scholarly journals Those Who Consume Diets Meeting the Acceptable Macronutrient Distribution Range for Carbohydrate Are More Likely to Meet Dietary Fiber Recommendations: The POUNDS LOST Study (P08-085-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Derek Miketinas ◽  
George Bray ◽  
Frank Sacks ◽  
Catherine Champagne

Abstract Objectives This study tested whether dietary carbohydrate intake influenced subjects’ ability to meet dietary fiber goals. Methods The POUNDS LOST study was a randomized clinical trial that examined the effects of four, calorie-restricted diets of varying macronutrient composition on weight loss in subjects with overweight or obesity. The macronutrient composition of the diets were either low or high fat (LF 20%; HF, 40%) and either average or high protein (AP, 15%; HP, 25%). This provided a graded carbohydrate intake of 35%, 45%, 55% or 65%. Energy content of each diet was 750 kcal below energy needs and each diet provided ≥20 g/d of dietary fiber. Participants (n = 345) who provided complete dietary recalls at baseline and 6-month follow-up were included in the analyses. The dietary fiber goal was defined as ≥20 g/d. Logistic regression analysis modeled the odds of meeting the dietary fiber goal and Adequate Intake (AI) for dietary fiber as a function of diet prescription while controlling for age, race, gender, and energy intake. A p-value of < 0.01 was statistically significant. Results Participants were 86.5% white and 43.9% female. Mean age was 52.7 + 8.7y. One hundred sixty-eight (48.7%) subjects met their dietary fiber goals and 146 (42.3%) met the AI for fiber at 6 months. The results from the logistic regression indicated the odds of a subject meeting their dietary fiber goals were 4.9 times greater (P < 0.0001) for the high carbohydrate (65%) diet compared to the 35% carbohydrate diet. Similarly, the odds of a subject meeting the AI for dietary fiber were 5.3 times greater (P < 0.0001) for the 65% carbohydrate diet compared to the 35% carbohydrate diet. Those randomized to either the 45% or 55% carbohydrate diets also had greater odds of meeting dietary fiber goals and the AI for dietary fiber compared to the 35% carbohydrate diet (P < 0.01). Conclusions Calorie-restricted diets are an effective approach for weight loss; however, diets should be designed to minimize the risk for inadequate nutrient intake. These results indicate that those who consumed a diet lower in carbohydrates are at an increased risk for not meeting the AI for fiber, which could lead to adverse health outcomes. Funding Sources Funded by grants from the National Heart, Lung, and Blood Institute (HL073286) and the General Clinical Research Center, National Institutes of Health (RR-02635).

Author(s):  
Devi Meenakshi K. ◽  
Arasar Seeralar A. T. ◽  
Srinivasan Padmanaban

Background: Very low birth weight (VLBW) babies are at increased risk of a number of complications both immediate and late. Worldwide it has been observed that these babies contribute to a significant extent to neonatal mortality and morbidity. Aim of the study was to study the risk factors contributing to mortality in VLBW babies and to evaluate the morbidity pattern in these infants.Methods: A retrospective analysis of data retrieved from the case records of VLBW babies admitted in the NICU of Kilpauk Medical College between January 2015 to December 2015. Out of the 2360 intramural babies admitted during the study period, 99 babies were less than 1500 gms. The risk factors for these babies were analyzed for their association with the outcome. Data were statistically analyzed.Results: In present study, we found that sex of the baby, gestational age, obstetric score, birth asphyxia, pulmonary haemorrhage, ROP and presence of shock were found to be associated with increased mortality. By logistic regression analysis it was observed that birth weight of the baby (p value 0.002), duration of stay (p value 0.0006), presence of shock (p<0.0001), were the risk factors significantly associated with poor outcome.Conclusions: Among the maternal and neonatal factors analyzed in the study using logistic regression analysis, birth weight, duration of hospital stay and presence of shock were significantly related to poor outcome. Of these presence of shock was the single most important factor that predicted increased mortality.


2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 11575-11575
Author(s):  
Luisa Carbognin ◽  
Ilaria Trestini ◽  
Isabella Sperduti ◽  
Clelia Bonaiuto ◽  
Valentina Zambonin ◽  
...  

11575 Background: Weight gain and overweight have been related to an increased risk of recurrence and mortality in patients affected by EBC. However, the adherence to nutritional intervention is not entirely explored. The aims of this prospective study were to evaluate the ADG and the effectiveness of nutritional intervention in terms of BWC in pts with EBC undergoing treatment. Methods: Entry criteria: EBC pts candidate to neoadjuvant/adjuvant therapy. At study entry, pts received a nutrition evidence-based tailored educational intervention by a skilled dietitian. Anthropometric and dietary assessments were performed. ADG was estimated through the validated Med-Diet 14-item questionnaire. Health-Related Quality of Life was analyzed with the EORTC QLQ-C30. Descriptive statistics was adopted. Associations between variables and groups according to nutritional variables were analysed (Chi-square test). Results: From February 2016 to December 2018, 204 pts were enrolled (median age 49 years): 27.5%/72.5% neoadjuvant/adjuvant treatment. At baseline, 2.5% of pts were underweight, 41.7% were normal weight, 33.3% were overweight and 22.5% were obese. Moreover, 47.5% of pts gained ≥5% of their usual weight and 25.5% performed physical activity. Significant nutritional impact symptoms were reported: dyspepsia (51.5%), constipation (62.3%) and dysgeusia (34.8%). The majority of pts presented dietary patterns high in fat (median fat intake: 35.2% from total energy intake) and low in dietary fiber (median dietary fiber intake: 17.2 g/day). A significant correlation between baseline BMI and tension was observed ( p < 0.0001) as well as BMI and worry, irritability and depression ( p < 0.0001, p < 0.0001 and p = 0.008, respectively). Six months after the intervention, the median ADG was high (median Med-Diet score was 12). A high adherence to nutrition guidelines (defines as a Med-Diet score ≥10, 112 patients) significantly correlated with a weight loss ≥5% from the baseline weight ( p = 0.005). Furthermore, the weight loss ≥5% was correlated with a lower rate of depression ( p = 0.05). Conclusions: A tailored nutritional intervention for EBC pts undergoing adjuvant or neoadjuvant therapy has the potential to improve their ADG, in order to achieve a weight loss.


2019 ◽  
Vol 18 (1) ◽  
Author(s):  
Soraiya Ebrahimpour-Koujan ◽  
Ammar Hassanzadeh Keshteli ◽  
Hamid Afshar ◽  
Ahmad Esmaillzadeh ◽  
Peyman Adibi

Abstract Background Although individual macronutrients were studied in relation to mental health, no information exist about the association between adherence to low carbohydrate diet and psychological disorders. This study was conducted to investigate the association between adherence to a low carbohydrate diet and prevalence of psychological disorders among Iranian adults. Methods In this cross-sectional study on 3362 adult men and women, dietary intakes were examined by the use of a validated semi-quantitative food frequency questionnaire. Low carbohydrate diet (LCD) score was computed for each participant based on deciles of percentages of energy from macronutrients. Then the scores of carbohydrate, protein and fat intake for each participant were summed up to achieve the overall LCD score, which ranged from 3 (highest carbohydrate intake and lowest fat and protein intakes) to 30 (lowest carbohydrate intake and highest fat and protein intakes). Anxiety, depression, and psychological distress were assessed by validated Iranian versions of the Hospital Anxiety and Depression Scale and General Health Questionnaire-12. Results Prevalence of depression, anxiety and psychological distress in the whole population were 28.0, 13.3 and 22.6%, respectively. No significant differences were observed in the distribution of depression, anxiety and psychological distress across different quartiles of LCD score. After controlling for potential confounders, no significant association was seen between LCD score and prevalence of depression (OR for the highest vs. the lowest quartile of LCD score: (1.15; 95% CI: 0.93, 1.39). Consumption of LCD was not also associated with increased risk of anxiety (0.82; 95% CI: 0.59, 1.14) and psychological distress (0.92; 95% CI: 0.72, 1.16). These associations did not alter when the analyses were done stratified by gender or BMI status. Conclusion Adherence to the low carbohydrate diet, which contains high amount of fat and proteins but low amounts of carbohydrates, was not associated with increased odds of psychological disorders including depression, anxiety and psychological distress. Given the cross-sectional nature of the study which cannot reflect causal relationships, longitudinal studies, focusing on types of macronutrients, are required to clarify this association.


2019 ◽  
Vol 149 (10) ◽  
pp. 1742-1748 ◽  
Author(s):  
Derek C Miketinas ◽  
George A Bray ◽  
Robbie A Beyl ◽  
Donna H Ryan ◽  
Frank M Sacks ◽  
...  

ABSTRACT Background The effects of dietary composition on weight loss are incompletely understood. In addition to energy intake, fiber intake, energy density, macronutrient composition, and demographic characteristics have all been suggested to contribute to weight loss. Objective The primary aim of this analysis was to assess the role of dietary fiber as a predictor of weight loss in participants who consumed calorie-restricted diets (−750 kcal/d from estimated energy needs) for 6 mo, using data from the POUNDS Lost (Preventing Overweight Using Novel Dietary Strategies) Study—a randomized trial that examined the effects of calorie-restricted diets varying in macronutrient composition on weight loss in adults. Methods Data were randomly partitioned to a training data set (70%) in which the effects of fiber and other weight-loss predictors were identified using adjusted Least Absolute Shrinkage and Selection Operator and model averaging. The retained predictors were then fit on the testing data set to assess predictive performance. Results Three hundred and forty-five participants (53.9% female) provided dietary records at baseline and 6 mo. Mean ± SD age and BMI for the full sample was 52.5 ± 8.7 y and 32.6 ± 3.9 kg/m2, respectively. Mean ± SD (99% CI) weight change at 6 mo for the full sample was −7.27 ± 5.6 kg (−8.05, −6.48 kg). The final, best fit model (R2 = 0.41) included fiber, energy density, fat, age, adherence, baseline weight, race, and changes from baseline in carbohydrate, fiber, PUFA, and MUFA intake, but the most influential predictor was fiber intake ($\hat{\beta }$ = −0.37; P < 0.0001). In addition, fiber was strongly associated with adherence to the macronutrient prescriptions (P < 0.0001). Interactions between race and adherence, age, baseline weight, carbohydrate, energy density, and MUFAs were also retained in the final model. Conclusion Dietary fiber intake, independently of macronutrient and caloric intake, promotes weight loss and dietary adherence in adults with overweight or obesity consuming a calorie-restricted diet. This trial was registered at clinicaltrials.gov as NCT00072995.


2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1131-1131
Author(s):  
Nankun Liu ◽  
Alexander Hien Vu ◽  
David Seres ◽  
Max Shen

Abstract Objectives The association between inflammation, malnutrition, and cancer is not well understood. The aim of this study was to examine the association between inflammatory-type cancer and diagnosed malnutrition, albumin level, and age in patients with cancer. Methods Malnutrition and cancer diagnoses were obtained using data from hospital medical records in patients admitted for cancer between Oct. 2017 and Dec. 2018. Demographics, as well as the first and lowest albumin levels were also obtained. A simple t-test is processed between age and malnutrition status. Also a chi-square test of independence was performed to examine the relation between malnutrition and hypoalbuminemia status. Logistic regression was conducted between malnutrition status, sarcoma cancer, age, and hypoalbuminemia. Results The study included 4034 patients (2084 males, 1949 females). Approximately 4% of the patients were diagnosed with malnutrition. Logistic regression on malnutrition status, sarcoma, age, and hypoalbuminemia showed a significant association on global test (3, 2433, P-value = 0.013). Hypoalbuminemia (&lt; 3.9 g/dL lower-limit) was significantly associated with malnutrition (X2 1, 2433 P-value = 0.0156). Sarcoma diagnosis was not significantly associated with malnutrition (X2 1, 2433 P-value = 0.267). Age is not significantly related to malnutrition status (X2 1, 2433 p-value = 0.449). A t-test was also performed malnutrition vs no malnutrition on age, resulting in a marginally significant association for malnutrition group (M = 65.33, SD = 15.50) vs no malnutrition group (M = 67.32, SD = 17.55) (t(1) = 3.7212, P = 0.0537). Conclusions Sarcoma is not significantly associated with an increased risk of malnutrition. Cancer patients with hypoalbuminemia have a higher risk for malnutrition compared to the patients with normal albumin level. Additionally, age may be a predictor for cancer patients’ risk of in-hospital malnutrition. Funding Sources None.


2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Sohrab Sali ◽  
Hossein Farhadnejad ◽  
Golaleh Asghari ◽  
Farshad Teymoori ◽  
Parvin Mirmiran ◽  
...  

Abstract Background To investigate the association of low carbohydrate diet (LCD) score with the risk of type 2 diabetes among adults. Methods This cohort study was conducted on 4356 healthy participants aged ≥ 19 years old, who were followed-up for a mean duration of 3 years within the framework of the Tehran Lipid and Glucose Study. LCD score was calculated using a food frequency questionnaire according to intake of carbohydrate, protein, and fat at baseline. Diabetes was defined according to the criteria of the American Diabetes Association. Multivariable logistic regression models, adjusted for potential confounders, were used to estimate risk of diabetes across quartiles of LCD score. Results Mean ± SD age of the study participants (44.4% men) was 40.5 ± 13.0 years. The median (25–75 interquartile range) of LCD score was 17.0 (12.0–21.0) and after a 3 year follow-up period, 123 (2.8%) incident cases of diabetes were ascertained. After adjustment for confounding variables, including age, sex, smoking status, physical activity, total calorie intake, saturated fatty acid, waist circumference, educational level, and family history of diabetes, the multivariable-adjusted ORs (95% CIs) of type 2 diabetes, comparing the highest with the lowest quartiles, were 2.16 (1.16–4.04) for total LCD score (P-value = 0.015), 1.81 (1.06–3.11) for animal-based LCD score (P-value = 0.029), and 1.47 (0.85–2.52) for plant-based LCD score (P-value = 0.160). Conclusion Our findings suggest that a higher adherence to LCD, mostly with higher intakes of protein and fat from animal-source foods, can increase the incidence of diabetes; however, a plant-based low-carbohydrate dietary pattern is not significantly associated with risk of type 2 diabetes.


2021 ◽  
Author(s):  
Robert W Aldridge ◽  
Helen Pineo ◽  
Ellen Fragaszy ◽  
Max Eyre ◽  
Jana Kovar ◽  
...  

Background: Household overcrowding is associated with increased risk of infectious diseases across cultures and countries. Limited data exist in England and Wales linking household overcrowding and risk of COVID-19. We used data collected from the Virus Watch cohort to examine the association between overcrowded households and infection to pandemic coronavirus SARS-CoV-2. Methods: The Virus Watch study is a household community cohort of acute respiratory infections in England & Wales that began recruitment in June 2020. We calculated the persons per room for each household and classified accommodation as overcrowded when the number of rooms was fewer than the number of people. We considered two primary outcomes - PCR-confirmed positive SARS-CoV-2 antigen tests and laboratory confirmed SARS-CoV-2 antibodies (Roche Elecsys anti-N total immunoglobulin assay). We used mixed effects logistic regression models that accounted for household structure to estimate the association between household overcrowding and SARS-CoV-2 infection. Results: The proportion of participants with a positive SARS-CoV-2 PCR result was highest in the overcrowded group (6.6%; 73/1,102) and lowest in the under-occupied group (2.9%; 682/23,219). In a mixed effects logistic regression model that included age, sex, ethnicity, household income and geographical region as fixed effects, and a household-level random effect, we found strong evidence of an increased odds of having a positive PCR SARS-CoV-2 antigen result (Odds Ratio 3.67; 95% CI: 1.91, 7.06; p-value < 0.001) and increased odds of having a positive SARS-CoV-2 antigen result in individuals living in overcrowded houses (2.99; 95% CI: 1.14, 7.81; p-value =0.03) compared to people living in under-occupied houses. Discussion: Public health interventions to prevent and stop the spread of SARS-CoV-2 should consider the much greater risk of infection for people living in overcrowded households and pay greater attention to reducing household transmission. There is an urgent need to better recognise housing as a leading determinant of health in the context of a pandemic and beyond.


2021 ◽  
Author(s):  
Basazinew Chekol Demilew ◽  
Fentaye Zewudu ◽  
Dinberu Dinberu Eshetie ◽  
Netsanet Temesgen Ayenew ◽  
Eshetie Molla

Abstract Background Intraoperative nausea and vomiting is common intraoperative conditions by which parturient feel discomfort and disturbed after spinal anesthesia. Methods Hospital based cross-sectional study was conducted on mothers underwent cesarean section with spinal anesthesia. Descriptive analysis and chi square test were employed. Bivariable and multivariable logistic regression were used to measure the association of factors with the outcome variable intraoperative nausea and vomiting. A p-value of ≤ 0.05 was used to decide statistical significance for multivariable logistic regression. Result A total of 246 parturients were participated in this study. The incidence of intraoperative nausea and vomiting was 40.2%. According to multivariable logistic regression, age greater than 30 years (AOR, 6.26; 95%CI, 2.2-17.78; p-value 0.001), primiparous ( AOR, 3.72; 95%CI, 1.35–10.24; p-value, 0.011), having motion sickness (AOR, 7.1; 95%CI, 2.75–18.33; p-value 0.001), emergency cesarean sectin (AOR, 9.85; 95%CI, 3.19–30.38; p-value 0.001), oxygen suplimentation (AOR, 0.021; 95%CI, 0.005–0.08; p-value 0.0001) and uterotonic agent (AOR, 2.99; 95%CI 1.24–7.22; p-value 0.015) had statistically significant association with intraoperative nausea and vomiting. Conclusion In our study, the overall incidence of intraoperative nausea and vomiting after spinal anesthesia was 40.2%. Parturients with age greater than 30 years, having motion sickness, didn’t got intraoperative supplemental oxygen, oxytocin used for uterotonic purpose, emergency surgery and primiparous were at increased risk intraoperative nausea and vomiting.


2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 1061-1061
Author(s):  
Derek Miketinas ◽  
Wesley Tucker ◽  
Mindy Patterson ◽  
Crystal Douglas

Abstract Objectives The objective of this study was to quantify usual total dietary fiber intake in US adults and to examine whether intake differed by diabetes status (normoglycemic, prediabetic, diabetic). Methods Data from the National Health and Nutrition Examination Survey (NHANES) cycles 2013 – 2018 were used to estimate US adults’ usual dietary fiber intake. Adults (&gt; 19y) who were not pregnant and provided at least 1 day of dietary intake were included for analysis. Diabetes status was determined using the diabetes section of the personal interview as well as participants’ hemoglobin A1c (HbA1c). Adults who reported that they had diabetes or had an HbA1c ≥6.5% were classified as having diabetes. Those who indicated they had prediabetes or had a HbA1c between 5.7%--6.4% were classified as having prediabetes. Those who indicated they never had diabetes or had an HbA1c &lt; 5.7% were classified as normoglycemic. Usual dietary intake was calculated using the National Cancer Institute method. Dietary intake of fiber supplements was not included in the analyses. Independent samples t-tests were used to compare mean intake across sub-populations. A P-value &lt; 0.01 was considered statistically significant. Results The eligible sample consisted of 14,640 adults (51.3% female) with 17.4% and 26.4% classified as having diabetes and prediabetes, respectively. Approximately 7.4% of US adults met the adequate intake (AI) for fiber: 14 g/1000 kcal. Females reported greater usual intake of total dietary fiber compared to males (9.9 ± 0.12 vs 8.7 ± 0.12 g/1000 kcal; P &lt; 0.0001). Adults with diabetes reported greater dietary fiber intake compared to those without diabetes for men (9.6 ± 0.20 vs 8.6 ± 0.12 g/1000 kcal; P &lt; 0.0001) and women (10.3 ± 0.21 vs 9.7 ± 0.14 g/1000 kcal; P &lt; 0.01). However, the proportion of adults who met the AI for fiber was low for all men (8.6% with diabetes vs 4.3% without diabetes; P &lt; 0.001) and women (11.5% with diabetes vs 8.0% without diabetes; P = 0.012). Conclusions Usual intake of total dietary fiber was poor overall, and most US adults failed to meet the AI. Although total dietary fiber intake varied across diabetes categories and was highest among participants with diabetes, intake was inadequate among all groups. Inadequate dietary fiber intake may result in increased risk for other chronic diseases in an already at-risk population. Funding Sources None.


2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Krisnawati Bantas

The objective of this study was to examine whether there was a gender difference in the occurrence of hypertension in Indonesian people, after controlling for individual and environment factors. Data were obtained from the Indonesia Basic Health Research 2007 and a cross-sectional design was used. Samples consisted of 13.262 men and women age 15 years or more. A multilevel logistic regression was used to analyze the data. There was a statistically significant association between gender and hypertension. Women were less likely to have hypertension than men (OR 0.86 P value < 0.0033). There was an interaction between variable of gender and variable of age. It suggested that the probability of having hypertension in women and men was varied by the strata of age. In the strata of age more than 60 years, women were more likely to have hypertension than men (OR 1.25, P value 0.0065); in strata of age 30-59 years, there was no difference of having hypertension between women and men (P value > 0.05); in strata of age <30 years, women were less likely to have hypertension than men (OR 0.67 Pvalue 0.0000). Among women, there was an increased of having hypertension with age. Age of ≥ 60 years was the highest risk of having hypertension. Among men, there was an increased of having hypertension with age, but at in the age of ≥ 60 years the increased risk of having hypertension was not as high as in women. 


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