Photoacoustic imaging of stimuli-responsive red blood cell drug delivery agents

2016 ◽  
Author(s):  
Adam Dixon ◽  
Justin Farry ◽  
Johnny Chen ◽  
Ali H. Dhanaliwala ◽  
John A. Hossack ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Photoacoustic Imaging ◽  
Stimuli Responsive

A Polymer-Triton X-100 Conjugate Capable of PH-Dependent Red Blood Cell Lysis: A Model System Illustrating the Possibility of Drug Delivery Within Acidic Intracellular Compartments

1994 ◽  
Vol 2 (4) ◽  
pp. 341-347 ◽  
Author(s):  
Ruth Duncan ◽  
Paolo Ferruti ◽  
Dionyssios Sgouras ◽  
Anthony Tuboku-Metzger ◽  
Elisabetta Ranucci ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Lysis ◽  
Model System ◽  
Intracellular Compartments ◽  
Ph Dependent ◽  
Triton X

scholarly journals High frequency photoacoustic detection of red blood cell aggregation

2021 ◽  
Author(s):  
Fayruz Kibria
Keyword(s):  
Blood Cell ◽  
Red Blood Cell ◽  
High Frequency ◽  
Photoacoustic Imaging ◽  
Low Frequency ◽  
Cell Aggregation ◽  
Center Frequency ◽  
Photoacoustic Detection ◽  
Rbc Aggregation

Red blood cell (RBC) aggregation was correctly reported in early 1768 as the increased deposition for blood to form spots of red in pathological conditions. However only recently have there been advances in technology to allow possible detection of RBC aggregation in vivo. Photoacoustic imaging (PA) shows a promising future in the detection of simultaneous in vivo RBC aggregation and oxygen saturation. This work presents, for the first time, the results of investigating aggregated RBCs using high frequency (> 20 MHz) photoacoustic (PA) imaging. Aggregation was induced by using 3% w/v concentration of 70 kDa Dextran and PA measurements were taken by a 25 MHz center frequency transducer. It was found that the spectral slope (SS) of the photoacoustic signals decreased by ~0.25 dB/MHz with RBC aggregation. The results are consistent with the findings of low frequency PA RBC aggregation study which also reported decrease in SS with increased aggregation.

scholarly journals Efficient RNA drug delivery using red blood cell extracellular vesicles

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Waqas Muhammad Usman ◽  
Tin Chanh Pham ◽  
Yuk Yan Kwok ◽  
Luyen Tien Vu ◽  
Victor Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Blood Cell ◽  
Extracellular Vesicles ◽  
Red Blood Cell

scholarly journals Red Blood Cell Extracellular Vesicle-Based Drug Delivery: Challenges and Opportunities

2021 ◽  
Vol 8 ◽  
Author(s):  
Wararat Chiangjong ◽  
Pukkavadee Netsirisawan ◽  
Suradej Hongeng ◽  
Somchai Chutipongtanate
Keyword(s):  
Drug Delivery ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Large Scale ◽  
Regulatory Protein ◽  
Extracellular Vesicle ◽  
Clinical Applications ◽  
Target Cells ◽  
Scale Production ◽  
Advantages And Disadvantages

Recently, red blood cell-derived extracellular vesicles (RBCEVs) have attracted attention for clinical applications because of their safety and biocompatibility. RBCEVs can escape macrophages through the binding of CD47 to inhibitory receptor signal regulatory protein α. Furthermore, genetic materials such as siRNA, miRNA, mRNA, or single-stranded RNA can be encapsulated within RBCEVs and then released into target cells for precise treatment. However, their side effects, half-lives, target cell specificity, and limited large-scale production under good manufacturing practice remain challenging. In this review, we summarized the biogenesis and composition of RBCEVs, discussed the advantages and disadvantages of RBCEVs for drug delivery compared with synthetic nanovesicles and non-red blood cell-derived EVs, and provided perspectives for overcoming current limitations to the use of RBCEVs for clinical applications.

A Numerical Study on Drug Delivery via Multiscale Synergy of Cellular Hitchhiking onto Red Blood Cells

Nanoscale ◽  
2021 ◽  
Author(s):  
Mehdi Nikfar ◽  
Meghdad Razizadeh ◽  
Ratul Paul ◽  
Vladimir N Muzykantov ◽  
Yaling Liu
Keyword(s):  
Drug Delivery ◽  
Blood Cell ◽  
Red Blood Cells ◽  
Erythrocyte Membrane ◽  
Intravenous Injection ◽  
Red Blood Cell ◽  
Blood Cells ◽  
Numerical Study

Red blood cell (RBC)-hitchhiking, in which different nanocarriers (NCs) shuttled on the erythrocyte membrane and disassociated from RBCs to the first organ downstream of the intravenous injection spot, has recently...

Positively charged helical chain-modified stimuli-responsive nanoassembly capable of targeted drug delivery and photoacoustic imaging-guided chemo-photothermal synergistic therapy

2019 ◽  
Vol 7 (5) ◽  
pp. 2050-2060 ◽  
Author(s):  
Jian Zhang ◽  
Zhu Qiao ◽  
Huan-Ying Liu ◽  
Jibin Song ◽  
Jun Yin
Keyword(s):  
Drug Delivery ◽  
Penetration Depth ◽  
Targeted Drug Delivery ◽  
Photoacoustic Imaging ◽  
Helical Chain ◽  
Stimuli Responsive ◽  
Cell Internalization ◽  
Targeted Drug ◽  
Positively Charged

Tumor targeted size-switchable CPT/IR780@H30-PCL-PPI(L−)/PEI(–COOH/FA) nanoassembly with a “pomegranate” construction was designed, which could efficiently expand the penetration depth and accelerate the cell internalization.

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