Survival of strain 129 dystrophic mice in parabiosis

1960 ◽  
Vol 199 (6) ◽  
pp. 1097-1100 ◽  
Author(s):  
R. S. Pope ◽  
E. D. Murphy
Keyword(s):  
Drinking Water ◽  
Weight Gain ◽  
Survival Time ◽  
Muscular Weakness ◽  
Same Sex ◽  
Histologic Analysis ◽  
Soft Diet ◽  
Significant Difference ◽  
Sufficient Concentration ◽  
Dystrophic Mice

Postweaning-age dystrophic mice were joined in parabiosis with normal and carrier partners of the same sex and strain. The parabionts and single dystrophic controls were fed a soft diet and received Terramycin in the drinking water. There was no significant difference in survival time or attained age among the groups of dystrophics. There was no evidence of amelioration of the dystrophic process by parabiosis in terms of survival time, weight gain, degree of muscular weakness, or histologic analysis at autopsy. The normal partners did not develop muscular weakness, nor was there histologic evidence of induction of the lesions of dystrophy. It is concluded that there is no evidence of a blood-borne substance present in sufficient concentration in the circulation of the normal partner which can influence the course of the disease, and that there is no indication of a blood-borne substance in the circulation of the dystrophic which can cause dystrophy.

scholarly journals Penambahan Konsentrasi Antibiotik Monensin dan Efeknya Terhadap Performa Ayam Broiler (Gallus gallus domestica)

2021 ◽  
Vol 6 (2) ◽  
pp. 40-45
Author(s):  
Hanim Nur Afifah ◽  
Hari Santoso ◽  
Ahmad Syauqi
Keyword(s):  
Drinking Water ◽  
Weight Gain ◽  
Water Consumption ◽  
Broiler Chicken ◽  
Growth Promoter ◽  
Antibiotic Administration ◽  
Significant Difference ◽  
Final Weight ◽  
Boiled Water ◽  
Basal Ration

Broiler chicken is one of the poultry farms whose growth is fast, can meet the needs of meat in the community. To accelerate chicken growth, addition of Antibiotic Growth Promoter (AGP) was added to the beverage. This study aims to analyze the effect of monensin antibiotic administration on weight gain. The research method uses a Completely Randomized Design (CRD), consisting of 4 treatments and 6 replications. P0 Treatment (Control): Basal ration + Water boiled in 1 liter; P1: Basal ration + Boiled water + 0.1 gr / day Antibiotic Monensin in 1 liter of water; P2: Basal ration + Boiled water + 0.5 gr / day Antibiotic Monensin in 1 liter of water; P3: Basal ration + Boiled water + 1 gram / day Antibiotic Monensin in 1 liter of water. Data analysis used ANOVA one way variance and continued with the Least Significant Difference Test (LSD) with a confidence level of 5%. The results of the study by giving various concentrations of monensin antibiotics to broilers had significantly affected ration conversion, drinking water consumption and final weight. The administration of 1 gram monensin antibiotic concentration tends to be better for ration consumption, body weight gain, drinking water consumption and final weight of broiler chickens compared to lower concentrations or controls. Keywords: Broiler Chicken, Monensin, Performance ABSTRAK Ayam broiler merupakan salah satu usaha ternak unggas yang pertumbuhannya cepat, dapat memenuhi kebutuhan daging dimasyarakat. Untuk mempercepat pertumbuhan ayam dilakukan penambahan Antibiotic Growth Promoter (AGP) pada minuman. Penelitian ini bertujuan untuk menganalisa pengaruh pemberian antibiotik monensin terhadap penambahan berat badan ayam. Metoda penelitian menggunakan Rancangan Acak Lengkap (RAL), terdiri dari 4 perlakuan dan 6 ulangan. Perlakuan P0 (Kontrol): Ransum Basal + Air yang direbus  dalam 1 liter; P1 : Ransum Basal + Air yang direbus + 0,1 gr/hari Antibiotik Monensin dalam 1 liter air; P2 : Ransum Basal + Air yang direbus + 0,5 gr/hari Antibiotik Monensin dalam 1 liter air; P3 : Ransum Basal + Air yang direbus + 1 gr/hari Antibiotik Monensin dalam 1 liter air. Analisa data menggunakan sidik ragam ANOVA one way dan dilanjutkan Uji Beda Nyata Terkecil (BNT) dengan taraf kepercayaan 5%. Hasil penelitian dengan pemberian berbagai konsentrasi antibiotik monensin terhadap ayam broiler berpengaruh nyata terhadap konversi ransum, konsumsi air minum dan bobot akhir. Pemberian konsentrasi antibiotik monensin 1 gr cenderung lebih baik untuk konsumsi ransum, pertambahan bobot badan, konsumsi air minum dan bobot akhir ayam broiler dibandingkan dengan konsentrasi yang lebih rendah maupun kontrol. Kata kunci: Ayam Broiler, Monensin, Performa

scholarly journals Effect of Aqueous Extract of Telfairia occidentalis Leaf on the Performance and Haematological Indices of Starter Broilers

2012 ◽  
Vol 2012 ◽  
pp. 1-4
Author(s):  
Onu P. N.
Keyword(s):  
Drinking Water ◽  
Weight Gain ◽  
Growth Performance ◽  
Aqueous Extract ◽  
Broiler Chicks ◽  
Feed Conversion ◽  
Highest Weight ◽  
Telfairia Occidentalis ◽  
Significant Difference ◽  
Haematological Indices

This experiment was conducted to determine the effect of aqueous extract of Telfairia occidentalis (Fluted Pumpkin) leaf on the performance and haematological indices of starter broilers. A total of 200, 8-day-old broiler chicks were randomly allotted to five (5) treatments, each with 4 replicate groups containing 10 chicks and fed with standard starter broiler diets. Telfaria occidentalis leaves extract (FPLE) was added at 0, 40, 80, 120, and 160 mL/litre of drinking water. Growth performance and haematological indices were evaluated. Results showed that there was significant () difference in weight gain, feed conversion, and protein efficiency ratios of the birds among the treatments. Birds fed 80 ml FPLE/litre of water had significantly the highest weight gain and the best feed conversion and protein efficiency ratios. There was no significant () variations in the feed and water intakes of the birds. Results also show no significant () difference in haematological indices of birds among the treatments. The results of this study indicate that, for enhanced weight gain and feed conversion efficiency, birds should be fed 80 mL FPLE/litre of water.

scholarly journals Performance Indices and Physiological Changes in Pearl Guinea Fowls (Numida Meleagris) Supplemented with Molasses through Drinking Water

2016 ◽  
Vol 18 (2) ◽  
pp. 102
Author(s):  
Buhari Habibu ◽  
Nizam Mustapha Ikira ◽  
Moses Ibrahim ◽  
Hajarah Uwale Buhari ◽  
Abdullahi Abdullahi ◽  
...  
Keyword(s):  
Drinking Water ◽  
Weight Gain ◽  
Rectal Temperature ◽  
Feed Consumption ◽  
Haematological Parameters ◽  
Performance Indices ◽  
Percentage Weight Gain ◽  
Numida Meleagris ◽  
Significant Difference ◽  
Percentage Weight

Abstract. The study was aimed at evaluating the performance indices and physiologic changes in pearl guinea fowls (Numida meleagris) supplemented with molasses through drinking water. A total of thirty-two (n=32) day-old pearl guinea fowls raised to 12-week-old were used for the study. The fowls were randomly allocated to two groups (control and experimental) of 16 fowls each, with each having two replicates. Experimental fowls were given 5 mL molasses per litre of drinking water for 8 weeks, while control fowls were given only drinking water. Performance indices which include: feed consumption, water intake and percentage weight gain were measured. Rectal temperature was measured and blood samples were collected to evaluate the changes in haematological parameters, serum triiodothyronine (T3) and thyroxine (T4) concentrations.  Results revealed that the molasses-treated fowls had significantly (P<0.05) higher percentage weight gain, blood total protein, packed cell volume and mean corpuscular volume compared to control. However, the feed consumptionwas significantly lower (P<0.05) in the molasses-treated fowls compared to control. In both groups, rectal temperature increased significantly (P<0.05) during the afternoon hours and was lower (P<0.05) in molasses-treated fowls than control during the evening hours. There was no significant difference in other haematological parameters, serum glucose, T4 and T3 betweengroups. In conclusion, molasses supplementation decreased feed consumption, improved body weight gain and enhanced nutritional status and erythropoiesis in guinea fowls.

Effect of central infusion of benzamil on Dahl S rat hypertension

1995 ◽  
Vol 269 (3) ◽  
pp. H1044-H1047 ◽  
Author(s):  
E. P. Gomez-Sanchez ◽  
C. E. Gomez-Sanchez
Keyword(s):  
Blood Pressure ◽  
Drinking Water ◽  
Weight Gain ◽  
Na Channel ◽  
Subcutaneous Infusion ◽  
Intracerebroventricular Infusion ◽  
Significant Difference ◽  
Induced Hypertension ◽  
Blood Pressures

The effect of continuous central infusion of benzamil, a Na+ channel-selective amiloride analogue, on the salt-induced hypertension in inbred Dahl salt-sensitive (SS/jr) rats was assessed. The continuous intracerebroventricular or subcutaneous infusion of benzamil at doses which have no effect when infused systemically was started at the same time or 2 wk after saline was substituted for drinking water, when the rats' blood pressures had become significantly elevated. Within 13 days, drinking saline caused a similar and significant increase in the blood pressures of rats receiving the vehicle intracerebroventricularly and 1 microgram/h of benzamil subcutaneously, which persisted throughout the 4-wk experiment. The intracerebroventricular infusion of 1 or 0.3 microgram/h benzamil, started at the same time the salt challenge was instituted, significantly deterred the increase in blood pressure over 4 wk. The intracerebroventricular, but not the subcutaneous, infusion of benzamil at 0.5 microgram/h arrested the increase in blood pressure in rats that were already hypertensive after 12 days on saline. Within 3 days the pressures in the intracerebroventricular and subcutaneous benzamil groups became significantly different, due to the further increase of the blood pressure in those animals receiving the intracerebroventricular vehicle with subcutaneous benzamil. There was no significant difference in weight gain throughout the experiment or in 24-h urine volumes and urinary Na(+)-to-K+ ratio at days 5 and 12 of benzamil infusion between groups.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Parasitism level by helminths and weight gain of calves kept in organic and conventional grazing

2013 ◽  
Vol 33 (5) ◽  
pp. 586-590 ◽  
Author(s):  
Jenevaldo Barbosa da Silva ◽  
Gisele Maria Fagundes ◽  
João Paulo Guimarães Soares ◽  
Adivaldo Henrique da Fonseca
Keyword(s):  
Weight Gain ◽  
Future Generations ◽  
Nematode Control ◽  
Successful Development ◽  
Organic Systems ◽  
Fecal Egg Count ◽  
Domestic Ruminants ◽  
Significant Difference ◽  
Feasible Alternative ◽  
Parasitism Level

Sustainable production is a principle in which we must meet the needs of the present without compromising the capacity of future generations. Despite the successful development of pesticides against endo and ectoparasites found in domestic ruminants, these parasites are still the major problem of the herbivore production system. The purpose of this study was to know the population of gastrintestinal parasites and their influence on weight gain of calves kept in organic and conventional grazing. Thus, organic and conventional calves were randomly selected in 2008 and 2009. The fecal egg count (FEC) indentified the following genders of helminths: Haemonchus, Trichostrongylus, Oesophagostomum, Cooperia, Strongyloides, Trichuris and oocysts of Eimeria. There was no significant difference (p>0.05) between FEC in organic and conventional animals. Calves younger than 6 months showed significant higher infection (p<0.05) than calves between 7 and 12 months of age. The weight gain observed during the study was of 327g/day and 280g/day for conventional and organic systems animals, respectively. Consequently, the combination of sustainable practices of grazing associated with the selective application of anthelmintics may be a feasible alternative for nematode control in a conventional system and in transition to an organic one.

scholarly journals Reduction of body-weight gain enhances in vitro embryo production in overfed superovulated dairy heifers

Reproduction ◽  
2006 ◽  
Vol 131 (4) ◽  
pp. 783-794 ◽  
Author(s):  
S Freret ◽  
B Grimard ◽  
A A Ponter ◽  
C Joly ◽  
C Ponsart ◽  
...  
Keyword(s):  
Weight Gain ◽  
Dietary Intake ◽  
Live Weight ◽  
Reproductive Hormones ◽  
Embryo Production ◽  
Live Weight Gain ◽  
Dairy Heifers ◽  
Period 2 ◽  
Significant Difference

The aim of our study was to test whether a reduction in dietary intake could improve in vitro embryo production in superovulated overfed dairy heifers. Cumulus–oocyte complexes of 16 Prim’ Holstein heifers (14 ± 1 months old) were collected by ovum pick-up (OPU), every 2 weeks following superovulation treatment with 250 μg FSH, before being matured and fertilized in vitro. Embryos were cultured in Synthetic Oviduct Fluid medium for 7 days. Heifers were fed with hay, soybean meal, barley, minerals and vitamins. From OPU 1 to 4 (period 1), all heifers received individually for 8 weeks a diet formulated for a 1000 g/day live-weight gain. From OPU 5 to 8 (period 2), the heifers were allocated to one of two diets (1000 or 600 g/day) for 8 weeks. Heifers’ growth rates were monitored and plasma concentrations of metabolites, metabolic and reproductive hormones were measured each week. Mean live-weight gain observed during period 1 was 950 ± 80 g/day (n = 16). In period 2 it was 730 ± 70 (n = 8) and 1300 ± 70 g/day (n = 8) for restricted and overfed groups respectively. When comparing period 1 and period 2 within groups, significant differences were found. In the restricted group, a higher blastocyst rate, greater proportions of grade 1–3 and grade 1 embryos, associated with higher estradiol at OPU and lower glucose and β-hydroxybutyrate, were observed in period 2 compared with period 1. Moreover, after 6 weeks of dietary restriction (OPU 7), numbers of day 7 total embryos, blastocysts and grade 1–3 embryos had significantly increased. On the contrary, in the overfed group, we observed more <8 mm follicles 2 days before superovulation treatment, higher insulin and IGF-I and lower nonesterified fatty acids in period 2 compared with period 1 (no significant difference between periods for embryo production). After 6 weeks of 1300 g/day live-weight gain (OPU 7), embryo production began to decrease. Whatever the group, oocyte collection did not differ between period 1 and 2. These data suggest that following a period of overfeeding, a short-term dietary intake restriction (6 weeks in our study) may improve blastocyst production and embryo quality when they are low. However, nutritional recommendations aiming to optimize both follicular growth and embryonic development may be different.

scholarly journals Cohort study of the overall survival of patients with pancreatic cancer in a hospital of specialties of Quito-Ecuador in the period 2007–2017

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Andrés Moreno Roca ◽  
Luciana Armijos Acurio ◽  
Ruth Jimbo Sotomayor ◽  
Carlos Céspedes Rivadeneira ◽  
Carlos Rosero Reyes ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cohort Study ◽  
Survival Time ◽  
Univariate Analysis ◽  
Rank Test ◽  
Kaplan Meier ◽  
Significant Difference ◽  
Icd 10 ◽  
The Difference ◽  
Clinical Records

Abstract Objectives Pancreatic cancers in most patients in Ecuador are diagnosed at an advanced stage of the disease, which is associated with lower survival. To determine the characteristics and global survival of pancreatic cancer patients in a social security hospital in Ecuador between 2007 and 2017. Methods A retrospective cohort study and a survival analysis were performed using all the available data in the electronic clinical records of patients with a diagnosis of pancreatic cancer in a Hospital of Specialties of Quito-Ecuador between 2007 and 2017. The included patients were those coded according to the ICD 10 between C25.0 and C25.9. Our univariate analysis calculated frequencies, measures of central tendency and dispersion. Through the Kaplan-Meier method we estimated the median time of survival and analyzed the difference in survival time among the different categories of our included variables. These differences were shown through the log rank test. Results A total of 357 patients diagnosed with pancreatic cancer between 2007 and 2017 were included in the study. More than two-thirds (69.9%) of the patients were diagnosed in late stages of the disease. The median survival time for all patients was of 4 months (P25: 2, P75: 8). Conclusions The statistically significant difference of survival time between types of treatment is the most relevant finding in this study, when comparing to all other types of treatments.

scholarly journals PSV-6 Effects of chilled drinking water and cooled floor pads on behavior of lactating sows under heat stress

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 153-154
Author(s):  
Yuzhi Li ◽  
Yunhui Zhu ◽  
Michael Reese ◽  
Eric Buchanan ◽  
Lee Johnston
Keyword(s):  
Drinking Water ◽  
Heat Stress ◽  
Time Budget ◽  
Calculated Data ◽  
Video Recordings ◽  
Significant Difference ◽  
Lactating Sows ◽  
Effect Of Treatment ◽  
Drinking Frequency ◽  
And Control

Abstract This study was conducted to evaluate effects of chilled drinking water and cooled floor pads on behavior of lactating sows under heat stress. Sows were housed in individual farrowing stalls in two rooms with temperatures being controlled at 29.4°C (0700h to 1900h) and 23.9°C (1900h to 0700h). Sows in one room (treatment), but not in the other room (control) were provided with chilled drinking water (13 to 15°C) and cooled floor pads (15 to 18°C). Behavior of sows (n=15 sows/treatment; parity=1 to 6) was video recorded during farrowing, and d 1, 3, 7, 14, and 21 after farrowing. Videos were viewed to register birth time of each piglet. Number of drinking bouts and duration of each bout were registered for 2 h (1530h to 1730h) each day after farrowing. Postures (lying laterally, lying ventrally, sitting, and standing) were recorded by scanning video-recordings at 5-min intervals for 24 h each day after farrowing, and time budget for each posture was calculated. Data were analyzed using the Glimmix Procedure of SAS. No effect of treatment was detected for litter size born, farrowing duration, or birth interval (P &gt;0.33; Table 1). Neither frequency nor duration of drinking bouts was affected by treatment (P &gt;0.27). No significant difference was observed in time budget for each posture (P &gt;0.46) between treatment and control groups. As lactation progressed, sows increased drinking frequency (from 1.2 drinks/2h on d 1 to 4.9 drinks/2h on d 21; P&lt; 0.001) and time spent lying ventrally (8% to 14%; P&lt; 0.0001), standing (4% to 10%; P&lt; 0.001), and sitting (2% to 4%; P&lt; 0.0001), and decreased time spent lying laterally (86% to 67%; P&lt; 0.0001) in both control and treatment rooms. These results indicate that chilled drinking water and cooled floor pads did not affect behavior of sows during farrowing and lactation in the current study.

scholarly journals The effect of early versus late lipid infusion in parenteral nutrition on the biochemical and cortical auditory evoked potential parameters in preterm neonates

2019 ◽  
Vol 67 (1) ◽  
Author(s):  
Rania Mohamed Abdou ◽  
Hoda Mahmoud Ibrahim Weheiba
Keyword(s):  
Weight Gain ◽  
Parenteral Nutrition ◽  
Biochemical Parameters ◽  
Evoked Potential ◽  
Demographic Data ◽  
Auditory Evoked Potential ◽  
Preterm Neonates ◽  
Lipid Infusion ◽  
Significant Difference ◽  
Cortical Auditory Evoked Potential

Abstract Background As brain activity depends greatly on the functions provided by lipid membranes, dietary fat in early life can affect the developing nervous system. Despite the adoption of an early more aggressive parenteral nutrition approach with amino acid infusions still reluctance to the early use of intravenous lipids in neonates. Aim To compare the effect of delayed versus early introduction of intravenous lipid in preterm on the biochemical parameters and on brain development by the cortical auditory evoked potential (CAEP) latency and amplitude. Methods This is a comparative study included 49 neonates admitted at the ain shams university NICUs. Participants were divided into two groups: 26 in group of early lipid infusion and 23 in late lipid infusion, Demographic data, and biochemical parameters were documented during the 1st 2 weeks of life. The CAEP was performed at age of 6 months. The latency and amplitude of P1 were recorded and compared between both groups. Results In the present work we found that group of early lipid infusion had reach their full oral intake earlier with shorter duration of parenteral nutrition and length of stay. They had better weight gain and significantly better glucose level control than group of late lipid infusion. There was no significant difference in the other chemical parameters between both groups expect for the higher incidence of cholestasis in the group of late lipid infusion. At 6 months of age, the group of early lipid infusion had significantly shorter latency and amplitude of P1 than the group of late lipid infusion. Conclusion Early effective nutrition positively affect feeding tolerance and weight gain and maturation of higher brain centers brain.

Long-Term Follow-up of Patients with Recurrent Malignant Gliomas Treated with Adjuvant Adoptive Immunotherapy

Neurosurgery ◽  
1991 ◽  
Vol 28 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Kevin O. Lillehei ◽  
Dawn H. Mitchell ◽  
Stephen D. Johnson ◽  
Larry E. McCleary ◽  
Carol A. Kruse
Keyword(s):  
Survival Time ◽  
Adoptive Immunotherapy ◽  
Peripheral Blood ◽  
Interleukin 2 ◽  
Peripheral Blood Lymphocytes ◽  
Lak Cells ◽  
Prior Chemotherapy ◽  
Blood Lymphocytes ◽  
Significant Difference

Abstract Between August 1986 and October 1987, the Denver Brain Tumor Research Group conducted a clinical trial using autologous human recombinant interleukin-2 (rIL-2)-activated lymphocytes to treat 20 patients with recurrent high-grade gliomas. The trial involved surgical resection and/or decompression followed by intracavitary implantation of lymphokine-activated killer (LAK) cells and autologous stimulated lymphocytes (ASL) along with rIL-2 in a plasma clot. One month later, stimulated lymphocytes and rIL-2 were infused through a Rickham reservoir attached to a catheter directed into the tumor bed. The LAK cells were rIL-2-activated peripheral blood lymphocytes cultured for 4 days; the ASL were lectin- and rIL-2-activated peripheral blood lymphocytes cultured for 10 days. Of the 20 patients treated, 11 were evaluated as a group (mean age, 44 years, range, 15-61 years; mean Karnofsky rating, 69, range, 50-100; mean Decadron dose at entry, 14 mg/d. range, 0-32). The average number of lymphocytes implanted was 7.6 × 109 (range, 1.9-27.5 × 109), together with 1 to 4 × 106 U of rIL-2. To date, 10 of the 11 patients died, all from recurrent tumor growth. The median overall survival time was 63 weeks (range, 36-201; mean, 86). The median survival time after immunotherapy was 18 weeks (range, 11-151; mean, 39). No significant difference in survival after immunotherapy was found between those patients who had received previous chemotherapy and those who had not. The use of steroids or prior chemotherapy did not influence the in vitro generation of ASL or LAK cells. Prior chemotherapy did correlate, however, with diminished in vitro cytotoxicity against the natural killer-sensitive (K562) target cell by LAK cells (P &lt; 0.05) but not that by ASL. There were no major adverse side effects. Although adoptive immunotherapy was safe and well tolerated, its therapeutic potential remains in question.

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