Sensitivity Analysis of the Added Mass Computation for a Rod Vibrating in a Fluid-Filled Cavity

1975 ◽  
Vol 42 (1) ◽  
pp. 199-204 ◽  
Author(s):  
D. Krajcinovic

This paper considers influence of small geometrical imperfections, such as out-of-roundedness and eccentricity, on the magnitude of the added (apparent, virtual) mass for a rod vibrating in acoustic fluid contained within a rigid cavity. Using the perturbation of boundary conditions method derived are simple formulas allowing qualitative and quantitative analyses for several types of imperfections.

Author(s):  
Jerrold L. Abraham

Inorganic particulate material of diverse types is present in the ambient and occupational environment, and exposure to such materials is a well recognized cause of some lung disease. To investigate the interaction of inhaled inorganic particulates with the lung it is necessary to obtain quantitative information on the particulate burden of lung tissue in a wide variety of situations. The vast majority of diagnostic and experimental tissue samples (biopsies and autopsies) are fixed with formaldehyde solutions, dehydrated with organic solvents and embedded in paraffin wax. Over the past 16 years, I have attempted to obtain maximal analytical use of such tissue with minimal preparative steps. Unique diagnostic and research data result from both qualitative and quantitative analyses of sections. Most of the data has been related to inhaled inorganic particulates in lungs, but the basic methods are applicable to any tissues. The preparations are primarily designed for SEM use, but they are stable for storage and transport to other laboratories and several other instruments (e.g., for SIMS techniques).


Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
T Jankovic ◽  
G Zdunic ◽  
K Savikin ◽  
I Beara ◽  
N Mimica-Dukić

Plants ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 123
Author(s):  
Mariangela Marrelli ◽  
Maria Rosaria Perri ◽  
Valentina Amodeo ◽  
Francesca Giordano ◽  
Giancarlo A. Statti ◽  
...  

Photochemotherapy is one of the most interesting current therapeutic approaches for the treatment of melanoma. Different classes of naturally occurring phytochemicals demonstrated interesting photoactive properties. The aim of this study was to evaluate the photocytotoxic potential of two Cachrys species from Southern Italy: C. sicula and C. libanotis (Apiaceae). The enriched-coumarin extracts were obtained from aerial parts through both traditional maceration and pressurized cyclic solid-liquid (PCSL) extraction using Naviglio extractor®. Qualitative and quantitative analyses of furanocoumarins were performed with GC-MS. The photocytotoxic effects were verified on C32 melanoma cells irradiated at a dose of 1.08 J/cm2. The apoptotic responses were also assessed. Moreover, phenolic content and the in vitro antioxidant potential were estimated. Xanthotoxin, bergapten, and isopimpinellin were identified. All the samples induced concentration-dependent photocytotoxic effects (IC50 ranging from 3.16 to 18.18 μg/mL). The C. libanotis sample obtained with Naviglio extractor® was the most effective one (IC50 = 3.16 ± 0.21 μg/mL), followed by C. sicula sample obtained with the same technique (IC50 = 8.83 ± 0.20 μg/mL). Both Cachrys samples obtained through PCSL induced up-regulation of apoptotic signals such as BAX (Bcl2-associated X protein) and PARP (poly ADP-ribose polymerase) cleavage. Moreover, these samples proved to be more photoactive, giving a greater upregulation of p21 protein in the presence of UVA radiation. Obtained results suggest that investigated species could be promising candidates for further investigations aimed to find new potential drugs for the photochemotherapy of skin cancer.


2020 ◽  
Vol 5 (12) ◽  
pp. e002938
Author(s):  
Austin Carter ◽  
Nadia Akseer ◽  
Kevin Ho ◽  
Oliver Rothschild ◽  
Niranjan Bose ◽  
...  

This paper introduces a framework for conducting and disseminating mixed methods research on positive outlier countries that successfully improved their health outcomes and systems. We provide guidance on identifying exemplar countries, assembling multidisciplinary teams, collecting and synthesising pre-existing evidence, undertaking qualitative and quantitative analyses, and preparing dissemination products for various target audiences. Through a range of ongoing research studies, we illustrate application of each step of the framework while highlighting key considerations and lessons learnt. We hope uptake of this comprehensive framework by diverse stakeholders will increase the availability and utilisation of rigorous and comparable insights from global health success stories.


1979 ◽  
Vol 46 (1) ◽  
pp. 26-30 ◽  
Author(s):  
J. W. Berglund

The transient dynamic response of an elastic circular plate subjected to a suddenly applied pressure is determined for several edge boundary conditions. The plate boundary is attached to a semi-infinite, radially rigid tube which is filled with an acoustic fluid, and pressure is applied to the in-vacuo side of the plate. The transient solution is determined by using a technique in which the plate is subjected to a periodic pressure function constructed of appropriately signed and time-shifted Heaviside step functions, and by relying on a physical mechanism which returns the plate and fluid near the plate to an unstrained state of rest between pulses. The plate response is presented for a number of radius-to-thickness ratios and edge boundary conditions when interacting with water. Comparisons are also made with solutions obtained using a plane wave approximation to the fluid field.


Science ◽  
2021 ◽  
Vol 372 (6549) ◽  
pp. 1424-1428
Author(s):  
Israel Hershkovitz ◽  
Hila May ◽  
Rachel Sarig ◽  
Ariel Pokhojaev ◽  
Dominique Grimaud-Hervé ◽  
...  

It has long been believed that Neanderthals originated and flourished on the European continent. However, recent morphological and genetic studies have suggested that they may have received a genetic contribution from a yet unknown non-European group. Here we report on the recent discovery of archaic Homo fossils from the site of Nesher Ramla, Israel, which we dated to 140,000 to 120,000 years ago. Comprehensive qualitative and quantitative analyses of the parietal bones, mandible, and lower second molar revealed that this Homo group presents a distinctive combination of Neanderthal and archaic features. We suggest that these specimens represent the late survivors of a Levantine Middle Pleistocene paleodeme that was most likely involved in the evolution of the Middle Pleistocene Homo in Europe and East Asia.


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