of work.


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