Clinical Chemistry
With so many tests available and increasingly fast laboratory processors, there is a growing temptation to request large numbers of blood tests on each and every patient. What we should remember is that they should be used as an adjunct to the history and clinical examination. Test results should reinforce the likely diagnosis and rule out our differentials, rather than be used to try and make the diagnosis per se. What makes things easier is to know how serum biochemistry and homeostasis are regulated and then to consider a number of questions: ● Which hormones are involved in the control of this electrolyte? ● What happens when these are increased or decreased? ● Does the patient have any renal or hepatic impairment? ● Are they taking any drugs that might be affecting serum electrolyte levels? ● Have they taken an overdose? ● Is the patient dehydrated/ hypovolaemic/ hypoxic? It can seem daunting at first when results come back unexpectedly out of range. They must be considered in combination with the patient’s clinical status; if the numbers just do not fit, then repeat the test— they may not be right. However, there are a few ‘unmissable’ electrolyte derangements that need to be dealt with immediately. Once detected, they should trigger the thoughts shown in Table 12.1. Interpreting serum values is important, but to prevent iatrogenic derangement, careful use and prescription of intravenous fluids are also needed. Does a patient who looks hypovolaemic, has a low blood pressure, and is tachycardic need crystalloids or blood? Colloids, such as ‘Gelofusine®’ or ‘Volplex®’, are now largely out of date, with evidence not supporting their use. Are they frail or do they have cardiac failure and therefore require cautious replacement? Do they have liver failure? Is their fluid balance so critical that close fluid monitoring in a level 2 critical care setting required? Gone are the days when central venous lines are used on the wards for fluid balance. This chapter will help consideration of the whole picture before putting pen to paper and (potentially) wrongly prescribing 4 L of fluids a day for a frail older man with left ventricular failure.