Rest activity rhythms characteristics of breast cancer women following endocrine therapy

SLEEP ◽  
2021 ◽  
Author(s):  
T Martin ◽  
M Duivon ◽  
N Bessot ◽  
J M Grellard ◽  
G Emile ◽  
...  

Abstract Rest-activity rhythm (RAR) disruptions are frequently associated with chemotherapy in breast cancer (BC), but they are less known in BC with endocrine therapy. The aim of this ancillary study was to characterize the RAR and estimated sleep characteristics from actigraphy in BC patients either treated (ET+) or untreated with endocrine therapy (ET-), compared to healthy controls (HC) and using a cross-sectional design. Eighteen ET+, 18 ET- and 16 HC completed questionnaires and wore wrist actigraphs at home for 2 weeks. Parametric and non-parametric RAR, sleep parameters, and quality of life were compared between groups (p<0.05). BC groups presented lower daytime activity than HC according to RAR analysis (mesor and M10 parameters). Compared to HC, ET- had lower inter-daily stability and ET+ had greater sleep complaints. Compared to ET-, ET+ had lower sleep efficiency, more time awake and higher activity levels at night, as assessed with actigraphy. Our results suggest an effect of cancer independent of treatment on RAR in BC, highlighting the need for further investigation of this topic. In contrast, sleep as assessed with actigraphy seems modified only during ET which matches with patients’ sleep complaints. Further longitudinal studies would aid in confirming the latter hypothesis.

2021 ◽  
Vol 7 (1) ◽  
pp. e000924
Author(s):  
Nick Beale ◽  
Emma Eldridge ◽  
Anne Delextrat ◽  
Patrick Esser ◽  
Oliver Bushnell ◽  
...  

ObjectivesTo establish pupil fitness levels, and the relationship to global norms and physical education (PE) enjoyment. To measure and describe physical activity (PA) levels during secondary school PE lessons, in the context of recommended levels, and how levels vary with activity and lesson type.MethodsA cross-sectional design; 10 697 pupils aged 12.5 (SD 0.30) years; pupils who completed a multistage fitness test and wore accelerometers to measure PA during PE lessons. Multilevel models estimated fitness and PE activity levels, accounting for school and class-level clustering.ResultsCardiorespiratory fitness was higher in boys than girls (ß=−0.48; 95% CI −0.56 to −0.39, p<0.001), within absolute terms 51% of boys and 54% of girls above the 50th percentile of global norms. On average, pupils spent 23.8% of PE lessons in moderate-to-vigorous PA (MVPA), and 7.1% in vigorous PA (VPA). Fitness-focused lessons recorded most VPA in co-educational (ß=1.09; 95% CI 0.43 to 1.74) and boys-only lessons (ß=0.32; 95% CI −0.21 to 0.85). In girls-only lessons, track athletics recorded most VPA (ß=0.13; 95% CI −0.50 to 0.75) and net/wall/racket games (ß=0.97; 95% CI 0.12 to 1.82) the most MVPA. For all lesson types, field athletics was least active (ß=−0.85; 95% CI −1.33 to −0.36). There was a relationship of enjoyment of PE to fitness (ß=1.03; 95% CI 0.83 to 1.23), and this relationship did not vary with sex (ß=−0.14 to 0.23; 95% CI −0.16 to 0.60).ConclusionsPE lessons were inactive compared with current guidelines. We propose that if we are to continue to develop a range of sporting skills in schools at the same time as increasing levels of fitness and PA, there is a need to introduce additional sessions of PE activity focused on increasing physical activity.Trial registration numberNCT03286725.


2007 ◽  
Vol 87 (3) ◽  
pp. 248-257 ◽  
Author(s):  
Kristie F Bjornson ◽  
Basia Belza ◽  
Deborah Kartin ◽  
Rebecca Logsdon ◽  
John F McLaughlin

Background and Purpose Assessment of walking activity in youth with cerebral palsy (CP) has traditionally been “capacity-based.” The purpose of this study was to describe the day-to-day ambulatory activity “performance” of youth with CP compared with youth who were developing typically. Subjects Eighty-one youth with CP, aged 10 to 13 years, who were categorized as being in Gross Motor Function Classification System (GMFCS) levels I to III and 30 age-matched youth who were developing typically were recruited. Methods Using a cross-sectional design, participants wore the StepWatch monitor for 7 days while documenting average daily total step counts, percentage of time they were active, ratio of medium to low activity levels, and percentage of time at high activity levels. Results The youth with CP demonstrated significantly lower levels of all outcomes than the comparison group. Discussion and Conclusion Daily walking activity and variability decreased as functional walking level (GMFCS level) decreased. Ambulatory activity performance within the context of the daily life for youth with CP appears valid and feasible as an outcome for mobility interventions in CP.


1998 ◽  
Vol 11 (1) ◽  
pp. 7-10 ◽  
Author(s):  
Jerome A. Yesavage ◽  
Leah Friedman ◽  
Helena C. Kraemer ◽  
Art Noda ◽  
Deryl Wicks ◽  
...  

This article reports cross-sectional and follow-up data with actigraphic measures of nocturnal sleep and rest/activity in 61 Alzheimer's disease (AD) patients as well as the relation of actigraphic measures to levels of behavioral disturbance across different stages of the disease. Over the course of approximately 1.5 years' follow-up, patients showed significant deterioration of nocturnal sleep parameters, but no significant change in rest/activity circadian rhythm parameters. There were also significant correlations among nocturnal sleep, rest/activity circadian rhythm, and behavioral disturbance measures, but only in relatively early stages of AD. It is argued that study of nocturnal sleep and circadian rhythm in relation to behavioral disturbance in AD requires longitudinal data and analyses that take into account the stage of disease at which patients are assessed.


2019 ◽  
Vol 1 ◽  
pp. 98-104
Author(s):  
EC. Fradelos

<br/><b>Introduction:</b> Death anxiety, fear of abundance, isolation, stigma of the disease and medication side effects are among the most common sources of anxiety and depression in patients with breast cancer. <br/><b>Purpose:</b> To examine the possible relationship between religiosity, psychological resilience and depression on breast cancer patients. <br/><b>Materials and methods:</b> A cross-sectional design was employed in this study which 152 breast cancer patients participated. Data were collected with the following instruments: Patient Health Questionnaire-2-item scale, Connor-Davidson Resilience Scale 25 and Centrality of Religiosity Scale and a special designed sheet reporting social, demographic and clinical characteristics. Statistical analyses were conducted with the Statistical Package for the Social Science V25. Descriptive statistics such means, and frequencies were calculated and inferential statistics such correlation test, simple and multiple regression analysis were applied. <br/><b>Results:</b> Approximately 1 in 3 patients suffered symptoms of depression while they were reporting moderate religiosity and resilience values. Based on the four-step mediation analysis religiosity was strongly associated with psychological resilience but it was not found to affect directly either depression, but psychological resilience can be a mediator between religiosity and depression. <br/><b>Conclusion:</b> This study supports the notion thatreligiosity and spirituality can have a beneficial influence on health outcomes.


2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 111-111
Author(s):  
Sasha M. Lupichuk ◽  
Cindy Railton ◽  
Jenny J. Ko ◽  
Jennifer McCormick ◽  
Lihong Zhong ◽  
...  

111 Background: Routine follow-up of breast cancer (BC) patients is largely transferred to primary care due to limited tertiary care resources and evidence supporting the acceptability and safety of this approach. It is unknown how BC survivors are faring in the community with treatment and surveillance goals, and if there is an unmet need for access to specialist care. Objectives of this cross-sectional study of BC survivors were to examine: concordance with endocrine therapy and follow-up recommendations; perceived need for help with achieving these recommendations; and, perceived need for a telephone follow-up clinic. Methods: Eligible participants were women with stage I-III BC diagnosed June 2006-September 2009 who had been seen in consultation at a tertiary cancer centre (TCC) in Alberta, Canada. 960 potentially eligible women were invited to participate via mail-out from the Alberta Cancer Registry. Consenting participants completed a structured telephone interview. Further patient, disease, endocrine therapy and surveillance data were obtained from the electronic chart and pharmacy databases. Results: 240 participants completed the telephone interview. 68.8% had been discharged from a TCC. 87.1% reported having had a clinical breast examination, and 97.1% with remaining breast tissue reported having had a surveillance mammogram within the past year. Concordance with endocrine therapy varied between pharmacy dispensing records (95.4%) versus self-report (82.0%). Top participant-identified gaps in post-treatment services were: side effect management, achieving body weight and physical activity goals, psychosocial health, and sexual health. 71.7% of participants reported that they would have used a telephone follow-up clinic. Factors associated with telephone follow-up clinic use included younger age, no endocrine therapy, fatigue, and non-urban residence. Conclusions: Concordance with measurable follow-up goals (exam, mammography, endocrine therapy) was better than expected. Despite this, interest in a nurse-led BC telephone follow-up clinic was high. Perceived needs included management of symptoms plus support for life-style behavior change.


2019 ◽  
Vol 5 (1) ◽  
pp. 14-17
Author(s):  
Chris Sriyanti

Breast cancer is a serious threat for women all over the world including Indonesia. Self Breast-Examination (BSE) is one of important early detection efforts in reducing morbidity and mortality due to breast cancer. The implementation of BSE as a behavior is influenced by many factors, including knowledge. This study aims was to analyze the relation of knowledge about breast cancer with the behavior of BSE implementation on childbearing age women at Bandung, West Java. Cross-sectional design was used with 420 respondents. Women over the age of 20 were randomly selected to participate in this study. Questionnaire was used as data collection instrument. Data was analyzed by using Chi-Square with statistical significance level at p <0.05. The results showed that 56.2% of respondents had good knowledge about breast cancer and 43.8% were still at low level, while the implementation of BSE was also still low at 39% (IK 95%: 34, 5% -43.8%). There was significant relation between knowledge about breast cancer and the behavior of BSE implementation on childbearing age women in Bandung (p <0.001).


2017 ◽  
Vol 3 (2) ◽  
pp. 218
Author(s):  
Kevin Patar Aruan ◽  
Muhammad Atoillah Isfandiari

In the city of Surabaya, the number of patients with breast cancer is found and treated in 2014 was amounted to 709 cases. Family social support is regarded as one of the drivers of the patient for treatment. This study aimed to quantify the proportion of delay in treatment of breast cancer based on family and social support and analyzing the relationship of social support by the family against in the treatment of breast cancer cases in Yayasan Kanker Wisnuwardhana Surabaya. The study was conducted using cross sectional design using a quantitative approach. The interview was conducted on 40 patients with breast cancer. Samples were selected by simple random sampling. The results of comparison of proportions delay breast cancer treatment according to the status of family social support is 7.5: 3.6. Testing single relationship between social support by the family to delay treatment shows that there was a signifi cant relationship between social support with treatment of breast cancer (p <0.05). The conclusions are the proportion of delay in treatment more on the respondents were less lack support and there is a relationship between social support to the treatment of breast cancer cases in Yayasan Kanker Wisnuwardhana Surabaya.Keywords: breast cancer, delay treatment, social support.


Author(s):  
Puspita Sari ◽  
Solihin Sayuti ◽  
M. Ridwan ◽  
La Ode Rekiaddin ◽  
Anisa Anisa

ABSTRAKLatar Belakang. Data WHO tahun 2018 menunjukkan kasus kanker yang paling banyak terjadi di Indonesia adalah kasus kanker payudara, yakni 58.256 kasus dari total 348.809 kasus kanker. Kanker payudara sebagai penyakit yang berisiko diderita perempuan. Perlu dilakukan upaya deteksi dini dengan SADARI.Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan dan dukungan tenaga kesehatan dengan perilaku pemeriksaan payudara sendiri (SADARI) pada wanita PUS di Kelurahan Bram Itam Kiri Kecamatan Bram Itam Kabupaten Tanjung Jabung Barat.Metode.Penelitian ini merupakan penelitian kuantitatif dengan desain cross-sectional. Penelitian ini melibatkan 93 responden yang dipilih dengan teknik Proporsionate Stratified Random Sampling untuk diwawancarai. Analisis data menggunakan chi-square.Hasil. Sebanyak 34,4% responden memiliki perilaku SADARI tidak baik. Ada hubungan bermakna antara pengetahuan dengan perilaku SADARI. Dukungan petugas kesehatan tidak memiliki hubungan yang bermakna dengan perilaku SADARI.Kesimpulan. Pemahaman responden tentang SADARI masih rendah dan  ada hubungan pengetahuan dengan perilaku pemeriksan payudara sendiri (SADARI). ABSTRACTBackground. According to WHO in 2018, most cancer cases in Indonesia are breast cancer cases, with 58,256 cases out of a total of 348,809 cancer cases. Breast cancer is a disease that is at risk for women. Early detection efforts with BSE should be initiated.Objective. This study aims to determine the relationship between knowledge and support of health workers with breast self-examination behavior (BSE) on women with PUS in Bram Itam Kiri Village, Bram Itam District, Tanjung Jabung Barat Regency.Method. This research was a quantitative study with a cross-sectional design. This study involved 93 respondents who were selected using a proportional stratified random sampling technique to be interviewed. Data analysis using chi-square.Results. As many as 34.4% of respondents had bad BSE behavior. There is a significant relationship between knowledge and BSE behavior. Support from health workers did not have a significant relationship with BSE behavior.Conclusion. Respondents' understanding of BSE is still low and there is a relationship between knowledge and breast self-examination behavior (BSE).


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