scholarly journals Info-metric Methods for the Estimation of Models with Group-Specific Moment Conditions

2020 ◽  
pp. 349-384
Author(s):  
Martyn Andrews ◽  
Alastair R. Hall ◽  
Rabeya Khatoon ◽  
James Lincoln

Motivated by empirical analyses in economics using repeated cross-sectional data, we propose info-metric methods (IM) for estimation of the parameters of statistical models based on the information in population moment conditions that hold at group level. The info-metric estimation can be viewed as the primary approach to a constrained optimization. The estimators can also be obtained via the dual approach to this optimization, known as generalized empirical likelihood (GEL). In Andrews, Hall, Khatoon and Lincoln (2019), we provide a comprehensive framework for inference based on GEL with the grouped-specific moment conditions. In this chapter, we compare the computational requirements of the primary and dual approaches. We also describe the IM/GEL inference framework in the context of a linear regression model that is estimated using the information that the mean of the error is zero for each group. For the latter setting, we use analytical arguments and a small simulation study to compare the properties of IM/GEL-based inferences to those of inferences based on certain extant methods. The IM/GEL methods are illustrated through an application to estimation of the returns to education in which the groups are defined via information on family background.

2019 ◽  
Vol 2019 ◽  
pp. 1-9
Author(s):  
Tilahun Kassew ◽  
Demeke Demilew ◽  
Addis Birhanu ◽  
Mesele Wonde ◽  
Biks Liyew ◽  
...  

Background. Poor attitude towards antipsychotic drugs is high, and it is a factor for non-adherence to treatment. This increases the risk of relapse, associated healthcare utilization, and costs. This study aimed to assess attitude towards antipsychotic medication among patients with schizophrenia. Objectives. The aim of this institution based cross-sectional study was to assess attitude towards antipsychotic medications and associated factors among patients with schizophrenia who attend the outpatient clinics at Amanuel Mental Specialized Hospital, 2018. Methods. In a cross-sectional study, 393 schizophrenic patients from Amanuel Mental Specialized Hospital were recruited by a systematic random sampling technique. Drug Attitude Inventory (DAI-10) was used to assess attitude, experience, and belief about antipsychotics. Glasgow antipsychotic side effect scale modified version, positive and negative syndrome scale, and Birch wood’s insight scale for psychosis were the instruments used to assess the associated factors. Simple and multiple linear regression analysis models were fitted, and the adjusted unstandardized beta (β) coefficient at 95% confidence interval was used. Results. The mean score of attitude towards antipsychotic medications was 6.51 with standard deviation (SD) of 2.22. In multiple linear regression, positive symptoms (β= -0.07, 95% CI: (-0.09, -0.05)), negative symptoms (β= -0.04, 95% CI: (-0.06,-0.02)), shorter (≤5 years) duration of illness (β= -0.39, 95% CI: (-0.63, -0.15)), first generation antipsychotics (β = -0.35, 95% CI: (-0.55,-0.14)), having sedation (β= -0.28, 95% CI: (-0.52, -0.02)), and extra-pyramidal side effects (β= -0.34, 95% CI: (-0.59,-0.09)) were factors negatively associated with attitude towards antipsychotic medication treatment. Insight to illness (β= 0.24, 95% CI: (0.20, 0.27) was a factor positively associated with attitude towards antipsychotic medications. Conclusion. The result suggests that the mean score of participants’ attitude towards antipsychotic medications was good. Prevention of side effects particularly due to first generation antipsychotics is necessary.


2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Mineaki Kitamura ◽  
Yasushi Mochizuki ◽  
Tsuyoshi Matsuda ◽  
Yuta Mukae ◽  
Hiromi Nakanishi ◽  
...  

Abstract Background Higher serum uric acid (UA) levels are associated with poorer renal prognosis. In kidney transplantation, both donors and recipients are diagnosed as having chronic kidney diseases (CKD) based on renal function; however, their UA levels slightly vary. Elucidating the differences in UA would help improve kidney prognosis, especially for recipients. Therefore, we investigated UA levels in kidney transplant recipients by comparing them to those in their donors. Methods In this retrospective cross-sectional survey, background information and blood examination results were collected from the donors just before donation and after transplantation in the donors and recipients. Associations between UA and sex estimated glomerular filtration rate (eGFR), and body mass index (BMI) were evaluated. Data were assessed by the Wilcoxon rank-sum test for continuous variables and the chi-squared test for categorical variables; multiple linear regression analyses were performed to determine which factors were associated with renal function before and after transplantation. Results Participant characteristics were as follows. The mean donor age (n = 45, 16 men and 29 women) was 55 ± 11 years, and the mean recipient age (n = 45, 25 men and 20 women) was 46 ± 16 years. Sex-related differences (UA levels in men were predominant) existed in the UA of donors before (P < 0.001) and after donation (P < 0.001). Conversely, there were no significant sex-related differences in the UA of recipients (P = 0.51); the mean standardized eGFRs were similar in donors and recipients after transplantation. Multivariate linear regression analysis showed donor UA only correlated with donor sex before donation (P = 0.008). After donation, donor UA was associated with donor sex (P = 0.006), eGFR (P < 0.001), and BMI (P = 0.02). Notably, the UA of recipients after transplantation was only associated with eGFR (P = 0.003). Conclusions Sex has less impact on UA in recipients than in donors. UA has a greater impact on renal prognosis in women than men, even at the same UA level. Therefore, attention should be given to UA levels in female recipients. These findings can be useful for determining patient prognosis following kidney transplantation in both donors and recipients.


BMJ Open ◽  
2020 ◽  
Vol 10 (7) ◽  
pp. e035651
Author(s):  
Ayman Al-Dahshan ◽  
Mohamad Chehab ◽  
Mohamed Bala ◽  
Mieaad Omer ◽  
Omayma AlMohamed ◽  
...  

ObjectiveThe current study aimed to assess the awareness of colorectal cancer (CRC) symptoms and risk factors among the at-risk population visiting the primary healthcare (PHC) centres in Qatar. The secondary objective was to assess the differences in awareness among population subgroups.DesignA cross-sectional study design was employed.SettingThe study was conducted across six PHC centres in Qatar.ParticipantsPatients, or their accompanying people, aged 50–74 years and Arabic or English speakers, were recruited from the main waiting areas of the selected PHC centres.Data collection and analysisParticipants were interviewed using the validated Bowel/Colorectal Cancer Awareness Measure questionnaire. A non-probability convenient sampling technique was applied to recruit participants. Descriptive and analytic statistics were used when appropriate. A multivariate linear regression model was constructed to identify the independent predictors of CRC awareness.ResultsThe study includes 448 participants (response rate=87%). The mean age of the participants was 58.48 years (SD ±6.37). The mean awareness score among the participants was 3.63/9 (SD ±2.7) for CRC symptoms and 5.43/11 (SD ±3.3) for CRC risk factors. The overall mean awareness score was 9.03/20 (SD ±5.5). Multivariate linear regression identified the female gender (2.52 (95% CI 1.15 to 3.88)), non-Qatari Arab (2.91 (95% CI 1.64 to 4.18)) or non-Arab nationalities (1.76 (95% CI 0.28 to 3.24)), and tertiary education (4.10 (95% CI 2.55 to 5.66)) as independent predictors of higher CRC awareness.ConclusionIn general, the awareness of CRC symptoms and risk factors was low among the at-risk population in Qatar. Specifically, the regression analysis showed men, Qataris, and those with no formal education had low awareness of CRC symptoms and risk factors. Such results emphasise the importance of tailoring future educational campaigns that are relevant, specific and appealing to such cohort.


2019 ◽  
Vol 40 (5) ◽  
pp. 467-475 ◽  
Author(s):  
Jacob I Tower ◽  
Neil A Gordon ◽  
Boris Paskhover

Abstract Background Midfacial volumizing procedures are increasingly common in facial rejuvenation. However, the changes that occur in midfacial fat with aging are poorly understood. Objectives The aim of this study was to determine how deep cheek fat volume is predicted by age. Methods We conducted retrospective cross-sectional and longitudinal studies of patients based on facial computed tomography (CT) scans. In the cross-sectional cohort, multiple linear regression analysis was performed to model the relations between age and deep cheek fat volumes. In the longitudinal analysis, changes to deep cheek fat volumes were tracked among subjects who underwent multiple facial CT scans. Results The cross-sectional cohort comprised 109 patients. The mean (SD) age of the subjects was 59.7 (15.0) years (range, 21.7-91.1 years). A linear regression analysis showed that increasing age was associated with increasing deep cheek fat volume (β = 0.015, P &lt; 0.001). Additional regression analyses showed that the gain of fat with aging was more pronounced in the caudal aspect of the cheek (β = 0.007, P &lt; 0.001) than in the cephalad (β = 0.005, P &lt; 0.001). Twenty-three subjects were identified for longitudinal analysis. The mean (SD) ages at initial and final imaging time points were 50.0 (5.8) and 60.3 (5.2) years. In the deep fat compartment, there was an average gain of 0.23 mL over 10.3 years (P = 0.03). Conclusions Age is an important predictor of midfacial deep cheek fat volume. In this study, there is no evidence of adipose volume loss in the deep cheek compartment. Rather, aging was associated with an increase in deep cheek fat, possibly reflecting pseudoherniation of buccal fat. Level of Evidence 2


2017 ◽  
Vol 36 (8) ◽  
pp. 776-784
Author(s):  
AS Reece ◽  
A Norman ◽  
GK Hulse

Introduction: Despite an increasing awareness that the activity of excitable membranes is determined by the underlying ionic gradients across them, and their importance in drug dependency, we were not able to identify any reports of comparing the electrolyte composition of opioid-dependent and non-addicted controls. Methods: Linear regression was used to compare clinical pathology blood results taken from 2699 opioid-dependent patients (ODP) and 5307 medical control (MC) patients on a total of 21,734 occasions for the period 1995–2015. The presence of a hepatitis C antibody test was used to separate OPD and MC patients. Results: The mean age among ODP and MC was 33.51 ± 0.16 and 37.99 ± 0.23 years, respectively ( p < 0.0001). The groups were 71.5% and 54.2% male ( p < 0.0001). Drug use in this cohort has been reported previously. Analysis of sodium, haemoglobin and albumin were used to exclude marked effects of haemodilution/haemoconcentration. Repeated measures linear regression against age and time showed depressed levels of bicarbonate ( p < 0.0001) and potassium ( p < 0.05) and elevated levels of chloride ( p < 0.025) and anions ( p < 0.01) in ODP in both sexes. Multiple regression in mixed-effects models showed that these effects were all worse in females ( p = 0.0001). Conclusion: This data shows that opioid dependence is associated with significant changes in chloride, potassium, bicarbonate and anions in both sexes, and worse in females. This likely has implications for the electrophysiological properties of excitable membranes. It is consistent with the reported impairment of potassium-chloride exchangers in opioid dependence. Explication of the mechanisms responsible must await further studies.


2017 ◽  
Vol 80 (10) ◽  
pp. 587-595 ◽  
Author(s):  
Laura Comber ◽  
Susan Coote ◽  
Marcia Finlayson ◽  
Rose Galvin ◽  
Gillian Quinn ◽  
...  

Introduction Psychosocial contributors to fall risk for people with multiple sclerosis are often overlooked in falls prevention practice. This study explored several fall-related, psychosocial variables and their association with falls self-efficacy in a sample of people with multiple sclerosis reporting a fall. Method A cross-sectional, structured telephone survey was employed. The survey explored socio-demographics, multiple sclerosis characteristics, and fall-related psychosocial variables. Multiple linear regression was employed to investigate associations with Falls Efficacy Scale – International scores. Results The mean Falls Efficacy Scale – International score for 140 participants was 38.14(SD = 10.16), and the mean Falls Control Scale score was 5.38(SD = 2.22). Fear of falling was expressed by 129 (92%) participants, with 111 (79%) reporting associated activity curtailment. A regression model including six predictors explained 47% of the variance in the Falls Efficacy Scale – International scores. Results of the multiple linear regression showed that fear of falling, associated activity curtailment, balance interference, falls control, and health status were associated with falls self-efficacy. Conclusion Fear of falling and associated activity curtailment, low falls self-efficacy, and compromised falls control are common among people with multiple sclerosis who have fallen. These fall-related psychosocial variables are distinct and each warrants attention during assessment. Findings suggest that falls self-efficacy among people with multiple sclerosis who have fallen is a complex construct associated with physical and psychosocial factors.


2010 ◽  
Vol 50 (2) ◽  
pp. 67 ◽  
Author(s):  
Markus Gunawan ◽  
Soetjiningsih Soetjiningsih ◽  
I Made Kardana

AbstractBackground Rectal mercury thermometer (RT) has beenconsidered to be a clinical thermometer that measures bodytemperature close to core temperature. Unfortunately it is relativelyuncomfortable to the patient. Axillary mercury thermometer (AT)is a relatively safe method, but time consuming and its accuracyhas been questioned. Temporal artery thermometer (TAT) isrelatively a new method that can measure body temperaturefaster, and well tolerated.Objective To compare the accuracy of temperature measurementbetween TAT and AT in neonates.Methods Cross-sectional analytic study was conducted atNeonatology Division at Sanglah Hospital, Denpasar. Every healthyterm newborn who met the criteria were measured their bodytemperature by using three kinds of thermometer consecutively. Thelimits of agreement, correlation and linear regression analysis weredone to find TAT and AT’s agreement and correlation to RT.Results One hundred and thirty four newborns were enrolledin this study. TAT had a better agreement to RT with the mean􀁇􀁌􀁉􀁉􀁈􀁕􀁈􀁑􀁆􀁈􀀃􀁒􀁉􀀃􀀐􀀓􀀑􀀓􀀔􀂞􀀦􀀃􀁚􀁌􀁗􀁋􀀃􀀕􀀃􀀶􀀧􀀃􀁏􀁒􀁚􀁈􀁕􀀃􀁏􀁌􀁐􀁌􀁗􀀃􀁒􀁉􀀃􀀐􀀓􀀑􀀕􀀙􀂞􀀦􀀃􀁄􀁑􀁇􀀃􀁘􀁓􀁓􀁈􀁕􀀃􀁏􀁌􀁐􀁌􀁗􀀃􀁒􀁉􀀃􀀓􀀑􀀕􀀖􀂞􀀦􀀏􀀃􀁆􀁒􀁐􀁓􀁄􀁕􀁈􀁇􀀃􀁗􀁒􀀃􀁄􀁊􀁕􀁈􀁈􀁐􀁈􀁑􀁗􀀃􀁅􀁈􀁗􀁚􀁈􀁈􀁑􀀃􀀤􀀷􀀃􀁄􀁑􀁇􀀃􀀵􀀷􀀏􀀃􀁚􀁌􀁗􀁋􀀃􀁐􀁈􀁄􀁑􀀃􀁇􀁌􀁉􀁉􀁈􀁕􀁈􀁑􀁆􀁈􀀃􀀐􀀓􀀑􀀖􀀘􀂞􀀦􀀏􀀃􀀕􀀃􀀶􀀧􀀃􀁏􀁒􀁚􀁈􀁕􀀃􀁏􀁌􀁐􀁌􀁗􀀃􀀐􀀓􀀑􀀚􀀓􀂞􀀦􀀃􀁄􀁑􀁇􀀃􀁘􀁓􀁓􀁈􀁕􀀃􀁏􀁌􀁐􀁌􀁗􀀃􀁒􀁉􀀃􀀓􀀑􀀓􀀓􀂞􀀦􀀑􀀃􀀷􀁋􀁈􀁕􀁈􀀃􀁚􀁄􀁖􀀃􀁄􀀃􀁖􀁌􀁊􀁑􀁌􀁉􀁌􀁆􀁄􀁑􀁗􀀃􀁏􀁌􀁑􀁈􀁄􀁕􀀃􀁄􀁖􀁖􀁒􀁆􀁌􀁄􀁗􀁌􀁒􀁑􀀃􀁅􀁈􀁗􀁚􀁈􀁈􀁑􀀃􀀷􀀤􀀷􀀃and RT with correlation coefficient 􀁕􀀃􀀠􀀃􀀓􀀑􀀛􀀚􀀃􀀋􀁓􀀟􀀓􀀑􀀓􀀓􀀔􀀌􀀏􀀃􀁌􀁑􀁗􀁈􀁕􀁆􀁈􀁓􀁗􀀃􀀓􀀑􀀜􀀛􀀚􀀃􀁄􀁑􀁇􀀃􀁖􀁏􀁒􀁓􀁈􀀃􀀓􀀑􀀘􀀓􀀜􀀑􀀃􀀷􀁋􀁈􀀃􀁏􀁌􀁑􀁈􀁄􀁕􀀃􀁄􀁖􀁖􀁒􀁆􀁌􀁄􀁗􀁌􀁒􀁑􀀃􀁅􀁈􀁗􀁚􀁈􀁈􀁑􀀃􀀤􀀷􀀃􀁄􀁑􀁇􀀃􀀵􀀷􀀃􀁖􀁋􀁒􀁚􀁈􀁇􀀃􀁗􀁋􀁈􀀃􀁆􀁒􀁕􀁕􀁈􀁏􀁄􀁗􀁌􀁒􀁑􀀃􀁆􀁒􀁈􀁉􀁉􀁌􀁆􀁌􀁈􀁑􀁗􀀃􀁕􀀃􀀠􀀃􀀓􀀑􀀚􀀙􀀃􀀋􀁓􀀟􀀓􀀑􀀓􀀓􀀔􀀌􀀏􀀃􀁌􀁑􀁗􀁈􀁕􀁆􀁈􀁓􀁗􀀃􀀔􀀓􀀏􀀕􀀚􀀔􀀃􀁇􀁄􀁑􀀃􀁖􀁏􀁒􀁓􀁈􀀃􀀓􀀏􀀚􀀖􀀓􀀑Conclusion TAT is more accurate than AT for body temperaturemeasurement in the healthy term newborns. [Paediatr Indones.2010;50:67-72].


1990 ◽  
Vol 2 ◽  
pp. 75-96
Author(s):  
Walter R. Mebane

Ordinary intuition about the relative exogeneity of demographic variables in a linear regression model is used to illustrate a general problem that can arise in statistical models for purely cross-sectional surveys: while the model that represents intuition is compatible with formal exogeneity criteria, the compatibility depends on information about variation over time with respect to each individual that a purely cross-sectional data collection lacks. That lack of information implies that the model usually used to represent the effects of demographic variables in cross-sectional surveys is seriously misspecified. The same limitation affects any specification motivated by ideas about temporal processes. The assumptions needed to translate ideas about temporal processes into a purely cross-sectional model are then identified, and found to include incredibly strong assumptions of homogeneity and stationarity. The difficulty of the assumptions appearing to be so extreme, the discussion then considers the possibility of a concept of causality that does not rely on variation over time, by briefly examining Lewin's field theory. The extent to which current survey practice draws on temporal ideas even in pure cross-sections is then indicated, with reference to The American Voter's image of a “funnel of causality.”


2004 ◽  
Vol 20 (4) ◽  
pp. 227-236 ◽  
Author(s):  
Sara Holmberg ◽  
Anders Thelin ◽  
Eva-Lena Stiernström

Summary: The concept of “sense of coherence” (SOC) has been widely recognized since it was first introduced by Antonovsky. The originality and usefulness of the SOC scale and its relation to other psychosocial measures has been the subject of lively debate. The aim of this paper was to test for associations between SOC and work-related psychosocial factors (mainly the Job Demand-Control model), general living conditions, education, and social network factors. Cross-sectional data from a population-based sample of 1782 rural males from nine counties in Sweden were analyzed with a multiple regression technique. The subjects were occupationally active at inclusion and the mean age was 50 years (range 40-60). SOC was assessed with the original 29-item questionnaire. Psychosocial variables and lifestyle factors were assessed using questionnaires and structured interviews. The mean SOC among the subjects was 152.3 (standard deviation, 19.4). A strong negative correlation was found between SOC and job demand, whereas a positive correlation with job control was demonstrated. A positive correlation with general living conditions and with social support was also found. However, there was no correlation to education and occupation. Thus, SOC was shown to be strongly correlated to work-related psychosocial factors and social support, but independent of sociodemographic factors.


1970 ◽  
Vol 4 (2) ◽  
pp. 74-77
Author(s):  
Rukshana Ahmed ◽  
Shamim Ara

Pathological changes in the prostate gland occur commonly with advancing age including inflammation, atrophy, hyperplasia and carcinoma and a change in volume is also evident. Estimation of volume of prostate may be useful in a variety of clinical settings. A cross-sectional descriptive study was designed to see the changes in volume of the prostate with advancing age and done in the Department of Anatomy, Dhaka Medical College, Dhaka from August 2006 to June 2007. The study was performed on 70 post-mortem human prostates collected from the unclaimed dead bodies that were under examination in the Department of Forensic Medicine, Dhaka Medical College, Dhaka. The samples were divided into three age groups; group A (10-20 years), group B (21-40 years) and group C (41-70 years). Volume of the sample was measured by using the ellipsoid formula. The mean ± SD volume of prostate was 7.68 ± 3.64 cm3 in group A, 10.61 ± 3.99 cm3 in group B and 15.40 ± 6.31 cm3 in group C. Mean difference in volume between group A and group C, group B and group C were statistically significant (p<0.001). Statistically significant positive correlation was found between age and volume of prostate (r = + 0.579, p < 0.001). Key Words: Prostate; volume; Bangladeshi. DOI: 10.3329/imcj.v4i2.6501Ibrahim Med. Coll. J. 2010; 4(2): 74-77


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