scholarly journals Macro- and Micronutrients in Milk from Healthy Cambodian Mothers: Status and Interrelations

2020 ◽  
Vol 150 (6) ◽  
pp. 1461-1469 ◽  
Author(s):  
Kyly C Whitfield ◽  
Setareh Shahab-Ferdows ◽  
Hou Kroeun ◽  
Prak Sophonneary ◽  
Timothy J Green ◽  
...  
Keyword(s):  
Maternal Diet ◽  
Pearson Correlation ◽  
Water Soluble ◽  
Nutrient Concentrations ◽  
Strong Correlations ◽  
Milk Volume ◽  
Protein Milk ◽  
Almost All ◽  
Fat Soluble Vitamins ◽  
Thiamin Pyrophosphate

ABSTRACT Background Except for low thiamin content, little is known about vitamins or macronutrients in milk from Cambodian mothers, and associations among milk nutrients. Objectives We measured fat-soluble vitamins (FSVs) and water-soluble vitamins (WSVs), and macronutrients, and explored internutrient associations in milk from Cambodian mothers. Methods Milk from women (aged 18–45 y, 3–27 wk postpartum, n = 68) who participated in a thiamin-fortification trial were analyzed for vitamins B-2 (riboflavin, FAD), B-3 (nicotinamide), B-5, B-6 (pyridoxal, pyridoxine), B-7, B-12, A, E [α-tocopherol and γ-tocopherol (γ-TPH)], carotenoids, carbohydrate (CHO), fat, and protein. Milk vitamin B-1 [thiamin, thiamin monophosphate (TMP), thiamin pyrophosphate (TPP)] was previously assessed for fortification effects. Milk nutrient concentrations were compared with the Adequate Intake (AI) values for infants aged 0–6 mo. Pearson correlation was used to examine internutrient associations after excluding nutrients affected by fortification. Results Fortification increased thiamin and B-1 and decreased γ-TPH. Less than 40% of milk samples met the AIs for all vitamins, and 10 samples did not reach any AI values for the analyzed nutrients. CHO, fat, and energy values were met in 1.5–11.8%, and protein in 48.5%, of the samples. Whereas fat, protein, and energy were related (all r < 0.5; P < 0.001) and associated with FSVs and WSVs, CHO correlated only with some WSVs. TPP was not correlated with B-1 vitamers, but with other WSVs (r = 0.28–0.58; P < 0.019). All FSVs, except α-carotene, were correlated with each other (r = 0.42–0.98; P < 0.002). TPP, FAD, B-2, and B-3 were associated with almost all FSVs (r = 0.24–0.63; P < 0.044). Conclusions Cambodian women might not provide sufficient nutrients to their exclusively breastfeeding infants. Besides thiamin, all other vitamins measured were much lower than the AI. There were many strong correlations among macronutrients and vitamins; the extent to which these are explained by maternal diet, milk volume, maternal physiology, or genetics requires additional exploration.

scholarly journals Micronutrient intakes of lactating mothers and their association with breast milk concentrations and micronutrient adequacy of exclusively breastfed Indonesian infants

2019 ◽  
Vol 110 (2) ◽  
pp. 391-400 ◽  
Author(s):  
Lisa Daniels ◽  
Rosalind S Gibson ◽  
Aly Diana ◽  
Jillian J Haszard ◽  
Sofa Rahmannia ◽  
...  
Keyword(s):  
Breast Milk ◽  
Maternal Diet ◽  
Pantothenic Acid ◽  
Sole Source ◽  
Cross Sectional Study ◽  
Nutrient Concentrations ◽  
Cross Sectional ◽  
Breastfed Infants ◽  
Lactating Mothers ◽  
Milk Volume

ABSTRACT Background Breast milk is the sole source of nutrition for exclusively breastfed infants in the first 6 mo of life, yet few studies have measured micronutrient concentrations in breast milk in light of maternal diet and subsequent infant micronutrient intakes. Objectives We evaluated the adequacy of micronutrient intakes of exclusively breastfed Indonesian infants by measuring milk volume and micronutrient concentrations and assessed maternal micronutrient intakes and their relationship with milk concentrations. Methods Mother–infant (2–5.3 mo) dyads (n = 113) were recruited for this cross-sectional study. Volume of breast-milk intake via the deuterium dose-to-mother technique over 14 d and analyzed micronutrient concentrations were used to calculate micronutrient intakes of exclusively breastfed infants. Maternal 3-d weighed food records were collected to assess median (IQR) micronutrient intakes. Multivariate regression analyses examined the association of usual maternal micronutrient intakes with milk micronutrient concentrations after adjustment for confounding variables. Results Mean ± SD intake of breast-milk volume was 787 ± 148 mL/d. Median daily infant intakes of iron, zinc, selenium, magnesium, sodium, and B-vitamins (thiamin, riboflavin, niacin, pantothenic acid, B-6, and B-12) were below their respective Adequate Intakes. Inadequacies in maternal intakes (as % < estimated average requirements) were >40% for calcium, niacin, and vitamins A, B-6, and B-12. Significant positive associations existed between maternal usual intakes of vitamin A, niacin and riboflavin and milk retinol, nicotinamide, and free riboflavin concentrations in both unadjusted and adjusted (for infant age, milk volume, and parity) analyses (all P < 0.05). Conclusions The majority of micronutrient intakes for these exclusively breastfed infants and their mothers fell below recommendations, with associations between maternal intakes and breast-milk concentrations for 3 nutrients. Data on nutrient requirements of exclusively breastfed infants are limited, and a better understanding of the influence of maternal nutritional status on milk nutrient concentrations and its impact on the breastfed infant is needed.

scholarly journals The Studying the Components of Social Capital and its Relationship with the Social Happiness in Iranian Students

2018 ◽  
Vol 7 (4.7) ◽  
pp. 19
Author(s):  
Zadeh Foroughinia ◽  
Hakimeh Mohammadzadeh ◽  
Reza Pourmirza Kalhori ◽  
Neda Kianipour
Keyword(s):  
Social Capital ◽  
Significant Relationship ◽  
Social Inclusion ◽  
Pearson Correlation ◽  
Cluster Sampling ◽  
Medical Sciences ◽  
The Social ◽  
Research Population ◽  
Iranian Students ◽  
Almost All

The concept of social capital, due to its nature and content, is associated with almost all the issues in the human, social and health fields. On the other hand, the role of happiness and joy in mental health, physical health, and social inclusion are very important in the field of health. The purpose of this study was to investigate the components of social capital and its relation with social happiness of students in Kermanshah University of Medical Sciences in 2017. This study is descriptive-correlational. The research population consisted of 450 students in Kermanshah University of Medical Sciences in 2017who were selected by cluster sampling. Bullen& Onyx Standard Social Capital Questionnaire and Oxford Happiness Questionnaire (OHQ) were used to collect data. Data were analyzed using descriptive and inferential statistics (Pearson correlation coefficient). Data analysis was performed using SPSS-23 software. In this research, social capital score was 3.17 ± 0.45 according to the students' score and the mean score of the social happiness was 3.68 ± 0.14. There was a positive and significant relationship between two variables of social capital and social happiness of students (r=0.423). Among the social capital fields, the variables of the value of life, trust, and security had the most and the least relationship with the overall social happiness. Social capital and its aspects have a direct and significant relationship with the social happiness; therefore, with increasing the social capital, the level of social happiness increases.  

scholarly journals Synthesis and Guest-Binding Properties of pH/Reduction Dual-Responsive Cyclophane Dimer

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3097
Author(s):  
Osamu Hayashida ◽  
Yudai Tanaka ◽  
Takaaki Miyazaki
Keyword(s):  
Electrostatic Interaction ◽  
Disulfide Bonds ◽  
Water Soluble ◽  
Guest Molecules ◽  
Binding Behavior ◽  
Dual Responsive ◽  
Guest Binding ◽  
Basic Solutions ◽  
Ph Conditions ◽  
Almost All

A water-soluble cyclophane dimer having two disulfide groups as a reduction-responsive cleavable bond as well as several acidic and basic functional groups as a pH-responsive ionizable group 1 was successfully synthesized. It was found that 1 showed pH-dependent guest-binding behavior. That is, 1 strongly bound an anionic guest, 6-p-toluidinonaphthalene-2-sulfonate (TNS) with binding constant (K/M−1) for 1:1 host-guest complexes of 9.6 × 104 M−1 at pH 3.8, which was larger than those at pH 7.4 and 10.7 (6.0 × 104 and 2.4 × 104 M−1, respectively), indicating a favorable electrostatic interaction between anionic guest and net cationic 1. What is more, release of the entrapped guest molecules by 1 was easily controlled by pH stimulus. Large favorable enthalpies (ΔH) for formation of host-guest complexes were obtained under the pH conditions employed, suggesting that electrostatic interaction between anionic TNS and 1 was the most important driving force for host-guest complexation. Such contributions of ΔH for formation of host-guest complexes decreased along with increased pH values from acidic to basic solutions. Upon addition of dithiothreitol (DTT) as a reducing reagent to an aqueous PBS buffer (pH 7.4) containing 1 and TNS, the fluorescence intensity originating from the bound guest molecules decreased gradually. A treatment of 1 with DTT gave 2, having less guest-binding affinity by the cleavage of disulfide bonds of 1. Consequently, almost all entrapped guest molecules by 1 were released from the host. Moreover, such reduction-responsive cleavage of 1 and release of bound guest molecules was performed more rapidly in aqueous buffer at pH 10.7.

scholarly journals Relationship Between the Critical Power Test and a 20-min Functional Threshold Power Test in Cycling

2021 ◽  
Vol 11 ◽  
Author(s):  
Bettina Karsten ◽  
Luca Petrigna ◽  
Andreas Klose ◽  
Antonino Bianco ◽  
Nathan Townsend ◽  
...  
Keyword(s):  
Critical Power ◽  
Pearson Correlation ◽  
Time Trial ◽  
Peak Oxygen Consumption ◽  
Threshold Power ◽  
Strong Correlations ◽  
Mean Power ◽  
Power Test ◽  
Paired Samples ◽  
The Mean

To investigate the agreement between critical power (CP) and functional threshold power (FTP), 17 trained cyclists and triathletes (mean ± SD: age 31 ± 9 years, body mass 80 ± 10 kg, maximal aerobic power 350 ± 56 W, peak oxygen consumption 51 ± 10 mL⋅min–1⋅kg–1) performed a maximal incremental ramp test, a single-visit CP test and a 20-min time trial (TT) test in randomized order on three different days. CP was determined using a time-trial (TT) protocol of three durations (12, 7, and 3 min) interspersed by 30 min passive rest. FTP was calculated as 95% of 20-min mean power achieved during the TT. Differences between means were examined using magnitude-based inferences and a paired-samples t-test. Effect sizes are reported as Cohen’s d. Agreement between CP and FTP was assessed using the 95% limits of agreement (LoA) method and Pearson correlation coefficient. There was a 91.7% probability that CP (256 ± 50 W) was higher than FTP (249 ± 44 W). Indeed, CP was significantly higher compared to FTP (P = 0.041) which was associated with a trivial effect size (d = 0.04). The mean bias between CP and FTP was 7 ± 13 W and LoA were −19 to 33 W. Even though strong correlations exist between CP and FTP (r = 0.969; P &lt; 0.001), the chance of meaningful differences in terms of performance (1% smallest worthwhile change), were greater than 90%. With relatively large ranges for LoA between variables, these values generally should not be used interchangeably. Caution should consequently be exercised when choosing between FTP and CP for the purposes of performance analysis.

scholarly journals Correlation of morphological parameters of donkey from Austria

2021 ◽  
Vol 53 (2) ◽  
Author(s):  
Darko Drobnjak ◽  
Radka Vlaeva ◽  
Goran Stanišić ◽  
Radomir Mandić ◽  
Natalija Grittner ◽  
...  
Keyword(s):  
Body Length ◽  
Pearson Correlation ◽  
Good Reason ◽  
Statistical Correlation ◽  
Head Length ◽  
Chest Circumference ◽  
Average Height ◽  
Face Width ◽  
Equus Asinus ◽  
Almost All

The donkey, as a work animal, is gradually losing its value. Agriculture industrialization, mechanization of many processes on mountain and valley farms have lead to a reduction of donkey livestock. This reduction gives cause for concern, and is good reason to study all aspects of these domestic animals in order to revive its role, to restart livestock growth in its familiar habitats, and to introduce it into new environments. This study focuses on these aspects. The domestic donkey (Equus asinus) originated from Africa, and there are two kinds of African donkeys: Nubian and Somali. Their enormous, almost mystical, endurance is well known. There is no place in the world where a donkey is not able to perform the most difficult work, above all in transporting goods. A donkey has an amazing capability of stable movement through the most difficult places. For study sample consisted of 44 donkeys (28 males and 16 females) from Austria. The following morphometric parameters were analysed: height at the withers, height at the back, height of the croup, body length, chest depth, chest width, chest circumference anterior, chest circumference posterior, shin circumference, head length, skull length, face length, skull width, face width, length of ears. Measurements were performed using a ruler, tape measure and vernier callipers. The average height at the withers of males was 116.40 cm, ranging from 99.60 to 140.60 cm, while for females, the average was 102.38 cm, ranging from 90.50 to 125.70 cm. Body length of males was on average 121.85 cm with a standard deviation of 11.79, while the mean body length for females is 115.80 cm, with a range of 101.00 to 131.00 cm. Male head length ranged from 48.00 to 71.00 cm, with an average of 55.60 cm, while in females, head length was on average 50.06 cm, ranging from 43.00 to 56.00 cm. Using the Pearson correlation, a very significant or significant positive statistical correlation was observed between almost all parameters of males, while for females, Pearson correlation values had slightly different values than for males. There was no statistically significant correlation between chest width and anterior chest circumference with nearly any other parameters. For females, a negative correlation between the skull width and all other parameters was also observed.

scholarly journals Characteristics and Seasonal Variations of Atmospheric Deposition of Selected Elements in the Urban and Industrial Environment of Košice (Slovakia)

2021 ◽  
Vol 906 (1) ◽  
pp. 012100
Author(s):  
Jozef Hančul’ák ◽  
Ol’ga Šestinová ◽  
Lenka Findoráková
Keyword(s):  
Atmospheric Deposition ◽  
Detailed Analysis ◽  
Pearson Correlation ◽  
Correlation Coefficients ◽  
Water Soluble ◽  
Dust Particles ◽  
Winter Period ◽  
Emission Sources ◽  
Summer Period ◽  
The Impact

Abstract This study aims to evaluate the impact of local emission sources on the environmental load through a detailed analysis of the atmospheric deposition (AD). The main sources of pollution are neighbouring iron and steelworks and typical urban sources, such as the heating plant, transport, construction, etc. Total atmospheric deposition, i.e. both wet and dry ones, were sampled from eleven sampling sites that have been placed on the roofs above the height of the surrounding buildings at a distance of 1 to 16 kilometers from the main source of pollution in the urban, suburban and rural areas. The atmospheric deposition fluxes of selected elements (Fe, Al, Mn, Zn, Pb, Cu, Cr, Cd, As) were determined separately for “water-soluble” and “insoluble phase” (particulate matter - PM) as well as in terms of the heating season for summer and winter half-year. The results from 2009–2020 are introduced. The average Fe deposition at urban stations in Košice was 2-3 times higher, compared with other urban areas. The very high values of iron deposition (9,181) and manganese (348 mg.m-2.yr-1) were measured mainly at sites near the ironworks. The highest values of correlation coefficients were calculated by Pearson correlation analysis for the elements Fe, Mn and Cr but also for Al and PM. Higher values of correlation coefficients were calculated for the winter period. The monitored elements are bound to the insoluble component AD in the order of Fe, Al, Cr, Pb, Mn and As. Cadmium and zinc are preferably bound to the soluble phase for sites north of the ironworks. Significant differences for fluxes of AD of the most observed parameters were found between the summer and winter periods. In winter, higher values of AD were found for the elements Fe, Pb, Mn, Cr, and Cd. In the case of zinc and arsenic higher values were recorded in the summer period. The share of emission sources of iron and steelworks on the fluxes of iron at the urban sites in winter was more than doubled compared to the summer period. The smallest seasonal differences for all observed components were found at localities near the ironworks. Detailed analysis of AD showed that in addition to Fe, Mn, and Cr, the ironworks complex is also a source of dust particles, aluminum and other observed elements in descending order of lead, zinc, copper, arsenic and cadmium.

scholarly journals Enterprise Value and Intellectual Capital: Study of BSE 500 Firms

2018 ◽  
Vol 7 (2) ◽  
pp. 123 ◽  
Author(s):  
Priti Sharma
Keyword(s):  
Regression Analysis ◽  
Multiple Regression Analysis ◽  
Multiple Regression ◽  
Intellectual Capital ◽  
Pearson Correlation ◽  
Market Value ◽  
Linear Multiple Regression ◽  
Listed Firms ◽  
Customer Capital ◽  
Almost All

The purpose of this paper is to estimate the intellectual capital coefficient of the firms under study and to study the relationship, if any between intellectual capital and intellectual capital and its constituents. In this empirical paper, analytical research design has been used. Pulic’s VAIC (modified) has been used to estimate the intellectual capital of BSE S&P 500 listed firms from 2007-2016. The data has been collected from CMIE and collected data has been analyzed using Pearson correlation and linear multiple regression analysis using CMIE PROWESS. Findings show that almost all firms under study have a good VAIC score means above 4 and the top VAIC scorer firms were mainly from refinery, metal, cement, steel, tobacco. Correlation analysis and Linear multiple regression analysis show that M/B ratio has a significant relationship with VACA, VAHU, Research and Development (Innovation capital) and Advertisement expenses (customer capital). Year-wise results depicts that value of adjusted R2 is increasing, in 2007 it was just .164 and in the year 2016 it is .607 which infers that VAIC’s role is improving in measuring the market value of firms under study. Year wise analysis shows that adjusted R2 is improving, so findings may serve as significant input for the firms to use intellectual capital as the main factor for improving the market value of firms. This paper will definitely contribute to the existing literature.

scholarly journals A critical evaluation of results from genome-wide association studies of micronutrient status and their utility in the practice of precision nutrition

2019 ◽  
Vol 122 (2) ◽  
pp. 121-130 ◽  
Author(s):  
Marie-Joe Dib ◽  
Ruan Elliott ◽  
Kourosh R. Ahmadi
Keyword(s):  
Large Scale ◽  
Association Studies ◽  
Critical Evaluation ◽  
Water Soluble ◽  
Genome Wide Association ◽  
Genome Wide Association Studies ◽  
Micronutrient Deficiencies ◽  
Micronutrient Status ◽  
Genome Wide ◽  
Fat Soluble Vitamins

AbstractRapid advances in ‘omics’ technologies have paved the way forward to an era where more ‘precise’ approaches – ‘precision’ nutrition – which leverage data on genetic variability alongside the traditional indices, have been put forth as the state-of-the-art solution to redress the effects of malnutrition across the life course. We purport that this inference is premature and that it is imperative to first review and critique the existing evidence from large-scale epidemiological findings. We set out to provide a critical evaluation of findings from genome-wide association studies (GWAS) in the roadmap to precision nutrition, focusing on GWAS of micronutrient disposition. We found that a large number of loci associated with biomarkers of micronutrient status have been identified. Mean estimates of heritability of micronutrient status ranged between 20 and 35 % for minerals, 56–59 % for water-soluble and 30–70 % for fat-soluble vitamins. With some exceptions, the majority of the identified genetic variants explained little of the overall variance in status for each micronutrient, ranging between 1·3 and 8 % (minerals), <0·1–12 % (water-soluble) and 1·7–2·3 % for (fat-soluble) vitamins. However, GWAS have provided some novel insight into mechanisms that underpin variability in micronutrient status. Our findings highlight obvious gaps that need to be addressed if the full scope of precision nutrition is ever to be realised, including research aimed at (i) dissecting the genetic basis of micronutrient deficiencies or ‘response’ to intake/supplementation (ii) identifying trans-ethnic and ethnic-specific effects (iii) identifying gene–nutrient interactions for the purpose of unravelling molecular ‘behaviour’ in a range of environmental contexts.

scholarly journals FORMULATION AND OPTIMIZATION OF CELECOXIB NANOEMULGEL

2017 ◽  
Vol 10 (8) ◽  
pp. 353
Author(s):  
Sankha Bhattacharya ◽  
Bhupendra G Prajapati
Keyword(s):  
Ex Vivo ◽  
Skin Irritation ◽  
Scale Up ◽  
Pilot Scale ◽  
Water Soluble ◽  
Thaw Cycle ◽  
Diffusion Enhancement ◽  
Intrinsic Solubility ◽  
Almost All

Objective: The main objective of this experiment was to prepare and optimized celecoxib nanoemulgel. This formulation can be used for acuterheumatoid arthritis patients.Methods: Celecoxib is a poorly water soluble drug. We prepared celecoxib nanoemulgel to improve intrinsic solubility of celecoxib and enhancedeeper permeation throughout the skin. After several screening, the combination of acetonitrile, triacetin, campul 908P was considered for oil phase;acconon MC8-2EP as surfactant, and capmul MCM C-10 as a co-surfactant accordingly. As per Box-Behnken surface design model, optimization wasdone for all the 13 formulations.Results: Based on pseudo ternary plot, it was found that 4:1 Smix ratio was optimum and possessed maximum drug solubility. Further, screeningshown, 0.25-0.75% carbopol-940 can be a stable candidate for hydrogel preparation. Prepared nanoemulsions and hydrogels were admixed to preparenanoemulgel. Based on overlay plot, EG14* formulation was consider as optimum one, and various evaluation parameters were performed along withother formulations. Using Franz diffusion cell, in-vitro diffusion studies was performed. Almost all the formulations produces good qualitative drugrelease profile. The EG14* shown 95.50% drug release after 12th hrs with standard Higuchi plot (R2 value 0.9989). The optimum viscosity was foundto be 521±0.81 mPas at 100 rpm. The appearance of the formulations was milky, yellowish white with expectable pH ranged from 5.8 to 6.7. Theoptimized formulation has good spreadability coefficient, good ex-vivo diffusion enhancement factor (3.03) as compare to marketed gel. Mostly, ourformulations have less skin irritation and higher anti-inflammatory activity (92.56% of inhibition of paw edema for EG14*).Conclusion: From the thermodynamic studies, it was confirmed that EG14* maintained excellent stability profile in various heating-cooling cycle,centrifugation, and freeze-thaw cycle condition. Hence, it can be conclude that, our formulation, can be consider for pilot scale up.

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