Intensity Of Therapeutic Range And Mean Anticoagulant Dosage Prescribed: An International Study
It has been suggested that anticoagulant dosage requirements vary in different parts of the world. An international survey on anticoagulant dosage involving over 500 laboratories was performed employing a questionnaire on the mean daily anticoagulant dosage of 20 stabilised patients. Replies received show a considerable variation in dosage between countries.In order to further investigate the influence of the intensity of the therapeutic range on local dosage differences, participants were asked to assess a lyophilised human coumarin plasma sample. Most agreed that the plasma was adequately anticoagulated. However, laboratories finding the plasma overdosed were prescribing a lower mean anticoagulant dosage than those laboratories finding the plasma underdosed. This suggests that some of the differences in dosage between laboratories may be accounted for by the varying intensities of the therapeutic ranges used in the different countries.