scholarly journals 0040 Relationship Between Inflammatory Markers and Sleep in Healthy Adolescents

SLEEP ◽  
2020 ◽  
Vol 43 (Supplement_1) ◽  
pp. A16-A16
Author(s):  
A Reddy ◽  
L Li
Keyword(s):  
Sleep Quality ◽  
Inflammatory Markers ◽  
Kidney Diseases ◽  
Pearson Correlation ◽  
Research Center ◽  
Inflammatory Factors ◽  
Poor Sleep ◽  
Diabetes Research ◽  
Hyperactive Behavior ◽  
Tnf Α

Abstract Introduction Multiple studies in different countries show a trend of adolescents having insufficient sleep. Review of literature strongly suggests role of cytokines in sleep regulation. Different inflammatory markers like tumor necrosis factor (TNF)α, C-reactive protein (CRP) and interleukins (IL) are sleep regulatory substances. Most of the studies showing relation between cytokines and sleep are seen in adults. In our study, we were interested in finding the relationship between sleep quality and inflammatory markers in healthy adolescents. Methods Twenty eight female and male, African American and White, healthy adolescents aged 15–18 completed the study. Sleep quality was measured using the Pediatric Sleep Questionnaires (PSQ), including snoring, daytime sleepiness and hyperactive behavior. Blood sample was collected from each participant for measuring the inflammatory factors. Results Partial Pearson correlation analysis showed that global PSQ score and hyperactive behavior were significantly correlated with TNF α (r=0.37 for both). Snoring was significantly correlated with leptin, CRP and IL-6 in healthy adolescents. No other correlations were observed. Conclusion Consistent with findings in adults, we have observed an association between inflammatory markers and poor sleep in healthy adolescents. Our findings suggest the importance to improve sleep quality in adolescents for better health outcomes. Support None of the authors have any conflict of interest. This research was supported by awards, P30DK056336 and P30DK079626, from the National Institute of Diabetes And Digestive And Kidney Diseases to Nutrition Obesity Research Center and Diabetes Research Center, respectively, at the University of Alabama at Birmingham.

scholarly journals Selected Clinical Features Fail to Predict Inflammatory Gene Expressions for TNF-α, TNFR1, NSMAF, Casp3 and IL-8 in Tendons of Patients with Rotator Cuff Tendinopathy

2021 ◽  
Vol 69 (1) ◽  
Author(s):  
Slawomir Struzik ◽  
Bozena Czarkowska-Paczek ◽  
Aleksandra Wyczalkowska-Tomasik ◽  
Paweł Maldyk ◽  
Leszek Paczek
Keyword(s):  
Gene Expression ◽  
Rotator Cuff ◽  
Pearson Correlation ◽  
Previous Treatment ◽  
Inflammatory Factors ◽  
Shoulder Injury ◽  
Rt Pcr ◽  
Gene Expressions ◽  
Tnf Α ◽  
Rotator Cuff Tendinopathy

AbstractThe pathophysiology of rotator cuff tendinopathy is not fully understood, particularly in terms of the local inflammatory process. This study aimed to investigate the expression of selected molecules in the tumour necrosis factor (TNF)-α transduction pathway, including TNF-α, TNF receptor 1 (TNFR1), neutral sphingomyelinase activation associated factor (NSMAF), caspase 3 (Casp3), and interleukin (IL)-8, in patients with rotator cuff tendinopathy that had undergone surgical treatment. We included 44 participants that underwent arthroscopy, due to rotator cuff tendinopathy. Samples from the injured tendon were collected during arthroscopy, and RT-PCR was performed to determine gene expression. Pearson correlation analyses or U-Mann–Whitney test were performed to identify associations with the following parameters: sex, age at admission, body mass index, the presence of night pain, previous treatment (nonsteroidal anti-inflammatory drugs and/or steroids), medical history of the shoulder injury, upper subluxation of the humeral head, and the number of tendons injured. RT-PCR showed that the selected pro-inflammatory factors involved in the TNF-α signalling pathway expression levels were expressed in the tendon tissues. However, the levels of expression varied from patient to patient. Variations were over 250-fold for TNF-α, about 130-fold for TNFR1, NSMAF, and Casp3, and 1000-fold for IL-8. We could not confirm that any of the clinical parameters investigated were associated with the level of gene expression in the TNF-α pathway and IL-8.

scholarly journals Salivary Inflammatory Molecules as Biomarkers of Sleep Alterations: A Scoping Review

Diagnostics ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 278
Author(s):  
Vanessa Ibáñez-del Valle ◽  
Rut Navarro-Martínez ◽  
Maria Luisa Ballestar-Tarín ◽  
Omar Cauli
Keyword(s):  
Sleep Quality ◽  
Sleep Disorders ◽  
Scoping Review ◽  
Inflammatory Markers ◽  
Healthy Subjects ◽  
Adult Population ◽  
Current Evidence ◽  
Poor Sleep ◽  
Necrosis Factor Alpha ◽  
The Relationship

Poor sleep quality and sleep disorders are the most common problems in people, affecting health-related quality of life. Various studies show an association between sleep disorders and altered levels of stress hormones and inflammatory cytokines measured in saliva. The main objective of this article is to provide an analysis of the current evidence related to changes in inflammatory markers in the saliva and their associations with sleep quality measurement (both objective and subjective methods) in healthy subjects and in sleep-related disorders. To that end, a scoping review was carried out, following the PRISMA criteria in the bibliographic search in several databases: PubMed, EBSCO, and SCOPUS. Eleven of the articles are from the adult population and two from the child-youth population. They mainly measure the relationship between sleep and interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNFα) alpha, as well as other inflammatory markers such as myeloperoxidase (MPO) and prostaglandin-endoperoxide synthase 2. An analysis shows the relationship between these salivary biomarkers and sleep quality, especially in the case of IL-6 in both healthy subjects and several pathologies associated with sleep-disorders. The results for TNFα and IL-1β measurements are still inconclusive and the difference with IL-6 was assessed. Two studies reported interventions that result in sleep improvement and are accompanied by the normalization of inflammatory changes detected in the saliva. As it is an easy-to-apply and non-invasive method, the measurement of salivary cytokines can be very useful in chronobiology studies. Further studies are required to determine the sensitivity of salivary inflammatory markers in monitoring biological rhythms and acting as biomarkers in the detection of sleep disorders and sleep interventions.

380 The role of self-esteem and sleep on inflammatory markers in young adults

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A151-A151
Author(s):  
Emily Squyres ◽  
Danica Slavish ◽  
Jennifer Graham-Engeland
Keyword(s):  
Young Adults ◽  
Sleep Quality ◽  
Inflammatory Markers ◽  
Sleep Disturbances ◽  
Short Form ◽  
Self Esteem ◽  
Coping Resources ◽  
Poor Sleep ◽  
Blood Draw ◽  
Disturbed Sleep

Abstract Introduction Disturbed sleep is common among young adults and is associated with poorer health and developmental outcomes. A large percentage of young adults also struggle with low self-esteem. Together, disturbed sleep and low self-esteem may deplete coping resources, heighten to reactivity to stress, and increase disease risk. Yet no studies to our knowledge have examined interactions between self-esteem and sleep on biomarkers of health among young adults. Methods To address this gap, we investigated associations between sleep quality, self-esteem, and two inflammatory markers, C-reactive protein (CRP) and interleukin-6 (IL-6), in a sample of 60 young adults (mean age 25.3 ± 4.0 years old, 53% female, 83% White). Participants completed a baseline survey to assess self-esteem (Rosenberg Self-Esteem Questionnaire) and sleep quality (Pittsburgh Sleep Quality Index [PSQI] sleep quality item), followed by 14 days of self-reported sleep disturbances each morning (PROMISTM sleep disturbances short-form; averaged across the 14 days). A plasma blood draw was then collected to assess CRP and IL-6 approximately one week after the end of the daily portion. Results Lower self-esteem (b = -0.04, 95%CI [-0.06,-0.01], p = 0.015) and lower sleep quality were each associated with higher CRP (b = -0.34, 95%CI [-0.62, -0.07], p = 0.015), but not IL-6. Greater daily sleep disturbances were marginally associated with higher CRP (b = 0.37, 95%CI [-0.06,-0.79], p = 0.088]. Interactions between self-esteem and either sleep quality or sleep disturbances did not predict CRP or IL-6. Conclusion Our results suggest low self-esteem and poorer sleep are each associated with higher levels of inflammation but may not interact to exacerbate risk. It is possible low self-esteem and poor sleep each lead to negative emotions or engagement in risky behaviors (e.g., substance use, sedentary behavior) that impact levels of inflammatory markers. Overall, our results highlight the importance of assessing both sleep and personality traits in relation to biomarkers of health among young adults. Support (if any) American Psychological Association Dissertation Research Award

Curcumin Nanomicelle Improves Lipid Profile, Stress Oxidative Factors and Inflammatory Markers in Patients Undergoing Coronary Elective Angioplasty; A Randomized Clinical Trial

2021 ◽  
Vol 21 ◽  
Author(s):  
Bijan Helli ◽  
Hadis Gerami ◽  
Maria Kavianpour ◽  
Habib Heybar ◽  
Seyed Kianoosh Hosseini ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Lipid Profile ◽  
Inflammatory Markers ◽  
Interleukin 1 ◽  
Stress Factors ◽  
Inflammatory Factors ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Tnf Α

Background: Curcumin demonstrated many pharmacological effects including antioxidants, anti-inflammation, eliminating free radicals, anti-tumor, lipid regulation, and anti-coagulation. Objective: This study aimed to assess and compare curcumin and nano-curcumin effects on lipid profile, oxidative stress, and inflammatory factors related to patients ‘heart. Method: This randomized, double-blind, placebo-controlled clinical trial was conducted on 90 patients undergoing coronary elective angioplasty which were randomly divided into 3 groups. The doses administered for 8 weeks were a 500 mg capsule of curcumin daily for the first group and an 80 mg capsule of nano-curcumin for the second group. However, the placebo group received capsules like curcumin. Lipid profile, oxidative stress factors, and inflammatory markers were measured at the baseline and end of the experiment. Results: Statistically significant changes were observed in the total cholesterol (TC), triacylglycerol (TG) and low-density lipoprotein cholesterol (LDL-C) in the intervention groups to the control group (p<0.05). Curcumin and nano-curcumin supplementation also improved significant changes in plasma levels of total antioxidant capacity (TAC), malondialdehyde (MDA), Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), high-sensitivity C-reactive protein (hs-CRP), Interleukin 1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) in comparison to the placebo (p<0.05). Furthermore, the nano-curcumin group compared to the curcumin group demonstrated significant changes (p<0.05) in TC, TG, SOD, MDA and TNF-α levels. Conclusion: The effects of curcumin on nano formula may be better for cardiac patients due to its high bioavailability.

scholarly journals The Correlation Between Fatigue and Sleep Quality among Patients with Heart Failure

2018 ◽  
Vol 3 (2) ◽  
pp. 100 ◽  
Author(s):  
Ferdy Lainsamputty ◽  
Hsing-Mei Chen
Keyword(s):  
Heart Failure ◽  
Sleep Quality ◽  
Medical Center ◽  
Pearson Correlation ◽  
Hypertensive Heart Disease ◽  
Renal Diseases ◽  
Poor Sleep ◽  
Poor Sleep Quality ◽  
Cross Sectional ◽  
The Mean

Heart failure (HF) patients may experience fatigue and poor sleep quality due to impairment in cardiac structure or function. These distressing symptoms may create a vicious circle leading to poor outcomes but often undervalued and ignored among patients. This study aimed to investigate the relationship between fatigue and sleep quality among patients with HF in Indonesia. A cross-sectional, correlational study design was performed with 153 convenience samples recruited from a cardiology outpatient department at a medical center in Indonesia. Descriptive statistics, bivariate analyses (independent t-tests, one-way Analysis of Variance, and Pearson correlation), and hierarchical regression analysis were utilized to analyze the data. Instruments included demographic characteristics and clinical variables questionnaire, the Multidimensional Assessment of Fatigue (MAF), and the Pittsburgh Sleep Quality Index (PSQI). The mean age of participants was 61.86±10.79 years old and the mean duration of HF diagnosis was 4.26±5.48 years. All participants complained of fatigue, while 73.2% had poor sleep quality. Participants who were poor sleepers had a higher proportion of individuals used massage, not having taken dyslipidemia drugs, had normotension or well-controlled blood pressure, and suffered from hypertensive heart disease (HHD) and renal diseases. All fatigue domains, except the degree of interference in ADL, was significantly associated with sleep quality. However, only the timing domain determined sleep quality, meaning, the longer the fatigue, the poorer the sleep quality. This study suggests future interventions should be directed to decrease the level of severity, distress reduction, and particularly shorten fatigue duration should be developed to improve the sleep quality.

scholarly journals Identification of inflammatory markers in eosinophilic cells of the immune system: fluorescence, Raman and CARS imaging can recognize markers but differently

2021 ◽  
Author(s):  
Aleksandra Borek-Dorosz ◽  
Marek Grosicki ◽  
Jakub Dybas ◽  
Ewelina Matuszyk ◽  
Marko Rodewald ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Inflammatory Process ◽  
Inflammatory Factors ◽  
Signalling Pathways ◽  
Tnf Α ◽  
Eosinophilic Cell ◽  
Cars Microscopy ◽  
Lipid Unsaturation ◽  
Anti Stokes ◽  
Stimulation Of

AbstractEosinophils (Eos) play an important role in the immune system’s response releasing several inflammatory factors and contributing to allergic rhinitis, asthma, or atopic dermatitis. Since Eos have a relatively short lifetime after isolation from blood, usually eosinophilic cell line (EoL-1) is used to study mechanisms of their activation and to test therapies. In particular, EoL-1 cells are examined in terms of signalling pathways of the inflammatory response manifested by the presence of lipid bodies (LBs). Here we examined the differences in response to inflammation modelled by various factors, between isolated human eosinophils and EoL-1 cells, as manifested in the number and chemical composition of LBs. The analysis was performed using fluorescence, Raman, and coherent anti-Stokes Raman scattering (CARS) microscopy, which recognised the inflammatory process in the cells, but it is manifested slightly differently depending on the method used. We showed that unstimulated EoL-1 cells, compared to isolated eosinophils, contained more LBs, displayed different nucleus morphology and did not have eosinophilic peroxidase (EPO). In EoL-1 cells stimulated with various proinflammatory agents, including butyric acid (BA), liposaccharide (LPS), or cytokines (IL-1β, TNF-α), an increased production of LBs with a various degree of lipid unsaturation was observed in spontaneous Raman spectra. Furthermore, stimulation of EoL-1 cells resulted in alterations of the LBs morphology. In conclusion, a level of lipid unsaturation and eosinophilic peroxidase as well as LBs distribution among cell population mainly accounted for the biochemistry of eosinophils upon inflammation.

scholarly journals EVALUATION OF A CORRELATION BETWEEN SLEEP HOURS, SLEEP QUALITY AND SALIVARY LEVELS OF 8-HYDROXY-2'-DEOXYGUANOSINE IN CHRONIC PERIODONTITIS PATIENTS- AN OBSERVATIONAL STUDY

2020 ◽  
pp. 1-4
Author(s):  
Ayswaria B ◽  
Mathew John ◽  
Sabari Chandramohan ◽  
Bindu Rachel Thomas ◽  
Aswathy S ◽  
...  
Keyword(s):  
Statistical Analysis ◽  
Sleep Quality ◽  
Chronic Periodontitis ◽  
Pearson Correlation ◽  
Tertiary Care ◽  
Poor Quality ◽  
Poor Sleep ◽  
Pocket Depth ◽  
Clinical Attachment Loss ◽  
Validated Questionnaire

Aims: To determine if there was a correlation between sleep hours, sleep quality with the salivary levels of 8-hydroxy-2’-deoxyguanosine in chronic periodontitis patients, and to decide its relationship with the established clinical periodontal parameters. Settings and Design: Observational analytical study with 100 patients based on the inclusion criteria, who visited the Department of Periodontology of a tertiary care setting. Methods and Material: Bleeding on probing, pocket depth, clinical attachment loss, plaque index score were recorded. Sleep behaviour longer than a month time stretch was surveyed by Pittsburgh Sleep Quality Index, a validated questionnaire. 8-OHdG levels in un-stimulated saliva of all subjects were examined by ELISA. Statistical analysis used: Sleep-hour correlations with sleep quality at salivary 8-OHdG levels as well as clinical periodontal parameters were assessed using the Pearson correlation coefficient. All statistical analysis was performed using SPSS software version 17.0. Results: Salivary 8-OHdG levels and clinical parameters (PPD, CAL, PI) were significantly higher among sleep deprived individuals. On comparison, subjects with a poor quality of sleep (PSQI score>5) showed a significantly higher 8-OHdG levels. Conclusions: Short sleep durations and poor sleep quality can instigate inflammation and oxidative stress and could be a risk factor for periodontitis.

scholarly journals Research Article. Comparative Analysis of Hepcidin-25 and Inflammatory Markers in Patients with Chronic Kidney Disease with and without Anemia

2017 ◽  
Vol 63 (1) ◽  
pp. 10-14 ◽  
Author(s):  
Carmen Denise Căldăraru ◽  
Dorin Ionuţ Tarta ◽  
Mirela Liana Gliga ◽  
Cristina Tarta ◽  
Emilian Caraşca ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Inflammatory Markers ◽  
Pearson Correlation ◽  
Linear Regression Analysis ◽  
Regulatory Protein ◽  
Inclusion Criteria ◽  
Exclusion Criteria ◽  
Tnf Α ◽  
Serum Hepcidin

Abstract Introduction: Hepcidin is a regulatory protein in iron metabolism; we do not know the role in chronic kidney disease anemia. Methods: 22 patients with CKD anemia and 15 patients with CKD without anemia were investigated. CKD anemia-inclusion criteria: over 18 years, hemoglobin ≤12 g/dl for women and ≤13 g/dl for men, no treatment for anemia 6 months before enrollment, glomerular filtration rate (eGFR) <60 ml/min/1.73m2 and stable creatinine three months before enrollment. Exclusion criteria: infection, bleeding, malignancy, systemic or liver disease, immunosuppression, renal replacement therapy. CKD without anemia-inclusion criteria: over 18 years, no anemia or treatment for anemia, CKD with stable creatinine values three months before enrollment. Exclusion criteria: medical conditions known to have a role in the development of polycythemia. Hepcidin-25 and ferritin were measured by ELISA method. Erythropoietin (EPO), tumor necrosis factor (TNF)-α, interleukin (IL)-6 were evaluated using chemiluminescent enzyme immunometric assays. Unpaired T test, Pearson correlation and multiple regression were used for statistical analysis. Results: Hemoglobin values were significantly lower in anemia group. There were no differences in terms of eGFR, age, body mass index, serum hepcidin, erythropoietin, fibrinogen, IL-6, and TNF-α between CKD patients with and without anemia. Serum hepcidin correlated positively with ferritin (r=0.45 p<0.05), TNF-α (r=0.54, p<0.05) and negatively with erythropoietin (r=-0.51, p<0.05). Multiple linear regression analysis demonstrated that TNF-α is an independent predictor of serum hepcidin in our patients (p=0.003, R=0.71). Conclusion: We found no differences in serum hepcidin, erythropoietin and inflammatory markers in non-dialysis CKD patients with and without anemia.

018 The Role of Inflammatory Markers in Sleep in Individuals Post-Myocardial Infarction

SLEEP ◽  
2021 ◽  
Vol 44 (Supplement_2) ◽  
pp. A9-A9
Author(s):  
Sophie Hirsch ◽  
Jane Gaultney ◽  
Patricia Crane
Keyword(s):  
Myocardial Infarction ◽  
Sleep Quality ◽  
Inflammatory Markers ◽  
Inflammatory Marker ◽  
Lifestyle Changes ◽  
Post Myocardial Infarction ◽  
Poor Sleep ◽  
Necrosis Factor Alpha ◽  
Markers Of Inflammation

Abstract Introduction Despite positive secondary prevention strategies post myocardial infarction (MI), including statin use and lifestyle changes, 32% of the annual MIs are recurrent (MIR). As coronary heart disease is related to atherosclerosis, a chronic inflammatory process, and sleep is associated with cardiovascular disease and innate immunity, understanding the role of sleep and inflammation and MIR is important in developing interventions to improve sleep, reduce inflammation, and delay or prevent MIR. This study aimed to explore the role of sleep quality and inflammatory markers on MIRs. Methods We conducted a secondary analysis of cross-sectional data of individuals (N=156) having at least one or more MIs within the last 3 to 7 years. Using the hypothalamus-pituitary-adrenal axis model (Irwin, 2019), we tested sleep quality (Pittsburgh Sleep Quality Index [PSQI]) predicting MIR, using inflammatory markers (hs C-Reactor Protein [CRP], Interleukin-1ß [IL-1ß] and Tumor Necrosis Factor alpha [TNFα]) as the simultaneous indirect paths. Race, sex and body mass index (BMI) were also examined using moderated mediation. Results The sample ranged in age from 34 to 92 (M = 65.37, SD = 12.13), BMI averaged 31.11 (SD = 7.34), and was comprised of mostly male (57.1%) and White adults (67.9%). PSQI predicted only IL-1ß (ß= .02; p &lt; .01). IL-1ß predicted MIR (ß = .80, p = .05). The direct effect of PSQI to MIR was not significant (p =.12), the indirect path via IL-1ß was. This relationship was not moderated by race, sex, nor BMI. Conclusion IL-1ß is an inflammatory marker elevated after acute MI which does not reflect our selected sample. Inflammation may be an important marker of risk for MIR in those with poor sleep quality. Future studies should examine other markers of inflammation and sleep in those with MIR. Support (if any):

scholarly journals Smartphone Addiction and Sleep Quality on Academic Performance of University Students: An Exploratory Research

2021 ◽  
Vol 18 (16) ◽  
pp. 8291
Author(s):  
Balan Rathakrishnan ◽  
Soon Singh Bikar Singh ◽  
Mohammad Rahim Kamaluddin ◽  
Azizi Yahaya ◽  
Mohd Azrin Mohd Nasir ◽  
...  
Keyword(s):  
Academic Performance ◽  
University Students ◽  
Sleep Quality ◽  
Pearson Correlation ◽  
Smartphone Addiction ◽  
Short Version ◽  
Poor Sleep ◽  
Exploratory Research ◽  
Poor Sleep Quality ◽  
The Relationship

This study was conducted to examine the relationship between smartphone addiction, sleep quality, and academic performance. The study presented quantitative research on 323 students in a public university in Sabah to explore the relationship between smartphone addiction, sleep quality, and academic performance. A simple random sampling was used in the study. The Smartphone Addiction Scale Short Version (SAS-SV) and the Pittsburgh Sleep Quality Index (PSQI) were used in this study. SPSS was used as a tool of analysis for descriptive and inferential analysis. Pearson correlation was involved to test the hypothesis of the study. The result indicated that the greater the smartphone addiction, the lower the academic performance of university students. The finding also proved that students with poor sleep quality might exhibit low academic performance. Smartphone addiction was found to be associated with sleep quality where overusing smartphones was related to poor sleep quality in university students. On this basis, the problem of smartphone addiction and sleep quality should be tackled in order to improve the academic performance of university students and their overall health.

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