The effect of X-rays on the glucose and hexose-phosphate glycolysis of tumour tissue
The clinical approach to questions concerning the effect of X-rays γ-rays on cells has, of necessity, been highly empirical. By methods of trial and error, in fact by experience, it has been found that certain tissues are more easily injured by radiation than others, certain types of tumour more responsive than others to treatment by irradiation. The experiments described here and in previous papers (Holmes 1933, 1935) on the effects of irradiation upon cell metabolism have also been conducted on empirical lines. They represent simply an attempt to carry the work done by others on the lethal effect of the rays one step further and to describe this effect in terms of cell metabolism. The possibility that detectable differences in the metabolism of different tissues may account for their variability in response to radiation must also be considered, and such experiments may eventually provide the data necessary for investigating this possibility.