scholarly journals Hepatoprotector Effect of Coconut Water (Cocos nucifera L.) and Folic Acid to the Liver Histopathological Desccription of Pregnant Wistar Female Rats (Rattus norvegicus) Induced by Carbamate

2020 ◽  
Vol 6 (1) ◽  
pp. 53
Author(s):  
Muhammad Rosyid Ridho ◽  
Aris Prasetyo ◽  
Hairrudin Hairrudin
Keyword(s):  
Free Radicals ◽  
Folic Acid ◽  
Liver Damage ◽  
Liver Cells ◽  
The Body ◽  
Coconut Water ◽  
Female Rats ◽  
Test Results ◽  
Liver Histopathology ◽  
Significant Difference

Abstract Carbamate is an insecticide with a working mechanism that inhibits the enzyme acetylcholineestrase (AChE). Obstacles to AChE will cause the formation of excessive free radicals in the body causing oxidative stress and causing lipid peroxidation in body cells, including hepatocyte cells in the liver. Pregnant women have a change in detoxification activity in the liver due to exposure to xenobiotic substances during pregnancy causing a decrease in cytochrome P450 1A2 (CYP1A2) which will cause an increase in free radicals and can damage liver cells. Coconut water contains antioxidants that can neutralize free radicals in the body. While folic acid can encourage improvement in morphology of liver cells. The purpose of this study was to determine the hepatoprotector effect of coconut water and folic acid on the histopathology of the liver of pregnant female wistar rats induced by carbamate. The design of this study is true experimental with a post test only control group design. The sampling method used is simple random sampling. The number of samples in this study were 28 rats divided into 4 groups K (aquades), P1 (carbamate), P2 (carbamate and coconut water), and P3 (carbamate and folic acid). At the end of the study rat liver was taken to then become histological preparations. The One Way ANOVA test results showed a significant difference between groups compared (p <0.05). Post hoc LSD test results showed that group P1 had damaged liver histopathology, there were significant differences with group K and P3 (p <0.05), but there were no significant differences when compared with group P2 (p = 0.826). Meanwhile, the P3 group had significant differences when compared with all groups (p <0.05). The conclusion of this study is that giving coconut water cannot prevent liver damage due to carbamate induction, while folic acid has been shown to prevent liver damage due to carbamate induction, from liver histopathology. Keywords: carbamate, coconut water, folic acid, liver histopathology

scholarly journals PO-288 Research on Norm Construction and Evaluating Levels of 20-m Running in Preschool Children

2018 ◽  
Vol 1 (5) ◽  
Author(s):  
Chuikun Li ◽  
Xue Li ◽  
Qiongjia Yuan ◽  
Zheng Zhao ◽  
Lan Li ◽  
...  
Keyword(s):  
Young Children ◽  
Physical Fitness ◽  
Evaluation System ◽  
The Body ◽  
Kindergarten Children ◽  
Test Results ◽  
Mean Values ◽  
Fitness Evaluation ◽  
Percentile Method ◽  
Significant Difference

Objective The study tested young children's 20-m running in Chengdu, analyzed of the characteristics of change in age and gender, to construct the norm and evaluation system of the 20-m running of young children and provide the basis for assessing children's sports ability and physical fitness. The results can used as one of the children's physical fitness evaluation content. Methods The stratified random sampling method was used to select kindergarten children in from 25 kindergartens in a district of Chengdu, and totally, 3089 children of 3-6 years old were tested．The best scores by two trials were used as the 20-m running performance. Results With the growth of the age, young children's 20 m running is gradually increased. There are significant differences in the mean values of boys and girls aged 3, 4, 5 and 6 (F = 228.696, F = 366.477, P < 0.01). Compared with boys and girls of the same age group, boys are superior to girls, and there is no significant difference between boys and girls aged 6 (F = 0.879, P > 0.05). The differences in other groups were statistically significant (F=0.138, F=0.204, F=0.133, P < 0.01). The percentile 10, 25, 50, 75, 90 values of the 20 m running of young children were recorded, respectively, and according to the statistical percentile method to divide the evaluation grade standards, the test results of the 10th, 25th, 75th and 90th percentage site test results were selected to develop the five-level rating system of children's 20 m running. Conclusions  With the growth of the age, young children's 20 m running is gradually increased, and there are significant differences between groups. It is suggested that the flexibility of nervous processes, the coordination of the body, the flexibility of joints and muscles, and the strength and endurance of muscles are gradually enhanced in children. Constructed the norm and five-grade evaluation system of preschool children's 20 m running, and provided the basis for formulating the grade standard of preschool children's physique evaluation in the future.

scholarly journals Correlation between Antistress and Hepatoprotective Effects of Schisandra Lignans Was Related with Its Antioxidative Actions in Liver Cells

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Hao-Jie Pu ◽  
Yun-Feng Cao ◽  
Rong-Rong He ◽  
Zhi-Long Zhao ◽  
Jin-Hui Song ◽  
...  
Keyword(s):  
Free Radicals ◽  
Liver Damage ◽  
Restraint Stress ◽  
Liver Cells ◽  
Protective Effects ◽  
Male Mice ◽  
Stress Effects ◽  
Restraint Tube ◽  
Hepatoprotective Effects ◽  
The Relationship

The present study was conducted to investigate the relationship between the anti-stress and hepato-protective effects of Schisandra Lignans Extract (SLE) on stress-induced liver damage. Seven weeks old male mice were fixed in a restraint tube for 18 h to induce liver damage. SLE was orally administered to animals for 5 days at dosages of 100 and 200 mg/kg/day before exposed to restraint stress. Oral administration of SLE significantly reduced restraint-induced liver damage in experimental animal. SLE was further found to significantly alleviate the provocation of corticosterone in stressed mice. SLE also significantly decreased oxidative damage and increased anti-oxidative capability of liver cells by preventing the over production and accumulation of free radicals. In conclusion, the protective effects of SLE on stress-induced liver damage were confirmed, and the correlation between hepatoprotective and anti-stress effects of schisandra lignans was possible related to its alleviation on the malignant effects of stressors for bio-homeostasis, such as balance of oxidation and reduction in cells.

scholarly journals Prevalence of temporomandibular disorder and its relation with plantar pressures in university students of health-related courses

2020 ◽  
pp. 1-5
Author(s):  
Ana Beatriz Bonsegno Oliveira ◽  
Camila Costa de Araujo ◽  
Tiago T. Del Antonio ◽  
Natali Maciel Folster ◽  
Joyce Karla Machado Da Silva
Keyword(s):  
University Students ◽  
Temporomandibular Disorders ◽  
Temporomandibular Disorder ◽  
The Body ◽  
Test Results ◽  
Pressure Center ◽  
Plantar Pressures ◽  
Significant Difference ◽  
Health Related ◽  
The University

Background: The temporomandibular disorders (TMD) are changes that occur at the structures that compose the temporomandibular joint. Changes in the temporomandibular complex provoke adaptations throughout the muscular system, which generate postural alterations, modifying the body biomechanics and interfering with their body alignment. Objective: To verify the prevalence of TMD in university students, and to analyze the plantar pressures of subjects with and without TMD. Methods: This research was approved by the Ethics Committee with number: 2.407.595. The 68 students of physiotherapy and dentistry courses were evaluated through the “Research Diagnostic Criteria for Temporomandibular Disorders” and through baropodometry. Plantar pressures of students were compared using the Mann-Whitney test. Results: 71% of the university students presented some type of TMD. Most subjects with TMD presented their pressure center located in the hindfoot contralateral to the disorder. Conclusion: There was no significant difference (p≥0.05) between the plantar pressures of the students with and without TMD.

scholarly journals Trigona sp. Propolis Ethanolic Extract Decreased Chloramphenicol-induced Serum Glutamic Oxaloacetic Transaminase and Alkaline Phosphatase Levels of Rats (Rattus novergicus)

2018 ◽  
Vol 9 (3) ◽  
pp. 110
Author(s):  
Chanif Mahdi ◽  
Anna Zukiaturrahmah ◽  
Dyah Ayu Oktavianie Ardhiana Pratama ◽  
Putranty Widha Nugraheni
Keyword(s):  
Alkaline Phosphatase ◽  
Free Radicals ◽  
Liver Damage ◽  
Therapy Group ◽  
Ethanolic Extract ◽  
The Body ◽  
Male Rats ◽  
Glutamic Oxaloacetic Transaminase ◽  
Serum Glutamic Oxaloacetic Transaminase ◽  
Propolis Extract

Liver has an important role in detoxification of toxins such as xenobiotic which could interfere the function of liver. Chloramphenicol is an antibiotic widely used,despite of its toxicity potentials. The enhancement of free radicals in the body could suppress antioxidant activity. Propolis of Trigona sp. has been known to contain very high amount of antioxidants. The enhanced serum glutamic oxaloacetic transaminase (SGOT) and alkaline phosphatase (ALP) levels in serum is used as marker of liver damage due to the increase of free radicals. The purpose of this study was to observe the effect of Trigona sp. propolis ethanolic extract on SGOT and ALP levels in rats (Rattus novergicus) pretreated by chloramphenicol to induce liver damage. Test animals used for this research were male rats aged 8-12 weeks divided into five treatment groups: negative controlgroup (normal), positive control group (induced by 400 mg/kgBW chloramphenicol), first therapy group, second therapy group, third therapy group induced by chloramphenicol with and propolis extract with the dose of 8 mg, 16 mg, and 24 mg, respectively. Chloramphenicol was injected subcutaneously for 14 days, whereas propolis extract were administered orally for 21 days. The level of SGOT and ALP was determined using spectophotometry. The results showed that propolis extract could reduce levels of SGOT and ALP. Dose of 24 mg/kg was the effective dose to decrease levels of SGOT and ALP significantly (p<0.01). Hence, it may be concluded that the ethanol extract of propolis could be used as herbal therapy in rats model of liver damage.Keywords : ALP, liver, chloramphenicol, propolis, SGOT

scholarly journals Perbedaan Efek Paparan Pestisida Kimia dan Organik terhadap Kadar Glutation (GSH) Plasma pada Petani Padi

2018 ◽  
Vol 17 (2) ◽  
pp. 63
Author(s):  
Ain Yuanita Insani ◽  
Ancah Caesarina Novi Marchianti ◽  
Septa Surya Wahyudi
Keyword(s):  
Free Radicals ◽  
Organ Damage ◽  
The Body ◽  
Plant Diseases ◽  
Cross Sectional ◽  
Significant Difference ◽  
Organic Farmers ◽  
Plasma Glutathione ◽  
Organic Pesticides ◽  
Chemical Pesticides

Latar belakang:Serangan hama dan penyakit tanaman semakin meluas, sehingga para petani tidak dapat menghindari penggunaan pestisida kimia. Pestisida kimia bersifat polutan dan mengakibatkan terbentuknya radikal bebas yang dapat menyebabkan kerusakan organ. WHO memperkirakan ada 1,5 juta kasus keracunan pestisida terjadi pada pekerja di sektor pertanian. Tubuh membutuhkan antioksidan untuk menanggulangi radikal bebas akibat pestisida kimia. Salah satu antioksidan yang sering diukur untuk melihat dampak peningkatan radikal bebas adalah glutation(GSH). Penelitian ini bertujuan untuk mengetahui perbedaan efek paparan pestisida kimia dan organik terhadap kadar GSH plasma pada petani padi. Metode:Jenis penelitian yang digunakan adalah analitik observasional dengan rancangan penelitiancross sectional. Penelitian ini menggunakan sampel 30 orang, 15 orang petani organik di Desa Lombok Kulon Kecamatan Wonosari Kabupaten Bondowoso dan 15 orang petani anorganik di Desa Dawuhan Kecamatan Tenggarang Kabupaten Bondowoso.  Pengambilan sampel darah dilakukan di vena mediana cubiti, selanjutnya dilakukan pengukuran kadar GSH plasma menggunakan metode Elman. Uji statistika dilakukan dengan menggunakan uji Unpaired T-test.Hasil:Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan antara kadar GSH plasma petani anorganik dan organik p<0.05. Petani anorganik memiliki rata-rata kadar GSH plasma lebih rendah dibandingkan dengan rata-rata kadar GSH plasma petani organik. Hal tersebut terjadi karena para petani anorganik mendapatkan paparan polutan berlebih dari zat-zat kimia dalam pestisida kimia sedangkan petani organik menggunakan bahan alami sehingga tidak menimbulkan residu dalam tubuh.Simpulan: Terdapat perbedaan yang signifikan antara kadar GSH plasma pada kelompok petani anorganik dan kelompok petani organik. Kadar GSH plasma petani anorganik lebih rendah dibandingkan dengan kadar GSH plasma petani organik. ABSTRACTTitle: The Difference Effect of Chemical and Organic Pesticides Exposure to Plasma Glutathione (GSH) on Rice FarmersBackground: Pests and plant diseases are widespread in agriculture so the use of chemical pesticides can not avoid. Pesticides are pollutants which forming free radicals and cause organ damage. WHO estimates that 1.5 million cases of pesticide poisoning occur in agricultural workers. The body needs antioxidant to cope free radicals due to chemical pesticides. GSH is one of antioxidants often measured to see the effects of increased free radicals in the body.This study aims to determine the differences effect of chemical and organic pesticide exposure on plasma glutathione (GSH) levels in rice farmers.Methods: The type of this research is observational analytics with cross sectional design. This study used 30 people as sample, 15 people organic farmers in the Desa Lombok Kulon, Kecamatan Wonosari, Bondowoso and 15 people inorganic farmers in Desa Dawuhan, Kecamatan Tenggarang, Bondowoso. Blood sampling was done in mediana cubiti vein, then measured of  plasma GSH using Elman method. The statistical test was done by using Unpaired T-test.Results: The resulf of this research showed that there is a significant difference between plasma GSH level of inorganic farmer and organic farmer p <0.05. The average plasma GSH level of inorganic farmersare lower than average plasma GSH levels of organic farmers. This result is caused by excessive pollutants of chemicals contained in the pesticide exposed inorganic farmers while the group of organic farmers used natural ingredients in the pesticide so it did not makes residues in the body of farmers.Conclusion: Based on this, it is advisable for farmers to be more wise to use chemical pesticides in accordance with established rules and better recommended to replace the use of chemical pesticides with organic pesticides.

scholarly journals EFFECTIVENESS OF YOGA MOVEMENT “SURYANAMASKAR” OF DYSMENORRHOEA PAIN REDUCTION OF ADOLESCENT

2018 ◽  
Vol 5 (1) ◽  
pp. 069-073 ◽  
Author(s):  
Levi Tina Sari
Keyword(s):  
Total Population ◽  
Physical Phenomenon ◽  
The Body ◽  
Oxygen Intake ◽  
Relaxation Techniques ◽  
Test Results ◽  
Experienced Pain ◽  
Significant Difference ◽  
Before And After ◽  
Provide Pain Relief

Abstract: In adolescence, a physical phenomenon associated with puberty is in biological processes that lead to the ability to reproduce years marked by menstruation, some women must have experienced pain during menstruation in the form of pain. The purpose of this research was to analyze the effectiveness of yoga suryanamaskar movement to decrease dysmenorrhea pain of adolescent girls. This research used pre-post design, with 20 respondents of the 27 total population. The research was measured by pain scale0-10 with data analysis using paired sample t-test. The results showed that there was an average increase before and after the intervention of 3.5 points. Test results obtained ñ Â á means there was a significant difference between before and after treatment. Yoga suryanamaskar combines motion, breathing and relaxation techniques, which aimed to feel comfortable. Yoga with body suryanamaskar movement re- quired adequate oxygen intake in order to burn glucose into ATP and burn fat in the body, at that time endorphin hormone appears in order to provide pain relief. So it can be recommended to adolescents as training to reduce dysmenorrhea disk. Keywords: yoga suryanamaskar, adolescent, dysmenorrhea

scholarly journals Doxorubicin Deteriorates the Histomorphology of the Kidneys of Albino Rats

2017 ◽  
Vol 15 (1) ◽  
pp. 40-43
Author(s):  
Anup Pandeya ◽  
Chandra Bhushan Jha ◽  
Smriti Karki ◽  
Gajendra Prashad Rauniar
Keyword(s):  
Body Weight ◽  
The Body ◽  
Female Rats ◽  
Control Group ◽  
Albino Rats ◽  
Final Body Weight ◽  
Histological Features ◽  
Male And Female Rats ◽  
Significant Difference ◽  
And Control

Background and Objectives: Nephrotoxicity is one of the limiting factors for using doxorubicin as an anticancer chemotherapeutic. Reactive oxygen species and cytokines have been implicated in the nephrotoxicity induced by doxorubicin. The main objective of the present study is to identify and compare the histomorphological features in kidneys of albino rats and gross morphological features such as weight of rats and weight of the kidneys due to administration of doxorubicin. Materials and Methods: In the study, albino rats were taken as the animal model. Sixty animals were taken as the sample size. They were divided into two equal groups: experimental (n=30) and control (n=30). Rats of experimental group were treated with anticancer drug doxorubicin at a single intraperitoneal dose of 10 mg/kg body weight while the Control group of rats received a similar volume of 0.9% normal saline. The ethical clearance was taken prior to the research from IERB committee BPKIHS Dharan.  Results: Our results showed that there was high effect of drug in experimental groups of rats. It was seen that there was significant decrease in the body weight and weight of kidneys. The final body weight and kidney weight between experimental and control group showed the significant difference. Similarly there were no significant differences in the normal architecture between the male and female rats. The normal renal histological features were seen on the kidneys in the control group whereas the rats intervened with the drug had some disrupted histological features which reveal the toxicity of the drugs in the kidneys. Conclusion: The study showed toxicity of the drug in the kidneys of experimental groups of rats irrespective of gender and suggest that doxorubicin causes significant loss of the body weight and weight of kidneys and causes the disruption in the normal histological features.

scholarly journals Effect of Ethanol Extract of Mangosteen Peel on Serum Malondialdehyde and Leukotriene B4 Levels in Male White Rats (Rattus norvegicus) Wistar Strain Exposed with Electric Cigarette Smoke

2021 ◽  
Vol 56 (4) ◽  
pp. 283
Author(s):  
Jemima Lewi Santoso ◽  
Harianto Notopuro ◽  
Ema Qurnianingsih
Keyword(s):  
Cigarette Smoke ◽  
Rattus Norvegicus ◽  
Ethanol Extract ◽  
Leukotriene B4 ◽  
The Body ◽  
Control Group ◽  
Test Results ◽  
White Rats ◽  
Mangosteen Peel ◽  
Significant Difference

This study aims to analyze the administration of mangosteen peel ethanol extract at different doses can reduce levels of malondialdehyde (MDA) and leukotriene B4 (LTB4) serum in male white rats (Rattus norvegicus) Wistar strains exposed to electric cigarette smoke. Electric cigarette induces mitochondrial ROS production and triggers oxidative stress. Antioxidants are needed by the body if there are many free radicals, for example mangosteen peel. This laboratory experimental study uses a randomized post test only control group design. Thirty male white rats were divided into 5 groups randomly (KK, KR, P1, P2, P3). KK given 0.5% Na-CMC, KR given smoke and 0.5% Na-CMC, P1, P2, P3 given smoke and mangosteen peel ethanol extract 100, 200, 300 mg / kg weight. Data were tested for normality and homogeneity tests. Data distribution was found not normal. Data were tested by Kruskal-Wallis Test and Mann-Whitney. Kruskal-Wallis Test results showed significant differences in MDA and LTB4 levels in each experimental group (KS, KR, P1, P2 and P3), p <0.05. Mann-Whitney test results showed a significant difference in the MDA levels of the KR against P3 and in the LTB4 level of the KR against P2 (p <0.05). The conclusion of the study was the administration of mangosteen peel ethanol extract can reduce MDA and LTB4 levels serum in male white rats (Rattus norvegicus) Wistar strains exposed to electric cigarette smoke.

THE EFFECT OF CUPPING THERAPY ON THE SCALE OF PAIN IN ADVANCED AGE WHO EXPERIENCED JOINT PAIN IN JEMBER

2020 ◽  
Vol 1 (1) ◽  
pp. 21-29
Author(s):  
Istiadhatul Magfiroh ◽  
Wahyudi Widada ◽  
Sofia Rhosma Dewi
Keyword(s):  
Pain Intensity ◽  
Joint Pain ◽  
Cupping Therapy ◽  
The Body ◽  
Wilcoxon Test ◽  
Control Group ◽  
P Value ◽  
Test Results ◽  
Significant Difference ◽  
Before And After

ABSTRACT   Joint inflammation characterized by swelling of the joints, redness, heat, pain and movement disorders. Arthralgia causes the elderly to have difficulty in carrying out activities that are burdening the joints of the body. Wet cupping therapy is a complementary therapy that has a working principle of vacuum, injury and blood-sucking in certain areas so it can cure the disease. This study was to identify the effect of cupping therapy on pain intensity in elderly patients with arthralgia in Bangsalsari Jember. It was a quasy experiment research with pretest-posttest with control group approach. The sample in this study was 30 elderly then divided into two groups, i.e. 15 elderly in the wet cupping therapy group and 15 elderly in the warm compress group. It used purposive sampling. The average pain intensity before moist cupping therapy was 7.47, and after wet cupping therapy 5.53. While the moderate pain intensity before warm compress was 7.00 and after warm compress 5.73. Wilcoxon test results moist cupping therapy obtained P-value 0.001 means there are significant differences before and after the wet cupping therapy. While Wilcoxon test results, warm compress got P-value 0.001 means there are substantial differences before and after the warm compress. Mann Whitney test result obtained P-value 0.383 means there is no significant difference of effect between the treatment group and the control group. There is an effect of cupping therapy and warm compress on pain intensity. Elderly can use wet cupping therapy as an alternative treatment to decrease joint pain intensity arthralgia.

scholarly journals Reducing Stress Level Cases of Hypogalactia Using Electric and Massage Stimulation Models

2019 ◽  
Vol 125 ◽  
pp. 05001
Author(s):  
Sheyla Najwatul Maula ◽  
Melyana Nurul Widyawati ◽  
Suryono Suryono
Keyword(s):  
Stress Level ◽  
T Test ◽  
The Body ◽  
Test Results ◽  
Lower Stress ◽  
Significant Difference ◽  
Stress Levels ◽  
Before And After ◽  
Postpartum Stress ◽  
And Control

Postpartum stress is very likely to take place as there are fluctuations in terms of feelings, pressure, anxiety, and guilt that may result in hypogalactia without proper treatment. Hypogalactia itself is an issue breastfeeding mothers face that may stall toddlers’ growth, and hence, the future of a nation. This research aims to lower stress levels in hypogalactia cases. It employs nor pharmacological methods of electric and massage stimulation models to activate the biomechanical, psychological, and neurological systems within the body. The electric stimulation model was performed for 10 minutes in acupoints SI, ST, and SP at 0.5 watts frequency. Meanwhile, the massage stimulation was performed for 30 minutes in acupoints GB, BL, ST, CV, and ST. Samples were divided into intervention and control groups, both characteristics and difference tests were performed. Paired t-test results show that there is a significant difference (p<0.05) in stress level with the treatment using both electric and massage stimulation models. Meanwhile, the unpaired t-test results also show differences in stress levels before and after treatment for each group, but the mean difference shows a decrease of 6.249. Therefore, it can be concluded that both electric and massage stimulation models lower stress levels for hypogalactia cases.

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