Effects of exercise and diet on chronic disease

2005 ◽  
Vol 98 (1) ◽  
pp. 3-30 ◽  
Author(s):  
Christian K. Roberts ◽  
R. James Barnard
Keyword(s):  
Chronic Disease ◽  
Chronic Diseases ◽  
Physical Inactivity ◽  
Intervention Studies ◽  
Lifestyle Modification ◽  
Developing Nations ◽  
Beneficial Effects ◽  
Overwhelming Evidence ◽  
The World

Currently, modern chronic diseases, including cardiovascular diseases, Type 2 diabetes, metabolic syndrome, and cancer, are the leading killers in Westernized society and are increasing rampantly in developing nations. In fact, obesity, diabetes, and hypertension are now even commonplace in children. Clearly, however, there is a solution to this epidemic of metabolic disease that is inundating today’s societies worldwide: exercise and diet. Overwhelming evidence from a variety of sources, including epidemiological, prospective cohort, and intervention studies, links most chronic diseases seen in the world today to physical inactivity and inappropriate diet consumption. The purpose of this review is to 1) discuss the effects of exercise and diet in the prevention of chronic disease, 2) highlight the effects of lifestyle modification for both mitigating disease progression and reversing existing disease, and 3) suggest potential mechanisms for beneficial effects.

scholarly journals Lupins and Health Outcomes: A Systematic Literature Review

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 327
Author(s):  
Lesley Bryant ◽  
Anna Rangan ◽  
Sara Grafenauer
Keyword(s):  
Blood Pressure ◽  
Chronic Disease ◽  
Serum Lipids ◽  
Intervention Studies ◽  
Current Evidence ◽  
Nutrient Profile ◽  
Beneficial Effects ◽  
Lupin Protein ◽  
Meta Analyses

Lupins have a unique nutrient profile among legumes and may have beneficial health effects when included in the diet. The aim of this systematic review was to investigate the effects of lupin on a range of health outcome measures. Databases included MEDLINE, Embase and CINAHL, and focused on controlled intervention studies on healthy adults and those with chronic disease such as type 2 diabetes, cardiovascular disease and overweight. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol was followed. Investigated intervention diets utilised whole lupin, lupin protein or lupin fibre, and outcomes were measured by markers of chronic disease, body weight and satiety. Quality assessment of results was performed using the Cochrane revised risk of bias tool. Overall, 21 studies with 998 participants were included: 12 using whole lupin, four used lupin protein and five lupin fibre. Beneficial changes were observed in 71% of studies that measured blood pressure, 83% measuring satiety and 64% measuring serum lipids. Unintended weight loss occurred in 25% of studies. Whole lupin demonstrated more consistent beneficial effects for satiety, glycaemic control and blood pressure than lupin protein or lupin fibre. Heterogeneity, low study numbers and a small participant base indicated further studies are required to strengthen current evidence particularly regarding the protein and dietary fibre components of lupin.

Waging war on modern chronic diseases: primary prevention through exercise biology

2000 ◽  
Vol 88 (2) ◽  
pp. 774-787 ◽  
Author(s):  
Frank W. Booth ◽  
Scott E. Gordon ◽  
Christian J. Carlson ◽  
Marc T. Hamilton
Keyword(s):  
Physical Activity ◽  
Health Care ◽  
Chronic Disease ◽  
Primary Prevention ◽  
Chronic Diseases ◽  
20Th Century ◽  
Physical Inactivity ◽  
Funding System ◽  
Sedentary Population ◽  
Biology Research

In this review, we develop a blueprint for exercise biology research in the new millennium. The first part of our plan provides statistics to support the contention that there has been an epidemic emergence of modern chronic diseases in the latter part of the 20th century. The health care costs of these conditions were almost two-thirds of a trillion dollars and affected 90 million Americans in 1990. We estimate that these costs are now approaching $1 trillion and stand to further dramatically increase as the baby boom generation ages. We discuss the reaction of the biomedical establishment to this epidemic, which has primarily been to apply modern technologies to stabilize overt clinical problems (e.g., secondary and tertiary prevention). Because this approach has been largely unsuccessful in reversing the epidemic, we argue that more emphasis must be placed on novel approaches such as primary prevention, which requires attacking the environmental roots of these conditions. In this respect, a strong association exists between the increase in physical inactivity and the emergence of modern chronic diseases in 20th century industrialized societies. Approximately 250,000 deaths per year in the United States are premature due to physical inactivity. Epidemiological data have established that physical inactivity increases the incidence of at least 17 unhealthy conditions, almost all of which are chronic diseases or considered risk factors for chronic diseases. Therefore, as part of this review, we present the concept that the human genome evolved within an environment of high physical activity. Accordingly, we propose that exercise biologists do not study “the effect of physical activity” but in reality study the effect of reintroducing exercise into an unhealthy sedentary population that is genetically programmed to expect physical activity. On the basis of healthy gene function, exercise research should thus be viewed from a nontraditional perspective in that the “control” group should actually be taken from a physically active population and not from a sedentary population with its predisposition to modern chronic diseases. We provide exciting examples of exercise biology research that is elucidating the underlying mechanisms by which physical inactivity may predispose individuals to chronic disease conditions, such as mechanisms contributing to insulin resistance and decreased skeletal muscle lipoprotein lipase activity. Some findings have been surprising and remarkable in that novel signaling mechanisms have been discovered that vary with the type and level of physical activity/inactivity at multiple levels of gene expression. Because this area of research is underfunded despite its high impact, the final part of our blueprint for the next millennium calls for the National Institutes of Health (NIH) to establish a major initiative devoted to the study of the biology of the primary prevention of modern chronic diseases. We justify this in several ways, including the following estimate: if the percentage of all US morbidity and mortality statistics attributed to the combination of physical inactivity and inappropriate diet were applied as a percentage of the NIH's total operating budget, the resulting funds would equal the budgets of two full institutes at the NIH! Furthermore, the fiscal support of studies elucidating the scientific foundation(s) targeted by primary prevention strategies in other public health efforts has resulted in an increased efficacy of the overall prevention effort. We estimate that physical inactivity impacts 80–90% of the 24 integrated review group (IRG) topics proposed by the NIH's Panel on Scientific Boundaries for Review, which is currently directing a major restructuring of the NIH's scientific funding system. Unfortunately, the primary prevention of chronic disease and the investigation of physical activity/inactivity and/or exercise are not mentioned in the almost 200 total subtopics comprising the IRGs in the Panel's proposal. We believe this to be a glaring omission by the Panel and contend that the current reorganization of NIH's scientific review and funding system is a golden opportunity to invest in fields that study the biological mechanisms of primary prevention of chronic diseases (such as exercise biology). This would be an investment to avoid US health care system bankruptcy as well as to reduce the extreme human suffering caused by chronic diseases. In short, it would be an investment in the future of health care in the new millennium.

scholarly journals Berries as a Treatment for Obesity-Induced Inflammation: Evidence from Preclinical Models

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 334
Author(s):  
Hannah Land Lail ◽  
Rafaela G. Feresin ◽  
Dominique Hicks ◽  
Blakely Stone ◽  
Emily Price ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Low Grade ◽  
Bioactive Components ◽  
Preclinical Models ◽  
Beneficial Effects ◽  
Increased Risk ◽  
Anti Inflammatory ◽  
Treatment Of Obesity ◽  
Low Grade Inflammation

Inflammation that accompanies obesity is associated with the infiltration of metabolically active tissues by inflammatory immune cells. This propagates a chronic low-grade inflammation associated with increased signaling of common inflammatory pathways such as NF-κB and Toll-like receptor 4 (TLR4). Obesity-associated inflammation is linked to an increased risk of chronic diseases, including type 2 diabetes, cardiovascular disease, and cancer. Preclinical rodent and cell culture studies provide robust evidence that berries and their bioactive components have beneficial effects not only on inflammation, but also on biomarkers of many of these chronic diseases. Berries contain an abundance of bioactive compounds that have been shown to inhibit inflammation and to reduce reactive oxygen species. Therefore, berries represent an intriguing possibility for the treatment of obesity-induced inflammation and associated comorbidities. This review summarizes the anti-inflammatory properties of blackberries, blueberries, strawberries, and raspberries. This review highlights the anti-inflammatory mechanisms of berries and their bioactive components that have been elucidated through the use of preclinical models. The primary mechanisms mediating the anti-inflammatory effects of berries include a reduction in NF-κB signaling that may be secondary to reduced oxidative stress, a down-regulation of TLR4 signaling, and an increase in Nrf2.

scholarly journals A Framework to Understand the Progression of Cardiovascular Disease for Type 2 Diabetes Mellitus Patients Using a Network Approach

2020 ◽  
Vol 17 (2) ◽  
pp. 596 ◽  
Author(s):  
Md Ekramul Hossain ◽  
Shahadat Uddin ◽  
Arif Khan ◽  
Mohammad Ali Moni
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Disease ◽  
Chronic Diseases ◽  
Australian Health ◽  
Disease Networks ◽  
Multiple Chronic Diseases

The prevalence of chronic disease comorbidity has increased worldwide. Comorbidity—i.e., the presence of multiple chronic diseases—is associated with adverse health outcomes in terms of mobility and quality of life as well as financial burden. Understanding the progression of comorbidities can provide valuable insights towards the prevention and better management of chronic diseases. Administrative data can be used in this regard as they contain semantic information on patients’ health conditions. Most studies in this field are focused on understanding the progression of one chronic disease rather than multiple diseases. This study aims to understand the progression of two chronic diseases in the Australian health context. It specifically focuses on the comorbidity progression of cardiovascular disease (CVD) in patients with type 2 diabetes mellitus (T2DM), as the prevalence of these chronic diseases in Australians is high. A research framework is proposed to understand and represent the progression of CVD in patients with T2DM using graph theory and social network analysis techniques. Two study cohorts (i.e., patients with both T2DM and CVD and patients with only T2DM) were selected from an administrative dataset obtained from an Australian health insurance company. Two baseline disease networks were constructed from these two selected cohorts. A final disease network from two baseline disease networks was then generated by weight adjustments in a normalized way. The prevalence of renal failure, fluid and electrolyte disorders, hypertension and obesity was significantly higher in patients with both CVD and T2DM than patients with only T2DM. This showed that these chronic diseases occurred frequently during the progression of CVD in patients with T2DM. The proposed network-based model may potentially help the healthcare provider to understand high-risk diseases and the progression patterns between the recurrence of T2DM and CVD. Also, the framework could be useful for stakeholders including governments and private health insurers to adopt appropriate preventive health management programs for patients at a high risk of developing multiple chronic diseases.

The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise

2009 ◽  
Vol 107 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Matthew M. Robinson ◽  
Karyn L. Hamilton ◽  
Benjamin F. Miller
Keyword(s):  
Chronic Disease ◽  
Drug Therapy ◽  
Mitochondrial Dysfunction ◽  
Chronic Diseases ◽  
Mitochondrial Biogenesis ◽  
Lifestyle Modification ◽  
Mitochondrial Dysfunctions ◽  
Exercise Induced ◽  
Potential Interactions ◽  
Mitochondrial Adaptations

The importance of mitochondrial dysfunctions in the progression of chronic disease has been well established. Patients with chronic diseases are often prescribed a variety of medications, many of which have been shown to induce mitochondrial dysfunction. Exercise is a known stimulus for mitochondrial biogenesis and also recommended to patients as a lifestyle modification to supplement drug therapy. However, the potential interference of those drugs with mitochondrial adaptations to exercise has not been thoroughly investigated. This review provides a summary and discussion of known and potential interactions of commonly consumed drugs with exercise-induced mitochondrial adaptations.

Sedentary Behaviors, Leisure-Time Physical Inactivity, and Chronic Diseases in Brazilian Workers: A Cross Sectional Study

2014 ◽  
Vol 11 (8) ◽  
pp. 1622-1634 ◽  
Author(s):  
Leandro Martin Totaro Garcia ◽  
Kelly Samara da Silva ◽  
Giovâni F. Del Duca ◽  
Filipe Ferreira da Costa ◽  
Markus Vinicius Nahas
Keyword(s):  
Type 2 Diabetes ◽  
Chronic Diseases ◽  
Physical Inactivity ◽  
Leisure Time ◽  
Cross Sectional Study ◽  
Sedentary Behaviors ◽  
Sectional Study ◽  
Cross Sectional ◽  
And Gender

Background:Our purpose was to examine the association of television viewing (hours/day), sedentary work (predominantly sitting at work), passive transportation to work (car or motorcycle), and the clustering of these behaviors (“sedentary lifestyle”), as well as leisure-time physical inactivity (LTPI), with chronic diseases (hypertension, hypercholesterolemia, type 2 diabetes, obesity, and clustering of chronic diseases) in Brazilian workers.Methods:Cross-sectional study conducted from 2006 to 2008 in 24 Brazilian federal units (n = 47,477). A questionnaire was applied. Descriptive statistics, binary and multinomial logistic regressions were used.Results:Magnitude of association with chronic diseases varied greatly across domains and gender. Sedentariness at work was the most consistent behavior associated with chronic diseases, especially in men (ORhypertension = 1.10, 95% CI: 1.01–1.20; ORhypercholesterolemia = 1.34, 95% CI: 1.21–1.48; ORobesity = 1.27, 95% CI: 1.15–1.41; OR1chronic disease = 1.17, 95% CI: 1.09–1.26; OR≥2chronic diseases = 1.61, 95% CI: 1.46–1.78) compared with women (ORhypercholesterolemia = 1.15, 95% CI: 1.01–1.31; ORobesity = 1.24, 95% CI: 1.04–1.48). LTPI was associated with all diseases in men (except type 2 diabetes), but only with obesity in women.Conclusion:Adverse health consequences may be differently associated according to behavior domain and gender. Sedentary work and LTPI were consistently associated with chronic disease in Brazilian workers, especially in men.

scholarly journals Reducing Deaths by Diet: A Call for Public Policy to Prevent Chronic Disease

1970 ◽  
Vol 11 (1) ◽  
Author(s):  
Norm Campbell CM, MD, FRCPC ◽  
Michel Sauvé MD FRCP FACP FCCP MSc
Keyword(s):  
Cardiovascular Disease ◽  
Public Policy ◽  
Risk Factor ◽  
Chronic Disease ◽  
Alcohol Consumption ◽  
Chronic Diseases ◽  
Physical Inactivity ◽  
Unhealthy Eating ◽  
Unhealthy Diet ◽  
Excess Alcohol Consumption

Chronic diseases including cardiovascular disease and cancer are the leading causes of disability and death in Canada.1,2 The majority of chronic diseases are caused by physical inactivity, tobacco use, excess alcohol consumption and unhealthy diet.3-6 In particular, unhealthy diet is the leading risk factor for death and disability in Canada resulting in an estimated 64,000 deaths and over 1 million years of disability (DALYs) in 2010 alone.7 Worldwide, a staggering 11 million deaths and over 200 million DALYs were attributed to unhealthy eating in 2010.

scholarly journals Effectiveness of Approaches to Increase Physical Activity Behavior to Prevent Chronic Disease in Adults: A Brief Commentary

2019 ◽  
Vol 8 (3) ◽  
pp. 295 ◽  
Author(s):  
Juliano Schwartz ◽  
Ryan Rhodes ◽  
Shannon Bredin ◽  
Paul Oh ◽  
Darren Warburton
Keyword(s):  
Physical Activity ◽  
Risk Factors ◽  
Chronic Disease ◽  
Behavior Change ◽  
Chronic Diseases ◽  
Physical Inactivity ◽  
Physical Activity Behavior ◽  
Chronic Medical Conditions ◽  
Activity Behavior ◽  
Physical Activity Behavior Change

Effective behavior change approaches are necessary to help individuals avoid or mitigate risk factors, engage in behavioral patterns that lead to better health, and consequently, prevent several chronic diseases. Physical inactivity is considered one of the most harmful risk factors for chronic medical conditions, and although different strategies are used to tackle this behavior, not all of them lead to the expected or desired results. This brief commentary examines recent approaches aimed at physical activity behavior change. We find that a combination of strategies focusing on streamlining the access to physical activity seems to be more effective than individual approaches, in order to increase physical activity engagement to prevent chronic diseases in adults.

scholarly journals Sex/gender considerations in school-based interventions to promote children’s and adolescents’ physical activity

2021 ◽  
Author(s):  
Annegret Schlund ◽  
Anne K. Reimers ◽  
Jens Bucksch ◽  
Stephanie Linder ◽  
Yolanda Demetriou
Keyword(s):  
Physical Activity ◽  
Systematic Review ◽  
Physical Inactivity ◽  
Intervention Studies ◽  
Meta Analysis ◽  
School Based Intervention ◽  
Effective Strategies ◽  
School Based ◽  
The World ◽  
School Based Interventions

AbstractPhysical inactivity is an increasing problem worldwide, but especially among girls. This difference by gender increases with age. Schools serve virtually all young people in most parts of the world and can thus play an important role in promoting physical activity. In this systematic review, we qualitatively and comprehensively assessed the treatment of sex/gender considerations (from study design to discussion of results) in 56 school-based intervention studies aiming to promote physical activity in children and adolescents. In all 56 studies, the factor of sex/gender was only rudimentarily considered, regardless of the effectiveness of the intervention. The meta-analysis revealed that the interventions had significant but relatively small effects with both girls and boys, along with high heterogeneity. To obtain better information about effective strategies that promote physical activity for both girls and boys equally, researchers conducting future intervention studies should pay attention to sex/gender differences and report on how they take this factor into account.

scholarly journals Novel Approaches in the Management of Type 2 Diabetes and Associated Vascular Complications

2021 ◽  
Author(s):  
K. V. S. Hari Kumar
Keyword(s):  
Diabetes Mellitus ◽  
Clinical Presentation ◽  
Vascular Complications ◽  
Epidemiological Studies ◽  
Developing Nations ◽  
Β Cell ◽  
Cell Dysfunction ◽  
The World ◽  
Novel Approaches

AbstractDiabetes mellitus (DM) is growing in pandemic proportion and affects the affluent and developing nations equally. India has the dubious distinction of being known as the diabetes capital of the world. Epidemiological studies have shown that DM is under diagnosed and inadequately treated in our country. Insulin resistance and β-cell dysfunction are the two key pathophysiological determinants of the DM. The disease has metamorphosed during the last couple of decades with a significant change in the clinical presentation. Simultaneously, the therapeutic options for the management of DM have also increased in the last decade. This article highlights the research conducted by us over the last decade in the areas of pathogenesis, management, and complications of DM.

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