scholarly journals Public health burden of pre-diabetes and diabetes in Luxembourg: finding from the 2013–2015 European Health Examination Survey

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e022206 ◽  
Author(s):  
Valéry Bocquet ◽  
Maria Ruiz-Castell ◽  
Carine de Beaufort ◽  
Jessica Barré ◽  
Nathalie de Rekeneire ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Medical Diagnosis ◽  
Undiagnosed Diabetes ◽  
Health Examination ◽  
Family History Of Diabetes ◽  
Unit Increase ◽  
History Of ◽  
European Health ◽  
Diagnosed Diabetes

ObjectiveThe aim of this study was to determine the burden and risk factors of prediabetes and diabetes in the general adult population of Luxembourg.DesignCross-sectional survey between 2013 and 2015.SettingData were collected as part of the European Health Examination Survey in Luxembourg (EHES-LUX).Participants1451 individuals were recruited in a random sample of the 25–64-year-old population of Luxembourg.OutcomesDiabetes was defined by a glycaemic biomarker (fasting plasma glucose (FPG) ≥7.0 mmol/L), self-reported medication and medical diagnosis; prediabetes by a glycaemic biomarker (FPG 5.6–6.9 mmol/L), no self-reported medication and no medical diagnosis. Undiagnosed diabetes was defined only from the glycaemic biomarker; the difference between total and undiagnosed diabetes was defined as diagnosed diabetes. Odds of diabetes and prediabetes as well as associated risk factors were estimated.ResultsThe weighted prevalence of prediabetes and diabetes was 25.6% and 6.5%, respectively. Nearly 4.8% (men: 5.8%; women: 3.8%) were diagnosed diabetes and 1.7% (men: 2.6%; women: 0.7%) were undiagnosed diabetes. The multivariable-adjusted OR (MVOR) for diabetes risk were: age 1.05 (95% CI 1.01 to 1.09), family history of diabetes 3.24 (1.95–5.38), abdominal obesity 2.63 (1.53–4.52), hypertension 3.18 (1.76–5.72), one-unit increase of triglycerides 1.16 (1.10–1.22) and total cholesterol 0.74 (0.64–0.86). The MVOR for prediabetes risk were: age 1.04 (95% CI 1.02 to 1.06), male sex 1.84 (1.30–2.60), moderate alcohol consumption 1.38 (1.01–1.89), family history of diabetes 1.52 (1.13–2.05), abdominal obesity 1.44 (1.06–1.97), second-generation immigrants 0.61 (0.39–0.95) and a one-unit increase of serum high-density lipoprotein cholesterol 0.70 (0.54–0.90).ConclusionsIn Luxembourg, an unexpectedly high number of adults may be affected by prediabetes and diabetes. Therefore, these conditions should be addressed as a public health priority for the country, requiring measures for enhanced detection and surveillance, which are currently lacking, especially in primary care settings.

scholarly journals Prevalence and Risk Factors for Undiagnosed Glucose Intolerance Status in Apparently Healthy Young Adults Aged <40 Years: The Korean National Health and Nutrition Examination Survey 2014–2017

2019 ◽  
Vol 16 (13) ◽  
pp. 2393 ◽  
Author(s):  
Young Sang Lyu ◽  
Sang Yong Kim ◽  
Hak Yeon Bae ◽  
Jin Hwa Kim
Keyword(s):  
Risk Factors ◽  
Young Adults ◽  
Family History ◽  
Significant Risk ◽  
Undiagnosed Diabetes ◽  
Nutrition Examination Survey ◽  
Family History Of Diabetes ◽  
Health And Nutrition ◽  
History Of ◽  
Apparently Healthy

Background: Early-onset diabetes results in longer lifetime hyperglycemic exposure that consequently leads to earlier chronic diabetes complications and premature death. The aim of this study was to quantify the prevalence and risk factors of undiagnosed diabetes and undiagnosed prediabetes in apparently healthy young adults aged <40 years. Methods: This study used data from the Korean National Health and Nutrition Examination Survey, a cross-sectional, nationally representative survey conducted by the Korean Ministry of Health and Welfare from 2014 to 2017. A total of 4442 apparently healthy young adults enrolled in this study. Multivariate logistic regression analyses were conducted separately to evaluate associated risk factors with undiagnosed diabetes and undiagnosed prediabetes in groups stratified by sex. Results: The prevalence of undiagnosed diabetes and undiagnosed prediabetes was 1.2% and 25.0%, respectively. Obesity (body mass index ≥ 30.0 kg/m2) was a significant risk factor of undiagnosed diabetes regardless of sex (men, odds ratio (OR): 9.808, 95% confidence interval (CI): 1.619–59.412; women, OR: 7.719, 95% CI: 1.332–44.747). Family history of diabetes was significantly associated with undiagnosed diabetes (OR: 3.407, 95% CI: 1.224–9.481) in women only. Increased age, obesity status, and family history of diabetes were significant risk factors for undiagnosed prediabetes. Alcohol consumption was found to be negatively associated with undiagnosed prediabetes in women. Conclusions: Increased attention and implementation of precise strategies for identifying young adults at high risk for undiagnosed diabetes would allow for increased wellbeing as well as reduced healthcare burdens associated with diabetes.

scholarly journals Prevalence and associated risk factors of undiagnosed diabetes among adult Moroccan Sahraoui women

2006 ◽  
Vol 9 (6) ◽  
pp. 722-727 ◽  
Author(s):  
Mohamed Rguibi ◽  
Rekia Belahsen
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Family History ◽  
Undiagnosed Diabetes ◽  
Adult Women ◽  
Obese Women ◽  
Family History Of Diabetes ◽  
History Of ◽  
Independent Association ◽  
Associated Risk Factors

AbstractObjectiveThe goal of the present work was to examine the prevalence and associated risk factors of undiagnosed diabetes among urban Moroccan Sahraoui women.Design and settingRandomised sample of adult women living in the city of Laayoune in south Morocco who visited public health centres during an immunisation campaign. Body weight, height, waist and hip circumferences, blood pressure, fasting plasma glucose (FPG), triglycerides, dietary intake and physical activity were collected.SubjectsData were obtained on 249 urban women aged 15 years and older, who were not pregnant. Only subjects identified as of Sahraoui origin were eligible for this investigation.ResultsThe prevalence of impaired fasting glucose (IFG) was 5.5% and that of undiagnosed diabetes 6.4%. Diabetes and IFG were more common among older and obese women as well as among women with hypertension or a family history of diabetes. In addition, sucrose intakes were higher in women with diabetes than in those with normal FPG. Also, physical activity estimated as the time spent in walking was negatively associated with FPG. Regression analyses showed an independent association of age, obesity, family history of diabetes and triglycerides with diabetes.ConclusionThe high proportion of unknown diabetes suggests the need for increased diabetes awareness in this population. The data suggest also the involvement of obesity in diabetes and the potential importance of intervention strategies to reduce population adiposity for the prevention and management of cardiovascular risk factors.

Abstract P175: Hypertension Burden in Luxembourg: Geographic Variations and Individual Risk Factors From the 2013-15 European Health Examination Survey

Circulation ◽  
2016 ◽  
Vol 133 (suppl_1) ◽  
Author(s):  
Maria Ruiz-Castell ◽  
Ngianga-Bakwin Kandala ◽  
Andrea Kuemmerle ◽  
Jessica Barré ◽  
Anna Schritz ◽  
...  
Keyword(s):  
Public Health ◽  
Risk Factors ◽  
Depressive Symptoms ◽  
Odds Ratio ◽  
Individual Risk ◽  
Health Examination ◽  
Geographic Variations ◽  
Hypertension Prevalence ◽  
Health Examination Survey ◽  
European Health

Introduction: Hypertension is a modifiable risk factor for cardiovascular disease, the latter still representing the main cause of death in Luxembourg. The aim of this study was to estimate the current prevalence of hypertension, associated risk factors, and its geographic variations in the Grand Duchy of Luxembourg. Methods: Cross-sectional, population-based data on 1,508 randomly selected residents of Luxembourg, aged 25 to 64, were collected as part of the European Health Examination Survey (EHES-LUX) between 2013 and 2015. Hypertension was defined as systolic/diastolic blood pressure of ≥140/90 mmHg, self-report of a physician diagnosis or on anti-hypertensive medication. Standard and Bayesian regressions were used to examine associations between hypertension and covariates. We mapped hypertension‘s geographic distribution by using a Bayesian geo-additive mixed model adjusted by health-related behaviours, socioeconomic characteristics, body mass index, depressive symptoms and general health status. Results: 31% (471 of 1508) of Luxembourg residents were hypertensive, and half of them were unaware of their condition. Among those who were aware of their condition, nearly 50% (121 of 261) were not adequately controlled. In men, the likelihood of being hypertensive was: lower in those being more physically active (>3h/week) (odds ratio [OR] and 95% credible region [CR]: 0.60[0.37, 0.92]) and consuming alcohol daily (0.33 [0.10, 0.83]), and higher in those with a low health perception (1.63 [1.01, 2.69]). In women, the likelihood of being hypertensive was higher in those experiencing depressive symptoms (1.83[1.27, 2.68]). There was a clear variation in hypertension prevalence across cantons and municipalities, with a North to South gradient: the highest odds ratio was observed in the South-West region of the country (1.21 [0.94, 1.57]), one of the most industrialized regions in Luxembourg. We observed a significant positive spatial effect in this region at 90% nominal level. Conclusions: In Luxembourg, the vast majority of people with hypertension are either unaware of their condition or not adequately controlled, which constitutes a major public health issue. There are geographic differences in hypertension prevalence in Luxembourg, which is remarkable given the size of the country. It is therefore necessary to consider the role of individual and regional (canton and commune level) risk factors in hypertension prevalence, as well as public health initiatives to control and promote awareness about this condition in order to reduce its burden in Luxembourg.

scholarly journals Incidence of diabetes mellitus and associated risk factors in the adult population of the Basque country, Spain

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Inés Urrutia ◽  
◽  
Alicia Martín-Nieto ◽  
Rosa Martínez ◽  
J Oriol Casanovas-Marsal ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Family History ◽  
Basque Country ◽  
Adult Population ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Family History Of Diabetes ◽  
History Of ◽  
Incident Cases

AbstractThe aim of this study was to estimate the incidence of diabetes mellitus in the Basque Country and the risk factors involved in the disease by reassessing an adult population after 7 years of follow-up. In the previous prevalence study, 847 people older than 18 years were randomly selected from all over the Basque Country and were invited to answer a medical questionnaire, followed by a physical examination and an oral glucose tolerance test. In the reassessment, the same variables were collected and the resulting cohort comprised 517 individuals of whom 43 had diabetes at baseline. The cumulative incidence of diabetes was 4.64% in 7 years and the raw incidence rate was 6.56 cases/1000 person-years (95%CI: 4.11–9.93). Among the incident cases, 59% were undiagnosed. The most strongly associated markers by univariate analyses were age > 60 years, dyslipidaemia, prediabetes and insulin resistance. We also found association with hypertension, obesity, family history of diabetes and low education level. Multivariate analysis adjusted for age and sex showed that a set of risk factors assessed together (dyslipidaemia, waist-to-hip-ratio and family history of diabetes) had great predictive value (AUC-ROC = 0.899, 95%CI: 0.846–0.953, p = 0.942), which suggests the need for early intervention before the onset of prediabetes.

scholarly journals POS0727 INSULIN RESISTANCE AND LEPTIN LEVELS IN SYSTEMIC LUPUS ERYTHEMATOSUS PATIENTS WITHOUT DIABETES MELLITUS OR FASTING HYPERGLYCEMIA

2021 ◽  
Vol 80 (Suppl 1) ◽  
pp. 613.2-614
Author(s):  
L. Kondrateva ◽  
T. Panafidina ◽  
T. Popkova ◽  
M. Cherkasova ◽  
A. Lila ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Insulin Resistance ◽  
Fasting Glucose ◽  
Family History Of Diabetes ◽  
History Of ◽  
Traditional Risk Factors ◽  
Risk Categories ◽  
Group 1

Background:Insulin resistance (IR) is considered as initial stage of diseases continuum from development of prediabetes to eventual progression to type 2 diabetes mellitus (T2DM). Individuals with prediabetes have also elevated leptin levels, so this adipocytokine along with IR can be considered as predictive laboratory markers of higher risk of T2DM. It is not yet clear whether presence of individual or multiple SLE-related and/or known traditional risk factors of T2DM (such as unhealthy diet, physical inactivity, family history of diabetes, or being overweight) can precipitate the development of IR.Objectives:To analyze the relationship between IR and increasing leptin levels rates. To identify the presence and evaluate the potential role of traditional and disease-related risk factors for IR in SLE patients without T2DM or hyperglycemia.Methods:A total of 49 SLE pts (46 women, 3 men, 40 [33;48] years old) without established DM and with normal fasting glucose levels (<6,1 mmol/l) were enrolled in the study. Median disease duration was 3,0[0,7;8,0] years, SLEDAI-2K was 5[2;8]. SLE pts were treated with glucocorticoids (GC) (84%), hydroxychloroquine (78%), immunosuppressive drugs (20%) and biological agents (10%). Insulin levels were measured using electrochemiluminescence assay Elecsys (Roche Diagnostics), serum leptin concentrations were estimated using ELISA (DBS-Diagnostics Biochem Canada Inc.). IR was defined as Homeostasis Model Assessment of Insulin Resistance index (HOMA-IR) ≥2,77. Leptin levels were considered elevated at values ≥11,1 ng/ml for women, ≥5.6 ng/ml for men. Eight traditional T2DM risk factors from the FINDRISK (Finnish Type 2 Diabetes Risk Assessment Form) questionnaire (older age, being overweight, abdominal obesity, family history of diabetes, sedentary lifestyle, lack of regular dietary fiber intake, taking antihypertensive medications as a surrogate marker of high blood pressure, documented episodes of hyperglycemia) were evaluated. This study used 5 risk categories for developing T2DM proposed by FINDRISK questionnaire: low, slightly elevated, moderate, high or very high.Results:Median HOMA-IR levels were 1,7 [1,2;2,5]. HOMA-IR correlated with leptin levels (r=0,7, p<0,001), body mass index (BMI) (r=0,6, p<0,001), waist circumference (WC) (r=0,5, p<0,001), T2DM risk categories by FINDRISK (r=0,3, p=0,03), SLEDAI-2K (r= -0,4, p<0,01), and duration of GCs therapy (r=0,3, p=0,03). Current GC use had no influence on HOMA-IR in SLE. IR was detected in 10 (20%) SLE pts. The traditional T2DM risk factors profiles were similar in pts with (Group 1) or without IR (Group 2) except for higher anthropometric parameters in group 1 (for BMI 27,2[24,8;32,2]kg/m2 vs 23,7[20,6;26,7]kg/m2, p<0,01; for WC: 93[86;102]cm vs 83[76;93]cm, p=0,02). Leptin levels were also higher in SLE pts with IR compared to pts without IR (74,2[30,4;112,7]ng/ml vs 25,0[6,7;42,4]ng/ml, p<0,01). Increased leptin levels were found in 35 (71%) pts, more often in pts with IR (100 vs 64%, p=0,04).Conclusion:IR was found in 20% of SLE pts without T2DM having normal serum fasting glucose concentration. Emergence of IR was commonly preceded by increased leptin levels. IR values were closely associated with accumulation of adipose tissue facilitated by long-term GCs use and disease activity decrease. Contribution of other traditional risk factors of T2DM seemed insignificant.Disclosure of Interests:None declared

scholarly journals Differing Contributions of Classical Risk Factors to Type 2 Diabetes in Multi-Ethnic Malaysian Populations

2018 ◽  
Vol 15 (12) ◽  
pp. 2813
Author(s):  
Noraidatulakma Abdullah ◽  
Nor Abdul Murad ◽  
John Attia ◽  
Christopher Oldmeadow ◽  
Mohd Kamaruddin ◽  
...  
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Family History ◽  
Characteristic Curve ◽  
Lifestyle Factors ◽  
Predictive Utility ◽  
Family History Of Diabetes ◽  
History Of

The prevalence of type 2 diabetes is escalating rapidly in Asian countries, with the rapid increase likely attributable to a combination of genetic and lifestyle factors. Recent research suggests that common genetic risk variants contribute minimally to the rapidly rising prevalence. Rather, recent changes in dietary patterns and physical activity may be more important. This nested case-control study assessed the association and predictive utility of type 2 diabetes lifestyle risk factors in participants from Malaysia, an understudied Asian population with comparatively high disease prevalence. The study sample comprised 4077 participants from The Malaysian Cohort project and included sub-samples from the three major ancestral groups: Malay (n = 1323), Chinese (n = 1344) and Indian (n = 1410). Association of lifestyle factors with type 2 diabetes was assessed within and across ancestral groups using logistic regression. Predictive utility was quantified and compared between groups using the Area Under the Receiver-Operating Characteristic Curve (AUC). In predictive models including age, gender, waist-to-hip ratio, physical activity, location, family history of diabetes and average sleep duration, the AUC ranged from 0.76 to 0.85 across groups and was significantly higher in Chinese than Malays or Indians, likely reflecting anthropometric differences. This study suggests that obesity, advancing age, a family history of diabetes and living in a rural area are important drivers of the escalating prevalence of type 2 diabetes in Malaysia.

scholarly journals New Onset Diabetes after Transplant – Risk Factors, Clinical Profile and Outcome

2018 ◽  
Vol 2 (1) ◽  
pp. 35-40
Author(s):  
Sakthirajan R ◽  
Dhanapriya J ◽  
Dineshkumar T ◽  
Balasubramaniyan T ◽  
Gopalakrishnan N ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Family History ◽  
Fasting Blood Glucose ◽  
Hcv Infection ◽  
Clinical Profile ◽  
Family History Of Diabetes ◽  
Onset Diabetes ◽  
History Of ◽  
New Onset

Background: New onset diabetes after transplant (NODAT) remains one among the significant threats to both renal allograft and patient survival. The aim of this study was to analyse the clinical profile and risk factors for NODAT.Methods: This prospective observational study involved patients who underwent renal transplantation in our centre between 2010 and 2015.Results: During the mean follow up period of 18 ± 6 months, incidence of NODAT was 26.6% and the cumulativeincidence was highest in the first year after transplant. Recipient age, pre transplant impaired fasting glucose, Hepatitis C virus (HCV) infection, family history of diabetes, tacrolimus, post transplant hypertriglyceridemia and metabolic syndrome were found to be statistically significant risk factors for NODAT. In Cox multivariate regression analysis, age and family history of diabetes were found to be independent risk factors for NODAT. Fasting C-peptide level underlines insulin resistance as predominant mechanism for NODAT in two third of patients. There were higher incidence of urinary tract infection in the NODAT patients. NODAT was found to be an independent risk factor for fungal infection and 10 year cardiovascular risk in the renal recipients. There was no significant impact of NODAT on short term graft and patient survival.Conclusion: Age, pre-transplant fasting blood glucose, family history of diabetes, HCV infection and tacrolimus were found to be the important risk factors, with insulin resistance as the predominant mechanism for NODAT.

scholarly journals Diabetes Burden in Urban and Rural Senegalese Populations: A Cross-Sectional Study in 2012

2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
S. M. Seck ◽  
D. G. Dia ◽  
D. Doupa ◽  
A. Diop-Dia ◽  
I. Thiam ◽  
...  
Keyword(s):  
Risk Factors ◽  
Abdominal Obesity ◽  
Rural Areas ◽  
Urban Areas ◽  
Cross Sectional Study ◽  
Biological Data ◽  
Cross Sectional ◽  
Family History Of Diabetes ◽  
Rural And Urban Areas ◽  
History Of

Diabetes represents a challenging global health issue in the 21st century. Data from sub-Saharan African populations are scarce and are usually restricted to urban settings. The objective of this study was to compare prevalence and risk factors of diabetes in rural and urban areas in Senegal.Methods.In a community-based survey between January and May 2012, we included 1027 adults aged≥18 years living in northern Senegal. Sociodemographic, clinical, and biological data were collected during household visits. Multivariate logistic regression was performed to identify factors associated with diabetes.Results.Mean age of participants was48.0±16.9years and 65.7% were female. Participants from urban area represented 55.7%. The age-standardized prevalence of diabetes was 7.6% (6.0% in men versus 9.0% in women). Prevalence of diabetes was higher in urban areas (8.1%) compared to rural areas (4.6%). Disease awareness rate was 43%. After multivariate analysis, age (OR = 1.63,p=0.001), familial history of diabetes (OR = 1.42,p=0.001), and abdominal obesity (OR = 1.17,p=0.05) were associated with diabetes.Conclusion.Diabetes is frequent in urban and rural areas in Senegal. Awareness rate is very low among populations. Age, family history of diabetes, and abdominal obesity are the main risk factors identified.

Incidence and risk factors for dysglycaemia in Asian-Indians: a 10-year population-based prospective cohort study

2021 ◽  
pp. postgradmedj-2021-141243
Author(s):  
Rahul Gupta ◽  
Satyam Singh Jayant ◽  
Ashu Rastogi ◽  
Sanjay K Bhadada ◽  
Anil Bhansali ◽  
...  
Keyword(s):  
Risk Factors ◽  
Asian Indians ◽  
Sedentary Lifestyle ◽  
Population Based ◽  
Incidence Rates ◽  
Study Cohort ◽  
Family History Of Diabetes ◽  
High Incidence ◽  
History Of ◽  
East Asia Region

BackgroundDiabetes prevalence estimates suggest an increasing trend in South-East Asia region, but studies on its incidence are limited. The current study aims to estimate the incidence of type 2 diabetes and pre-diabetes in a population-based cohort from India.MethodsA subset of Chandigarh Urban Diabetes Study cohort (n=1878) with normoglycaemia or pre-diabetes at baseline was prospectively followed after a median of 11 (0.5–11) years. Diabetes and pre-diabetes were diagnosed as per WHO guidelines. The incidence with 95% CI was calculated in 1000 person-years and Cox proportional hazard model was used to find the association between the risk factors and progression to pre-diabetes and diabetes.ResultsThe incidence of diabetes, pre-diabetes and dysglycaemia (either pre-diabetes or diabetes) was 21.6 (17.8–26.1), 18.8 (14.8–23.4) and 31.7 (26.5–37.6) per 1000 person-years, respectively. Age (HR 1.02, 95% CI 1.01 to 1.04), family history of diabetes (HR 1.56, 95% CI 1.09 to 2.25) and sedentary lifestyle (HR 1.51, 95% CI 1.05 to 2.17) predicted conversion from normoglycaemia to dysglycaemia, while obesity (HR 2.43, 95% CI 1.21 to 4.89) predicted conversion from pre-diabetes to diabetes.ConclusionA high incidence of diabetes and pre-diabetes in Asian-Indians suggests a faster conversion rate to dysglycaemia, which is partly explained by sedentary lifestyle and consequent obesity in these individuals. The high incidence rates call for a pressing need for public health interventions targeting modifiable risk factors.

Sign in / Sign up

Export Citation Format

Share Document