scholarly journals COVID-19 gender difference pattern in Iranian population, compared to the global pattern; a systematic review and meta-analysis

2021 ◽  
Author(s):  
misagh rajabinejad ◽  
Hossein Asgarian-Omran
Keyword(s):  
Gender Differences ◽  
General Population ◽  
Meta Analysis ◽  
Iranian Population ◽  
Detection Methods ◽  
Antibody Isotype ◽  
Global Pattern ◽  
Men And Women ◽  
Significant Difference ◽  
Subgroup Analyses

The coronavirus disease 2019 (COVID-19) pandemic has highlighted Sex-related immune responses. In this review, gender differences in seroprevalence, severity, mortality, and recovery in the Iranian population were systematically compared to the COVID-19 global pattern. This compressive meta-analysis was conducted on studies published up to April 1, 2021, examining seroprevalence in the general population as well as disease outcomes in hospitalized patients. Data were analyzed based on gender to determine differences between men and women in COVID-19. The PubMed, Scopus, Google Scholar, WOS, medRxiv, and bioRxiv were searched. The odds ratio (OR) was calculated based on the random-effects model, with a corresponding 95% confidence interval (CI), according to the number of participants reported in papers. Subgroup analyses were performed according to the age, antibody isotype, and detection assay. Overall, 61 studies with 225799 males and 237017 females were eligible for meta-analysis. Seroprevalence was 1.13 times higher (95% CI: 1.03, 1.24), mortality was 1.45 times higher (95% CI: 1.19, 1.77), and severity was up to 1.37 times higher (95% CI: 1.13, 1.67) in males than those of females in the general population across the globe. Mortality was higher in Iranian patients up to 26% in men (95% CI: 1.20, 1.33), but no significant difference was observed between disease severity and serum prevalence between men and women. Besides, the rate of recovery was 29% (global pattern) and 21% (Iran pattern) lower in males than in females. The results of subgroup analyses for seroprevalence were not significant for the age, antibody isotype, and detection methods. The results of our meta-analyses showed that the patient mortality and recovery patterns are similar in Iran and other countries in the context of gender differences, and the disease is more fatal in men.

The Role of Deceptive Communication and Gender in Shaping Online Dating Interactions

2019 ◽  
pp. 460-474
Author(s):  
Anna Maria Kuzio
Keyword(s):  
Gender Differences ◽  
General Population ◽  
Online Dating ◽  
Significant Others ◽  
Online Environment ◽  
Men And Women ◽  
Significant Difference ◽  
And Gender ◽  
Deceptive Communication

Online dating is becoming an increasingly used method for meeting significant others. As the research of lying behavior has advanced so has the technique of detecting the act of lying, especially in the online environment where deception is more likely to happen. The aim of this chapter is to simplify the perception of lying behavior to the general population and examine gender differences of lying behavior, namely, to verify whether one can observe a statistically significant difference in the speech behavior and exploitation of lying cues among men and women. The study shows correlation between gender and deception in online environment.

Abstract 17356: Gender Differences in Clinical Presentation and Outcomes of Patients With Acute Myocardial Infarction and Spontaneous Coronary Artery Dissection: A Nationwide Inpatient Sample Matched Analysis

Circulation ◽  
2018 ◽  
Vol 138 (Suppl_1) ◽  
Author(s):  
Setri Fugar ◽  
Juliet A Yirerong ◽  
Alfred Solomon ◽  
Ahmed A Kolkailah ◽  
Tauseef Akthar ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Gender Differences ◽  
Clinical Presentation ◽  
Artery Dissection ◽  
P Value ◽  
Spontaneous Coronary Artery Dissection ◽  
Coronary Artery Dissection ◽  
Men And Women ◽  
Significant Difference

Introduction: Spontaneous Coronary Artery Dissection (SCAD) is reported to occur predominantly in young women. Gender differences in the clinical presentation and outcomes of patients with SCAD have not been studied on a population level. We sought to compare the in-hospital outcomes of men and women presenting with acute myocardial infarction (AMI) and SCAD. Methods: We identified patients from the National Inpatient Sample (NIS) between 2005 and 2015 who presented with primary diagnoses of AMI and SCAD. We identified SCAD with ICD-9 code 414.12. A 1:1 propensity-matched cohort was created to examine the outcomes between men and women. Primary endpoint was in-hospital mortality. Secondary endpoints included in-hospital cardiac and non-cardiac complications. Results: Of the 6617 (32017 weighted national estimates) patients with SCAD over the study period, majority were males 3667 (55.4%). Males were younger than females (60.32 yr vs. 61.59 yr) and presented more often with ST-elevation myocardial infarction (STEMI) (53.0% vs. 45.9% P=<0.001). Propensity matching yielded 2366 males and 2366 females. In the matched group, there was no significant difference in in-hospital mortality between males and females (OR 1.20 95% CI -0.93-1.54). With regards to in-hospital complications, ventricular tachycardia (V-Tach) was significantly less frequent in females as compared to males (8.0% vs. 10.1% OR 0.76 p-value 0.003). There was no significant difference between females and males in the frequency of other complications, including intracranial hemorrhage (0.2% vs 0.2% OR 1.45 p-value 0.50), GI bleed (1.8% vs 1.3% OR 1.35 p-value 0.13), cardiogenic shock (9.8% vs 9.7% OR 1.01 p-value 0.86), acute heart failure (3% vs 2.6% OR 1.18 p-value 0.26), ventricular fibrillation(vfib) (5.6% vs 6.0% OR 0.928 p-value 0.48) or stroke ( 1.5% vs 1.0% OR 1.535 p-value 0.06) Conclusion: In our large population-based analysis, compared to females, males were more likely to present with STEMI as compared to females. With the except of V-Tach, which was higher in males, there were no significant gender differences in hospital outcomes namely inpatient mortality, cardiogenic, Vfib or acute heart failure.

scholarly journals Tryptophan Catabolites in Bipolar Disorder: A Meta-Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Kaat Hebbrecht ◽  
Katrien Skorobogatov ◽  
Erik J. Giltay ◽  
Violette Coppens ◽  
Livia De Picker ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
Cerebrospinal Fluid ◽  
Methodological Quality ◽  
Meta Analysis ◽  
Random Effect ◽  
Healthy Controls ◽  
Significant Difference ◽  
Subgroup Analyses ◽  
Tryptophan Catabolites

ObjectiveTryptophan catabolites (TRYCATs) are implicated in the pathophysiology of mood disorders by mediating immune-inflammation and neurodegenerative processes. We performed a meta-analysis of TRYCAT levels in bipolar disorder (BD) patients compared to healthy controls.MethodsA systematic literature search in seven electronic databases (PubMed, Embase, Web of Science, Cochrane, Emcare, PsycINFO, Academic Search Premier) was conducted on TRYCAT levels in cerebrospinal fluid or peripheral blood according to the PRISMA statement. A minimum of three studies per TRYCAT was required for inclusion. Standardized mean differences (SMD) were computed using random effect models. Subgroup analyses were performed for BD patients in a different mood state (depressed, manic). The methodological quality of the studies was rated using the modified Newcastle-Ottawa Quality assessment Scale.ResultsTwenty-one eligible studies were identified. Peripheral levels of tryptophan (SMD = -0.44; p &lt; 0.001), kynurenine (SMD = - 0.3; p = 0.001) and kynurenic acid (SMD = -.45; p = &lt; 0.001) were lower in BD patients versus healthy controls. In the only three eligible studies investigating TRP in cerebrospinal fluid, tryptophan was not significantly different between BD and healthy controls. The methodological quality of the studies was moderate. Subgroup analyses revealed no significant difference in TRP and KYN values between manic and depressed BD patients, but these results were based on a limited number of studies.ConclusionThe TRYCAT pathway appears to be downregulated in BD patients. There is a need for more and high-quality studies of peripheral and central TRYCAT levels, preferably using longitudinal designs.

scholarly journals Regional and chronological differences in prevalences of olfactory and gustatory dysfunction in coronavirus disease (COVID-19): a systemic review and meta-analysis

2020 ◽  
Author(s):  
Jeong-Whun Kim ◽  
Seung Cheol Han ◽  
Hyung Dong Jo ◽  
Sung-Woo Cho ◽  
Jin Youp Kim
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Random Effect ◽  
Random Effect Model ◽  
Olfactory Dysfunction ◽  
Systemic Review ◽  
Effect Model ◽  
Geographical Regions ◽  
Significant Difference ◽  
Subgroup Analyses

Abstract Olfactory and gustatory dysfunction are frequently reported in patients with coronavirus disease (COVID-19). However, the reported prevalence of olfactory and/or gustatory dysfunction varies widely, and the reason for the inter-study differences is unclear. Hence, in this meta-analysis, we performed subgroup analyses to investigate the factors that contribute to the inter-study variability in the prevalence of olfactory and gustatory dysfunction. Out of 943 citations, we included 55 eligible studies with 13,527 patients with COVID-19 for a systematic review. The overall pooled prevalences of olfactory and gustatory dysfunction were 51.4% and 47.5%, respectively, in the random-effect model. In subgroup analyses, the prevalences of olfactory and gustatory dysfunction were significantly different among four geographical regions (both P < 0.001, respectively). Although the prevalences of olfactory and gustatory dysfunction did not significantly differ according to the time of enrollment, the subgroup analyses including only studies from the same geographical region (Europe) revealed a significant difference in olfactory dysfunction according to the time of enrollment. The regional and chronological differences in the prevalences of olfactory and gustatory dysfunctions partly explain the wide inter-study variability.

Chemoradiation versus chemotherapy after D2 gastrectomy: A meta-analysis including randomized and real-world trials.

2020 ◽  
Vol 38 (15_suppl) ◽  
pp. e16590-e16590
Author(s):  
Chai Hong Rim ◽  
In-soo Shin ◽  
Hye yoon Lee ◽  
Sunmin Park
Keyword(s):  
Recurrence Rate ◽  
Real World ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Disease Free Survival ◽  
Pooled Analysis ◽  
R0 Resection ◽  
D2 Gastrectomy ◽  
Significant Difference ◽  
Subgroup Analyses

e16590 Background: The ARTIST trial failed to achieve positive result regarding benefit of chemoradiation (CRT) after D2 gastrectomy. In most of clinical guidelines and practices, postoperative CRT has been recommended only for those with R1 resection or lesser extent surgery than D2. Our study is to evaluate oncologic benefit of CRT after D2 gastrectomy, integrating data from randomized clinical trials (RCTs) and real-world studies so far. Methods: Systematic searches for Medline and Embase were performed for controlled trials comparing CRT and chemotherapy (CT) arms after D2 gastrectomy with R0 resection, for gastric cancer. Subgroup analyses were performed including RCTs, and balanced studies without significant difference regarding major clinical indicators. Primary endpoint was disease free survival (DFS), and secondary endpoints included overall survival (OS), locoregional recurrence rate (LRR), distant recurrence rate (DRR), and grade ≥3 complications. Results: A total of 13 studies, comprised of 6 RCTs and 7 non-RCTs, involving 2,603 patients were included. DFS benefit was found in overall pooled analysis [odds ratio (OR): 1.264, p = 0.053, I2= 37.5%], and more evident in subgroup analyses using RCTs (OR: 1.440, p = 0.006, I2= ~0%) and balanced studies (OR: 1.417, p < 0.001, I2= ~0%). OS benefit was not significant. LRR reduction was noted in overall pooled analysis (OR: 0.559, p = 0.012, I2 = 46.1%), and clearer in the subgroup analyses with RCTs (OR: 0.495, p < 0.001, I2= ~0%) and balanced studies (OR 0.472, p < 0.001, I2= 9.2%). Pooled LRR rates were 11.3% (95% confidence interval: 7.5-16.8) and 18.1% (13.1-24.4) in CRT and CT arms. DRR was lower in CRT arms (OR: 0.768, p = 0.023, I2= ~0.0%), but the difference was less significant in subgroup analyses. A grade 5 complication was found in each of the two arms among all studies. Comparison of complications varies and will be shown descriptively in the manuscript. Conclusions: Benefit of DFS and LRR with CRT after D2 gastrectomy was well shown in the present study. Identifying subgroup population mostly benefitable from CRT might yield positive results regarding OS and DRR in future studies.

Abstract 14810: Gender Differences in the Prevalence of Physical Frailty in Heart Failure

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Mary C Davis ◽  
Christopher S Lee ◽  
Amy Corcoran ◽  
Nandita Gupta ◽  
Izabella Uchmanowicz ◽  
...  
Keyword(s):  
Heart Failure ◽  
Gender Differences ◽  
Absolute Risk ◽  
Meta Analysis ◽  
Significant Heterogeneity ◽  
Physical Frailty ◽  
Risk Increase ◽  
Significant Difference ◽  
Future Work ◽  
Risk Ratios

Introduction: The intersection of frailty and heart failure (HF) continues to garner interest. Almost half of patients with HF are frail; however, gender differences in the prevalence of frailty in HF are poorly understood. The objective of this study was to quantify gender differences in the prevalence of frailty in HF. Methods: Data from a subset of studies from a previous meta-analysis were analyzed if they included prevalence of frailty by gender. We performed a random-effects meta-analysis to quantify the relative and absolute risk of frailty in women compared to men with HF overall, and divided into Physical and Multidimensional Frailty measures. Risk ratios (RR) along with their confidence intervals (CI) were estimated. Results: Thirteen studies involving 3,662 women and men with HF were included in this meta-analysis. The estimated prevalence of frailty in HF was 51.4% for women and 33.9% for men. The overall absolute risk increase for women compared to men with HF being frail was 14% (z = 3.92, p < 0.001). Overall, women with HF had a 42.1% higher risk of being frail (RR = 1.42 (CI = 1.19-1.69), p < 0.001) compared to men with HF, and there was significant heterogeneity in RRs across studies ( I 2 = 81.7%). Among studies that used Physical Frailty measures, women with HF had a 43.7% higher risk of being frail (RR = 1.44 (CI = 1.20-1.73), p < 0.001) compared with men. Among studies that used Multidimensional Frailty measures, there was no significant difference in risk of frailty between women and men (RR = 1.36 (CI = 0.94,1.96), p = 0.105). Conclusions: In HF, frailty affects women significantly more than men, although this was only noted among studies that measured physical frailty, and there was significant heterogeneity across studies. Future work should focus on elucidating potential causes of gender differences in frailty in HF.

Association of isolated T inversion and sudden cardiac death – etiology and gender differences

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M.A.E Haukilahti ◽  
L Holmstrom ◽  
J Vahatalo ◽  
T.V Kentta ◽  
L Pakanen ◽  
...  
Keyword(s):  
Gender Differences ◽  
Sudden Cardiac Death ◽  
General Population ◽  
Cardiac Death ◽  
Left Ventricular ◽  
Common Finding ◽  
Control Group ◽  
Funding Source ◽  
Increased Risk ◽  
Significant Difference

Abstract Background Inferolateral T wave inversion has been associated with increased risk of mortality and sudden cardiac death (SCD) in general population. However, the association between isolated T inversion and SCD is still unclear. Purpose The purpose of this study was to examine whether isolated T inversion associates with SCD, and find out possible gender differences. Methods FinGesture Study has systematically collected clinical data and medico-legal autopsy data from 5,869 consecutive SCD victims (mean age 64.9±12.4 yrs.) in Northern of Finland between years 1998 and 2017. Previously recorded electrocardiograms (ECG) were available and analyzed in 1,101 subjects. The control group consisted of 7,217 subjects representative of Finnish general population (mean age 51.5±12.4 yrs.). T inversion was interpreted isolated if there was at least two T inversions ≥−0.1 mV in at least two contiguous leads, and there were no ECG signs of left ventricular hypertrophy (LVH) defined by Sokolow-Lyon criteria or bunchle brand block (BBB) attached to it. Results In a current study, isolated T inversion was more common finding among SCD victims compared to general population: isolated T inversion in any leads 10.9% vs. 0.9% (SCD vs. general population, p&lt;0.001), laterally 7.7% vs. 0.1% (p&lt;0.001), inferiorly 3.2% vs. 0.5% (p&lt;0.001) and anteriorly 2.9% vs. 0.4% (p&lt;0.001). Particularly, isolated T inversion seemed to assoaciate with ischemic SCD taking into account that 61.5% of the total isolated T inversions were seen in ischemic SCD victims (p=0.018). In addition, 62.1% of the inferior isolated T inversions (p=0.023) and 61.7% of the lateral isolated T inversions (p=0.031) were in ischemic SCD victims versus 37.9% and 38.3% in non-ischemic SCD victims, respectively. The prevalence of isolated T inversion in any lead was also higher among male SCD victims compared to female victims (12.8% vs. 8.2%, p&lt;0.001, respectively). There was no statistically significant difference in the prevalence of LVH and strain changes between the populations. Among bundle branch blocks left BBB was predictably more typical in SCD victims (5.8% vs. 0.5%, p&lt;0.001). Conclusion We noticed an association between isolated T inversion and SCD. The association was most prominent in males and in those with ischemic etiology of SCD. Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): The Finnish Medical Foundation, Finnish Foundation for Cardiovascular Research

scholarly journals Mental health and well-being of fathers of children with intellectual disabilities: systematic review and meta-analysis

BJPsych Open ◽  
2019 ◽  
Vol 5 (6) ◽  
Author(s):  
Kirsty Dunn ◽  
Deborah Kinnear ◽  
Andrew Jahoda ◽  
Alex McConnachie
Keyword(s):  
Mental Health ◽  
General Population ◽  
Intellectual Disabilities ◽  
Meta Analysis ◽  
Well Being ◽  
Poor Mental Health ◽  
Exclusion Criteria ◽  
General Mental Health ◽  
Significant Difference ◽  
Health And Well Being

Background Caring for a child with intellectual disabilities can be a very rewarding but demanding experience. Research in this area has primarily focused on mothers, with relatively little attention given to the mental health of fathers. Aims The purpose of this review was to summarise the evidence related to the mental health of fathers compared with mothers, and with fathers in the general population. Method A meta-analysis was undertaken of all studies published by 1 July 2018 in Medline, PsycINFO, CINAHL and EMBASE, using terms on intellectual disabilities, mental health and father carers. Papers were selected based on pre-defined inclusion and exclusion criteria. Results Of 5544 results, 20 studies met the inclusion criteria and 12 had appropriate data for meta-analysis. For comparisons of fathers with mothers, mothers were significantly more likely to have poor general mental health and well-being (standardised mean difference (SMD) −0.38, 95% CI −0.56 to −0.20), as well as higher levels of depression (SMD, −0.46; 95% CI −0.68 to −0.24), stress (SMD, −0.32; 95% CI −0.46 to −0.19) and anxiety (SMD, −0.30; 95% CI −0.50 to −0.10). Conclusions There is a significant difference between the mental health of father and mother carers, with fathers less likely to exhibit poor mental health. However, this is based on a small number of studies. More data is needed to determine whether the general mental health and anxiety of father carers of a child with intellectual disabilities differs from fathers in the general population.

EVALUATION OF SIGNAL PROCESSING TECHNIQUES IN DISCRIMINATING ECG SIGNALS OF MEN AND WOMEN DURING REST CONDITION AND EMOTIONAL STATES

2018 ◽  
Vol 30 (04) ◽  
pp. 1850028 ◽  
Author(s):  
Ateke Goshvarpour ◽  
Atefeh Goshvarpour ◽  
Ataollah Abbasi
Keyword(s):  
Gender Differences ◽  
Signal Processing ◽  
Emotional States ◽  
Men And Women ◽  
Wide Range ◽  
Significant Difference ◽  
Rest Condition ◽  
Processing Techniques ◽  
The Impact ◽  
Signal Processing Techniques

Great range of electrocardiogram (ECG) signal processing methods can be found in the literature. In addition, the importance of gender differences in physiological activities was also identified in various conditions. This article aims to provide a comprehensive evaluation of linear and nonlinear ECG parameters to indicate suitable signal processing approaches which can show significant differences between men and women. These differences were investigated in two conditions: (i) during rest condition, and (ii) during the affective image inducements. A wide range of parameters from time-, frequency-, wavelet-, and nonlinear-techniques were examined. Applying the Wilcoxon rank sum test, significant differences between two genders were inspected. The analysis was performed on 47 college students at rest condition and while subjects watching four types of affective pictures, including sadness, happiness, fear, and peacefulness. The impact of these emotions on the results was also investigated. The results indicated that 72.95% and 72.61% of all features were significantly different between male and female in rest condition and affective inducements, respectively. In addition, the highest percentage of the significant difference between ECG parameters of men and women was achieved using nonlinear characteristics. Considering all features together, the highest significant difference between two genders was achieved for negative emotions, including sadness and fear. In conclusion, the results of this study emphasized the importance of gender role in cardiac responses during rest condition and different emotional states. Since these gender differences are well manifested by nonlinear signal processing techniques, dynamical gender-specific ECG system may improve the automatic emotion recognition accuracies.

scholarly journals The prevalence of cardiovascular disease in Ethiopia: a systematic review and meta-analysis of institutional and community-based studies

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dessie Abebaw Angaw ◽  
Rahma Ali ◽  
Afework Tadele ◽  
Shegaye Shumet
Keyword(s):  
Cardiovascular Disease ◽  
General Population ◽  
Meta Analysis ◽  
Group Analysis ◽  
Premature Death ◽  
Design Quality ◽  
Cross Sectional ◽  
Mesh Terms ◽  
Pooled Prevalence ◽  
Significant Difference

Abstract Background Worldwide cardiovascular disease is the major cause of disability and premature death. This is due to the ascending trend of consuming an unhealthy diet and obesity which increases the risk of hypertension and type 2 diabetes mellitus. Thus this study aimed to determine the pooled prevalence of the cardiovascular disease in Ethiopia. Methods Medline, Scopus, and Google Scholar search engines were accessed using medical subject heading (MeSH) terms for studies based in Ethiopia, from 2000 to 2018. However, studies done among a specific group of the population were excluded from the study. Data were extracted by one reviewer and then checked independently by a second reviewer. Studies were qualitatively synthesis in terms of design, quality, study population, outcomes, and result. Sub-group analysis and sensitivity tests were conducted to identify potential influences on the prevalence estimates. Quantitative results were pooled in a statistical meta-analysis using STATA version 14 software. Result Nine eligible cross-sectional studies were included in the analysis. The prevalence ranges from 1 to 20%. The pooled prevalence of cardiovascular disease (CVD) was 5% (95% CI: 3–8%). The prevalence was higher in the population who visits hospitals, 8% (95% CI: 4–12%) compared to the general population, 2% (95% CI: 1–5%). There was no significant difference in the overall prevalence of CVD between males and females. Conclusion The prevalence of cardiovascular disease was high. A higher prevalence of CVD was found among patients who visited health institutions than the general population and no observed significant sex difference in the prevalence

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