CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study

Associations between cholesteryl ester transfer protein (CETP) polymorphisms and high-density lipoprotein cholesterol (HDL-c) levels before and after 20 wk of endurance training were investigated in the HERITAGE Family Study. Plasma HDL-c, HDL2-c, HDL3-c, and apolipoprotein (apo)A1 levels were measured, and 13 CETP single nucleotide polymorphisms (SNPs) were genotyped in 265 blacks and 486 whites. Three haplotypes defined by SNPs at the −1337, −971, and −629 sites were strongly associated with baseline HDL-c levels in whites. Both C−1337T and C−629A were associated with baseline HDL-c ( P < 0.001) and apoA1 ( P < 0.01) when tested separately. However, only C−629A remained significant in a combined model. G−971A was not associated with HDL phenotypes, but showed significant interactions with C−629A ( P = 0.002) on baseline traits. Genotype-by-sex interactions were observed at the −629 locus for HDL3-c ( P = 0.004) and apoA1 ( P = 0.02) training responses in whites. In women, the −629 A/A homozygotes showed greater increases in HDL3-c ( P = 0.02) and apoA1 ( P = 0.02) levels than the other genotypes. Finally, apolipoprotein E (APOE) genotype and the CETP C−629A locus contributed independently and in additive fashion to the HDL traits, explaining 6.0–8.8% of the variance. The CETP −1337T and −629A alleles are associated with higher baseline HDL-c and apoA1 levels. The beneficial effects of endurance training on plasma HDL3-c and apoA1 levels are evident in white women homozygous for the −629A allele. The CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study.

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Impaired postprandial clearance of triacylglycerol-rich lipoproteins in adipose tissue in obese subjects

AJP Endocrinology and Metabolism ◽

10.1152/ajpendo.1995.268.4.e588 ◽

1995 ◽

Vol 268 (4) ◽

pp. E588-E594 ◽

Cited By ~ 8

Author(s):

J. L. Potts ◽

S. W. Coppack ◽

R. M. Fisher ◽

S. M. Humphreys ◽

G. F. Gibbons ◽

...

Keyword(s):

Adipose Tissue ◽

Low Density Lipoprotein ◽

Postprandial Lipemia ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Control Group ◽

Postprandial Period ◽

Before And After ◽

Obese Subjects ◽

Subcutaneous Adipose

Adipose tissue is an important site of clearance of circulating triacylglycerol (TAG), especially in the postprandial period. Postprandial lipemia is usually increased in obesity. We studied the extraction of TAG from plasma and TAG-rich lipoproteins (TRLs) in subcutaneous adipose tissue in 11 control and 8 obese subjects before and after a mixed meal. Clearance of plasma TAG and very low-density lipoprotein (VLDL)-TAG was decreased in the obese subjects after an overnight fast. After the meal, chylomicron-TAG extraction increased in the control group whereas VLDL-TAG clearance decreased; these changes were not seen in the obese group, in whom the VLDL particles appeared to be better able to compete with the chylomicrons for clearance by lipoprotein lipase. In the control subjects, removal of TAG from the TRL in the postprandial period was accompanied by a shift toward addition of cholesterol to the high-density lipoprotein (HDL) fraction; this was not observed in the obese subjects. We conclude that disturbed TRL-TAG clearance in adipose tissue is related both to the elevated plasma TAG concentrations and the depressed HDL-cholesterol concentrations typical of obesity.

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Aerobic fitness modulates the association between APOE genotypes and serum lipemia in adolescents

Motriz Revista de Educação Física ◽

10.1590/s1980-65742014000300013 ◽

2014 ◽

Vol 20 (3) ◽

pp. 332-338

Author(s):

Maria Fátima Glaner ◽

Thales Boaventura Rachid Nascimento ◽

Otávio de Tôledo Nóbrega

Keyword(s):

High Density Lipoprotein ◽

Total Cholesterol ◽

Aerobic Fitness ◽

Low Density Lipoprotein ◽

Apoe Genotype ◽

Density Lipoprotein ◽

European Ancestry ◽

Low Density ◽

Genotype Group ◽

Apoe Genotypes

The purpose of this study was to analyze the association between APOE alleles and serum lipemia in adolescents with low and adequate aerobic fitness. The sample was comprised of 105 boys and 151 girls (49% and 46% from rural area) of European ancestry, aged 11 to 17 years, and classified according to: 1) APOE genotype: group ε2 (ε2/3+ε2/2), ε3 (ε3/3), and ε4 (ε3/4+ε4/4); 2) aerobic fitness: adequate or low; 3) serum lipemia: elevated total cholesterol (TC), low-density lipoprotein (LDL) and triglycerides, and low high-density lipoprotein (HDL). The results showed that aerobic fitness modulates the association between APOE alleles and serum lipemia in adolescents, suggesting that adequate aerobic fitness levels exert a greater effect of reducing TC and LDL in ε2 carriers, as well as of increasing HDL and reducing triglycerides in ε3 and ε4 carriers.

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The Effect of Haplotypes in the CETP and LIPC Genes on the Triglycerides to HDL-C Ratio and Its Components in the Roma and Hungarian General Populations

Genes ◽

10.3390/genes11010056 ◽

2020 ◽

Vol 11 (1) ◽

pp. 56 ◽

Cited By ~ 1

Author(s):

Peter Piko ◽

Szilvia Fiatal ◽

Nardos Abebe Werissa ◽

Bayu Begashaw Bekele ◽

Gabor Racz ◽

...

Keyword(s):

Cardiovascular Diseases ◽

Odds Ratio ◽

Hepatic Lipase ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Nucleotide Polymorphisms ◽

Single Nucleotide ◽

Roma Population ◽

Transfer Protein ◽

General Populations

Background: The triglycerides (TG) to high-density lipoprotein (HDL)-cholesterol (HDL-C) ratio (TG/HDL-C) is a well-known predictor for cardiovascular diseases (CVDs) with great heritability background. The cholesteryl ester transfer protein (CETP) and hepatic lipase (LIPC) gene affect TG/HDL-C ratio. This study aims to explore the association between haplotypes (H) in CETP (based on 5 single nucleotide polymorphisms (SNPs)) and LIPC (based on 6 SNPs) genes and the TG/HDL-C ratio and its components, among Roma and Hungarian general populations. Methods: The prevalence of haplotypes and their effect on HDL-C, TG and TG/HDL-C ratio were calculated in both populations and compared. Results: Ten haplotypes in CETP and 6 in LIPC gene were identified. Three haplotypes in CETP and 3 in LIPC have significant effect on HDL-C level, whereas two in CETP and 3 in LIPC on TG level. The H6 in CETP (β = 0.52, p = 0.015; odds ratio (OR) = 1.87, p = 0.009) and H5 in LIPC (β = 0.56, p < 0.001; OR = 1.51, p = 0.002) have a significant increasing effect on TG/HDL-C ratio and have shown higher prevalence among the Roma, as compared to Hungarian general population. The H2 in the CETP gene has a decreasing effect on the TG/HDL-C ratio (OR = 0.58, p = 0.019) and is significantly less frequent among the Roma. Conclusions: Accumulation of harmful haplotypes in CETP and LIPC genes might have a role in the elevated TG/HDL-C ratio in the Roma population, which contributes to a higher risk in the development of cardiovascular diseases.

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PENGARUH LATIHAN ZUMBA TERHADAP KADAR KOLESTEROL HIGH DENSITY LIPOPROTEIN DARAH

Jurnal e-Biomedik ◽

10.35790/ebm.2.2.2014.5191 ◽

2014 ◽

Vol 2 (2) ◽

Author(s):

Reynaldo Stevanus Pantouw ◽

Djon Wongkar ◽

Shane H. R. Ticoalu

Keyword(s):

High Density Lipoprotein ◽

Exercise Program ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

High Density ◽

The Body ◽

Normal Body Mass Index ◽

Nursing Science ◽

Before And After ◽

Post Test

Abstract: High density lipoprotein cholesterol (HDL) is a heterogeneous class of lipoproteins with density 1063 - 1:21 g / mL. HDL cholesterol has protective properties to heart because it is able to bind cholesterol and carry it to the liver for excretion. High levels of HDL in the body will increase the protection against coronary heart disease. One way to increase HDL cholesterol levels is by doing physical activity. This study have a purpose to find out the influence of zumba exercise on hemoglobin levels. Methods: This study is experimental with one group pre and post test design, that criteria includes are normal Body Mass Index, sedentary people, not consuming HDL booster supplements and not have bone abnormalities. Subjects were a total of 20 female students class of 2013 at the Medical Faculty of Nursing Science of Sam Ratulangi University. Subjects participated in exercise program three times per week for 2 weeks total exercise with duration of one hour. The HDL levels were examined before and after zumba exercise during two weeks. Data was analyzed by paired t test using SPSS. Result: Based on the research that has done from 20 subjects were obtained result in increase on HDL levels after zumba exercise for two weeks. Conclusion: Zumba exercise can increase cholesterol high density lipoprotein levels. Keywords: high density lipoprotein, zumba. Abstrak: Latar belakang: Kolesterol High density lipoprotein (HDL) merupakan lipoprotein kelas heterogen dengan kepadatan 1.063 – 1.21 g/mL. Kolesterol HDL memiliki sifat proteksi terhadap jantung karena sifatnya yang dapat mengikat kolesterol dan membawanya ke hati untuk diekskresikan. Kadar HDL yang tinggi dalam tubuh akan meningkatkan proteksi terhadap penyakit jantung koroner. Salah satu cara meningkatkan kadar kolesterol HDL adalah dengan melakukan aktivitas fisik. Penelitian ini bertujuan untuk mengetahui pengaruh latihan zumba terhadap kadar kolesterol HDL darah. Metode: Penelitian ini bersifat eksperimental dengan rancangan one group pre and post test yang memenuhi kriteria-kriteria yaitu IMT normal, tidak rutin melakukan aktivitas fisik, tidak mengonsumsi suplemen penambah HDL, dan tidak ada kelainan tulang. Sampel penelitian yaitu mahasiswi Program Studi Ilmu Keperawatan Universitas Sam Ratulangi angkatan 2013 berjumlah 20 orang. Subjek penelitian berpartisipasi dalam latihan yang dilakukan 3 kali dalam seminggu dari total 2 minggu latihan dengan durasi 1 jam. Kadar HDL diukur sebelum latihan zumba pertama dan sesudah latihan zumba terakhir. Data dianalisis dengan uji t berpasangan menggunakan SPSS. Hasil: Berdasarkan penelitian yang telah dilakukan terhadap 20 orang subjek penelitian didapatkan hasil yaitu terjadi peningkatan kadar kolesterol HDL setelah melakukan latihan zumba selama 2 minggu. Simpulan: Latihan zumba dapat meningkatkan kadar kolesterol HDL darah. Kata Kunci: high density lipoprotein, zumba.

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HDL cholesterol efflux capacity and concentration in patients with rheumatoid arthritis: a systematic review and meta-analysis

10.21203/rs.3.rs-61508/v2 ◽

2020 ◽

Author(s):

Binbin Xie ◽

Jiang He ◽

Yong Liu ◽

Ting Liu ◽

Chaoqun Liu

Keyword(s):

Rheumatoid Arthritis ◽

Cholesterol Efflux ◽

Human Subjects ◽

Meta Analysis ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Cochrane Library ◽

Future Research ◽

Cholesterol Efflux Capacity ◽

Beneficial Effects

Abstract Background: Poor cholesterol efflux capacity (CEC) has been proposed to be an independent risk factor for cardiovascular diseases. However, the current evidences in the literature are inconsistent. This meta-analysis aimed to identify whether CEC is impaired or altered by drug therapy in individuals with rheumatoid arthritis (RA).Methods: The PubMed, Embase, and Cochrane library databases were searched to identify studies on CEC in RA patients. The searches were focused on studies in human subjects that were published before 10 June 2020, without language restrictions. The primary outcomes were CEC and the high-density lipoprotein cholesterol (HDL-C) and C-reactive protein levels (CRP) levels.Results: A total of 11 eligible articles, including 6 observational and 5 intervention studies, were retrieved. The pooled results showed that CEC is not significantly lower in RA patients than in healthy controls (SMD: -0.22, 95% CI: -0.65 to 0.20), whereas the plasma HDL-C level is not significantly (WMD: -3.98, 95% CI: -8.32 to 0.37, I² = 54%, P for heterogeneity = 0.050) but is significantly decreased in the RA patients with moderate body mass index (BMI) (WMD: -5.46, 95% CI: -9.40 to -1.52, I² = 37%, P for heterogeneity = 0.175). Furthermore, in the before-after studies, the CEC of RA patients (SMD: 0.20, 95% CI: 0.03 to 0.38) increased, but the plasma HDL-C level (WMD: 3.26, 95% CI: -0.17 to 6.69) remained at a similar level after anti-rheumatic treatment compared to the baseline. In addition, stratified analysis suggested that the Disease Activity Score for 28 joints could be a potential source of heterogeneity for CEC. The funnel plot was relatively symmetric and did not suggest the presence of publication bias.Conclusion：The current meta-analysis demonstrated that HDL-mediated CEC can be improved by the early control of inflammation and anti-rheumatic treatment in RA patients, which is independent of HDL-C levels. Future research is needed to determine whether therapeutic strategies to enhance CEC in RA patients have beneficial effects for preventing CVD.

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Multifaceted Effect of Rubus Occidentalis on Hyperglycemia and Hypercholesterolemia in Mice with Diet-Induced Metabolic Diseases

Nutrients ◽

10.3390/nu10121846 ◽

2018 ◽

Vol 10 (12) ◽

pp. 1846 ◽

Cited By ~ 2

Author(s):

Jiyeon Kim ◽

Jinho An ◽

Heetae Lee ◽

Kyungjae Kim ◽

Su Lee ◽

...

Keyword(s):

Metabolic Syndrome ◽

Metabolic Diseases ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Experimental Period ◽

Tolerance Test ◽

Metabolic Phenotype ◽

Simultaneous Occurrence ◽

Beneficial Effects ◽

Rubus Occidentalis

Metabolic syndrome is characterized by a combination of several metabolic disorders, including obesity, hyperglycemia, and hyperlipidemia. A simultaneous occurrence is one of the most crucial features of metabolic syndrome; therefore, we selected an animal model in which this would be reflected. We fed C57BL/6N mice a high-fat diet for 23 weeks to develop metabolic syndrome and examined the efficacy of Rubus occidentalis (RO) for hyperglycemia and hypercholesterolemia. Oral administration of RO for 16 weeks improved hyperglycemia as indicated by significantly decreased fasting glucose levels and a glucose tolerance test. Improvements were also observed in hypercholesterolemia, in which significant decreases in serum total cholesterol, non-high-density lipoprotein (non-HDL) cholesterol, apolipoprotein A-1, and apolipoprotein B levels were observed. The time comparison of major biomarkers, observed at the initiation and termination of the experimental period, consistently supported the beneficial effects of RO on each metabolic phenotype. In addition, RO treatment attenuated the excessive fat accumulation in hepatic and adipose tissue by decreasing the size and number of lipid droplets. These results suggested that RO simultaneously exerted antihyperglycemic and antihyperlipidemic effects in mice with diet-induced metabolic syndrome.

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Alcohol Drinking, Apolipoprotein Polymorphisms and the Risk of Cardiovascular Diseases

Current Neurovascular Research ◽

10.2174/1567202618666210406123503 ◽

2021 ◽

Vol 18 ◽

Author(s):

Flavio Maria Ceci ◽

Mauro Ceccanti ◽

Carla Petrella ◽

Mario Vitali ◽

Marisa Patrizia Messina ◽

...

Keyword(s):

Risk Factor ◽

Alcohol Drinking ◽

Protective Factor ◽

Heavy Drinking ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Protective Role ◽

Nucleotide Polymorphisms ◽

Moderate Drinking ◽

Apolipoprotein E4

: Lipoprotein disorders are a major risk factor for atherosclerotic neuro-cardiovascular disease (ACVD) and are heavily influenced by lifestyle, including alcohol drinking. Moderate drinkers have a lower ACVD risk than abstainers because of their higher levels of high-density lipoprotein (HDL) cholesterol, an important protective factor against ACVD. On the contrary, heavy drinking increases ACVD risk. According to a large literature body, ethanol intoxication modifies lipid serum profile and induces endothelial dysfunction. Single nucleotide polymorphisms may influence the relationship between alcohol drinking, HDL cholesterol level, and atherosclerotic risk. The risk of ACVD in heavy drinkers seems enhanced in patients with apolipoprotein E4 allele, interleukin-6-174 polymorphism, and cholesteryl ester transfer protein TaqIB polymorphism. Apolipoprotein E4 is a known risk factor for ACVD, while apolipoprotein E2 has mixed effects. Therefore, even if a "protective role" may be attributed to moderate drinking, this effect cannot be extended to everyone.

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Association Between HDL Cholesterol and Incident Cognitive Impairment in Black and White Adults in The Reasons For Geographic and Racial Differences in Stroke Study

10.21203/rs.3.rs-961604/v1 ◽

2021 ◽

Author(s):

Robert Rosenson ◽

Mary Cushman ◽

Emily C. McKinley ◽

Paul Muntner ◽

Zhixin Wang ◽

...

Keyword(s):

Cognitive Impairment ◽

Black Women ◽

Racial Differences ◽

White Women ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Stroke Event ◽

Low Hdl ◽

Regards Study

Abstract BACKGROUND: Low levels of high-density lipoprotein cholesterol (HDL-C) have been associated with incident cognitive impairment (ICI) in some, but not all studies. METHODS: We examine the association between HDL-C and ICI among 18,378 Reasons for Geographic and Racial Differences in Stroke (REGARDS) study participants without cognitive impairment or stroke at baseline in 2003 to 2007, and who did not have a stroke event during follow-up. RESULTS: Over a median follow-up of 9.6 years, 1,359 participants developed ICI. In fully adjusted models, the RR for ICI was 1.51 (95% CI 1.06, 2.15) in White women and 1.25 (95% CI 0.95, 1.65) in Black women. The association was not statistically significant afrter adjustment for triglycerides. There was no evidence of an association between HDL-C and ICI among White or Black men. CONCLUSIONS: Low HDL-C was associated with a higher risk of ICI in White and Black women in models not including triglycerides.

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Assessment and Evaluation of the Leaf Extract of Begonia barbata to the Reduction LDL-Cholesterol in Carbamazepine Induced Obese Rats

American Journal of Pure and Applied Biosciences ◽

10.34104/ajpab.021.017028 ◽

2021 ◽

pp. 17-28

Keyword(s):

Cholesterol Level ◽

Ldl Cholesterol ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Liver Weight ◽

Normal Diet ◽

The Body ◽

Lipid Lowering ◽

Beneficial Effects

Scientific endeavor has made it possible to discover and synthesize lipid-lowering drugs but, in most cases, their beneficial effects are overshadowed by their adverse effects. Hence, research interest in the screening of medicinal plants has intensified in recent years with a view of discovering potential antioxidants, lipid, and glucose-lowering phytochemicals. Four-month feeding of carbamazepine (both 5 mg/kg and 20 mg/kg body weight) with a normal diet increased the body mass of rats. Low-density lipoprotein (LDL) cholesterol level was increased based on the oral execution of carbamazepine. But high-density lipoprotein (HDL) cholesterol level and weight of the liver increased slightly and the level of triacylglycerol (TG) and total cholesterol (TC) level remain unchanged. Nonetheless, the Begonia barbata feeding with a normal diet reduced carbamazepine-induced obesity at both high and low doses. The level of LDL cholesterol and liver weight was significantly decreased due to the oral execution of B. barbata together with normal diet and carbamazepine, where HDL level was changed but not significantly.

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AGT M235T and ACE ID polymorphisms and exercise blood pressure in the HERITAGE Family Study

AJP Heart and Circulatory Physiology ◽

10.1152/ajpheart.2000.279.1.h368 ◽

2000 ◽

Vol 279 (1) ◽

pp. H368-H374 ◽

Cited By ~ 53

Author(s):

Tuomo Rankinen ◽

Jacques Gagnon ◽

Louis Pérusse ◽

Yvon C. Chagnon ◽

Treva Rice ◽

...

Keyword(s):

Blood Pressure ◽

Endurance Training ◽

Gene Polymorphisms ◽

Maximal Exercise ◽

Family Study ◽

Submaximal Exercise ◽

Exercise Tests ◽

Exercise Blood Pressure ◽

Before And After ◽

The Difference

We investigated the association between angiotensinogen (AGT) and angiotensin-converting enzyme (ACE) gene polymorphisms and exercise training responses of resting and exercise blood pressure (BP). BP at rest and during submaximal (50 watts) and maximal exercise tests was measured before and after 20 wk of endurance training in 476 sedentary normotensive Caucasian subjects from 99 families. AGT M235T and ACE insertion/deletion polymorphisms were typed with PCR-based methods. Men carrying the AGT MM and MT genotypes showed 3.7 ± 0.6 and 3.2 ± 0.5 (SE) mmHg reductions, respectively, in diastolic BP at 50 watts (DBP50), whereas, in the TT homozygotes, the decrease was 0.4 ± 1.0 mmHg ( P = 0.016 for trend, adjusted for age, body mass index, and baseline DBP50). Men with the ACE DD genotype showed a slightly greater decrease in DBP50 (4.4 ± 0.6 mmHg) than the II and ID genotypes (2.8 ± 0.7 and 2.4 ± 0.5 mmHg, respectively, P = 0.050). Furthermore, a significant ( P = 0.022) interaction effect between the AGT and ACE genes was noted for DBP50; the AGT TT homozygotes carrying the ACE D allele showed no response to training. Men with the AGT TT genotype had greater ( P = 0.007) diastolic BP (DBP) response to acute maximal exercise at baseline. However, the difference disappeared after the training period. No associations were found in women. These data suggest that, in men, the genetic variation in the AGT locus modifies the responsiveness of submaximal exercise DBP to endurance training, and interactions between the AGT and ACE loci can alter this response.

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