scholarly journals Strengthening MT6D Defenses with LXC-Based Honeypot Capabilities

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Dileep Basam ◽  
J. Scot Ransbottom ◽  
Randy Marchany ◽  
Joseph G. Tront
Keyword(s):  
Research Effort ◽  
Network Activity ◽  
Local Network ◽  
Moving Target ◽  
Database Integration ◽  
Proof Of Concept ◽  
Traffic Pattern ◽  
On Demand ◽  
Previous Solution ◽  
Ipv6 Networks

Moving Target IPv6 Defense (MT6D) imparts radio-frequency hopping behavior to IPv6 networks by having participating nodes periodically hop onto new addresses while giving up old addresses. Our previous research efforts implemented a solution to identify and acquire these old addresses that are being discarded by MT6D hosts on a local network besides being able to monitor and visualize the incoming traffic on these addresses. This was essentially equivalent to forming a darknet out of the discarded MT6D addresses, but the solution presented in the previous research effort did not include database integration for it to scale and be extended. This paper presents a solution with a new architecture that not only extends the previous solution in terms of automation and database integration but also demonstrates the ability to deploy a honeypot on a virtual LXC (Linux Container) on-demand based on any interesting traffic pattern observed on a discarded address. The proposed architecture also allows an MT6D host to query the solution database for network activity on its relinquished addresses as a JavaScript Object Notation (JSON) object. This allows an MT6D host to identify suspicious activity on its discarded addresses and strengthen the MT6D scheme parameters accordingly. We have built a proof-of-concept for the proposed solution and analyzed the solution’s feasibility and scalability.

Magnetic anisotropy on demand exploiting high-pressure as remote control: an ab initio proof-of-concept

2021 ◽  
Author(s):  
Matteo Briganti ◽  
Federico Totti
Keyword(s):  
High Pressure ◽  
High Temperature ◽  
Remote Control ◽  
Magnetic Anisotropy ◽  
Ab Initio ◽  
Single Molecule ◽  
Boiling Temperature ◽  
Proof Of Concept ◽  
Single Molecule Magnets ◽  
On Demand

Lanthanide based single molecule magnets have recently become very promising systems for creating single molecule device working at high temperature (nitrogen boiling temperature). However, the variation of direction of the...

Programmable shape-morphing microrobots for localized cancer cells treatment

2021 ◽  
Author(s):  
Chen Xin ◽  
Dongdong Jin ◽  
Yanlei Hu ◽  
Liang Yang ◽  
Rui Li ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Targeted Drug Delivery ◽  
Biological Applications ◽  
Proof Of Concept ◽  
Ph Responsive ◽  
Solution Ph ◽  
Shape Morphing ◽  
On Demand ◽  
Targeted Drug

Abstract Microrobots have attracted great attentions due to their wide applications in microobjects manipulation and targeted drug delivery. To realize more complex micro/nano cargos manipulation (e.g., encapsulation and release) in biological applications, endowing microrobots with shapes adaptability with the environment is highly desirable. Here, designable shape-morphing microrobots (SMMRs) have been developed by programmatically encoding different expansion rate in a pH-responsive hydrogel. Combined with magnetic propelling, the shape-morphing microcrab (SMMC) is capable of performing targeted microparticle delivery, including gripping, transporting, and releasing through claws morphing. As a proof-of-concept demonstration, the shape-morphing microfish (SMMF) is designed to encapsulate drug (doxorubicin (DOX)) by closing mouth in phosphate buffer saline (PBS, pH~7.4) and release them by opening mouth in slightly acid solution (pH<7), which realize localized Hela cells treatment in an artificial vascular network. These SMMRs with powerful shape morphing capabilities and remote motion controllability provide new platforms for complex microcargos operation and on-demand drug release.

scholarly journals Distinct mechanisms of signal processing by lamina I spino-parabrachial neurons

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
K. Agashkov ◽  
V. Krotov ◽  
M. Krasniakova ◽  
D. Shevchuk ◽  
Y. Andrianov ◽  
...  
Keyword(s):  
Signal Processing ◽  
Ex Vivo ◽  
Network Activity ◽  
Local Network ◽  
Cellular Mechanisms ◽  
Afferent Stimulation ◽  
Lamina I ◽  
C Fiber ◽  
Nociceptive Input ◽  
High Output

AbstractLamina I spino-parabrachial neurons (SPNs) receive peripheral nociceptive input, process it and transmit to the supraspinal centres. Although responses of SPNs to cutaneous receptive field stimulations have been intensively studied, the mechanisms of signal processing in these neurons are poorly understood. Therefore, we used an ex-vivo spinal cord preparation to examine synaptic and cellular mechanisms determining specific input-output characteristics of the neurons. The vast majority of the SPNs received a few direct nociceptive C-fiber inputs and generated one spike in response to saturating afferent stimulation, thus functioning as simple transducers of painful stimulus. However, 69% of afferent stimulation-induced action potentials in the entire SPN population originated from a small fraction (19%) of high-output neurons. These neurons received a larger number of direct Aδ- and C-fiber inputs, generated intrinsic bursts and efficiently integrated a local network activity via NMDA-receptor-dependent mechanisms. The high-output SPNs amplified and integrated the nociceptive input gradually encoding its intensity into the number of generated spikes. Thus, different mechanisms of signal processing allow lamina I SPNs to play distinct roles in nociception.

scholarly journals Dopaminergic Modulation of Local Network Activity in Rat Prefrontal Cortex

2007 ◽  
Vol 97 (6) ◽  
pp. 4120-4128 ◽  
Author(s):  
Susanta Bandyopadhyay ◽  
John J. Hablitz
Keyword(s):  
Prefrontal Cortex ◽  
Synaptic Transmission ◽  
Receptor Agonist ◽  
Neuronal Networks ◽  
Brain Slices ◽  
Pyramidal Cells ◽  
Network Activity ◽  
Lateral Spread ◽  
Local Network ◽  
Evoked Activity

Dopamine modulates prefrontal cortex excitability in complex ways. Dopamine's net effect on local neuronal networks is therefore difficult to predict based on studies on pharmacologically isolated excitatory or inhibitory connections. In the present work, we have studied the effects of dopamine on evoked activity in acute rat brain slices when both excitation and inhibition are intact. Whole cell recordings from layer II/III pyramidal cells under conditions of normal synaptic transmission showed that bath-applied dopamine (30 μM) increased the outward inhibitory component of composite postsynaptic currents, whereas inward excitatory currents were not significantly affected. Optical imaging with the voltage-sensitive dye N-(3-(triethylammonium)propyl)-4-(4-(p-diethylaminophenyl)buta-dienyl)pyridinium dibromide revealed that bath application of dopamine significantly decreased the amplitude, duration, and lateral spread of activity in local cortical networks. This effect of dopamine was observed both with single and train (5 at 20 Hz) stimuli. The effect was mimicked by the D1-like receptor agonist R(+)-6-chloro-7,8-dihydroxy-1-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide (1 μM) and was blocked by R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (10 μM), a selective antagonist for D1-like receptors. The D2-like receptor agonist quinpirole (10 μM) had no significant effect on evoked dye signals. Our results suggest that dopamine's effect on inhibition dominates over that on excitation under conditions of normal synaptic transmission. Such neuromodulation by dopamine may be important for maintenance of stability in local neuronal networks in the prefrontal cortex.

Modeling the carrier dependencies on demand-side in a smart multi-energy local network

2014 ◽  
Author(s):  
Nilufar Neyestani ◽  
Maziar Yazdani Damavandi ◽  
Miadreza Shafie-khah ◽  
Joao P. S. Catalao ◽  
Gianfranco Chicco
Keyword(s):  
Local Network ◽  
Demand Side ◽  
On Demand

scholarly journals IgSF11 homophilic adhesion proteins promote layer-specific synaptic assembly of the cortical interneuron subtype

2021 ◽  
Vol 7 (29) ◽  
pp. eabf1600
Author(s):  
Yasufumi Hayano ◽  
Yugo Ishino ◽  
Jung Ho Hyun ◽  
Carlos G. Orozco ◽  
André Steinecke ◽  
...  
Keyword(s):  
Molecular Mechanisms ◽  
Pyramidal Neurons ◽  
Cell Types ◽  
Network Activity ◽  
Local Network ◽  
Immunoglobulin Superfamily ◽  
Specific Cell ◽  
Loss Of Function ◽  
Adhesion Proteins ◽  
Homophilic Adhesion

The most prominent structural hallmark of the mammalian neocortical circuitry is the layer-based organization of specific cell types and synaptic inputs. Accordingly, cortical inhibitory interneurons (INs), which shape local network activity, exhibit subtype-specific laminar specificity of synaptic outputs. However, the underlying molecular mechanisms remain unknown. Here, we demonstrate that Immunoglobulin Superfamily member 11 (IgSF11) homophilic adhesion proteins are preferentially expressed in one of the most distinctive IN subtypes, namely, chandelier cells (ChCs) that specifically innervate axon initial segments of pyramidal neurons (PNs), and their synaptic laminar target. Loss-of-function experiments in either ChCs or postsynaptic cells revealed that IgSF11 is required for ChC synaptic development in the target layer. While overexpression of IgSF11 in ChCs enlarges ChC presynaptic boutons, expressing IgSF11 in nontarget layers induces ectopic ChC synapses. These findings provide evidence that synapse-promoting adhesion proteins, highly localized to synaptic partners, determine the layer-specific synaptic connectivity of the cortical IN subtype.

scholarly journals Multi-Domain Time-Sensitive Networks—Control Plane Mechanisms for Dynamic Inter-Domain Stream Configuration

Electronics ◽  
2021 ◽  
Vol 10 (20) ◽  
pp. 2477
Author(s):  
Martin Böhm ◽  
Diederich Wermser
Keyword(s):  
Use Cases ◽  
Batch Size ◽  
Proof Of Concept ◽  
Control Plane ◽  
Test Environment ◽  
On Demand ◽  
End To End

Inter-domain communication in time-sensitive networks (TSN) has been identified as a requirement for various use cases. The TSN Toolbox provides standards for dynamic stream reservations, which is needed for, e.g., batch size 1 production, but these standards do not support the interaction on the control plane between multiple TSN domains. This paper presents control plane mechanisms for multi-domain time sensitive networks (MDTSNs) integrating an east–westbound protocol in the existing TSN control plane, in order to achieve multi-domain on-demand end-to-end bounded-latency TSN streams. Solutions for issues resulting from MDTSN, particularly the inter-domain forwarding offset, are presented. A proof of concept has been implemented and evaluated in a physical MDTSN test environment in order to prove the viability of the mechanisms developed.

scholarly journals Understanding Traversal of a Packet in Internet

2020 ◽  
Author(s):  
Ram Rustagi P
Keyword(s):  
Experiential Learning ◽  
Network Protocols ◽  
Network Activity ◽  
Local Network ◽  
Application Layer ◽  
Web Page ◽  
Web Browser ◽  
Holistic View ◽  
Packet Delivery ◽  
Networking Technologies

In this series of articles on Experiential Learning of Networking Technologies, we have discussed a number of network protocols starting from HTTP [7] at application layer, TCP [3] and UDP [1] protocols at transport layers that provide end to end communications, and IP addressing [2] and routing for packet delivery at network layer. We have defined a number of experiential exercises for each underlying concept which provide a practical understanding of these protocols. Now, we would like to take a holistic view of these protocols which we have learned so far and look at how all these protocols come into play when an internet user makes a simple web request, e.g., what happens from network perspective when a user enters google.com in the URL bar of a web browser [12]. From the perspective of user, web page of Google’s search interface is displayed in the browser window, but inside the network both at the user’s local network and the internet, a lot of network activity takes place. The focus of this article is to understand the traversal of packets in the network triggered by any such user activity.

scholarly journals Encoding stereochemical molecular information on cyclophanes using non-directional interactions and achiral building blocks

2021 ◽  
Author(s):  
Yuan Zhang ◽  
Benjamin Ourri ◽  
Pierre-Thomas Skowron ◽  
Emeric Jeamet ◽  
Ana Belenguer ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Building Blocks ◽  
Proof Of Concept ◽  
Electronic Information ◽  
Physiological Conditions ◽  
Molecular Programming ◽  
On Demand ◽  
Molecular Information ◽  
Synthetic Chemist ◽  
Configuration Information

The stereoselective assembly of achiral constituents through a single spontaneous process into complex covalent architectures bearing multiple stereogenic elements currently seems out of reach to the synthetic chemist. It even seems beyond what nature itself has managed to attain through evolution. Here, we show that such an extreme level of control can be achieved by molecular programming, i.e. by implementing stereo-electronic information on synthetic organic building blocks and exploiting the features of the covalent reactions and interactions, whose interplay acts as a powerful assembling algorithm. Remarkably, we show that non-directional bonds and interactions can reliably transfer this information, delivering in near to physiological conditions, high-molecular weight macrocyclic species carrying up to 8-bits of conformational and configuration information. Beyond the field of supramolecular chemistry, this proof of concept should stimulate the on-demand production of highly structured polyfunctional architectures.

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