Effects of enteral glutamine on gut mucosal protein  synthesis in healthy humans receiving glucocorticoids

In hypercatabolic patients, the beneficial effects of glutamine on gut mucosa could be partly due to a stimulation of protein synthesis. The fractional synthesis rate (FSR) of gut mucosal protein was measured in four groups of healthy volunteers treated with glucocorticoids for 2 days. Two groups were studied in the postabsorptive state while receiving glutamine or a nitrogen equivalent (control) and two groups in the fed state with or without glutamine, using a 5-h intravenous infusion of [13C]leucine, [2H5]phenylalanine, and cortisone. After nutrient and tracer infusion, duodenal biopsies were taken. In the postabsorptive state, FSR of gut mucosal protein were 87 and 76%/day in the control group and 130% ( P = 0.058 vs. control) and 104% ( P = 0.17 vs. control)/day in the glutamine group, with leucine and phenylalanine as tracers, respectively. During feeding, FSR did not increase and no significant difference was observed between glutamine and control groups. Overall, FSR of the four groups were two- to threefold higher than those obtained previously in healthy humans, suggesting that glucocorticoids may increase gut mucosal protein synthesis. However, in this situation, a moderate enteral glutamine supply failed to demonstrate a significant effect on gut mucosal protein synthesis in the postabsorptive state and during feeding.

Download Full-text

Gut mucosal protein synthesis in fed and fasted humans

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1998.274.3.e541 ◽

1998 ◽

Vol 274 (3) ◽

pp. E541-E546 ◽

Cited By ~ 21

Author(s):

Corinne Bouteloup-Demange ◽

Yves Boirie ◽

Pierre Déchelotte ◽

Pierre Gachon ◽

Bernard Beaufrère

Keyword(s):

Protein Synthesis ◽

Intravenous Infusion ◽

Young Men ◽

Duodenal Mucosa ◽

Liquid Diet ◽

Synthesis Rate ◽

Protein Synthesis Rate ◽

Fed State ◽

Precursor Pool ◽

Mucosal Protein

Fractional protein synthesis rate (FSR) of duodenal mucosa was measured in two groups of six healthy young men, either in the fed state at the end of a 10-day standardized diet or after a 36-h fast. Protein synthesis rate was measured during a 9-h intravenous infusion of [13C]leucine and [2H5]phenylalanine. The fed group also received an intragastric tracer, [2H3]leucine, mixed with the liquid diet. At the end of the tracer infusion, an endoscopy was performed to take duodenal mucosal biopsies. The major results were that 1) duodenal mucosal protein synthesis was high, 48.0 ± 8.5% (SE)/day by use of intravenous leucine tracer and intracellular leucine enrichment; 2) it was not affected by feeding whatever the tracer or the precursor pool used for the calculations; 3) the two intravenous tracers gave different FSR values; and 4) with the intragastric tracer, FSR was 25–220% of the rate calculated with the intravenous tracer, depending on the precursor pool used for the calculation. Thus absolute values of FSR should be taken with caution, because they depend on the precursor pool chosen, the route of tracer administration, and the tracer itself. However, gut mucosal protein synthesis as assessed by an intravenous tracer is not affected by feeding in humans.

Download Full-text

The Application of Cultural Model for Literacy through Legends to Enhance Speaking Ability of Second Semester English Students of Sriwijaya University

JOURNAL OF SOCIAL SCIENCE RESEARCH ◽

10.24297/jssr.v5i2.3356 ◽

2014 ◽

Vol 5 (2) ◽

pp. 710-716

Author(s):

Fitri Suci Puspita Sari Sari ◽

Rita Inderawati ◽

Zuraida Blani

Keyword(s):

Undergraduate Students ◽

T Test ◽

Control Group ◽

Cultural Model ◽

Significant Difference ◽

Post Test ◽

Quasi Experimental ◽

Equivalent Control ◽

And Control ◽

English Students

This study aimed to find out whether or not there was any significant difference in speaking ability of the students who were taught by implementing CML (Cultural Model for Literacy) through legends and those who were not. The sample was 41 undergraduate students enrolled in English course at FKIP of Sriwijaya University which were taken by purposive sampling method from 85 total of population. This study used one of the quasi-experimental designs that were pretest posttest non equivalent control group or comparison group design. The students were divided into two groups the experimental and control groups. The experimental group was required to do some phases in treatment of 16 meetings including pre-test and posttest in accordance with introducing new model of teaching speaking that was CML through legends. The data were obtained through speaking test by measuring their oral interpretations to know the students speaking ability. The test was administered twice as pre-test and post-test in both groups. The results indicated that there were any significant differences at level 0.05 level found in the data which were analyzed by using paired sample t-test (t=12.156>t-table=2.080) and independent sample t-test (t=3.252, p<0.05). The results also showed that CML through legends could enhance students speaking ability of the second semester English students of Sriwijaya University.

Download Full-text

DESCRIBING AND DRAWING PICTURE TECHNIQUE IN TEACHING TRANSACTIONAL SPEAKING

ETERNAL (English Teaching Learning and Research Journal) ◽

10.24252/eternal.v42.2018.a10 ◽

2018 ◽

Vol 4 (2) ◽

pp. 268

Author(s):

Nur Aliyah Nur

Keyword(s):

English Education ◽

Sampling Technique ◽

Control Group ◽

Education Department ◽

Control Group Design ◽

Significant Difference ◽

Post Test ◽

Quasi Experimental ◽

Equivalent Control ◽

And Control

The research aimed to find out the effectiveness of describing and drawing picture technique in teaching transactional speaking at the second semester students of English Education Department at State Islamic University of Alauddin Makassar. This research employed quasi-experimental with non-equivalent control group design with pre-test and post-test. The population of this research was the second semester students of English education department at State Islamic University of Alauddin Makassar. The population was selected by using purposive sampling technique to determine the sample for experimental class and control class. The instrument used in this research was test. The test was used in the pre-test and post-test. The data indicated that there was a significant difference between the students’ post-test in the experimental class and post-test in the control class. Based on the findings of the research, the researchers concluded that describing and drawing picture technique was effective in teaching transactional speaking. Therefore, describing and drawing picture technique gave student opportunity to practice transactional speaking in classroom, it also could increase students’ motivation in learning in English since they feel their purpose of learning English so that they could use it and also could achieve it.The research aimed to find out the effectiveness of describing and drawing picture technique in teaching transactional speaking at the second semester students of English Education Department at State Islamic University of Alauddin Makassar. This research employed quasi-experimental with non-equivalent control group design with pre-test and post-test. The population of this research was the second semester students of English education department at State Islamic University of Alauddin Makassar. The population was selected by using purposive sampling technique to determine the sample for experimental class and control class. The instrument used in this research was test. The test was used in the pre-test and post-test. The data indicated that there was a significant difference between the students’ post-test in the experimental class and post-test in the control class. Based on the findings of the research, the researchers concluded that describing and drawing picture technique was effective in teaching transactional speaking. Therefore, describing and drawing picture technique gave student opportunity to practice transactional speaking in classroom, it also could increase students’ motivation in learning in English since they feel their purpose of learning English so that they could use it and also could achieve it.

Download Full-text

The Effect of Cognitive Acceleration Programme on Critical Thinking of Science Students at Secondary Level

International Journal of Innovation in Teaching and Learning (IJITL) ◽

10.35993/ijitl.v7i2.1516 ◽

2021 ◽

Vol 7 (2) ◽

pp. 87-100

Author(s):

Shazia Sarwar ◽

Muhammad Samiullah ◽

Fazal-ur- Rahman

Keyword(s):

Critical Thinking ◽

Thinking Skills ◽

Critical Thinking Skills ◽

Control Group ◽

Control Group Design ◽

Significant Difference ◽

Equivalent Control ◽

Cognitive Acceleration ◽

Faculty Of Education ◽

And Control

Abstract This study was conducted to determine the effect of Cognitive Acceleration Programme on the critical thinking skills of 9th graders. The posttest only non-equivalent control group design was used. Two sections of class 9th were selected conveniently for experimentation. There were 80 participants (girls) in the experiment. There were 30 intervention lessons in the experimental classrooms. The posttest was designed based on Cornell Critical thinking test. Test was validated by experts from the Faculty of Education, Allama Iqbal Open University Islamabad. The data were analyzed by the SPSS. The independent sample t-statistics were applied for control and experimental groups separately. The t-value for the comparison of performance of experimental and control group in sub-skills of critical thinking i.e., inference, deduction, assumption, interpretation, and argumentation showed significant difference. The results showed that critical thinking skills can be developed significantly through cognitive acceleration programme. So, the thinking science activities were recommended to science educators to incorporate into the classroom to accelerate critical thinking of students. Keywords: Cognitive Acceleration, Critical Thinking, Inference, Deduction, Assumption, Interpretation, Argumentation

Download Full-text

Implementing AMETTA (Active, Joyful, and Unstressed) in Increasing Learning Activity and Outcomes

AL-ISHLAH: Jurnal Pendidikan ◽

10.35445/alishlah.v13i1.300 ◽

2021 ◽

Vol 13 (1) ◽

pp. 144-155

Author(s):

Yenni Hasnah ◽

Pirman Ginting ◽

Selamat Husni Hasibuan

Keyword(s):

Student Learning ◽

Learning Outcomes ◽

Learning Model ◽

Learning Activity ◽

Control Group ◽

Control Group Design ◽

Significant Difference ◽

Quasi Experimental ◽

Equivalent Control ◽

And Control

This research aims to analyze the learning model's practice and its effect on increasing student activity and learning outcomes in listening subjects. This study employed quasi-experimental research with a non-equivalent control group design. The data were gained using observation and tests. It is analyzed by reflection and statistical test of SPPS. The results show that the application of the AMETTA learning model effectively develops student learning activities and outcomes. The result of hypothesis testing with sig. (2-tailed) was 0.033 (˂ 0.05) It indicates that Ho is rejected. Thus, there is a significant difference between the average student learning outcomes in the experimental and control classes. In other words, the application of AMETTA learning model has a significant effect on students’ learning outcomes.

Download Full-text

Penerapan Metode Pembelajaran Think, Pair, and Share dalam Pembelajaran Menulis Teks Berita

MIMBAR PENDIDIKAN ◽

10.17509/mimbardik.v3i1.10640 ◽

2018 ◽

Vol 3 (1) ◽

pp. 71-82

Author(s):

Suci Noor Anisa Putri Rahayudianti ◽

Andoyo Sastromiharjo ◽

Yulianeta Yulianeta

Keyword(s):

Language Learning ◽

Junior High School ◽

Hypothesis Test ◽

Control Group ◽

Control Group Design ◽

Significant Difference ◽

Post Test ◽

Equivalent Control ◽

And Control ◽

Experimental Group

ABSTRAKSI: Penelitian ini bertujuan untuk mengetahui perbedaan signifikan penerapan metode “think, pair, and share” di kelas eksperimen dan kelas kontrol tentang kemampuan siswa dalam menulis teks berita. Metode yang digunakan adalah eksperimen kuasi, dengan desain kelompok kontrol “non-equivalent”, dan sampel bertujuan terdiri dari dua kelompok: 30 siswa di kelas kontrol dan kelas eksperimen. Hasil penelitian menunjukan bahwa kemampuan menulis teks berita siswa sebelum mendapat perlakuan, secara keseluruhan, masih kurang maksimal. Perolehan nilai pre-test di kelas eksperimen, rata-rata sebesar 41; sedangkan kelas kontrol sebesar 46.8. Pada saat post-test, kelas eksperimen mendapat nilai 80; sedangkan kelas kontrol sebesar 53.8. Kemampuan menulis teks berita siswa kelas eksperimen dan kelas kontrol, dengan demikian, mengalami peningkatan. Hasil uji hipotesis pada siswa kelas VIII SMP (Sekolah Menengah Pertama) Laboratorium UPI (Universitas Pendidikan Indonesia) Kampus Cibiru, Bandung, Jawa Barat, Indonesia ini dapat disimpulkan bahwa terdapat perbedaan signifikan antara kemampuan menulis teks berita siswa kelas eksperimen dan kelas kontrol. KATA KUNCI: Pembelajaran Bahasa; Teknik Berpikir, Berpasangan, Berbagi; Teks Berita; Kemampuan Menulis Siswa.ABSTRACT: “Application of Think, Pair, and Share Learning Methods in News Text Writing Lesson”. This study aims to investigate a significant difference in the implementation of think, pair, share method in the experimental and control groups of students’ ability in writing the news text. The method used is quasi experiment, with non-equivalent control group design, and the purposive sampling was consisted of 30 students for each groups. The finding shows that before the treatment, the students’ achievements in both groups were not maximal. The pre-test score results of the experimental group was 41; while the control group was 46.8. However, the post-test results of the experimental group was 80; but the control group as 53.8. It indicates the students’ ability in writing the news text in the experimental groups improved. The hypothesis test to the students in Year VIII of SMP (Junior High School) Laboratorium School UPI (Indonesia University of Education) Cibiru Campus, Bandung, West Java, Indonesia can be concluded that there is a significant difference in ability of writing the news text between the students in the experimental and control groups.KEY WORD: Language Learning; Think, Pair, Share’s Method; News Text; Student’s Writing Competences. About the Authors: Suci Noor Anisa Putri Rahayudianti, S.Pd. adalah Alumni Departemen Pendidikan Bahasa dan Sastra Indonesia FPBS UPI (Fakultas Pendidikan Bahasa dan Sastra, Universitas Pendidikan Indonesia) di Bandung, lulus tahun 2017. Dr. Andoyo Sastromiharjo dan Dr. Yulianeta adalah Dosen Senior di Departemen Pendidikan Bahasa dan Sastra Indonesia FPBS UPI di Bandung, Jawa Barat, Indonesia. Alamat e-mail penulis: [email protected] Citation: Rahayudianti, Suci Noor Anisa Putri, Andoyo Sastromiharjo Yulianeta. (2018). “Penerapan Metode Pembelajaran Think, Pair, and Share dalam Pembelajaran Menulis Teks Berita” in MIMBAR PENDIDIKAN: Jurnal Indonesia untuk Kajian Pendidikan, Volume 3(1), March, pp.73-84. Bandung, Indonesia: UPI [Indonesia University of Education] Press, ISSN 2527-3868 (print) and 2503-457X (online). Article Timeline: Accepted (October 9, 2017); Revised (March 2, 2018); and Published (March 30, 2018).

Download Full-text

Improvement of Psychological Health Aspect of Tuberculosis Client Through Psychoeducation

Babali Nursing Research ◽

10.37363/bnr.2020.1224 ◽

2020 ◽

Vol 1 (2) ◽

pp. 91-96

Author(s):

Nurul Khoirun Nisa

Keyword(s):

Psychological Health ◽

Sampling Technique ◽

Simple Random Sampling ◽

Psychological Aspects ◽

Control Group ◽

Control Groups ◽

Significant Difference ◽

Post Test ◽

Equivalent Control ◽

And Control

Introduction: Tuberculosis is well known as an infectious disease on lungs system caused by Mycobacterium tuberculosis in physical, social and mental health conditions. Methods: This research applied quasi-experiment and consisted of pre and post-test on non-equivalent control group. The subjects were divided into two groups, control group (35) and treatment group (35) by using simple random sampling technique based on inclusion criteria. The research was conducted at Health Center, Jombang. The variables involved in this research were psycho-education psychological aspects. Results: The results of the research showed that physical and psychological aspects on both treatment and control groups is with p = 0.000 (<0.05) which means that there is significant difference on psychological aspect between treatment and control groups. Psycho-education significantly influenced psychological among the patients with tuberculosis. Conclusion: This change occurred due to the increase of health on the patient with tuberculosis in psychological aspects and also it followed by the decrease of symptoms on the patient.

Download Full-text

Effects of Advance Organizers on Students’ Achievement in Biology in Secondary Schools in Kilifi County, Kenya

Frontiers in Education Technology ◽

10.22158/fet.v1n2p191 ◽

2018 ◽

Vol 1 (2) ◽

pp. 191

Author(s):

Kevin K. Omondi ◽

Fred N. Keraro ◽

Zephania O. Anditi

Keyword(s):

Secondary Schools ◽

Study Data ◽

Advance Organizers ◽

Control Group ◽

School Students ◽

Control Group Design ◽

Significant Difference ◽

Equivalent Control ◽

Level Of Significance ◽

And Control

This study investigated the effects of using advance organizers on students’ achievement in biology in secondary schools in Kilifi County. Solomon Four, Non-Equivalent control group design was used in this study. The study targeted all secondary school students in Kilifi County. The accessible population consisted of all form two students in Kilifi County. Purposive sampling was used to select four co-educational secondary schools in Kilifi County. The four schools were randomly assigned to experimental groups (E1) and (E2) and control groups C1 and C2. A total of 156 students participated in the study. Data was collected using Biology Achievement Test (BAT). The reliability of BAT was estimated using Kuder-Richardson (K-R) 20 and Cronbach’s coefficient. This yielded a reliability coefficient of 0.82 and 0.79 respectively. BAT was validated by experts in science education from Egerton University. The data collected was analyzed using mean, one-way ANOVA and t-test. The level of significance was 0.05. The findings of this study show that there was statistically significant difference in achievement between learners in favour of those taught using advance organizers compared to those taught using conventional teaching methods. The findings also indicate that there was no statistically significant gender difference in achievement.

Download Full-text

An Investigation Into the Beneficial Effects of High-Dose Interferon beta 1-a, Compared to Low-Dose Interferon Beta 1-a (the base therapeutic regimen) in moderate to severe COVID-19

10.21203/rs.3.rs-138540/v2 ◽

2021 ◽

Author(s):

Ilad Alavi Darazam ◽

Firouze Hatami ◽

Mohammad Mahdi Rabiei ◽

Mohamad Amin Pourhoseingholi ◽

Minoosh Shabani ◽

...

Keyword(s):

Low Dose ◽

Interferon Beta ◽

Intervention Group ◽

Control Group ◽

High Dose ◽

Research Committee ◽

Subcutaneous Injections ◽

Beneficial Effects ◽

Significant Difference ◽

And Control

Abstract Introduction: Coronavirus disease 2019 (COVID-19) has been a serious obstacle in front of public health. Interferon-beta 1a (IFN-β 1a) has been used to treat patients with COVID-19. We aimed to compare the effectiveness of high-dose IFN-β 1a compared to low dose IFN-β 1a in moderate to severe COVID-19 cases.Methods: In this randomized, controlled, and clinical trial, eligible patients with confirmed SARS-CoV-2 infections were randomly assigned to receive one of the two following therapeutic regimens: The intervention group was treated with high-dose IFN-β 1a (Recigen) (Subcutaneous injections of 88μg (24,000 IU) on days 1, 3, 6) + lopinavir /ritonavir (Kaletra) and the control group was treated with low-dose IFN-β 1a (Recigen) (Subcutaneous injections of 44μg (12,000 IU) on days 1, 3, 6) + lopinavir /ritonavir (Kaletra) (400mg/100 mg twice a day for 10 days, orally, in two groups). Result: A total of 168 COVID- 19 confirmed patients underwent randomization; 83 were assigned to the intervention group and 85 were assigned to the control group. Median Time To Clinical Improvement (TTIC) for cases treated with low-dose IFN-β1a was shorter than that for cases treated with high-dose IFN-β1a (6 vs10 days). Due to differences between some baseline clinical factors between intervention and control group, we performed an adjusted analysis. The model failed to reach a significant difference between two groups. Conclusion: The use of high-dose IFN-β 1a did not improve TTCI in hospitalized patients with moderate to severe COVID-19. Also, it did not have any significant effect on mortality reduction compared with treating with low-dose IFN-β 1a.Trial registration: The trial was confirmed by the Ethics in Medical Research Committee of the Shahid Beheshti University of Medical Sciences. Signed informed consents were obtained from all the participants or their legally authorized representatives. This trial has been registered as ClinicalTrials.gov, NCT04521400.

Download Full-text

Effects of Virgin Coconut Oil as Adjunct Therapy in the Treatment of Allergic Rhinitis

Journal of Clinical and Health Sciences ◽

10.24191/jchs.v1i1.5850 ◽

2016 ◽

Vol 1 (1) ◽

pp. 22

Author(s):

Nazli Zainuddin ◽

Nurul Azira Mohd Shah ◽

Rosdan Salim

Keyword(s):

Allergic Rhinitis ◽

Side Effects ◽

Coconut Oil ◽

Test Group ◽

Nasal Symptom ◽

Control Group ◽

Virgin Coconut Oil ◽

Control Groups ◽

Significant Difference ◽

And Control

Introduction: The role of virgin coconut oil in the treatment of allergic rhinitis is controversial. Thus, the aim of the present study is to determine the effects of virgin coconut oil ingestion, in addition to standard medications, on allergic rhinitis. We also studied the side effects of consumption of virgin coconut oil. Methods: Fifty two subjects were equally divided into test and control groups. All subjects received a daily dose of 10mg of loratadine for 28 days. The test group was given 10ml of virgin coconut oil three times a day in addition to loratadine. The symptoms of allergic rhinitis were scored at the beginning and end of the study. Results:, the symptom score were divided into nasal and non-nasal symptom scores. Sneezing score showed a significant difference, however the score was more in control group than test group, indicating that improvement in symptom was more in control group. The rest of the nasal symptom and non-nasal symptom score showed no significant difference between test and control groups. Approximately 58% of the test subjects developed side effects from consumption of virgin coconut oil, mainly gastrointestinal side effects. Conclusion: In the present study, ingestion of virgin coconut oil does not improve the overall and individual symptoms of allergic rhinitis, furthermore it has side effects.

Download Full-text