P–324 Pregnancy outcome after IVF for endometriosis or male infertility: What differs?

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
G Porcu-buisson ◽  
V Chaber. Orsini ◽  
L Stefan. Morcillo ◽  
M Colomban. Barlesi ◽  
E Glowaczower ◽  
...  
Keyword(s):  
Male Infertility ◽  
Endometrial Thickness ◽  
Placenta Previa ◽  
Placenta Praevia ◽  
Childbearing Age ◽  
Number Of Children ◽  
Increased Risk ◽  
Significant Difference ◽  
Set Up ◽  
Two Populations

Abstract Study question Are endometriosis women pregnant after IVF at increased risk of preeclampsia or placenta praevia than patients monitored for male infertility? Summary answer Patients with endometriosis are at greater risk than patients monitored for male infertility of developing preeclampsia and placenta previa. What is known already Endometriosis is a chronic estrogen-dependent disease that affects women of childbearing age which represents 10% of the general population[.The main symptoms found are chronic pelvic pain, infertility, dyspareunia and dysmenorrhea. Numerous publications have highlighted the deleterious effect of endometriosis on pregnancy i.e miscarriage, placental abnormalities, preeclampsia, preterm birth, low gestational weight. This complication may be related to the molecular and cellular abnormalities present in the endometrium of these patients and to the inflammatory state that may lead to abnormal contractility of the uterus at the time of the implantation window and trophoblastic invasion. Study design, size, duration This study is a retrospective, non-interventional monocentric cohort study conducted between January 2011 and December 2017 in Institut de Medecine de la Reproduction - Clinique Bouchard in Marseilles, France. Participants/materials, setting, methods The outcome of pregnancies obtained after IVF and/or ICSI in patients with endometriosis (n = 270) was compared with patients,free of endometriosis,monitored for male infertility (n = 366) The statistical study was carried out using GraphPad Version 8 The Student T-test was used to compare means across them. Results were considered significant for p < 0.05. Main results and the role of chance Patients with endometriosis and monitored during this period were older than those managed for male infertility. (33.59 vs 32.78) (p = 0.04). There was no difference between the two populations regarding BMI (p = 0.31) or smoking (p > 0.9). The rate of miscarriage observed in the two populations was comparable (25.37 vs. 25.78%) (p > 0.9), so was the rate of IUGR (5.81% vs. 2.29%) despite the observed percentages (p > 0.9). The rate of premature deliveries did not differ between the two populations (18.37% vs. 14.29%) (p = 0.55) neither did the number of children born with a weight <2500g at term (13.68% vs. 12.5%) (p = 0.83). Although the rate of gestational diabetes was comparable in both groups (4.11% vs 4.56%), the rate of preeclampsia was higher in the group of patients with endometriosis with a statistically significant difference (4.79% vs 0.79%) (p = 0.01). Similarly, the rate of placenta previa was higher in patients with endometriosis (4.11% vs 0.76%) (p = 0.02). All pregnancies complicated by placenta previa resulted from J2/J3 embryo transfer. Estradiol levels on the day of induction (2166 pg/ml vs 2452) (p = 0.67) and endometrial thickness was not different between patients with placenta praevia or no (10.45 vs 10.51) (p = 0.66). Limitations, reasons for caution Our study is retrospective which may introduce several biases despite the size of our sample i;e patients with endometriosis are older, adenomyosis was not included in the criteria. In our study we have not found any additional risk related to the type of embryo transferred. Wider implications of the findings: Patients with endometriosis are at greater risk than patients managed for male infertility of developing preeclampsia and placenta previa. It is advisable to warn patients of this possible complication, to promote e-SET and to set up early monitoring in order to place the appropriate management around these patients. Trial registration number Not applicable

scholarly journals Perinatal mortality of placenta previa: a 1-year retrospective study

2018 ◽  
Vol 8 (1) ◽  
pp. 31
Author(s):  
Shibram Chattopadhyay ◽  
Siddhartha Majumder ◽  
Kajal Kumar Patra ◽  
A. H. Mostafa Kamal
Keyword(s):  
Retrospective Study ◽  
Perinatal Mortality ◽  
Placenta Previa ◽  
Birth Asphyxia ◽  
Severe Anaemia ◽  
Placenta Praevia ◽  
Perinatal Morbidity ◽  
Mortality And Morbidity ◽  
Vaginal Deliveries ◽  
Increased Risk

Background: Antepartum haemorrhage is one of the important causes of perinatal mortality and morbidity in India. The increased risk of perinatal morbidity and mortality in placenta praevia is due to preterm birth, low birth weight, birth asphyxia and neonatal sepsis. This is a retrospective study done over a period of 5years to determine the incidence, demographic features, risk factors, obstetric management, maternal mortality and morbidity, and perinatal outcome in women presenting with placenta praevia.Methods: This was a retrospective study done at Nil Ratan Sircar Medical College and Hospital over a period of five years starting from January 2016 to December 2017. Antenatal women with more than 28 weeks of gestational age with a complaint of painless vaginal bleeding or those diagnosed as having placenta praevia on routine ultrasound examination were included in this study and hospitalised.  Among them cases of placenta praevia were 21.Results: There were21 cases of placenta praevia registered amounting to 0.23% incidence. The various antenatal complications seen associated with placenta praevia were severe anaemia (14.28%), coexisting PIH (4.76%), IUD (4.76%), IUGR/Oligohydraminos (4.76%). All the patients in the study had undergone caesarean deliveries. Perinatal morbidity studied as percentage of new-borns requiring resuscitation followed by NICU admission was 33.3%. Among the delivered patients of placenta praevia incidence of perinatal mortality was 23.8%. Prematurity (42.85%) contributed to most cases of perinatal mortality, followed by RDS (14.28%) and asphyxia (14.28%).Conclusions: In this study placenta praevia is seen more commonly in 28-34 weeks of gestation and patients mainly presented with a bout of bleeding eventually had preterm deliveries. Although vaginal deliveries are appropriate in selected cases of placenta paevia liberal use of caesarean section in well-equipped hospitals with availability of blood transfusion services have helped to lower complications.

Effect of Pregnancy on Survival in Women With Cutaneous Malignant Melanoma

2004 ◽  
Vol 22 (21) ◽  
pp. 4369-4375 ◽  
Author(s):  
Marko B. Lens ◽  
Inger Rosdahl ◽  
Anders Ahlbom ◽  
Bahman Y. Farahmand ◽  
Ingrid Synnerstad ◽  
...  
Keyword(s):  
Overall Survival ◽  
Cutaneous Melanoma ◽  
Cox Model ◽  
Multivariable Analysis ◽  
Hazard Ratio ◽  
Childbearing Age ◽  
Risk Of Death ◽  
Increased Risk ◽  
Significant Difference ◽  
Pregnancy Status

Purpose An adverse influence of pregnancy on the risk of death in women with cutaneous melanoma was suggested historically by anecdotal reports. Previous studies included small numbers of women observed for short periods. Methods Using data from the Swedish National and Regional Registries, we performed a retrospective cohort study of all Swedish women who were diagnosed with cutaneous melanoma during their reproductive period, from January 1, 1958, to December 31, 1999. The relationship between pregnancy status at the diagnosis of melanoma and overall survival was examined in multivariable proportional-hazards models. Results The cohort comprised 185 women (3.3%) diagnosed with melanoma during pregnancy and 5,348 (96.7%) women of the same childbearing age diagnosed with melanoma while not pregnant. There was no statistically significant difference in overall survival between pregnant and nonpregnant groups (log-rank χ21[r] = 0.84, P = .361). Pregnancy status at the time of diagnosis of melanoma was not related to survival in a multivariable Cox model in the 2,101 women (hazard ratio for death in the pregnant group was 1.08; 95% CI, 0.60 to 1.93). In the multivariable analysis, pregnancy status after diagnosis of melanoma was not a significant predictor of survival (hazard ratio for death in women who had pregnancy subsequent to the diagnosis of melanoma was 0.58; 95% CI, 0.32 to 1.05). Conclusion The survival of pregnant women with melanoma is not worse than the survival of nonpregnant women with melanoma. Pregnancy subsequent to the diagnosis of primary melanoma was not associated with an increased risk of death.

scholarly journals Maternal and fetal outcome of Placenta Previa at a tertiary centre in North Kerala, India

2018 ◽  
Vol 7 (5) ◽  
pp. 1723
Author(s):  
Mohammed Sidhiq C.
Keyword(s):  
Postoperative Complications ◽  
Caesarean Section ◽  
Placenta Previa ◽  
Caesarean Section Rate ◽  
Previous History ◽  
Admission Rate ◽  
First Trimester ◽  
Placenta Praevia ◽  
Significant Difference ◽  
Nicu Admission

Background: Placenta previa is defined as placenta that is implanted somewhere in the lower uterine segment either over or very near the internal cervical os. Placenta previa and coexistent accrete syndromes contribute substantively to maternal and perinatal morbidity and mortality.Methods: This study was conducted in the Department of Obstetrics and Gynaecology during the period from June 2016 to May 2017 including antenatal patients of 24 weeks of gestation regardless of their parity. They would be selected from the same O.P day as that of case in a 1:4 case: control manner. Statistical analysis was done using SPSS version 16.0 for Windows.Results: Age, booking status, Gestational age at delivery and gravidity was comparable between the two groups. The risk for placenta praevia was more among patients with a previous history of CS. Risk for antepartum bleeding was significantly higher among cases of placenta praevia. CS rate and proportion of patients who required blood transfusion was significantly high among cases. Intraoperative and postoperative complications were significantly higher among cases. There was no significant difference in neonatal death rate and NICU admission rate between the two groups.Conclusions: Incidence of placenta previa is 0.78%. There is significant association with placenta previa and maternal morbidity, first trimester and second trimester bleeding increased blood transfusions, need for caesarean section, prolonged hospital stay, previous caesarean section, previous dilatation and curettage, placenta accreta, postoperative complications and NICU admission. Measures to reduce the primary caesarean section rate should be adopted.

scholarly journals Pengaruh Pemberian Hormon Medroxy Progesterone Acetat terhadap Ketebalan Endometrium Rattus Norvegicus Betina Strain Wistar

2020 ◽  
Vol 20 (2) ◽  
pp. 682
Author(s):  
Defi Yulita ◽  
M Biomed
Keyword(s):  
Family Planning ◽  
Treatment Group ◽  
Sample Size ◽  
Rattus Norvegicus ◽  
Endometrial Thickness ◽  
Female Rats ◽  
Control Group ◽  
Childbearing Age ◽  
Wistar Strain ◽  
Significant Difference

Based on the National Population and Family Planning Agency (BKKBN) data in 2013, there were 8,500,247 couples of childbearing age who were new KB (family planning) participants with the total number using injection was 4,128,115 (48.56%). Research Objectives to find out The Effect of The Administration OF Medroxy Progesterone Acetate Hormone to Endometrial Thickness of The Female Rattus Norvegicus Wistar Strain. The design of this research is the post test only control group design by having  white rats species Rattus Norvegicus Wistar Strain as the poplulation, the samples are taken randomly from all populations that met the following sample criteria: female rats, Aged 12-14 weeks, having body weight of 150 - 200 grams. Based on the calculation of the sample size, the sample size / number of animals r = 10 rats was obtained, with a total sample size for both groups of treatment and control were 20 female rats which included: group 1 amounted to 10 rats that were not given Medroxy Progesterone Acetat hormones as a control group where group 2 amounted to 10 rats which given Medroxy Progesterone Acetat as a treatment group. The results showed the average endometrial thickness in the (P1) Medroxy Progesterone Acetate Hormone group was 493.17 µm ± 114.96, this result was lower than the control group 1192.56 µm ± 428.94. From the ANOVA test table, the P value <0.05 means that there is a very significant difference in the average endometrial thickness between the control group and the treatment group. Based on the results of the Post Hoc Bonfferoni Test, it can be seen that the average endometrial thickness between Control and P1 showed a significant difference (P <0.05). The analysis of the result and discussion of the research can be concluded that: the Medroxy Progesterone Acetate hormone affects the endometrial thickness, and there is a difference in the histological picture of endometrial thickness due to the administration of the Medroxy Progesterone Acetate hormone and without the administration of to the administration of the Medroxy Progesterone Acetate hormone.

scholarly journals Risk assessment of acquiring SARS-CoV-2 infection among employees of a tertiary cancer care center

2021 ◽  
Vol 0 ◽  
pp. 1-5
Author(s):  
Sandeep S. Sawakare ◽  
Sandeep P. Tandon ◽  
C. S. Pramesh ◽  
Sudeep Gupta ◽  
Manju Sengar ◽  
...  
Keyword(s):  
Health Care ◽  
Cancer Care ◽  
Care Center ◽  
Healthcare Facility ◽  
Health Care Facilities ◽  
Care Workers ◽  
Increased Risk ◽  
Significant Difference ◽  
Set Up ◽  
Doctors And Nurses

Objectives: Continuation of health-care facilities for non-COVID illness during the SARS-CoV-2 pandemic is mired with apprehension of infection to health care workers (HCWs). The lack of facilities can result in dire outcomes for patients of NCDs such as cancer. The Objective of this paper is to assess the risk of running a healthcare facility during the pandemic. Material and Methods: A retrospective analysis was carried out at a tertiary cancer hospital to understand the quantum of risk to HCWs while providing care to patients of cancer and to SARS-CoV-2 patients, within the same set-up with optimal segregation. Data were collected for 6 weeks during which attendance, exposure, and infection status of doctors and nurses were recorded along with comorbidities. Results: Of 1041 doctors and nurses who attended duties during the study period, 299 worked in dedicated COVID care areas while 742 worked in routine cancer care areas. The proportion of HCWs that developed symptoms or were tested positive for COVID-19 was 3.7% and 3.9%, respectively, with no statistically significant difference between the two. The proportion for the same was found to be 1.2% among the 645 staffs who were on leave. No correlation could be established between pre-existing comorbidities and risk of acquiring infection. Conclusion: Providing COVID care and routine specialty care within the same hospital premises do not put the HCWs at a drastically increased risk of acquiring infection subject to clear demarcation of work areas, screening at gates by trained personnel, regulation of number of hospital visitors, and optimal use of PPEs.

P–114 Correlation of GSTM1 polymorphism and oxidative stress with male infertility

2021 ◽  
Vol 36 (Supplement_1) ◽  
Author(s):  
D Mavrogianni ◽  
A Voitse ◽  
L Evgeni ◽  
S Stavros ◽  
P Drakakis
Keyword(s):  
Oxidative Stress ◽  
Male Infertility ◽  
Sperm Count ◽  
Sperm Parameters ◽  
Control Group ◽  
Genetic Profile ◽  
Oxidative Potential ◽  
Increased Risk ◽  
Significant Difference ◽  
Gstm1 Polymorphism

Abstract Study question Is GSTM1 polymorphism a putative biomarker of male infertility. Is there a possible correlation between GSTM1 presence, oxidative stress and male infertility? Summary answer A possible correlation may be established between GSTM1 polymorphism, and sperm mobility and morphology. Additionally oxidative potential may also be associated with fertility. What is known already Approximately 7% of men worldwide are affected by male infertility, which contributes to 40–50% of all infertility cases. Basic sperm analysis remains the main procedure of diagnosing male infertility, although there is still doubt whether it provides accurate clinical outcomes More accurate tests are essential for the diagnosis of male infertility. Oxidative stress is involved in the etiology of male infertility, with 30% to 80% of infertile men having increased levels of sperm free radicals. Recent research has shown that oxidative stress when combined with GSTM1-null genotype negatively affected the sperm quality of infertility group compared to the control group. Study design, size, duration Ninety semen samples were collected and divided into 2 groups. The study group consisted of sperm samples from 51 men identified as infertile according to WHO guidelines(case group).Sperm samples from 39 men with normal sperm count parameters (control group) were used for the control group. Participants/materials, setting, methods For all samples a sperm diagram was performed. and DNA was extracted. Polymerase chain reaction with specific for GSTM1 gene primers followed by agarose electrophoresis was applied to detect the presence of polymorphism. The MiOXSYS method was used to detect the oxidative potential. Main results and the role of chance This study shows that in the control group the presence of polymorphism was associated with a reduced number of immobile sperm cells (p = 0,035) while it appears to affect the normal morphology of the sperm(p = 0,042). In the infertility group the presence of the gene was significantly correlated with age(p = 0.046). No statistically significant difference was observed for the presence of the polymorphism between the 2 groups.In addition, we investigated the effect of oxidative potential with the MiOXSYS system and its relationship with sperm parameters. It was found that the two groups differed significantly when measuring oxidative potential, and that oxidoreduction potential affects sperm concentration/ml, total sperm count, type B motility and viscosity in the infertile male group. Limitations, reasons for caution A larger sample size could increase the accuracy of the results. Wider implications of the findings: Studying the relation of the oxidative stress with sperm parameters may lead to the establishment of a genetic profile of increased risk of infertility, which would be of major importance especially in cases of idiopathic infertility. Trial registration number Not applicable

Risk of venous thromboembolism following surgical treatment of superficial venous incompetence

VASA ◽  
2017 ◽  
Vol 46 (6) ◽  
pp. 484-489 ◽  
Author(s):  
Tom Barker ◽  
Felicity Evison ◽  
Ruth Benson ◽  
Alok Tiwari
Keyword(s):  
Venous Thromboembolism ◽  
Varicose Vein ◽  
Lower Incidence ◽  
Varicose Veins ◽  
Secondary Data ◽  
Foam Sclerotherapy ◽  
Increased Risk ◽  
Significant Difference ◽  
Chi Squared ◽  
One Year

Abstract. Background: The invasive management of varicose veins has a known risk of post-operative deep venous thrombosis and subsequent pulmonary embolism. The aim of this study was to evaluate absolute and relative risk of venous thromboembolism (VTE) following commonly used varicose vein procedures. Patients and methods: A retrospective analysis of secondary data using Hospital Episode Statistics database was performed for all varicose vein procedures performed between 2003 and 2013 and all readmissions for VTE in the same patients within 30 days, 90 days, and one year. Comparison of the incidence of VTEs between procedures was performed using a Pearson’s Chi-squared test. Results: In total, 261,169 varicose vein procedures were performed during the period studied. There were 686 VTEs recorded at 30 days (0.26 % incidence), 884 at 90 days (0.34 % incidence), and 1,246 at one year (0.48 % incidence). The VTE incidence for different procedures was between 0.15–0.35 % at 30 days, 0.26–0.50 % at 90 days, and 0.46–0.58 % at one year. At 30 days there was a significantly lower incidence of VTEs for foam sclerotherapy compared to other procedures (p = 0.01). There was no difference in VTE incidence between procedures at 90 days (p = 0.13) or one year (p = 0.16). Conclusions: Patients undergoing varicose vein procedures have a small but appreciable increased risk of VTE compared to the general population, with the effect persisting at one year. Foam sclerotherapy had a lower incidence of VTE compared to other procedures at 30 days, but this effect did not persist at 90 days or at one year. There was no other significant difference in the incidence of VTE between open, endovenous, and foam sclerotherapy treatments.

Interpersonal Violence and Substance Use Among Female Sexual Minorities

2019 ◽  
Author(s):  
Cort M. Dorn-Medeiros ◽  
Cass Dykeman ◽  
Timothy Bergquist
Keyword(s):  
New York ◽  
Tobacco Use ◽  
Interpersonal Violence ◽  
Sexual Minorities ◽  
Sample Population ◽  
Life Outcomes ◽  
City Community ◽  
Increased Risk ◽  
Significant Difference ◽  
Community Health Survey

This archived data study used results from the New York City Community Health Survey to explore the relationship between interpersonal violence among female sexual minorities (FSM) and their levels of alcohol and tobacco use. A total of 92 FSM were included in the sample population. There was a significant difference in the mean number of alcoholic drinks consumed between FSM who reported past experience of interpersonal violence and those who did not. No difference was found in levels of tobacco use between FSM who reported interpersonal violence and those who did not. Results of the present study support current research indicating FSM may be at increased risk for elevated alcohol use and respective negative life outcomes related to the experience of interpersonal violence.

Effect of short-term use of oral contraceptive pills on intraocular pressure

2020 ◽  
Vol 35 (3) ◽  
Author(s):  
Tayyaba Gul Malik ◽  
Hina Nadeem ◽  
Eiman Ayesha ◽  
Rabail Alam
Keyword(s):  
Oral Contraceptive ◽  
Childbearing Age ◽  
Short Term ◽  
Oral Contraceptive Pills ◽  
Contraceptive Pills ◽  
Time Period ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Short Time

Objective: To study the effect of short-term use of oral contraceptive pills on intra-ocular pressures of women of childbearing age.   Methods: It was a comparative observational study, conducted at Arif memorial teaching hospital and Allied hospital Faisalabad for a period of six months. Hundred female subjects were divided into two groups of 50 each. Group A, included females, who had been taking oral contraceptive pills (OCP) for more than 6 months and less than 36 months. Group B, included 50 age-matched controls, who had never used OCP. Ophthalmic and systemic history was taken. Careful Slit lamp examination was performed and intraocular pressures (IOP) were measured using Goldman Applanation tonometer. Fundus examination was done to rule out any posterior segment disease. After collection of data, we analyzed and compared the intra ocular pressures between the two groups by using ANOVA in SPSS version 21.   Results: Average duration of using OCP was 14.9 months. There was no significant difference of Cup to Disc ratios between the two groups (p= 0.109). However, significant difference was noted between the IOP of OCP group and controls. (p=0.000). Conclusion: OCP significantly increase IOP even when used for short time period.

Association between hTERT Polymorphisms and Female Papillary Thyroid Carcinoma

2019 ◽  
Vol 14 (3) ◽  
pp. 268-279
Author(s):  
Ying Liu ◽  
Zhi Li ◽  
Xinyue Tang ◽  
Min Li ◽  
Feng Shi
Keyword(s):  
Papillary Thyroid Carcinoma ◽  
Thyroid Carcinoma ◽  
Genome Wide Association Study ◽  
Papillary Thyroid ◽  
Clinicopathologic Characteristics ◽  
Female Population ◽  
Genome Wide ◽  
Increased Risk ◽  
Significant Difference ◽  
Thyroid Cancer Risk

Background: A previous genome-wide association study showed that hTERT rs10069690 and rs2736100 polymorphisms were associated with thyroid cancer risk. Objective: This study further investigated the association between increased risk and clinicopathologic characteristics for Papillary Thyroid Carcinoma (PTC) and hTERT polymorphisms rs10069690 or rs2736100 in a Chinese female population. Methods: The hTERT genotypes of 276 PTC patients and 345 healthy subjects were determined with regard to SNPs rs10069690 and rs2736100. The association between these SNPs and the risk of PTC and clinicopathologic characteristics was investigated by logistic regression. Results: We found a significant difference between PTC and rs10069690 (Odds Ratio (OR) = 1.515; P = 0.005), but not between PTC and rs2736100. When the analysis was limited to females, rs10069690 and rs2736100 were both associated with increased risk for PTC in female individuals (OR = 1.647, P = 0.007; OR = 1.339, P = 0.041, respectively). Further haplotype analysis revealed a stimulative effect of haplotypes TC and CA of TERT rs10069690-rs2736100, which increased risk for PTC in female individuals (OR = 1.579, P = 0.014; OR = 0.726, P = 0.025, respectively). Furthermore, the heterozygote A/C of rs2736100 showed significant difference for age (OR = 0.514, P = 0.047). Conclusion: Our finding suggests that hTERT polymorphisms rs10069690 and rs2736100 are associated with increased risk for PTC in Chinese female population and rs2736100 may be related to age. Consistent with US20170360914 and US20170232075, they are expected to be a potential molecular target for anti-cancer therapy.

Sign in / Sign up

Export Citation Format

Share Document