Physical interaction analysis of the human body dorsal region with a robotic manipulator

2021 ◽  
Author(s):  
Christian M. F. Lacerda ◽  
Lucas D. P. Melo ◽  
Gustavo J. G. Lahr ◽  
Marcelo Becker ◽  
Glauco A. P. Caurin
Keyword(s):  
Human Body ◽  
Interaction Analysis ◽  
Robotic Manipulator ◽  
Physical Interaction ◽  
Dorsal Region

scholarly journals Rheological and Interaction Analysis of Asphalt Binder, Mastic and Mortar

Materials ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 128 ◽  
Author(s):  
Meng Chen ◽  
Barugahare Javilla ◽  
Wei Hong ◽  
Changluan Pan ◽  
Martin Riara ◽  
...  
Keyword(s):  
Phase Change ◽  
Interaction Analysis ◽  
Asphalt Binder ◽  
Asphalt Mixtures ◽  
Physical Interaction ◽  
Fine Aggregate ◽  
Mineral Filler ◽  
Asphalt Mastic ◽  
Fine Aggregates ◽  
Asphalt Mortar

This paper investigated the rheological properties of asphalt binder, asphalt mastic and asphalt mortar and the interaction between asphalt binder, mineral filler and fine aggregates. Asphalt binder, mastic and mortar can be regarded as the binding phase at different scales in asphalt concrete. Asphalt mastic is a blend of asphalt binder and mineral filler smaller than 0.075 mm while asphalt mortar consists of asphalt binder, mineral filler and fine aggregate smaller than 2.36 mm. The material compositions of mastic and mortar were determined from the commonly used asphalt mixtures. Dynamic shear rheometer was used to conduct rheological analysis on asphalt binder, mastic and mortar. The obtained test data on complex modulus and phase angle were used for the construction of rheological master curves and the investigation of asphalt-filler/aggregate interaction. Test results indicated a modulus increase of three- to five-fold with the addition of filler and a further increase of one to two orders of magnitude with cumulative addition of fine aggregates into asphalt binder. Fine aggregates resulted in a phase change for mortar at high temperatures and low frequencies. The filler had stronger physical interaction than fine aggregate with an interaction parameter of 1.8–2.8 and 1.15–1.35 respectively. Specific area could enhance asphalt-filler interaction. The mastic and mortar modulus can be well predicted based on asphalt binder modulus by using particle filling effect. Asphalt mortar had a significant modulus reinforcement and phase change and thus could be the closest subscale in terms of performance to that of asphalt mixtures. It could be a vital scale that bridges the gap between asphalt binder and asphalt mixtures in multiscale performance analysis.

scholarly journals Reciprocal interplay between asporin and decorin: Implications in gastric cancer prognosis

PLoS ONE ◽  
2021 ◽  
Vol 16 (8) ◽  
pp. e0255915
Author(s):  
Dipjit Basak ◽  
Zarqua Jamal ◽  
Arnab Ghosh ◽  
Pronoy Kanti Mondal ◽  
Priyanka Dey Talukdar ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Western Blot ◽  
Interaction Analysis ◽  
Cancer Prognosis ◽  
Gastric Epithelium ◽  
Tumor Promoter ◽  
Physical Interaction ◽  
Mrna Levels ◽  
Normal Tissues ◽  
Tgfβ Pathway

Effective patient prognosis necessitates identification of novel tumor promoting drivers of gastric cancer (GC) which contribute to worsened conditions by analysing TCGA-gastric adenocarcinoma dataset. Small leucine-rich proteoglycans, asporin (ASPN) and decorin (DCN), play overlapping roles in development and diseases; however, the mechanisms underlying their interplay remain elusive. Here, we investigated the complex interplay of asporin, decorin and their interaction with TGFβ in GC tumor and corresponding normal tissues. The mRNA levels, protein expressions and cellular localizations of ASPN and DCN were analyzed using real-time PCR, western blot and immunohistochemistry, respectively. The protein-protein interaction was predicted by in-silico interaction analysis and validated by co-immunoprecipitation assay. The correlations between ASPN and EMT proteins, VEGF and collagen were achieved using western blot analysis. A significant increase in expression of ASPN in tumor tissue vs. normal tissue was observed in both TCGA and our patient cohort. DCN, an effective inhibitor of the TGFβ pathway, was negatively correlated with stages of GC. Co-immunoprecipitation demonstrated that DCN binds with TGFβ, in normal gastric epithelium, whereas in GC, ASPN preferentially binds TGFβ. Possible activation of the canonical TGFβ pathway by phosphorylation of SMAD2 in tumor tissues suggests its role as an intracellular tumor promoter. Furthermore, tissues expressing ASPN showed unregulated EMT signalling. Our study uncovers ASPN as a GC-promoting gene and DCN as tumor suppressor, suggesting that ASPN can act as a prognostic marker in GC. For the first time, we describe the physical interaction of TGFβ with ASPN in GC and DCN with TGFβ in GC and normal gastric epithelium respectively. This study suggests that prevention of ASPN-TGFβ interaction or overexpression of DCN could serve as promising therapeutic strategies for GC patients.

TWO-DIMENSIONAL ATOMISTIC SIMULATION OF METALLIC NANOPARTICLES PUSHING

2009 ◽  
Vol 23 (22) ◽  
pp. 2695-2702 ◽  
Author(s):  
SEYED HANIF MAHBOOBI ◽  
ALI MEGHDARI ◽  
NADER JALILI ◽  
FARSHID AMIRI
Keyword(s):  
Atomistic Simulation ◽  
Metallic Nanoparticles ◽  
Interaction Analysis ◽  
Physical Interaction ◽  
Metallic Nanoparticle ◽  
Gravitational Forces ◽  
Volume Properties ◽  
And Control ◽  
Physical Phenomena ◽  
Size Matter

Nanomanipulation as a new emerging area enables precise manipulation, interaction and control at the nanoscale. Currently, the modeling schemes are based on continuum mechanics approaches. A main consideration in the nanomanipulation process is the fact that surface attraction forces are greater than gravitational forces at the nanoscale. In other words, surface area properties dominate volume properties. Especially at the nanoscale (i.e. the manipulation of fine nanoparticles with size of about 5 nm) the physical phenomena have not been completely understood. Along this line of reasoning, the aim of this paper is to conduct an atomistic investigation of physical interaction analysis of particle–substrate system for manipulation and positioning purposes. In the present paper, 2D molecular dynamics have been conducted to simulate metallic nanoparticle behavior during the pushing process. Dependency of the aforementioned behavior on size, matter, temperature, etc. is investigated.

scholarly journals Recognizing Sit-Stand and Stand-Sit Transitions for a Bionic Knee Exoskeleton

2017 ◽  
Author(s):  
Xiuhua Liu ◽  
Zhihao Zhou ◽  
Qining Wang
Keyword(s):  
Human Body ◽  
Computational Cost ◽  
Barometric Pressure ◽  
Measurement Unit ◽  
Support Vector ◽  
Physical Interaction ◽  
Processing Unit ◽  
Recognition Method ◽  
Mechanical Sensors ◽  
Neurological Injuries

Sit-to-stand and stand-to-sit transitions (STS), as one of the most demanding functional task in daily life, are affected by aging or stroke and other neurological injuries. Lower-limb exoskeletons can provide extra assistance for affected limbs to recover functional activities [1]. Several studies presented locomotion mode recognition of sitting, standing and STS, or only STS, or static modes [2–6]. They are based on fusing information of the mechanical sensors worn on the human body, e.g. inertial measurement unit (IMU) [2–4], plantar pressure force [5], barometric pressure[2], EMG [6]. However, most of them put sensors on the human body and did not show experiments integrated with exoskeletons. Since the physical interaction between the exoskeleton and human body, the recognition method might be different when wearing a real exoskeleton. To deal with these problems, in this study we proposed a recognition method about STS based on the multi-sensor fusion information of interior sensors of a light-weight bionic knee exoskeleton (BioKEX). A simple classifier based on Support Vector Machine (SVM) was used considering the computational cost of the processing unit in exoskeleton.

The practical implications of animals responses to man (specifically effects on production parameters)

1992 ◽  
Vol 1992 ◽  
pp. 34-34
Author(s):  
Martin F. Seabrook ◽  
Nicola C. Bartle
Keyword(s):  
Human Body ◽  
Animal Production ◽  
Individual Factors ◽  
Physical Interaction ◽  
Production Parameters ◽  
Research Paradigms ◽  
Production Research ◽  
Practical Implications

The paper outlines the major problems in scientifically assessing the nature and quality of the man-animal interface and the difficulties in isolating its effects on animal production. Research epistemologies in this area are thwart with difficulties as it is virtually impossible to isolate individual factors. For example, while it is possible to devise ‘pleasant’ and ‘unpleasant’ handling treatments; as defined by level and nature of the physical interaction of the human body with that of the animal; it is not possible to separate physical handling from aspects such as voice tones, gestures, smell, sound of foot movements, or other ‘vibes’ transmitted in the experiment. Thus, any changes in ‘production’ may arise from a number of inter-woven components. It is also of relevance that the quality of the man-animal interface is a perceived construct and that the animal may perceive both applied ‘pleasant’ and ‘unpleasant’ stimuli as undesirable. Limitations of research paradigms are raised, for example, in experimental situations the environment may well be ‘richer', and with more humans present, than in commercial situations. The nature of the interface may thus be somewhat different.

scholarly journals Arabidopsis ABIG1 Functions in Laminar Growth and Polarity Formation through Regulation by REVOLUTA and KANADI

2021 ◽  
Author(s):  
Jesus Preciado ◽  
Kevin Begcy ◽  
Tie Liu
Keyword(s):  
Leucine Zipper ◽  
Genetic Interaction ◽  
Interaction Analysis ◽  
Cell Types ◽  
Physical Interaction ◽  
Loss Of Function ◽  
Lateral Organs ◽  
Aba Insensitive ◽  
New Evidence

Leaf laminar growth and adaxial-abaxial boundary formation are fundamental outcomes of plant development. Boundary and laminar growth coordinate the further patterning and growth of the leaf, directing the differentiation of cell types within the top and bottom domains and promoting initiation of lateral organs along their adaxial/abaxial axis. Leaf adaxial-abaxial polarity specification and laminar out-growth are regulated by two transcription factors, REVOLUTA (REV) and KANADI (KAN). ABA INSENSITIVE TO GROWTH 1 (ABIG1) is a HOMEODOMAIN-LEUCINE ZIPPER (HD-ZIP) Class II transcription factor and is a direct target of the adaxial-abaxial regulators REV and KAN. To investigate the role of ABIG1 in the leaf development and establishment of polarity, we examined the phenotypes of both gain-of-function and loss-of-function mutants. Through genetic interaction analysis with REV and KAN mutants, we have determined that ABIG1 plays a role in leaf laminar-growth as well as in adaxial-abaxial polarity establishment. Genetic and physical interaction assays showed that ABIG1 interacts with the transcriptional corepressor TOPLESS (TPL). This study provides new evidence that another HD-ZIP II gene, ABIG1, facilitates growth through the corepressor TPL.

scholarly journals Compound-Protein Interaction Analysis in Condition Following Cardiac Arrest

2018 ◽  
Vol 7 ◽  
pp. e1380
Author(s):  
Mona Zamanian Azodi ◽  
Mostafa Rezaei-Tavirani ◽  
Majid Rezaei-Tavirani
Keyword(s):  
Gene Expression ◽  
Cardiac Arrest ◽  
Human Body ◽  
Interaction Analysis ◽  
Gene Expression Omnibus ◽  
Survey Result ◽  
Literature Survey ◽  
The Body ◽  
Biochemical Compounds ◽  
Chloride Sulfate

Background: Cardiac arrest (CA) and differentially expressed genes (DEGs) relative to post-CA have attracted the attention of scientist to prevent damages, which threaten patients. In the present study, metabolites relevant to DEGs of post-CA condition investigated via protein-compound interaction to understand the pathological mechanisms in the human body. Materials and Methods: STITCH plug-in integrated into Cytoscape V.3.6.1 was used to detect the most significant interacting compounds relative to DEGs of pig’s brain after 5 minutes’ CA. The genes were obtained from the Gene Expression Omnibus database. The identified elements were considered for further evaluation and validation by literature survey. Result: Findings indicate that biochemical compounds including magnesium, calcium, glucose, glycerol, hydrogen, chloride, sulfate, and estradiol interact with DEGs in the two up- and down-regulated networks. Conclusion: The compounds interacting with DEGs are suitable subjects to analysis for re-regulation of the body after CA.[GMJ.2018;7:e1380]     

scholarly journals Differential Soft Sensor-Based Measurement of Interactive Force and Assistive Torque for a Robotic Hip Exoskeleton

Sensors ◽  
2021 ◽  
Vol 21 (19) ◽  
pp. 6545
Author(s):  
Sun’an Wang ◽  
Binquan Zhang ◽  
Zhenyuan Yu ◽  
Yu’ang Yan
Keyword(s):  
Human Body ◽  
Force Measurement ◽  
Low Cost ◽  
Wearable Sensors ◽  
Force Sensor ◽  
Interaction Force ◽  
Soft Sensor ◽  
Sensor System ◽  
Physical Interaction ◽  
Indirect Measure

With the emerging of wearable robots, the safety and effectiveness of human-robot physical interaction have attracted extensive attention. Recent studies suggest that online measurement of the interaction force between the robot and the human body is essential to the aspects above in wearable exoskeletons. However, a large proportion of existing wearable exoskeletons monitor and sense the delivered force and torque through an indirect-measure method, in which the torque is estimated by the motor current. Direct force/torque measuring through low-cost and compact wearable sensors remains an open problem. This paper presents a compact soft sensor system for wearable gait assistance exoskeletons. The contact force is converted into a voltage signal by measuring the air pressure within a soft pneumatic chamber. The developed soft force sensor system was implemented on a robotic hip exoskeleton, and the real-time interaction force between the human thigh and the exoskeleton was measured through two differential soft chambers. The delivered torque of the hip exoskeleton was calculated based on a characterization model. Experimental results suggested that the sensor system achieved direct force measurement with an error of 10.3 ± 6.58%, and torque monitoring for a hip exoskeleton which provided an understanding for the importance of direct force/torque measurement for assistive performance. Compared with traditional rigid force sensors, the proposed system has several merits, as it is compact, low-cost, and has good adaptability to the human body due to the soft structure.

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