P173 Subfertility in young women and men patients with Crohn′s disease

Abstract Background Crohn’s disease (CD) affects young adults on reproductive age. They are likely to desire pregnancy and are often concerned about the potential effects of inflammatory bowel disease on fertility. Aims to investigate the effect of CD in fertility, studying the ovarian reserve in women by serum anti-Müllerian hormone (AMH) and Sertoli cell function in men measured by serum Inhibine (IB). Methods Cross-sectional, prospective, case-control study, including CD patients, aged 18–40 yr, and healthy controls(HC) matched by gender and age(ratio 2:1). Morning IB was measured using ELISA. Serum AMH was measured by ECLIA. Sociodemographic and phenotypic features of CD patients and controls were collected. We defined impaired fertility potential as IB level < 89 pg/mL and AMH <1.66 ug/L 0–24 yr, <1. 18 ug/L 25–29 yr, <0.67 ug/L 30–34 yr, <0.77 ug/L 35–39 yr, <0.01 ug/L 40–44 yr. AMH < 2 ug/L under 40 yr was considered low. Results A total of 122 subjects were included:73 men(48 CD, 25 HC) and 49 women(21 CD, 28 HC). No statistical difference was found between mean serum AMH levels in CD and HC women(2,23±1,8 vs 2,86±1,9 ug/L, p=0,5). The rate of abnormal serum AMH levels according to age did not differ between groups (19% CD vs 25% HC, p=0,4). When classified according to age(<30 and >30 yr), the serum AMH levels remained comparable in <30 yr (3.3±2.06 CD vs 3,2±1.96 ug/L HC, P=0.9). However, a low AMH level(<2 ug/L) was measured in 13 CD women(61%) and in 9 HC(32%)(P < 0.03), especially in>30 yr, 9 CD(90%)vs 4 in HC(40%)(p=0.02). Serum IB levels were significantly lower in CD men vs HC (175.4 ±62.3 vs 234.12±75.56 ug/L, p=0.002). We did not find abnormal IB(<89 pg/mL) in HC vs 3(6%) among CD men. Conclusion Women with CD did not have severe ovarian reserve alterations compared to a control population. However higher proportion of CD women showed low AMH (< 2 ug/L), especially those > 30 years. These data could be helpful for female CD patients who want to have children. Inhibine levels, as biomarker of Sertoli cell function, were lower in CD men compared to healthy controls.

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Serum anti-Müllerian hormone levels in reproductive-age women with relapsing–remitting multiple sclerosis

Multiple Sclerosis Journal ◽

10.1177/1352458514540843 ◽

2014 ◽

Vol 21 (1) ◽

pp. 41-47 ◽

Cited By ~ 31

Author(s):

Jan Thöne ◽

Susanne Kollar ◽

Darryl Nousome ◽

Gisa Ellrichmann ◽

Ingo Kleiter ◽

...

Keyword(s):

Multiple Sclerosis ◽

Ovarian Reserve ◽

Ovarian Function ◽

Reproductive Age ◽

Unexpected Finding ◽

Healthy Controls ◽

Relapsing Remitting ◽

Disease Modifying Treatment ◽

Relapsing Remitting Multiple Sclerosis ◽

Control Study

Background: Fertility might be reduced in women with multiple sclerosis (MS), although only few studies exist and the underlying reasons are not well understood. Similar to other autoimmune diseases, a decreased ovarian reserve may contribute to impaired fertility in women with MS. Anti-Müllerian hormone (AMH) is an established marker of the ovarian reserve and an objective indicator of ovarian function, which is independent of the hypothalamus-pituitary-gonadal axis function. Objective: The purpose of this study was to determine AMH levels in females with relapsing–remitting MS (RRMS) in combination with other reproduction and lifestyle factors. Methods: A total of 76 reproductive-age females with RRMS and 58 healthy controls were included in this case control study. An enzymatically amplified two-site immunoassay was used to measure serum AMH level. Results: Mean AMH level was significantly decreased in females with RRMS ( p<0.04), and a higher proportion of females with RRMS showed very low AMH values (<0.4 ng/ml) compared to healthy controls ( p<0.05). The majority of these women were currently without any disease modifying treatment. Conclusions: Our data contribute to our understanding of impaired fertility in women with MS. The unexpected finding that the majority of MS subjects with very low AMH levels were currently without medication requires further evaluation.

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Anti-Müllerian Hormone Concentrations Are Inversely Associated With Subclinical Atherosclerosis in Premenopausal Women

Angiology ◽

10.1177/0003319720914493 ◽

2020 ◽

Vol 71 (6) ◽

pp. 552-558 ◽

Cited By ~ 3

Author(s):

Irene Lambrinoudaki ◽

Stefanos Stergiotis ◽

Panagiota Chatzivasileiou ◽

Areti Augoulea ◽

Panagiotis Anagnostis ◽

...

Keyword(s):

Risk Factors ◽

Ovarian Reserve ◽

Augmentation Index ◽

Subclinical Atherosclerosis ◽

Premenopausal Women ◽

Reproductive Age ◽

Inverse Association ◽

Cross Sectional ◽

Carotid Imt ◽

Negatively Associated

Anti-Müllerian hormone (AMH), which is secreted by granulosa cells of late preantral and small antral follicles, is a marker of ovarian reserve. The association of ovarian reserve with subclinical atherosclerosis in women of reproductive age is currently unknown. We primary investigated whether AMH levels are associated with markers of subclinical atherosclerosis in healthy, normally menstruating women. In this cross-sectional study, vascular structure and function were assessed by measurement of carotid and femoral intima–media thickness (IMT), flow-mediated dilation, carotid–femoral pulse wave velocity and augmentation index. Lipid profile and serum AMH concentrations were also measured. Seventy premenopausal women, aged 32.7 ± 6.5 years, were included. Mean AMH levels were lower in smokers than in non-smokers and negatively associated with total cholesterol (TC) levels. An inverse association between mean AMH concentrations and femoral and carotid IMT in all segments was observed. No correlation with other markers of subclinical atherosclerosis or established cardiovascular (CV) risk factors was found. After multivariable adjustment, the association between AMH concentrations and combined carotid IMT or carotid bulb IMT remained significant. In conclusion, in healthy, normally ovulating women, AMH concentrations are negatively associated with subclinical atherosclerosis indices and TC levels, independently of established CV risk factors.

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Visfatin Levels May be an Early Marker of Atherosclerosis in Patients with Acromegaly

Hormone and Metabolic Research ◽

10.1055/a-0998-4079 ◽

2019 ◽

Vol 51 (10) ◽

pp. 649-654

Author(s):

Hamide Piskinpasa ◽

Yildiz Okuturlar ◽

Sema Ciftci Dogansen ◽

Yasemin Sefika Akdeniz ◽

Ayse Esen ◽

...

Keyword(s):

Ankle Brachial Index ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Control Group ◽

Healthy Controls ◽

Cross Sectional ◽

Normal Ratio ◽

Visfatin Level ◽

And Control ◽

Control Study

AbstractThe purpose of the study was to compare serum visfatin levels between patients with acromegaly and healthy controls and to evaluate the relationships between visfatin levels and epicardial fat thickness (EFT), carotid intima media thickness (cIMT), and ankle brachial index (ABI). We conducted a cross-sectional case-control study of 54 patients with acromegaly (37 females and 17 males) and 34 healthy controls (22 females and 12 males). Serum visfatin was measured by ELISA. Acromegalic and control participants and those with active or controlled acromegaly were compared with respect to their serum visfatin, clinical and metabolic parameters, EFT, cIMT, and ABI. Linear correlation was used to identify associations between these parameters and visfatin in all participants. Serum visfatin and glycated hemoglobin (HbA1c) were higher in the acromegaly group than in the control group (p<0.001 and p=0.007, respectively). There was no difference in visfatin between the active and controlled acromegaly groups, but HbA1c was higher in the active than the controlled acromegaly group (p<0.04). EFT, cIMT, and ABI were similar between the acromegaly and control groups and between the active and controlled acromegaly groups. Serum visfatin positively correlated with HbA1c, growth hormone (GH), and insulin-like growth factor-1 (IGF-1)/upper limit of normal ratio (r=0.245, p=0.024; r=0.259, p=0.017; and r=0.282, p=0.009, respectively). This study has revealed that a high visfatin level is associated with glycemic dysregulation and higher levels of GH and IGF-1 in acromegalic patients.

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P–645 Abnormal thyroid hormone levels are associated with biochemical primary ovarian insufficiency and low ovarian reserve: a cross-sectional study

Human Reproduction ◽

10.1093/humrep/deab130.644 ◽

2021 ◽

Vol 36 (Supplement_1) ◽

Author(s):

C Feng

Keyword(s):

Thyroid Hormones ◽

Ovarian Reserve ◽

Thyroid Dysfunction ◽

Cross Sectional Study ◽

Primary Ovarian Insufficiency ◽

Reproductive Age ◽

Sectional Study ◽

Ovarian Insufficiency ◽

Cross Sectional ◽

Chi Square Analysis

Abstract Study question To address whether there was a correlation between thyroid parameters and primary ovarian insufficiency. Summary answer Thyroid dysfunction was related with bPOI and LOR. What is known already In our daily clinical work, there seems to be a link between thyroid disease and POI. A recent study reported that subclinical hypothyroidism was associated with lower ovarian reserve during later reproductive age. Animal studies demonstrated that thyroid hormones played important roles in ovarian functions, and both maternal hypothyroidism and hyperthyroidism were related with reduced primordial, primary and secondary follicle number in rats. However, others reported that thyroid autoimmunity (TAI) and hypothyroidism were not associated with DOR. In all, accumulative animal and epidemiological studies indicated the connection between thyroid function and ovarian reserve, but the results were still inconsistent. Study design, size, duration This is a cross-sectional study with consecutive women performed ovarian reserve assessment and thyroid test in the Second Hospital of Zhejiang University School of Medicine from April 2016 to March 2019. A total of 2109 women were included, with 111 with bPOI and 1771 without bPOI. To exclude the influence of age the participants were categorized into low ovarian reserve (LOR) and non-LOR groups based on age-specific AMH, including 78 LOR and 2031 non-LOR. Participants/materials, setting, methods At the outpatient, a doctor carried out an interview, recorded age, body mass index (BMI), past history, and current treatment, and made a diagnosis. Serum AMH, FSH, TPOAb, TgAb, Tg, TT3, FT3, TT4, FT4, and TSH levels were measured with electrochemiluminescence method. Main results and the role of chance TT3, FT3, FT4 was significantly positively correlated with serum AMH level. Further logistic regression analysis found that abnormal TT3, FT3 and TT4 levels were related to increased risks of bPOI and LOR. Chi-square analysis also proved that the incidence of abnormal TT3, FT3 and TT4 increased significantly in women with bPOI or LOR. The incidence of bPOI and LOR increased significantly in women with 2 or 3 abnormal thyroid hormones. The above analyses demonstrate in multiple aspects that thyroid dysfunction is related with decreased ovarian reserve. Limitations, reasons for caution Since this is a retrospective cross-sectional study, we only got the correlation between factors, and we could not achieve causal relationship. Further prospective cohort or randomized controlled trial (RCT) studies are required to make the results more robust. Wider implications of the findings: The present study demonstrated that thyroid dysfunction was related with bPOI and LOR. It might be thyroid hormones, not TSH or thyroid antibodies, played the major role in ovarian reserve impairment. The treatment of euthyroxine may improve the ovarian reserve function. Trial registration number Not applicable

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Body Mass Index (BMI) dependent effect of thyroid stimulating hormone (TSH) and gonadotropins on ovarian reserve markers in the secondary infertile women at fertile age.

10.21203/rs.3.rs-296169/v1 ◽

2021 ◽

Author(s):

Haroon Latif Khan ◽

Komal Fatima ◽

Shahzad Bhatti ◽

Sammar Nathanial ◽

Hooria Younus

Keyword(s):

Ovarian Reserve ◽

Medical Condition ◽

Tertiary Care ◽

Thyroid Stimulating Hormone ◽

Reproductive Age ◽

P Value ◽

Cross Sectional ◽

Infertile Women ◽

Ovarian Reserve Markers ◽

Tsh Levels

Abstract Background: Infertility is a medical condition when a couple fails to conceive after having regular unprotected intercourse without the use of any contraceptive, it a complex global health issue that can be primary with no previous conception or secondary with one or more previous conceptions. A number of anomalies in the reproductive track govern the state of infertility in female of reproductive age.Materials and Methods: The study was conducted on 100 secondary infertile women based on BMI groups {Normal 18-23.9 kg/m2 (N=35) and Overweight 24-27 kg/m2 (N=65)}, attending tertiary care infertility center: Lahore Institute of Fertility and Endocrinology, Hameed Latif Hospital. The present analytical cross sectional study was conducted to assess the BMI based combinatorial effect of gonadotropins with thyrotropin and ovarian reserve markers in secondary infertile women. Serum hormonal levels of TSH, LH, FSH and AMH were measured by using Roche electrochemiluminescence immunoassay (ECLIA) and AFC was recorded by transvaginal ultrasonography. The results were statistically analyzed by Spearman correlation test using XLSTAT, considered significant at p-value <0.05. Results: A total of 18% of secondary infertile women with normal BMI were found to have a lower serum TSH levels (<0.27µIU/ml) which can be characterized as hyperthyroidism as compared to overweight population. A strong significant positive correlation was found in the TSH, age and BMI, however, these factors were found to be negatively correlated with AMH and AFC. Gonadotropins level was increased with increase in TSH levels among participants with normal BMI but decreased with TSH escalation values among overweight population. Conclusion: TSH was found to be one of the most important diagnostic factors of infertility must be monitored in relation with other parameters (AMH, AFC, FSH, and LH) in order to spot instigation point, as it directly acts upon ovulation surge by controlling gonadotropins related actions on ovarian reserve. Weight should also be assessed regularly with age to minimize the infertility issues.

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Ovarian reserve evaluation in women of reproductive age suffering from inflammatory bowel diseases

Fertility and Sterility ◽

10.1016/j.fertnstert.2008.07.111 ◽

2008 ◽

Vol 90 ◽

pp. S118

Author(s):

T. Freour ◽

D. Masson ◽

A. Boureille ◽

T. Dejoie ◽

M. Jean ◽

...

Keyword(s):

Ovarian Reserve ◽

Inflammatory Bowel Diseases ◽

Reproductive Age ◽

Women Of Reproductive Age ◽

Bowel Diseases ◽

Inflammatory Bowel

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Increased resting cerebral blood flow in adult Fabry disease

Neurology ◽

10.1212/wnl.0000000000005330 ◽

2018 ◽

Vol 90 (16) ◽

pp. e1379-e1385 ◽

Cited By ~ 8

Author(s):

Po Phyu ◽

Aine Merwick ◽

Indran Davagnanam ◽

Fay Bolsover ◽

Fatima Jichi ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Fabry Disease ◽

Arterial Spin Labeling ◽

Cerebral White Matter ◽

Healthy Controls ◽

Cross Sectional ◽

Whole Brain ◽

The Mean ◽

Control Study

ObjectiveTo assess resting cerebral blood flow (CBF) in the whole-brain and cerebral white matter (WM) and gray matter (GM) of adults with Fabry disease (FD), using arterial spin labeling (ASL) MRI, and to investigate CBF correlations with WM hyperintensity (WMH) volume and the circulating biomarker lyso-Gb3.MethodsThis cross-sectional, case-control study included 25 patients with genetically confirmed FD and 18 age-matched healthy controls. We quantified resting CBF using Quantitative Signal Targeting With Alternating Radiofrequency Labeling of Arterial Regions (QUASAR) ASL MRI. We measured WMH volume using semiautomated software. We measured CBF in regions of interest in whole-brain, WM, and deep GM, and assessed correlations with WMH volume and plasma lyso-Gb3.ResultsThe mean age (% male) for FD and healthy controls was 42.2 years (44%) and 37.1 years (50%). Mean whole-brain CBF was 27.56 mL/100 mL/min (95% confidence interval [CI] 23.78–31.34) for FD vs 22.39 mL/100 mL/min (95% CI 20.08–24.70) for healthy controls, p = 0.03. In WM, CBF was higher in FD (22.42 mL/100 mL/min [95% CI 17.72–27.12] vs 16.25 mL/100 mL/min [95% CI 14.03–18.48], p = 0.05). In deep GM, CBF was similar between groups (40.41 mL/100 mL/min [95% CI 36.85–43.97] for FD vs 37.46 mL/100 mL/min [95% CI 32.57–42.35], p = 0.38). In patients with FD with WMH (n = 20), whole-brain CBF correlated with WMH volume (r = 0.59, p = 0.006), not with plasma lyso-Gb3.ConclusionIn FD, resting CBF is increased in WM but not deep GM. In FD, CBF correlates with WMH, suggesting that cerebral perfusion changes might contribute to, or result from, WM injury.

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Compensatory function of the remaining testis is dissociated in boys and adolescents with monorchidism

Acta Endocrinologica ◽

10.1530/eje-15-0938 ◽

2016 ◽

Vol 174 (3) ◽

pp. 399-407 ◽

Cited By ~ 12

Author(s):

Romina P Grinspon ◽

Carolina Habib ◽

Patricia Bedecarrás ◽

Silvia Gottlieb ◽

Rodolfo A Rey

Keyword(s):

Leydig Cells ◽

Cell Function ◽

Serum Testosterone ◽

Compensatory Hypertrophy ◽

Reproductive Hormones ◽

Testicular Volume ◽

Healthy Controls ◽

Cross Sectional ◽

And Function ◽

Circulating Levels

ObjectiveCompensatory hypertrophy has been classically described in patients with monorchidism. However, it remains unclear whether there is a functional compensatory activity of the different cell populations. Our aim was to assess the functional capacity of the solitary testis in monorchid males from infancy through puberty in order to determine whether the remaining gonad is capable of compensating the functional activity of Sertoli and Leydig cells of the absent gonad.DesignIn a retrospective, cross-sectional, analytical study performed at a tertiary paediatric public hospital, we included 89 boys with monorchidism and 358 healthy controls, aged 6 months–18 years. Testicular volume and circulating levels of reproductive hormones were compared between patients with monorchidism and normal boys. Serum anti-Müllerian hormone (AMH) and FSH were used as biomarkers of the functional mass of prepubertal Sertoli cells, whereas serum testosterone and LH were used as biomarkers of Leydig cells.ResultsIn the vast majority of the cases, the testicular volume of monorchid boys was smaller than the sum of the volume of both testes of healthy controls. Serum AMH was lower and FSH was higher in patients with monorchidism than in controls aged <3 and >13 years. Serum testosterone and LH did not differ significantly between patients and controls.ConclusionIn boys and adolescents with monorchidism, there is a dissociated capacity of the remaining testis to compensate for the absence of the other gonad: while Leydig cell function is largely compensated, Sertoli cell proliferation and function was lower than in controls.

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Homocysteine Levels Show Significant Differences among Mediterranean Dietary Quality Index Variables Compared to Folate and Vitamin B12 Status in Women

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000237 ◽

2015 ◽

Vol 85 (3-4) ◽

pp. 202-210 ◽

Cited By ~ 4

Author(s):

Ivona Višekruna ◽

Ivana Rumbak ◽

Ivana Rumora Samarin ◽

Irena Keser ◽

Jasmina Ranilović

Keyword(s):

Mediterranean Diet ◽

Diet Quality ◽

Quality Index ◽

Fruits And Vegetables ◽

Reproductive Age ◽

Dietary Quality ◽

Vitamin B ◽

Cross Sectional ◽

Poor Diet ◽

The Mediterranean

Abstract. Results of epidemiologic studies and clinical trials have shown that subjects following the Mediterranean diet had lower inflammatory markers such as homocysteine (Hcy). Therefore, the aim of this cross-sectional study was to assess female diet quality with the Mediterranean diet quality index (MDQI) and to determine the correlation between MDQI, homocysteine, folate and vitamin B12 levels in the blood. The study participants were 237 apparently healthy women (96 of reproductive age and 141 postmenopausal) between 25 and 93 years. For each participant, 24-hour dietary recalls for 3 days were collected, MDQI was calculated, and plasma Hcy, serum and erythrocyte folate and vitamin B12 levels were analysed. Total MDQI ranged from 8 to 10 points, which represented a medium-poor diet for the subjects. The strength of correlation using biomarkers, regardless of group type, age, gender and other measured parameters, was ranked from best (0.11) to worst (0.52) for olive oil, fish, fruits and vegetables, grains, and meat, in this order. Hcy levels showed the best response among all markers across all groups and food types. Our study shows significant differences between variables of the MDQI and Hcy levels compared to levels of folate and vitamin B12 in participants with medium-poor diet quality, as evaluated according to MDQI scores.

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