scholarly journals Adaptive and pathological responses of cyprinidae liver towards habitat in the Volga delta

2021 ◽  
Vol 937 (2) ◽  
pp. 022068
Author(s):  
Ivan Burlakov ◽  
Irina Volkova ◽  
Vicktor Kryuchkov ◽  
Vera Egorova ◽  
Leila Seidalieva
Keyword(s):  
Living Environment ◽  
Protective Mechanism ◽  
Anthropogenic Influence ◽  
Pathological Changes ◽  
Standard Methods ◽  
Functional Load ◽  
Volga Delta ◽  
Physiological Processes ◽  
Organ Systems ◽  
Living Organisms

Abstract Human impact on ecosystems makes it imperative to monitor populations of different fish species from various perspectives. The consequence of environmental impact on living organisms is the reactions of organs and organ systems, which find their reflection in pathological changes in the fish body particularly. Reactions in the fish body are the result of the combined influence of environmental factors and natural physiological processes associated with feeding, migrations, generative cycles, etc. The changes in the structure of organs detected in fish make it possible to assess the influence of the environment on fish. The research was carried out in the Volga delta, the Bereket (upper delta) and the Kostyl (lower delta) rivers. Reservoirs for research were chosen in such a way that they were subject to anthropogenic influence to varying degrees. Unfavorable living environment represented by pollutants increase the functional load on the liver. The research has shown an increase in the liver index in fish from reservoirs with a higher level of anthropogenic load. Metabolic functioning of liver cells is considered as an important protective mechanism against toxicants, while the associated transformations are somehow connected with detoxification. Histological preparations were made according to standard methods.

Fluorescence-Raman dual-mode quantitative detection and imaging of small-molecule thiols in cell apoptosis with DNA-modified gold nanoflowers

2022 ◽  
Author(s):  
Chenbiao Li ◽  
Peifang Chen ◽  
Imran Mahmood Khan ◽  
Zhouping Wang ◽  
Yin Zhang ◽  
...  
Keyword(s):  
Small Molecule ◽  
Cell Apoptosis ◽  
Quantitative Detection ◽  
Dual Mode ◽  
Physiological Processes ◽  
Gold Nanoflowers ◽  
Living Organisms

The monitoring of small-molecule thiols (especially glutathione) has attracted widespread attention due to their involvement in numerous physiological processes in living organisms and cells. In this work, the dual-mode nanosensor...

scholarly journals Polyamine Action under Metal/Metalloid Stress: Regulation of Biosynthesis, Metabolism, and Molecular Interactions

2019 ◽  
Vol 20 (13) ◽  
pp. 3215 ◽  
Author(s):  
Mirza Hasanuzzaman ◽  
Haifa Abdulaziz S. Alhaithloul ◽  
Khursheda Parvin ◽  
M.H.M. Borhannuddin Bhuyan ◽  
Mohsin Tanveer ◽  
...  
Keyword(s):  
Stress Tolerance ◽  
Defense Mechanism ◽  
Vital Role ◽  
Cultivated Plants ◽  
Nitric Oxides ◽  
Growth Physiology ◽  
Physiological Processes ◽  
Enzymatic Regulation ◽  
Regulation Of Biosynthesis ◽  
Living Organisms

Polyamines (PAs) are found in all living organisms and serve many vital physiological processes. In plants, PAs are ubiquitous in plant growth, physiology, reproduction, and yield. In the last decades, PAs have been studied widely for exploring their function in conferring abiotic stresses (salt, drought, and metal/metalloid toxicity) tolerance. The role of PAs in enhancing antioxidant defense mechanism and subsequent oxidative stress tolerance in plants is well-evident. However, the enzymatic regulation in PAs biosynthesis and metabolism is still under research and widely variable under various stresses and plant types. Recently, exogenous use of PAs, such as putrescine, spermidine, and spermine, was found to play a vital role in enhancing stress tolerance traits in plants. Polyamines also interact with other molecules like phytohormones, nitric oxides, trace elements, and other signaling molecules to providing coordinating actions towards stress tolerance. Due to the rapid industrialization metal/metalloid(s) contamination in the soil and subsequent uptake and toxicity in plants causes the most significant yield loss in cultivated plants, which also hamper food security. Finding the ways in enhancing tolerance and remediation mechanism is one of the critical tasks for plant biologists. In this review, we will focus the recent update on the roles of PAs in conferring metal/metalloid(s) tolerance in plants.

scholarly journals d-amino Acids in Health and Disease: A Focus on Cancer

Nutrients ◽  
2019 ◽  
Vol 11 (9) ◽  
pp. 2205 ◽  
Author(s):  
Jacco J.A.J. Bastings ◽  
Hans M. van Eijk ◽  
Steven W. Olde Damink ◽  
Sander S. Rensen
Keyword(s):  
Amino Acids ◽  
Human Physiology ◽  
Amyotrophic Lateral Sclerosis ◽  
Human Body ◽  
Physiological Processes ◽  
Gut Barrier Function ◽  
Age Related ◽  
Health And Disease ◽  
Living Organisms ◽  
Lateral Sclerosis

d-amino acids, the enantiomeric counterparts of l-amino acids, were long considered to be non-functional or not even present in living organisms. Nowadays, d-amino acids are acknowledged to play important roles in numerous physiological processes in the human body. The most commonly studied link between d-amino acids and human physiology concerns the contribution of d-serine and d-aspartate to neurotransmission. These d-amino acids and several others have also been implicated in regulating innate immunity and gut barrier function. Importantly, the presence of certain d-amino acids in the human body has been linked to several diseases including schizophrenia, amyotrophic lateral sclerosis, and age-related disorders such as cataract and atherosclerosis. Furthermore, increasing evidence supports a role for d-amino acids in the development, pathophysiology, and treatment of cancer. In this review, we aim to provide an overview of the various sources of d-amino acids, their metabolism, as well as their contribution to physiological processes and diseases in man, with a focus on cancer.

The Physical Environment as a Determinant of the Health Status of Older Populations

1999 ◽  
Vol 18 (3) ◽  
pp. 313-327 ◽  
Author(s):  
Kathy M. Shipp ◽  
Laurence G. Branch
Keyword(s):  
Physical Activity ◽  
Health Status ◽  
Physical Environment ◽  
The Elderly ◽  
Living Environment ◽  
Activity Level ◽  
Retirement Communities ◽  
Negative Consequences ◽  
Environmental Press ◽  
Organ Systems

ABSTRACTAlthough the physical environment as a co-determinant of health could be approached in many ways, we chose to focus on an understudied area: how the immediate living environment can act as a persuasive force affecting physical activity level in older people, with physical activity in turn affecting health status. To explore this topic, the methods and findings of a literature search are described, the theoretical underpinnings of our thesis are presented, and an example is given of how a planned environment, which upon first glance seems supportive, may have unexpected and negative consequences on the activity level, and ultimately the health status, of the residents. Theory related to changes with aging in homeostatic capacity and reserve capacity of organ systems as well as Lawton's environmental press-competence model are applied to environmental characteristics (e.g., staircases) of continuing care retirement communities. We argue that physically challenging aspects of the environment, such as stairs, should be included in the design of living spaces for the elderly with the goal of encouraging greater daily physical activity and improved health status.

Towards an Exergy Analysis of Diffusive and Non-Diffusive Processes in Living Organisms

2016 ◽  
Vol 7 ◽  
pp. 177-184
Author(s):  
Antonio F. Miguel
Keyword(s):  
Exergy Analysis ◽  
Balance Equations ◽  
Physiological Processes ◽  
Performance Of Systems ◽  
Laws Of Thermodynamics ◽  
Living Organisms ◽  
Diffusive Processes ◽  
Cellular Components ◽  
Exergy Balance ◽  
Insight Into

Living organisms are open dissipative thermodynamic systems that rely on mechano-thermo-electrochemical interactions to survive. Plant physiological processes allow plants to survive by converting solar radiation into chemical energy, and store that energy in form that can be used. Mammals catabolize food to obtain energy that is used to fuel, build and repair the cellular components. The exergy balance is a combined statement of the first and second laws of thermodynamics. It provides insight into the performance of systems. In this paper, exergy balance equations for both mammal’s and green plants are presented and analyzed.

scholarly journals Histo-pathological changes in kidneys in autopsies of flame burns at a tertiary care center in North Western India: an autopsy based study at SMS medical college Jaipur (2015-2016)

2017 ◽  
Vol 5 (8) ◽  
pp. 3659
Author(s):  
Vivek Kumar Mangare ◽  
Rakesh Kumar Punia
Keyword(s):  
Acute Tubular Necrosis ◽  
Burn Injury ◽  
Care Center ◽  
Tertiary Care ◽  
Pathological Finding ◽  
Western India ◽  
Pathological Changes ◽  
Medical College ◽  
Tubular Necrosis ◽  
Organ Systems

Background: Burn injury is associated with an intricate patho-physiological response with rapid involvement of various organ systems and which in turn impact the patient with multisystem disruption. These damages can be attributed to the alteration occurring at the tissue and cellular level leading to the histological changes in the renal tissue.Methods: The main aim of this study was to document the histo-pathological changes in kidneys of fatal cases of flame burns. This study was hospital based observational descriptive study carried out at mortuary of SMS medical college and attached hospitals, Jaipur, Rajasthan, India to study and document the histo-pathological changes in the fatal cases due to flame burns.Results: In this study, most common histo-pathological finding in kidneys was cloudy degeneration followed by congestion. Acute tubular necrosis of proximal convoluted necrosis was most commonly observed during 3 to 7 days of mortality (18 cases) followed by mortality during 0 to 48 hours. Acute tubular necrosis of distal convoluted tubules was most commonly observed during 3 to 7 days followed by mortality during 0 to 48 hours.Conclusions: This study revealed that cloudy degeneration and acute tubular necrosis were the hallmark changes in burn patients which were most prominent at 3-7 days after sustaining burn injuries. This reflects the role of immediate management provided to the patient during this period with timely and effective fluid restoration and it possibly will change the prognosis of patients.

Oxygen free radicals and disorders of pregnancy

2001 ◽  
Vol 12 (4) ◽  
pp. 273-298 ◽  
Author(s):  
Irina A Buhimschi ◽  
Carl P Weiner
Keyword(s):  
Reactive Oxygen Species ◽  
Free Radicals ◽  
Free Radical ◽  
Oxygen Radicals ◽  
Oxygen Free Radicals ◽  
Energy State ◽  
Oxygen Species ◽  
Chemical Bonds ◽  
Physiological Processes ◽  
Living Organisms

Oxygen radicals and reactive oxygen species are normal attributes of aerobic life. In most molecules, the electrons are paired and, with the exception of hydrogen, the four outer most pairs of each atom form chemical bonds. Electrons are in a relatively stable energy state when paired. A free radical is a molecule with an unpaired electron. Free radicals of oxygen are of particular importance to living organisms in which they are involved in the genesis of a wide array of diseases and physiological processes (e.g. life span and ageing).

Positronium as a biomarker of hypoxia

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Paweł Moskal ◽  
Ewa Ł. Stępień
Keyword(s):  
Partial Pressure ◽  
High Sensitivity ◽  
Partial Pressure Of Oxygen ◽  
Physiological Processes ◽  
Positron Emission ◽  
Positronium Lifetime ◽  
Total Body ◽  
Living Organisms ◽  
Cancer Tissues

Abstract In this review article, we present arguments demonstrating that the advent of high sensitivity total-body PET systems and the invention of the method of positronium imaging, open realistic perspectives for the application of positronium as a biomarker for in-vivo assessment of the degree of hypoxia. Hypoxia is a state or condition, in which the availability of oxygen is not sufficient to support physiological processes in tissue and organs. Positronium is a metastable atom formed from electron and positron which is copiously produced in the intramolecular spaces in the living organisms undergoing positron emission tomography (PET). Properties of positronium, such as e.g., lifetime, depend on the size of intramolecular spaces and the concentration in them of oxygen molecules. Therefore, information on the partial pressure of oxygen (pO2) in the tissue may be derived from the positronium lifetime measurement. The partial pressure of oxygen differs between healthy and cancer tissues in the range from 10 to 50 mmHg. Such differences of pO2 result in the change of ortho-positronium lifetime e.g., in water by about 2–7 ps. Thus, the application of positronium as a biomarker of hypoxia requires the determination of the mean positronium lifetime with the resolution in the order of 2 ps. We argue that such resolution is in principle achievable for organ-wise positronium imaging with the total-body PET systems.

Bridging the gap between physiology and molecular biology: new approaches to perpetual questions

1994 ◽  
Vol 267 (4) ◽  
pp. R865-R878 ◽  
Author(s):  
V. F. Norwood ◽  
R. A. Gomez
Keyword(s):  
Molecular Biology ◽  
Molecular Physiology ◽  
Physiological Processes ◽  
Regulatory Systems ◽  
Electrolyte Homeostasis ◽  
Health And Disease ◽  
Living Organisms ◽  
Scientific Endeavor ◽  
Physiological Research ◽  
Disease Understanding

Living organisms are the result of precise and complex associations of regulatory systems in which active biomolecules interact with one another and respond to the challenges of growth and development, alterations in the environment, and disease. Understanding of body homeostasis may be accomplished at various levels of scientific endeavor. Physiological research has brought about an enormous understanding of the fundamental principles that sustain life in health and disease. The field of molecular biology has provided new tools and strategies with which to examine physiological processes as viewed from the level of fundamental biomolecules. The integration of both fields as "molecular physiology" has provided the opportunity for another level of scientific understanding and the opening of new avenues of research. Renin is one such molecule that participates in the control of several diverse physiological responses including changes in blood pressure, fluid and electrolyte homeostasis, renal function, and perhaps some elements of growth and differentiation. Because of the authors' bias, this review article will use renin to introduce many of the techniques of molecular biology and illustrate the areas of ongoing and potential interdependent activities resulting in the emerging field of molecular physiology.

3. Kill or be killed

2018 ◽  
pp. 24-32
Author(s):  
Dorothy H. Crawford
Keyword(s):  
Immune Response ◽  
Herpes Simplex ◽  
The Body ◽  
Protective Mechanism ◽  
Human Immune Response ◽  
Human Immune ◽  
Epstein Barr ◽  
Living Organisms ◽  
Simplex Virus

‘Kill or be killed’ shows how viruses survive—they must reproduce before the host either dies or its immune system recognizes and eliminates them. The transmission routes of viruses such as flu, measles, common cold, herpes simplex virus, HIV, Epstein–Barr, and hepatitis B are discussed. How do we fight viruses? All living organisms have defences against invading viruses. Vertebrates, and possibly some invertebrates, are immune to re-infection by the same virus. Another protective mechanism, used by plants, but also by insects and other animal species, is gene silencing by RNA interference. The human immune response is explained, discussing the role of lymphocytes and immunopathology, where the immune response may actually harm the body.

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