The Formulation and Physical Evaluation of Emulgel the Kalakai (Stenochlaena Palustris Bedd) Roots Ethanol Extract As a Sunscreen

ABSTRACT Sesewanua Leaves (Clerodendron squamatum Vahl.) have the potential to be made as skin care cosmetic preparations but must be in the right formulation to achieve the desired effect. The aim of this study was to determine the physical stability of a cream from Sesewanua leaf extract. This study used a experimental method by making ethanol extract of Sesewanua leaves with a concentration of 0.5% and physical stability test. Physical evaluation was carried out before and after cycling test through organoleptic observation, homogenety test, pH test, dispersion test, adhesion test, viscosity test, centrifugation test and cream type determination. The results of the physical evaluation showed that F1 without Sesewanua leaf extract and F2 with Sesewanua leaf extract creams met the requirements of physical stability, so can be concluded that Sesewanua leaf extract can be formulated into cream preparations with concentration of 0.5% which is physically stable before and after cycling test. Keywords: Sesewanua Leaves, Cream, Physical Stability ABSTRAK Daun Sesewanua (Clerodendron squamatum Vahl.) berpotensi untuk dibuat sebagai sediaan kosmetik perawatan kulit namun harus dengan formulasi yang tepat agar mencapai efek yang diinginkan. Penelitian ini bertujuan untuk mengetahui stabilitas fisik sediaan krim ekstrak daun sesewanua. Penelitian ini menggunakan metode eksperimental dengan membuat krim ekstrak etanol daun Sesewanua dengan konsentrasi 0,5% dan uji stabilitas fisik. Evaluasi fisik dilakukan sebelum dan sesudah cycling test melalui pengamatan organoleptis, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, uji viskositas, uji sentrifugasi dan penentuan tipe krim. Hasil evaluasi fisik menunjukkan krim F1 tanpa ekstrak daun Sesewanua dan F2 dengan ekstrak daun Sesewanua memenuhi persyaratan stabilitas fisik. Berdasarkan hasil penelitian dapat disimpulkan ekstrak daun sesewanua dapat diformulasi menjadi sediaan krim dengan konsentrasi 0,5% yang stabil secara fisik sebelum dan sesudah cycling test. Kata Kunci : Daun Sesewanua, Krim, Stabilitas Fisik

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FORMULASI DAN EFEK ANTIBAKTERI MASKER PEEL-OFF EKSTRAK ETANOL DAUN KERSEN (Muntingia calabura L.) TERHADAP BAKTERI Staphlococcous epidermidis

PHARMACON ◽

10.35799/pha.8.2019.29393 ◽

2019 ◽

Vol 8 (3) ◽

pp. 686

Author(s):

Regita Daimunon ◽

Paulina V. Y. Yamlean ◽

Imam Jayanto

Keyword(s):

Staphylococcus Epidermidis ◽

Ethanol Extract ◽

Homogeneity Test ◽

Power Test ◽

Cycling Test ◽

Physical Evaluation ◽

Before And After ◽

Time Test ◽

Ethanol Extracts ◽

Muntingia Calabura

ABSTRACT Kersen leaf (Muntingia calabura L.) contains flavonoids, saponins and tannins, which could inhibit bacterial activity. This study aimed to formulate, evaluate, and to test the effectiveness of antibacterial preparations for the Kersen leaf ethanol extracts mask. This study uses the experimental method by testing the parameters of the physical evaluation requirements for the masker. Physical evaluation of preparations included organoleptic test, homogeneity test, pH test, scattering power test, dry time test, sticky test and cycling test, all tests were carried out before and after cycling test. The results of the preparation study meet the requirements of physical evaluation before the cycling test but after the cycling test is is not in accordance to the requirements for the preparation of the peel-off mask. The antibacterial test of mask peel-off ethanol extract of Kersen's leaves on Staphylococcus epidermidis bacteria produced a moderate inhibition. So it can be concluded that the ethanol extracts of Kersen leaves at a concentration of 20%. can be formulated as a peel-off mask that is physically stable and has moderate antibacterial activity.Keywords: Kersen, Peel-off mask, Antibacterial, Staphlococcous epidermidis ABSTRAK Daun Kersen (Muntingia calabura L.) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan masker peel-off ekstrak etanol daun Kersen. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik masker peel-off. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji waktu sediaan mengering, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian sediaan memenuhi persyaratan eveluasi fisik sebelum uji cycling test namun setelahnya tidak sesuai dengan persyaratan sediaan masker peel-off. Penelitian uji antibakteri masker peel-off ekstrak etanol daun Kersen pada bakteri staphylococcus epidermidis menghasilkan daya hambat yang sedang. Dapat disimpulkan pada kosentrasi 20% ekstrak etanol daun Kersen dapat diformulasi sebagai sediaan masker peel-off yang stabil secara fisik dan memiliki aktivitas antibakteri yang sedang .Kata kunci : Kersen, Masker peel-off, Antibakteri, Staphlococcous epidermidis

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Formulation and Physical Evaluation of Edible Film Dosage from Ethanol Extract of Betel Leaves (Piper betle L) for Canker Sore Drugs

Indonesian Journal of Pharmaceutical Science and Technology ◽

10.24198/ijpst.v8i1.29225 ◽

2021 ◽

Vol 8 (1) ◽

pp. 42

Author(s):

Yenni Puspita Tanjung ◽

Andi Ika Julianti ◽

Aghnia Wulan Rizkiyani

Keyword(s):

Leaf Extract ◽

Corn Starch ◽

Hydroxypropyl Methylcellulose ◽

Ethanol Extract ◽

Edible Film ◽

Dissolution Time ◽

Piper Betle ◽

Betel Leaf ◽

Physical Evaluation ◽

Bad Breath

Canker sore which in medical terms is called aphthous stomatitis is a wound in the mouth that can cause pain and discomfort. Piper betel leaf can be used for strengthening the teeth, cure canker sores, treat the bad breath and stop the gum from bleeding. The research aimed to determine the edible film formula of betel leaf ethanol extract that met the physical evaluation requirements and to determine the effect of variation concentration of sorbitol and HPMC (Hydroxypropyl methylcellulose) on the physical evaluation. Edible film preparation from betel leaf extract is a thin layer made from the basic ingredients of corn starch, sorbitol, and HPMC. In this research, 3 edible film formulas were made with variations in the concentration of sorbitol and HPMC, namely: F1 (5%;5%), F2 (4%;4%), F3 (3%;3%). Data of evaluation results were analyzed statistics by Kruskal wallis method. The results showed that F1, F2 and F3 meet the physical evaluation requirements for edible film dosage. Variations in the concentration of sorbitol and HPMC gave different results significantly influence (p<0.05) on weight uniformity, film thickness, solubility and dissolution time, and did not significantly influence (p>0.05) on the organoleptic test, fragility of edible film, water resistance (swelling) and moisture content.Keywords: Betel leaf extract, edible film, HPMC, canker sore, sorbitol

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FORMULASI DAN UJI EFEKTIVITAS ANTIOKSIDAN SEDIAAN MASKER PEEL-OFF EKSTRAK ETANOL DAUN SESEWANUA (Cleodendron squamatum Vahl.)

PHARMACON ◽

10.35799/pha.8.2019.29305 ◽

2019 ◽

Vol 8 (2) ◽

pp. 388

Author(s):

Ferrna Rompis ◽

Paulina V. Y. Yamlean ◽

Widya A. Lolo

Keyword(s):

Ethanol Extract ◽

Homogeneity Test ◽

Analytic Method ◽

Drying Time ◽

Power Test ◽

Cycling Test ◽

Physical Evaluation ◽

Antioxidant Effectiveness ◽

Before And After ◽

Time Test

ABSTRACT Sesewanua leaves (Cleodendron squamatum Vahl.) contain alkaloids and flavonoids which are efficacious as antioxidants. This study aimed to fomulate, evaluate, and test the effectiveness of antioxidants in the form of peel-off mask of ethanol extract from the Sesewanua leaves. This study used descriptive-analytic method with the treatment of variations in concentrations of PVA 12 % , 14% and 16 %, respectively. Physical evaluation of preparations included organoleptic observation, homogeneity test, pH test, scattering power test, drying time test, and cycling test, all tests were carried out before and after the cycling test. The results showed that all preparations met the requirements of physical evaluation before the cycling test while after the cycling test only preparations with 12% PVA concentrations met the requirement, whereas preparations with 14% and 16% of PVA did not met the requirement after the cycling test and after testing antioxidant effectiveness using the DPPH (1,1-diphenyl-2-pikrilhidrazil) method were obtained. The value of IC50 before cycling test was 179.120 mg/L and after cycling test was 504.74mg/L. Based on the results of the study it can be concluded that the ethanol extract of Sesewanua leaves can be formulated into a peel-off mask with 12% PVA concentration which is physically stable and has moderate antioxidant effectiveness before the cycling test, while after cycling test the preparation of peel-off mask ethanol extract of Sesewanua leaves is less effective as an antioxidant. Keywords: Sesewanua leaves (Cleodendron squamatum Vahl.), peel-off mask, antioxidantsABSTRAK Daun Sesewanua (Cleodendron squamatum Vahl.) mengandung alkaloid dan flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antioksidan sediaan masker peel-off ekstrak etanol daun Sesewanua. Penelitian ini menggunakan metode deskriptif-analitik dengan perlakuan variasi konsentrasi PVA 12%, 14% dan 16%. Evaluasi fisik sediaan meliputi pengamatan organoleptik, uji homogenitas, uji pH, uji daya sebar, uji waktu mengering dan uji cycling test semua pengujian dilakukan sebelum dan sesudah uji cycling test. Hasil penelitian menunjukkan bahwa semua sediaan memenuhi persyaratan evaluasi fisik sebelum uji cycling test sedangkan setelah uji cycling test hanya sediaan dengan konsentrasi PVA 12% yang memenuhi persyaratan sedangkan sediaan dengan konsentrasi PVA 14% dan 16% tidak memenuhi persyaratan setelah uji cycling test, dan setelah dilakukan uji efektivitas antioksidan dengan metode DPPH (1,1-difenil-2-pikrilhidrazil) diperoleh nilai IC50 sebelum uji cycling test sebesar 179,120 mg/L dan sesudah cycling test sebesar 504,74 mg/L. Berdasarkan hasil penelitian dapat disimpulkan bahwa ekstrak etanol daun Sesewanua dapat diformulasi menjadi sediaan masker peel-off dengan konsentrasi PVA 12% yang stabil secara fisik dan memiliki efektivitas antioksidan yang sedang sebelum uji cycling test sedangkan setelah cycling test sediaan masker peel-off ektrak etanol daun sesewanua kurang efektif sebagai antioksidan. Kata Kunci : Sesewanua (Cleodendron squamatum Vahl.), masker peel-off, Antioksidan.

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Cream Formulation of Ethanol Extract of Banana Peel (Musa Paradisiaca Var. Sapientum (L))

Jurnal Dunia Farmasi ◽

10.33085/jdf.v1i1.4348 ◽

2019 ◽

Vol 1 (1) ◽

pp. 22-29

Author(s):

Idarwati Duha ◽

Adek Chan

Keyword(s):

Ethanol Extract ◽

Herbaceous Plants ◽

Banana Peel ◽

Homogeneity Test ◽

Musa Paradisiaca ◽

Physical Evaluation ◽

The Family ◽

Type Test ◽

Test Result ◽

Peel Extract

Introduction: Musa Paradisiaca Var. Sapientum (L) or know as the banana plants in Indonesia is a herbaceous plants that belongs to the family Musaceaa. Objective: This Study Aims tho determine the rind of banana (Musa Paradisiaca Var. Sapientum (L)) can be formulated in Cream.Methode: This research the conducted experimental, the sample is extracted by maceration using 70% ethanol. Extract later in pekatkan at temperatrs 400C with a pressure of 100 atm. Viscous extract obtained of used at an concentration of 5%, 10% and 15%. Results: Results showed that banana peel extract can be prepared as a cream and meet the pyshical Evaluation of the stocks. Homogeneity test result that the preparation made sufficiently homogeneous, pH 6.5 to 6.9 is obtained cream still meet the skin’s Ph ranging between 6.0 to 7.0 and cream type test. Colculsion: Dosage formulations cream bark ethanol extract banana (Musa Paradisiaca Var. Sapientum (L)) qualified physical evaluation preparations include homogeneity, pH test dan thest type cream.

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FORMULASI DAN UJI EFEKTIVITAS ANTIFUNGI KRIM EKSTRAK ETANOL DAUN SALAM (Syzygium polianthum (Wight) Walp.) TERHADAP JAMUR Candida albicans

PHARMACON ◽

10.35799/pha.10.2021.34033 ◽

2021 ◽

Vol 10 (2) ◽

pp. 841

Author(s):

Sheren N. Lolowang ◽

Paulina V.Y. Yamlean ◽

Karlah L.R. Mansauda

Keyword(s):

Candida Albicans ◽

Antifungal Activity ◽

Leaf Extract ◽

Physical Stability ◽

Ethanol Extract ◽

Average Diameter ◽

Statistical Test ◽

Adhesion Test ◽

Physical Evaluation ◽

Dispersion Test

ABSTRACT Bay leaf (Syzygium polianthum (Wight) Walp.) are used as natural medicinal ingredients because contain compounds such as flavonoid, saponin and tannin that can inhibit the growth of fungal. The purpose of this study was to test the antifungal effectiveness of bay leaf ethanol extract cream and evaluate the preparation of physical stability. The research that was carried out was laboratory experimental. Bay leaf extract was obtained by maceration using 96% ethanol. The cream preparation was made with variations in the concentration of Bay leaf ethanol extract formula 1%; 3%; 6% and 9%. The method used to test the antifungal effectiveness is the well method. The result of the antifungal test showed an average diameter value for formula I (1%) 6.67 mm; formula II (3%) 9.5 mm; formula III (6%) 10.83 mm and formula IV (9%) 15 mm. Statistical test of ethanol extract cream of Bay leaf produced the largest inhibiton zone of 15 mm at a concentration of 9%. Physical evaluation showed that the cream preparations met organoleptic requirements, homogeneity, pH 4.83, dispersion test 5.30 cm, adhesion test 7.01 seconds. It can be concluded that the ethanol extract of bay leaf can be formulated into a cream preparation that is physically stable and has strong antifungal activity. Keywords: Bay Leaf, Antifungal Cream, Candida albicans ABSTRAK Daun Salam (Syzygium polianthum (Wight) Walp.) dimanfaatkan sebagai bahan obat alami karena memiliki kandungan senyawa flavonoid, saponin dan tannin yang dapat menghambat pertumbuhan jamur. Penelitian ini bertujuan menguji efektivitas antijamur sediaan krim ekstrak etanol daun salam dan mengevaluasi kestabilan fisik sediaan. Penelitian yang dilakukan bersifat eksperimental laboratorium. Ekstrak daun Salam diperoleh dengan cara maserasi menggunakan etanol 96%. Sediaan krim dibuat dengan variasi konsentrasi formula ekstrak daun Salam 1%; 3%; 6% dan 9%. Metode yang digunakan untuk uji efektivitas antijamur yaitu metode sumuran. Hasil pengujian antijamur menunjukkan nilai diameter rata-rata pada formula I (1%) 6.67 mm; formula II (3%) 9.5 mm; formula III (6%) 10.83 mm dan formula IV (9%) 15 mm. Uji statistika krim ekstrak etanol daun salam menghasilkan zona hambat terbesar yaitu 15 mm pada formula IV konsentrasi 9%. Evaluasi fisik menunjukkan bahwa sediaan krim memenuhi persyaratan organoleptik, homogenitas, pH 4.83, daya sebar 5.30 cm, dan daya lekat 7.01 detik. Dapat disimpulkan bahwa ekstrak etanol daun salam dapat diformulasikan menjadi sediaan krim yang stabil secara fisik dan memiliki aktivitas antijamur yang kuat. Kata kunci: Daun Salam, Krim Antijamur, Candida albicans

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FORMULASI DAN UJI ANTIBAKTERI GEL EKSTRAK ETANOL DAUN KEDONDONG (Spondias dulcis) TERHADAP BAKTERI Pseudomonas aeruginosa

PHARMACON ◽

10.35799/pha.9.2020.27404 ◽

2020 ◽

Vol 9 (1) ◽

pp. 8

Author(s):

Kevin Yosua Pakpahan ◽

Paulina V. Y. Yamlean ◽

Imam Jayanto

Keyword(s):

Pseudomonas Aeruginosa ◽

Ethanol Extract ◽

Homogeneity Test ◽

Cycling Test ◽

Physical Evaluation ◽

Before And After ◽

Dispersion Test ◽

Gel Preparation ◽

Ethanol Extracts ◽

Weak Antibacterial Activity

ABSTRACT Kedondong leaves (Spondias dulcis) contain flavonoid compounds, saponins and tannins that inhibit bacterial activity. This study aims to formulate, evaluate, and test the antibacterial effectiveness of the ethanol extracts gel of the Kedondong leaves (Spondias dulcis) at a concentration of 6%, 8%, 10%, respectively. This study uses an experimental method by testing the physical evaluation requirements of gel preparations. Physical evaluation of preparations includes organoleptic test, homogeneity test, pH test, dispersion test, adhesion test and cycling test, all tests are carried out before and after the cycling test. The results of the study on the gel dispersion test did not meet the physical evaluation requirements before the cycling test and after the cycling test there was a synergetic and did not meet the requirements. Antibacterial test of ethanol extracts gel of Kedondong leaves against Pseudomonas aeruginosa produced weak inhibitory properties. It can be concluded that the gel concentration of 6%, 8%, 10% of ethanol extract of Kedondong leaves cannot be formulated as a gel preparation because it is less physically stable and has weak antibacterial activity. Keywords: Antibacterial, HPMC Gel, Kedondong (Spondias dulcis), Pseudomonas aeruginosa ABSTRAK Daun Kedondong (Spondias dulcis) mengandung senyawa flavonoid, saponin dan tannin yang mampu menghambat aktivitas bakteri. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antibakteri sediaan gel ekstrak etanol daun Kedondong (Spondias dulcis) pada kosentrasi 6%, 8%, 10%. Penelitian ini menggunakan metode ekperimental dengan melakukan pengujian parameter persyaratan evaluasi fisik sediaan gel. Evaluasi fisik sediaan meliputi uji organoleptik, uji homogenitas, uji pH, uji daya sebar, uji daya lekat dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cycling test. Hasil penelitian pada uji daya sebar sediaan gel tidak memenuhi persyaratan eveluasi fisik sebelum uji cycling test dan setelah cycling test terjadi sineresis dan tidak memenuhi syarat. Penelitian uji antibakteri sediaan gel ekstrak etanol daun Kedondong pada bakteri Pseudomonas aeruginosa menghasilkan daya hambat yang lemah. Dapat disimpulkan pada gel kosentrasi 6%, 8%, 10% ekstrak etanol daun Kedondong tidak dapat diformulasi sebagai sediaan gel karena kurang stabil secara fisik dan memiliki aktivitas antibakteri yang lemah. Kata kunci : Antibakteri, Gel HPMC, Kedondong (Spondias dulcis), Pseudomonas aeruginosa

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Formulasi Sediaan Krim Dari Ekstrak Kulit Pisang Kapas (Musa paradisiaca Linn).

Prosiding Seminar Nasional Kesehatan ◽

10.48144/prosiding.v1i.786 ◽

2021 ◽

Vol 1 ◽

pp. 1035-1045

Author(s):

D Dananirroh ◽

Urmatul Waznah ◽

W Wirasti ◽

S Slamet

Keyword(s):

Ethanol Extract ◽

Banana Peel ◽

Homogeneity Test ◽

Herbaceous Plant ◽

Test Results ◽

Adhesion Test ◽

Banana Plant ◽

Musa Paradisiaca ◽

Physical Evaluation ◽

Dispersion Test

AbstractMusa paradisiaca Linn, also known as the banana plant in Indonesia, is a herbaceous plant that belongs to the Musaceaa family. Cotton banana peel (Musa paradisiaca Linn.) can be used as a wound medicine. For use, it is still simple, namely by applying the inside of the banana peel to the injured body part, and by scraping the banana peel from the inside to bandage the wound. For this reason, it is necessary to develop a dosage form of this cotton banana peel so that it is easier and provides comfort in its use. Purpose: To find out the skin of cotton banana (Musa paradisiaca Linn) is formulated in cream preparations. The method in this study was experimental, the sample was extracted by maceration using 96% ethanol as solvent. The viscous extract obtained was used at concentrations of 0.08%, 0.10%, and 0.12%. The results showed that cotton banana peel extract (Musa paradisiaca Linn) could be made as a cream and fulfilled the physical evaluation of the preparation. The results of the homogeneity test were that the preparations were made homogeneous, the pH of the cream was obtained at pH 5-7 still fulfilling the skin pH range of 4-7, the adhesion test results obtained more than 5 seconds, the dispersion test results obtained 6-7 cm, the viscosity test at formula I is 3564 – 4253 cPas, Formula II is 4042 – 4746 cPas, Formula III is 4466 – 5254 cPas. The conclusion of this study, the formulation of the ethanol extract cream of cotton banana peel (Musa paradisiaca Linn) met the requirements for physical evaluation of the preparation including homogeneity test, pH test, organoleptic test, dispersibility test, adhesion test, viscosity test and stability test.Keywords: Formulation, banana peel, cream, evaluation. AbstrakMusa paradisiaca Linn atau dikenal dengan nama tumbuhan pisang di Indonesia adalah tumbuhan herba yang termasuk dalam keluarga Musaceaa. Kulit buah pisang kapas (Musa paradisiaca Linn.) dapat digunakan sebagai obat luka. Untuk penggunaan masih sederhana yaitu dengan mengoleskan bagian dalam dari kulit buah pisang pada bagian tubuh yang luka, dan dengan cara mengorek kulit buah pisang dari dalam untuk membalut luka. Untuk itu perlu adanya pengembangan bentuk sediaan dari kulit pisang kapas ini sehingga lebih memudahkan dan memberikan kenyamanan dalam penggunaannya. Tujuan Untuk mengetahui kulit buah pisang kapas (Musa paradisiaca Linn) diformulasikan dalam sediaan krim. Metode pada penelitian ini dilakukan secara eksprimental, sampel di ekstraksi dengan cara maserasi dengan menggunakan pelarut etanol 96%. Ekstrak kental yang diperoleh digunakan pada konsentrasi 0.08%, 0.10%, dan 0.12%. Hasil penelitian menunjukkan bahwa ekstrak kulit pisang kapas (Musa paradisiaca Linn) dapat dibuat sebagai krim dan memenuhi evaluasi fisik sediaan. Hasil uji homogenitas bahwa sediaan yang dibuat homogen, pH krim diperoleh pH 5-7 masih memenuhi kisaran pH kulit 4-7, uji daya lekat hasil yang diperoleh lebih dari 5 detik, uji daya sebar hasil yang diperoleh 6 – 7 cm, uji viskositas pada formula I yaitu 3564 – 4253 cPas, Formula II yaitu 4042 – 4746 cPas, Formula III yaitu 4466 – 5254 cPas. Kesimpulan pada penelitian ini, formulasi sediaan krim ekstrak etanol kulit pisang kapas (Musa paradisiaca Linn) memenuhi syarat evaluasi fisik sediaan meliputi uji homogenitas , uji pH, uji organoleptis, uji daya sebar, uji daya lekat, uji viskositas dan uji stabilias.Kata kunci: Formulasi, kulit pisang, krim, evaluasi.

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