scholarly journals Effect of maternal feed restriction during pregnancy on glucose tolerance in the adult guinea pig

2003 ◽  
Vol 284 (1) ◽  
pp. R140-R152 ◽  
Author(s):  
Karen L. Kind ◽  
Peter M. Clifton ◽  
Patricia A. Grant ◽  
Phillip C. Owens ◽  
Annica Sohlstrom ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Birth Weight ◽  
Young Adult ◽  
Glucose Tolerance ◽  
Guinea Pig ◽  
Male Offspring ◽  
Feed Restriction ◽  
Glucose Ratio ◽  
Ad Libitum ◽  
Ad Libitum Intake

Maternal nutrient restriction and impaired fetal growth are associated with postnatal insulin resistance, hyperinsulinemia, and glucose intolerance in humans but not consistently in other species, such as the rat or sheep. We therefore determined the effect of mild (85% ad libitum intake/kg body wt) or moderate (70% ad libitum intake/kg body wt) maternal feed restriction throughout pregnancy on glucose and insulin responses to an intravenous glucose tolerance test (IVGTT) in the young adult guinea pig. Maternal feed restriction reduced birth weight (mild and moderate: both P < 0.02) in male offspring. Moderate restriction increased plasma glucose area under the curve ( P < 0.04) and decreased the glucose tolerance index ( K G) ( P < 0.02) during the IVGTT in male offspring compared with those of mildly restricted but not of ad libitum-fed mothers. Moderate restriction increased fasting plasma insulin ( P < 0.04, adjusted for litter size) and the insulin response to IVGTT ( P < 0.001), and both moderate and mild restriction increased the insulin-to-glucose ratio during the IVGTT ( P < 0.003 and P < 0.02) in male offspring. When offspring were classed into tertiles according to birth weight, glucose tolerance was not altered, but fasting insulin concentrations were increased in low compared with medium birth weight males ( P < 0.03). The insulin-to-glucose ratio throughout the IVGTT was increased in low compared with medium ( P < 0.01) or high ( P < 0.05) birth weight males. Thus maternal feed restriction in the guinea pig restricts fetal growth and causes hyperinsulinemia in young adult male offspring, suggestive of insulin resistance. These findings suggest that mild to moderate prenatal perturbation programs postnatal glucose homeostasis adversely in the guinea pig, as in the human.

scholarly journals Sex-specific Alterations in Hepatic Cholesterol Metabolism in Young Uteroplacental Insufficiency-induced Low Birth Weight Adult Guinea Pig Offspring

2020 ◽  
Author(s):  
Ousseynou Sarr ◽  
Katherine E. Mathers ◽  
Christina Vanderboor ◽  
Aditya Devgan ◽  
Daniel B. Hardy ◽  
...  
Keyword(s):  
Risk Factor ◽  
Birth Weight ◽  
Young Adult ◽  
Low Birth Weight ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Cholesterol Metabolism ◽  
Later Life ◽  
Male Offspring ◽  
Hepatic Cholesterol

AbstractBackgroundIntrauterine growth restriction (IUGR) and low birth weight (LBW) have been widely reported as an independent risk factor for hypercholesterolemia and increased hepatic cholesterol underlying liver dysfunction in adulthood. However, the specific impact of uteroplacental insufficiency (UPI), a leading cause of LBW in developed world, on hepatic cholesterol metabolism in later life, is ill defined and is clinically relevant in understanding later life liver metabolic health trajectories.MethodsHepatic cholesterol metabolism pathways were studied in uterine artery ablation-induced LBW and normal birth weight (NBW) male and female guinea pig offspring at postnatal day 150.ResultsHepatic free and total cholesterol were increased in LBW versus NBW males. Transcriptome analysis of LBW versus NBW livers revealed that “Cholesterol metabolism” was an enriched pathway in LBW males but not females. Microsomal triglyceride transfer protein and cytochrome P450 7A1 protein, involved in hepatic cholesterol efflux and catabolism, respectively, and catalase activity were decreased in LBW male livers. Superoxide dismutase activity was reduced in LBW males but increased in LBW females.ConclusionsUPI environment is associated with a later life programed hepatic cholesterol accumulation via impaired cholesterol elimination, in a sex-specific manner. These programmed alterations could underlie later life cholesterol-induced hepatic lipotoxicity in LBW male offspring.Impact StatementLow birth weight (LBW) is a risk factor for adult hypercholesterolemia and increased hepatic cholesterol.Uteroplacental insufficiency (UPI) resulting in LBW increased hepatic cholesterol content, altered hepatic expression of cholesterol metabolism-related genes in young adult guinea pigs.UPI-induced LBW was also associated with markers of a compromised hepatic cholesterol elimination process and failing antioxidant system in young adult guinea pigs.These changes, at the current age studied, were sex-specific, only being observed in LBW males and not LBW females.These programmed alterations could lead to further hepatic damage and greater predisposition to liver diseases in UPI-induced LBW male offspring as they age.

Whole body insulin resistance in rat offspring of mothers consuming alcohol during pregnancy or lactation: comparing prenatal and postnatal exposure

2004 ◽  
Vol 96 (1) ◽  
pp. 167-172 ◽  
Author(s):  
Li Chen ◽  
B. L. Grégoire Nyomba
Keyword(s):  
Insulin Resistance ◽  
Birth Weight ◽  
Glucose Tolerance ◽  
The Body ◽  
Whole Body ◽  
Glucose Disposal ◽  
Tolerance Index ◽  
Sensitivity Index ◽  
Intravenous Glucose ◽  
Rat Offspring

This study examined the effects of maternal ethanol (EtOH) consumption during pregnancy or lactation on glucose homeostasis in the adult rat offspring. Glucose disposal was determined by minimal model during an intravenous glucose tolerance test in rats that had a small or normal birth weight after EtOH exposure in utero and in rats whose mothers were given EtOH during lactation only. All three EtOH groups had decreased glucose tolerance index and insulin sensitivity index, but their glucose effectiveness was not different from that of controls. In addition, EtOH rat offspring that were small at birth had elevated plasma, liver, and muscle triglyceride levels. The data show that EtOH exposure during pregnancy programs the body to insulin resistance later in life, regardless of birth weight, but that this effect also results in dyslipidemia in growth-restricted rats. In addition, insulin resistance is also evident after EtOH exposure during lactation.

Restricted fetal growth and the response to dietary cholesterol in the guinea pig

1999 ◽  
Vol 277 (6) ◽  
pp. R1675-R1682 ◽  
Author(s):  
Karen L. Kind ◽  
Peter M. Clifton ◽  
Arkadi I. Katsman ◽  
Maria Tsiounis ◽  
Jeffrey S. Robinson ◽  
...  
Keyword(s):  
Birth Weight ◽  
Guinea Pig ◽  
Cholesterol Metabolism ◽  
Cholesterol Homeostasis ◽  
Cholesterol Feeding ◽  
Plasma Total Cholesterol ◽  
Maternal Undernutrition ◽  
Prenatal Growth ◽  
Ad Libitum ◽  
Size At Birth

Epidemiological studies suggest that retarded growth before birth is associated with increased plasma total and low-density lipoprotein (LDL) cholesterol concentrations in adult life. Thus perturbations of prenatal growth may permanently alter cholesterol metabolism. To determine directly whether restriction of prenatal nutrition and growth alters postnatal cholesterol homeostasis, the plasma cholesterol response to cholesterol feeding (0.25% cholesterol) was examined in adult guinea pig offspring of ad libitum-fed or moderately undernourished mothers. Maternal undernutrition (85% ad libitum intake throughout pregnancy) reduced birth weight (−13%). Plasma total cholesterol was higher prior to and following 6 wk cholesterol feeding in male offspring of undernourished mothers compared with male offspring of ad libitum-fed mothers ( P< 0.05). The influence of birth weight on cholesterol metabolism was examined by dividing the offspring into those whose birth weight was above (high) or below (low) the median birth weight. Plasma total cholesterol concentrations prior to cholesterol feeding did not differ with size at birth, but plasma total and LDL cholesterol were 31 and 34% higher, respectively, following cholesterol feeding in low- compared with high-birth weight males ( P < 0.02). The response to cholesterol feeding in female offspring was not altered by variable maternal nutrition or size at birth. Covariate analysis showed that the effect of maternal undernutrition on adult cholesterol metabolism could be partly accounted for by alterations in prenatal growth. In conclusion, maternal undernutrition and small size at birth permanently alter postnatal cholesterol homeostasis in the male guinea pig.

Effect of feeding different sources of fat during gestation and lactation on reproduction of beef cows and calf performance

2006 ◽  
Vol 86 (2) ◽  
pp. 235-243 ◽  
Author(s):  
H. V. Petit ◽  
R. Berthiaume
Keyword(s):  
Fatty Acids ◽  
Body Weight ◽  
Birth Weight ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Fat Supplementation ◽  
Grass Silage ◽  
Calf Mortality ◽  
Ad Libitum ◽  
Ad Libitum Intake

Experiment 1: Over a 2-yr period, a total of 231 Angus crossbred cows were assigned randomly to one of three gestation diets to evaluate the effects of fat sources on birth weight, weaning weight and average daily gain of calves, calf condition at birth, calf mortality, body weight of cows, gestation length, calving percentage, and the percentages of retained placenta and dystocia. Isonitrogenous and isoenergetic supplements were based on whole flaxseed (FLA), calcium salts of palm oil (Megalac®, MEG) or no fat (CON). All cows were fed grass silage (90% of ad libitum intake) until 1 mo before calving. Cows were then fed grass silage for ad libitum intake until they were put on pasture. Cows were offered 600 g of supplement per head per day starting 43 d before the first calving for a period averaging 78 d. Diet had no effect on body weight (BW) of cows at calving. Birth weights of calves were similar among treatments. However, calf mortality percentage at birth was almost four times higher (P = 0.03) for cows fed CON compared with those fed FLA and MEG. More than 90% of cows rejected placenta within 12 h of calving and treatment had no effect. Cows fed FLA and CON tended (P ≤ 0.10) to have higher cumulative pregnancy rates (92.9 and 91.9%, respectively) than those fed MEG (76.7%). Experiment 2: From 2000 Jan. 19 to 2000 Sep. 05, 41 heifers received 600 g per head per day of one of the three supplements used in exp. 1 to determine the effect of fat supplementation during pregnancy and breeding. Diet had no effect on calf birth weight, but contrasts indicated that heifers fed MEG tended (P = 0.09) to have a lower pregnancy rate than those fed CON. These data suggest that cows and heifers fed grass silage and/or on pasture would not be deficient in omega 3 fatty acids, thus would not benefit from a supplement rich in omega 3 fatty acids such as flaxseed. However, fat supplementation contributed to lower calf mortality at birth in cows, but not in heifers. Key words: Beef, flaxseed, reproduction, fatty acids

scholarly journals Performance and hormonal profile in broiler chickens fed with different energy levels during post restriction period

2003 ◽  
Vol 38 (6) ◽  
pp. 697-702 ◽  
Author(s):  
Poliana Fernanda Giachetto ◽  
Erika Nomura Guerreiro ◽  
Jesus Aparecido Ferro ◽  
Maria Inês Tiraboschi Ferro ◽  
Renato Luis Furlan ◽  
...  
Keyword(s):  
Energy Level ◽  
Broiler Chickens ◽  
Energy Levels ◽  
High Energy ◽  
Feed Restriction ◽  
Feed Conversion ◽  
Feeding Program ◽  
Ad Libitum ◽  
Ad Libitum Intake ◽  
Metabolic Hormone

The aim of this work was to investigate the influence of diet energy level on performance and hormonal profiles of broilers during post restriction period. It was a split-plot experiment, and the main treatments were in a 2x2 factorial scheme. Birds were fed restricted to 30% of the ad libitum intake, from 7 to 14 days of age. After the restriction period, birds were fed ad libitum with diets containing low (2,900 kcal ME/kg) or high (3,200 kcal ME/kg) energy until 49 days of age. Broilers fed with high energy ration showed lower feed intake and better feed conversion and decreased carcass protein; however, abdominal fat pad, and total carcass fat were not affected by ration energy levels or feeding program. Neither diet energy level nor feed restriction program changed body weight at 49 days. The profile of insulin-like growth factor-1 (IGF-1) was reduced during the feed restriction period, but increased at refeeding period. Feeding program and ration energy level did not affect T3, T4 and growth hormone serum concentrations. Feed restriction at 30% of ad libitum intake is not enough to promote changes on carcass quality, related to fat deposition, and on metabolic hormone levels, except IGF-1 seric level that has rapid increase after feed restriction.

scholarly journals Effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose–insulin dynamics in young adult horses

2016 ◽  
Vol 8 (2) ◽  
pp. 206-215 ◽  
Author(s):  
O. A. Valenzuela ◽  
J. K. Jellyman ◽  
V. L. Allen ◽  
N. B. Holdstock ◽  
A. J. Forhead ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Birth Weight ◽  
Insulin Sensitivity ◽  
Young Adult ◽  
Glucose Tolerance ◽  
Metabolic Phenotype ◽  
Whole Body ◽  
Sexually Dimorphic ◽  
Genetic And Environmental Factors ◽  
Glucose Stimulated Insulin Secretion

In several species, adult metabolic phenotype is influenced by the intrauterine environment, often in a sex-linked manner. In horses, there is also a window of susceptibility to programming immediately after birth but whether adult glucose–insulin dynamics are altered by neonatal conditions remains unknown. Thus, this study investigated the effects of birth weight, sex and neonatal glucocorticoid overexposure on glucose–insulin dynamics of young adult horses. For the first 5 days after birth, term foals were treated with saline as a control or ACTH to raise cortisol levels to those of stressed neonates. At 1 and 2 years of age, insulin secretion and sensitivity were measured by exogenous glucose administration and hyperinsulinaemic–euglycaemic clamp, respectively. Glucose-stimulated insulin secretion was less in males than females at both ages, although there were no sex-linked differences in glucose tolerance. Insulin sensitivity was greater in females than males at 1 year but not 2 years of age. Birth weight was inversely related to the area under the glucose curve and positively correlated to insulin sensitivity at 2 years but not 1 year of age. In contrast, neonatal glucocorticoid overexposure induced by adrenocorticotropic hormone (ACTH) treatment had no effect on whole body glucose tolerance, insulin secretion or insulin sensitivity at either age, although this treatment altered insulin receptor abundance in specific skeletal muscles of the 2-year-old horses. These findings show that glucose–insulin dynamics in young adult horses are sexually dimorphic and determined by a combination of genetic and environmental factors acting during early life.

scholarly journals Carcass characteristics of Canindé goats subjected to feed restriction

2017 ◽  
Vol 47 (8) ◽  
Author(s):  
Andreia Batista Bezerra ◽  
Severino Gonzaga Neto ◽  
Ariosvaldo Nunes de Medeiros ◽  
Francisco Fernando Ramos de Carvalho ◽  
Safira Valença Bispo ◽  
...  
Keyword(s):  
Body Weight ◽  
Block Design ◽  
Carcass Characteristics ◽  
Chest Circumference ◽  
Feed Restriction ◽  
Mean Values ◽  
Randomized Block Design ◽  
Ad Libitum ◽  
Ad Libitum Intake

ABSTRACT: This study aimed to evaluate the effects of feed restriction on the carcass characteristics of castrated Canindé goat kids. A randomized block design was used, in which 21 goat kids with a body weight (BW) of 15.9±1.0kg were allocated to three levels of feed restriction: ad libitum, 20% and 40% restriction related to the ad libitum intake. The diet consisted of 55% forage (Tifton) and 45% concentrate. All animals were slaughtered when the kids fed ad libitum reached a BW of 25kg. After slaughter, the carcasses were chilled for 24 hours and subsequently measured. Kids fed ad libitum and subjected to 20% feed restriction showed similar morphometric carcass measurements, except for the chest circumference. Goat kids fed ad libitum exhibited greater values for warm and cold carcass yields compared with those subjected to 40% feed restriction and did not differ from the kids under 20% feed restriction. Weights of the commercial cuts showed decreasing mean values according to the intensity of feed restriction. Castrated Canindé goat kids subjected to 20% feed restriction presented similar carcass yields and proportion of commercial cuts to those fed ad libitum.

scholarly journals Effects of feeding level on efficiency of high- and low-residual feed intake beef steers

2020 ◽  
Vol 98 (10) ◽  
Author(s):  
Emily M Andreini ◽  
Sheyenne M Augenstein ◽  
Carrie S Fales ◽  
Roberto D Sainz ◽  
James W Oltjen
Keyword(s):  
Feed Intake ◽  
Energy Requirement ◽  
Average Daily Gain ◽  
Residual Feed Intake ◽  
Energy Requirements ◽  
Feed Restriction ◽  
Maintenance Energy ◽  
Ad Libitum ◽  
Ad Libitum Intake ◽  
Daily Intakes

Abstract Comparing heat production after ad libitum (ADLIB) and restricted (RESTRICT) feeding periods may offer insight into how residual feed intake (RFI) groups change their energy requirements based on previous feeding levels. In this study, the authors sought to explain the efficiency changes of high- and low-RFI steers after feed restriction. To determine RFI classification, 56 Angus-cross steers with initial body weight (BW) of 350 ± 28.7 kg were individually housed, offered ad libitum access to a total mixed ration, and daily intakes were recorded for 56 d. RFI was defined as the residual of the regression of dry matter intake on mid-test BW0.75 and average daily gain. High- and low-RFI groups were defined as &gt;0.5 SD above or below the mean of zero, respectively. Fourteen steers from each high and low groups (n = 28) were selected for the subsequent 56-d RESTRICT period. During the RESTRICT period, intake was restricted to 75% of previous ad libitum intake on a BW0.75 basis, and all other conditions remained constant. After the RESTRICT period, both RFI groups had decreased maintenance energy requirements. However, the low-RFI group decreased maintenance energy requirements by 32% on a BW0.75 basis, more (P &lt; 0.05) than the high-RFI group decreased maintenance requirements (18%). Thus, the low-RFI steers remained more efficient after a period of feed restriction. We conclude that feed restriction decreases maintenance energy requirement in both high- and low-RFI groups that are restricted to the same degree.

Chronic maternal feed restriction impairs growth but increases adiposity of the fetal guinea pig

2005 ◽  
Vol 288 (1) ◽  
pp. R119-R126 ◽  
Author(s):  
Karen L. Kind ◽  
Claire T. Roberts ◽  
Annica I. Sohlstrom ◽  
Arkadi Katsman ◽  
Peter M. Clifton ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Guinea Pig ◽  
Relative Weight ◽  
Adult Life ◽  
Volume Density ◽  
Feed Restriction ◽  
Biceps Muscle ◽  
Increased Risk ◽  
Ad Libitum Intake ◽  
Size At Birth

Small size at birth has been associated with an increased risk of central obesity and reduced lean body mass in adult life. This study investigated the time of onset of prenatally induced obesity, which occurs after maternal feed restriction, in the guinea pig, a species that, like the human, develops substantial adipose tissue stores before birth. We examined the effect of maternal feed restriction [70% ad libitum intake from 4 wk before to midpregnancy, then 90% until day 60 gestation (term ∼69 days)] on fetal growth and body composition in the guinea pig. Maternal feed restriction reduced fetal (−39%) and placental (−30%) weight at 60 days gestation and reduced liver, biceps muscle, spleen, and thymus weights, relative to fetal weight, while relative weights of brain, lungs, and interscapular and retroperitoneal fat pads were increased. In the interscapular depot, maternal feed restriction decreased the volume density of multilocular fat and increased that of unilocular fat, resulting in an increased relative weight of interscapular unilocular fat. Maternal feed restriction did not alter the relative weight of perirenal fat or the volume density of adipocyte populations within the depot but increased unilocular lipid locule size. Maternal feed restriction in the guinea pig is associated with decreased weight of major organs, including liver and skeletal muscle, but increased adiposity of the fetus, with relative sparing of unilocular adipose tissue. If this early-onset obesity persists, it may contribute to the metabolic and cardiovascular dysfunction that these offspring of feed-restricted mothers develop as adults.

scholarly journals Influence of Different Regimes of Moderate Maternal Feed Restriction during Pregnancy of Primiparous Rabbit Does on Long-Term Metabolic Energy Homeostasis, Productive Performance and Welfare

Animals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2736
Author(s):  
Carlota Fernández-Pacheco ◽  
Pilar Millán ◽  
María Rodríguez ◽  
Nora Formoso-Rafferty ◽  
Ana Sánchez-Rodríguez ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Artificial Insemination ◽  
Energy Homeostasis ◽  
Metabolic Energy ◽  
Feed Restriction ◽  
Productive Performance ◽  
Long Term Effects ◽  
Esterified Fatty Acids ◽  
Ad Libitum

In this study, a maternal feed restriction (MFR; 105 g/d) in primiparous rabbit does was applied from day 0 to 7 post artificial insemination (AI) (R07, n = 96), from day 7 to 21 post AI (R721, n = 92), from day 0 to 21 post AI (R021, n = 94) or fed ad libitum during whole pregnancy (Control, n= 92). Feed intake (FI) was measured after MFR was over. On day 28 of gestation, fetoplacental development was evaluated (n = 11/group) and the productive parameters of the remaining dams were analyzed. Plasma free tri-iodothyronine (T3) and thyroxine, glucose, insulin, non-esterified fatty acids (NEFA), and corticosterone were analyzed during gestation and lactation (n = 5/group). After MFR, all groups significantly increased their voluntary FI. The longer MFR was, the lower the weight and length of the fetuses, but no long-term effects over litter performance were observed. R021 groups had the lowest T3 and the highest NEFA concentrations during pregnancy and showed insulin resistance at the end of gestation, but during lactation, energy homeostasis was balanced in all groups. MFR did not affect corticosterone concentrations. In conclusion, the ration setting applied slightly involved the energy homeostasis and metabolism of the animals, but their overall metabolic condition, productive performance and welfare were not compromised.

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