Stress Reaction and Biochemical Shock as Interrelated and Unavoidable Components in the Formation of High Radioresistance of the Body in Acute Hypoxia

2018 ◽  
Vol 45 (1) ◽  
pp. 73-81 ◽  
Author(s):  
M. V. Vasin ◽  
I. B. Ushakov ◽  
I. V. Bukhtiyarov
Keyword(s):  
Acute Hypoxia ◽  
Stress Reaction ◽  
The Body

Evaluation of the activity of antihypoxants with an isothiourea structure in a model of hypercapnic hypoxia with a shutdown of the cerebral hemispheres

2021 ◽  
Vol 19 (1) ◽  
pp. 55-63
Author(s):  
Vera V. Marysheva ◽  
Vladimir V. Mikheev ◽  
Petr D. Shabanov
Keyword(s):  
Acute Hypoxia ◽  
Life Time ◽  
The Body ◽  
Cerebral Hemispheres ◽  
Antihypoxic Activity ◽  
Hypoxic Episode ◽  
Hypoxia With Hypercapnia ◽  
Hypercapnic Hypoxia ◽  
Outbred Mice ◽  
The Brain

PURPOSE: To study the effect of amtizol, 2-aminobenzthiazole (2-ABT) and 2-amino-4-acetylthiazolo[5,4-b]indole (BM-606) on the resistance of male outbred mice to acute hypoxia with hypercapnia under conditions of isolated functioning of one from the hemispheres, as well as both hemispheres of the brain. METHODS: A model of acute hypoxia with hypercapnia (canned hypoxia) was used in mice of the same mass, the lifespan of all animals was determined. Temporary shutdown of the cortex of one of the hemispheres or both hemispheres was achieved by epidural application of filter paper moistened with 25% potassium chloride solution, creating a spreading depression according to Leao. Amtizol, 2-aminobenzthiazole (2-ABT) and 2-amino-4-acetylthiazolo[5,4-b]indole (BM-606) at equimolar doses of 25, 32.5, and 50 mg/kg, respectively were used as pharmacological analyzers, the compounds were injected intraperitoneally 30 min before the hypoxic episode. RESULTS: It was shown that, in contrast to amtizol, 2-ABT and VM-606 increase the life time of experimental animals when any hemisphere is turned off. The use of drugs when both hemispheres were turned off revealed that amtizol has approximately equal effect on the brain and the rest of the body, in 2-ABT antihypoxic activity is 1/3 associated with the brain, in VM-606 exclusively with the brain. CONCLUSION: The experimental model used in this work makes it possible to quite easily evaluate the effect of either one drug or compare several drugs, their role in the functioning of the cerebral hemispheres, on which part of the sample highly resistant or low resistant to hypoxia they have the greatest effect.

scholarly journals Fasting promotes acute hypoxic adaptation by suppressing mTOR-mediated pathways

2021 ◽  
Vol 12 (11) ◽  
Author(s):  
Ruzhou Zhao ◽  
Xingcheng Zhao ◽  
Xiaobo Wang ◽  
Yanqi Liu ◽  
Jie Yang ◽  
...  
Keyword(s):  
Acute Hypoxia ◽  
Survival Rates ◽  
The Body ◽  
Utilization Efficiency ◽  
Ros Generation ◽  
Oxygen Utilization ◽  
Mtor Inhibition ◽  
Atp Production ◽  
Hypoxic Adaptation ◽  
Hypoxic Tolerance

AbstractRapid adaptation to a hypoxic environment is an unanswered question that we are committed to exploring. At present, there is no suitable strategy to achieve rapid hypoxic adaptation. Here, we demonstrate that fasting preconditioning for 72 h reduces tissue injuries and maintains cardiac function, consequently significantly improving the survival rates of rats under extreme hypoxia, and this strategy can be used for rapid hypoxic adaptation. Mechanistically, fasting reduces blood glucose and further suppresses tissue mTOR activity. On the one hand, fasting-induced mTOR inhibition reduces unnecessary ATP consumption and increases ATP reserves under acute hypoxia as a result of decreased protein synthesis and lipogenesis; on the other hand, fasting-induced mTOR inhibition improves mitochondrial oxygen utilization efficiency to ensure ATP production under acute hypoxia, which is due to the significant decrease in ROS generation induced by enhanced mitophagy. Our findings highlight the important role of mTOR in acute hypoxic adaptation, and targeted regulation of mTOR could be a new strategy to improve acute hypoxic tolerance in the body.

Stress Management through Yoga

2000 ◽  
Vol 10 (1) ◽  
pp. 11-16 ◽  
Author(s):  
Ellen Serber
Keyword(s):  
Psychological Distress ◽  
Stress Response ◽  
Stress Reaction ◽  
The Body ◽  
Common Element ◽  
Self Awareness ◽  
Yoga Practice ◽  
Common Condition ◽  
Physical Threat ◽  
Physical Functions

Stress is a common condition, a response to a physical threat or psychological distress, that generates a host of chemical and hormonal reactions in the body. In essence,the body prepares to fight or flee, pumping more blood to the heart and muscles and shutting down all nonessential functions. As a temporary state, this reaction serves the body well to defend itself. When the stress reaction is prolonged, however, the normal physical functions that have in response either been exaggerated or shut down become dysfunctional. Many have noted the benefits of exercise in diminishing the stress response,and a host of studies points to these benefits. Yoga, too,has been recommended and studied in relationship to sffess, although the studies are less scientifically replicable. Nonetheless, several researchers claim highly beneficial results from Yoga practice in alleviating stress and its effects. The practices recommended range from intense to moderate to relaxed asana sequences, along with pranayama and meditation. In all these approaches to dealing with stress, one common element stands out:The process is as important as the activity undertaken. Because it fosters self-awareness, Yoga is a promising approach for dealing with the stress response.

Nutritional requirement at high-altitude with special emphasises to behaviour of gastro-intestinal tract and hormonal changes

2017 ◽  
Vol 2 (2) ◽  
pp. 120
Author(s):  
Naveen Shivanna ◽  
M. B. Anusha ◽  
K. R. Anilakumar
Keyword(s):  
Oxidative Stress ◽  
Partial Pressure ◽  
High Altitude ◽  
Acute Hypoxia ◽  
The Body ◽  
Nutritional Requirement ◽  
Hormonal Changes ◽  
Partial Pressure Of Oxygen ◽  
The Individual ◽  
Loss Of Appetite

<p>When people are exposed to the extreme environmental conditions, such as high altitude (HA) where there is decrease in temperature and partial pressure of oxygen induces fatigue, insomnia, loss of appetite and increased cardiac output. Hence there is need to improve the appetite through the diet and digestion clout of the individual. In the present review paper we have discussed the efficiency of digestion is compromised at HA. Also about, Hypoxia, resulting by decreased partial pressure of oxygen can be classified into acute hypoxia and chronic hypoxia based on the exposure time. There is increased formation of reactive oxygen species (ROS) due to less oxygen available in the air at HA which leads to oxidative stress. Lipid peroxidation caused by oxidative stress. Hypoxia is mediated through hypoxia inducible factors which maintain oxygen haemostasis in the body. At HA diet rich in carbohydrates have been found to be beneficial as it increases glucose metabolism. Requirement of nutrients such as vitamin A, vitamin E and vitamin C as well as micronutrients such as zinc, iron, selenium, copper and manganese will be required at HA. Hypoxia effect on the intestine leads to malabsorption and the lipid storage is stimulated and lipid catabolism is inhibited through β-oxidation.</p>

scholarly journals Software Stress Assessment Test: A Preliminary Invstigation

1970 ◽  
Vol 1 (1) ◽  
Author(s):  
S Soujanya ◽  
H S Ashok ◽  
Bhogle Sudha
Keyword(s):  
Occupational Stress ◽  
Stress Reaction ◽  
The Body ◽  
Reliability Test ◽  
Positive Experience ◽  
Moderate Amount ◽  
Stress Assessment ◽  
Individual Perception ◽  
Software Firm ◽  
State Of Exhaustion

Though research on stress has been on the increase in recent years, occupational stress literature is based, to a large extent, on individual perception rather than substantiated fact. The present study was undertaken with the objective of developing a stress assessment test for the software professional. The test consists of 57 items covering four factors namely, job-related, organisational, personal and behavioural. The test was administered to 33 software specialists from a software firm in Bangalore. Based on the data, percentile norms were established. The scale was subjected to reliability test. The split half reliability is 0.816**. Work is currently on in the area and further research is required in this direction. Individual moves into a state of exhaustion, from which tissue breakdown and even death can result. In other words, continued stress can lead to bodily damage. The body manifests the stress reaction by a rise in blood pressure, increased adrenaline, changed heartbeat, more RBCs, slower digestion, and so on. However, Selye argued that a moderate amount of stress could be a positive experience while too little stress could be negative.

scholarly journals EVALUATION OF THE BIOLOGICAL RELATIONSHIPS OF CORTICOSTERONE AND CORTISOL IN THE BODY OF CHICKENS DURING A STRESS REACTION

2021 ◽  
Vol 246 (2) ◽  
pp. 187-193
Author(s):  
L.N. Sayfutdinova ◽  
◽  
M.A. Derkho ◽  
◽  
Keyword(s):  
Laying Hens ◽  
Biological Effects ◽  
Technological Factor ◽  
Stress Reaction ◽  
The Body ◽  
Stress Conditions ◽  
Group Iii ◽  
Group I ◽  
Group Ii ◽  
Cortisol Ratio

The variability of corticosterone and cortisol concentrations and their ratio in laying hens during the development of a stress reaction, as well as the correlation of hormone levels with the variability of protein parameters in the blood, are evaluated. It was found that when the technological factor (the density of birds in the cage) changes by 1.5 times, the amount of glucocorticoids in the blood of birds during the stress reaction increases, both due to corticosterone and cortisol. Therefore, the balance between the hormones were not significantly changed and is in the range of 4.23-5,43conv. Units. When the technological factor is increased by 2 times, the content of corticosterone in the blood of birds mainly increases, determining an increase in the value of the corticosterone/cortisol ratio by 16.56-28.71%. The biological effects of glucocorticoids in the body of birds are realized by corticosterone, the level of which in a moderate and strong degree, including statistically significant, both under normal and stress conditions, is associated with the activity of transamination enzymes: Corticosterone-AlAT (r(group I) = 0,69±0,32 – 0,88±0,21; r(group II) =0.63±0.24 – 0.91±0.13; r(group III) = 0,59±0,22 – 0,76±0,16) and Corticosterone-AsAT (r(I group) = 0,57±0,36 – 0,83±0,25; r(group II) =0,68±0,23 – 0,72±0,22; r(group III) = 0,67±0,19 – 0,89±0,12), and also with the concentration of albumins during the development of a stress reaction (Corticosterone-Alb: r(group II) = -0,69±0,22 – -0,81±0,19; r(group III) = -0,58±0,21 – -0,81±0,16).

Tolerance of cooled animals to acute hypoxia during rewarming

1959 ◽  
Vol 197 (6) ◽  
pp. 1357-1358 ◽  
Author(s):  
J. Davidović ◽  
Ines Wesley
Keyword(s):  
Survival Rate ◽  
Body Temperature ◽  
Rectal Temperature ◽  
Acute Hypoxia ◽  
The Body ◽  
Simulated Altitude ◽  
Closed Vessel ◽  
Interesting Phenomenon ◽  
Hypoxic Tolerance ◽  
Tolerance To Hypoxia

Rats cooled to a rectal temperature of 20°C were permitted to rewarm at a simulated altitude of 11,500 m. A greater survival rate was observed in animals so treated than in controls not previously exposed to hypothermia. The loss of hypoxic tolerance was more pronounced within the range of 28°–36°C than in the range of 22°–28°C. The depth of cooling has a notable influence on the tolerance to hypoxia during rewarming when the body temperature of 33°C is reached. Thus far, the most resistant were rats cooled by the closed vessel technique to 18°C and those cooled by immersion to 22°C. The mechanism of this interesting phenomenon is unknown.

scholarly journals PATHOLOGIC FEATURES OF PERIODONTAL TISSUES IN EXPERIMENTAL OSTEOPOROSIS

2017 ◽  
Vol 21 (2) ◽  
pp. 76-78
Author(s):  
N. I Bykova ◽  
T. L Kobylkina ◽  
V. A Grigoryan ◽  
A. A Adamchik ◽  
A. V Arutyunov
Keyword(s):  
Acute Hypoxia ◽  
Nerve Fibers ◽  
The Body ◽  
Histological Structure ◽  
Pathological Changes ◽  
Periodontal Tissues ◽  
Pathologic Features ◽  
Experimental Osteoporosis ◽  
Autologous Mesenchymal Stem Cells

The article presents information about some pathological changes in periodontal tissues during experimental osteoporosis. The experiments were conducted on 8 three-year sheep, which have at different times after ovariectomy removed dentoalveolar segments in the region of incisors of the lower jaw. Pathological changes in periodontal animals in experimental osteoporosis were local manifestations of the general condition of the body that are typical of acute hypoxia mixed character. It was found that experimental osteoporosis in periodontal develop processes accompanied by acute circulatory disorders, which worsen the conditions of metabolism, which ultimately leads to destructive changes of argyrophilic and collagen fibrils, as well as individual nerve fibers. Studies have shown that these effects are reversible, and after 120 days to the fore the phenomenon of compensation in periodontal starting to recover basic histological structure. Prolonged hypoxia, as the main link in the pathogenesis of degenerative and inflammatory of forms of periodontal disease may be modified by the proven of efficiency pharmacological means. The detected changes at the osteoporosis models can be the basis for further study of the role of autologous mesenchymal stem cells and materials-matrices of various origins in optimizing the osseointegration process.

scholarly journals BLOOD PROTEINS AND THEIR INFORMATIVENESS IN ASSESSING THE ADAPTIVE RESOURCES OF CHICKENS UNDER TECHNOLOGICAL STRESS

2021 ◽  
Vol 245 (1) ◽  
pp. 169-176
Author(s):  
L.N. Sayfutdinova ◽  
◽  
M.A. Derkho ◽  
◽  
Keyword(s):  
Uric Acid ◽  
Total Protein ◽  
Free Amino ◽  
Technological Factor ◽  
Blood Stream ◽  
Stress Reaction ◽  
The Body ◽  
Blood Proteins ◽  
Adrenal System ◽  
Technological Stress

In the body of chickens, when exposed to the technological factor (the density of birds in the cage), a stress reaction developed as a result of activation of the hypathalamic-pituitary-adrenal system. The response and state of the neuroendocrine pathway is associated with the magnitude of the technological stress factor. When it is increased by 1.50 times, the maximum changes in the body of chickens are detected 4 hours after the start of the experiment. At the same time, the level of corticosterone and cortisol in the blood of birds increases by 3.42 and 2.99 times, increasing the rate of catabolic reactions in protein metabolism. Therefore, the amount of total protein in the blood-stream of chickens increases by 34.32 %, albumins by 26.74 %, urea and uric acid by 2.07 and 2.29 times, and the activity of AsAT and AlAT increases by 2.15 and 4.53 times (p<0.05). The catabolic processes involve mainly blood albumins, whose nitrogen is used for the synthesis of uric acid. This is evidenced by a decrease in the value of Alb/uric acid by 42.74 % (p<0.05). With an increase in the density of birds in the cage by 2 times, the reaction of the GGNS more pronounced and long-lasting. Although the maximum changes are registered 2 hours after the initiation of stress, they per-sist throughout the study period. At the same time, the level of corticosterone and cortisol in the blood of chickens increases by 4.17 and 3.67 times, the concentration of total protein by 39.44 %, both due to albumins (by 41.78 %) and globulins (by 37.82 %); the increase in the amount of urea and uric acid is 2.18 and 2.45 times. Both albumins and blood globulins are subjected to oxidative decomposition, which determines the decrease in the ratio TP/Urea, Alb/urea at, TP/uric acid and Alb/uric acid at 35.72-43.18 %. At the same time, the activity of AlAT increases by 7.56 times and AsAT by 2.21 times, determining the predominant use of carbon residues of free amino acids in the processes of gluconeogenesis (AlAT/AsAT increased by 3.75 times).

scholarly journals Hypoxia and antihypoxants, focus on brain injury

2019 ◽  
Vol 17 (1) ◽  
pp. 7-16
Author(s):  
Petr D. Shabanov ◽  
Irina V. Zarubina
Keyword(s):  
Acute Hypoxia ◽  
Combined Treatment ◽  
Recovery Period ◽  
Craniocerebral Trauma ◽  
Anxiolytic Effect ◽  
The Body ◽  
Metabolic Disturbances ◽  
Early Recovery ◽  
The Individual ◽  
The Brain

Experiments on rats showed that the individual resistance of the body to acute hypoxia is of decisive importance in the early recovery period after mechanical craniocerebral trauma. Antihypoxant ethomersol administration (25 mg/kg, 3 days, intraperitoneally) following trauma decreased behavioral impairments in rats with different levels of resistance to acute hypoxia, restored the structure of individual behavior, and prevented metabolic disturbances in the brain. Monotherapy of consequences of craniocerebral trauma with antidepressant pyrazidol (1 mg/kg) produced an anxiolytic effect in animals highly resistant to hypoxia and activating effect on low resistant animals. Treatment with bemithyl, an antihypoxant of benzimidazole structure, in a dose of 25 mg/kg produced a cerebroprotective effect and normalized individual behavioral characteristics, parameters of energy metabolism, and state of the antioxidant system in the brain of highly and low resistant rats. The effect of bemithyl was most pronounced in highly resistant animals. During combined treatment, pyrazidol and bemithyl had an additive effect in animals of both groups. They normalized behavioral reactions and prevented the development of metabolic disturbances in the brain.

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