Spexin Levels Are Associated with Metabolic Syndrome Components

Background. Spexin (SPX) is a novel peptide that is implicated in obesity and related energy homeostasis in animals and adult humans. Little is known about its role in adults’ overall cardiometabolic health. The aim of the study was to determine whether circulating levels of spexin (SPX) is associated with components of metabolic syndrome (MetS).Methods. The present cross-sectional study included 124 participants (41 males and 83 females; aged 42.4 ± 10.3 y) (MetS group) and 136 (21 male and 115 females; aged 33.1 ± 8.7 y) (non-MetS group). SPX was measured using commercially available assays. Anthropometrics were measured, and fasting serum glucose levels as well as lipid profile were quantified routinely. MetS was screened according to common definitions.Results. SPX levels were significantly lower in participants with MetS vs. non-MetS (0.18 ng/ml (0.13–0.24) vs. 0.26 ng/ml (0.17–0.50);p<0.001). In all MetS definitions used, SPX was significantly lower in the MetS group than the non-MetS group using the WHO definition after adjustment for age and BMI. Stratification according to sex revealed that SPX was associated with MetS only in women, and this significance was lost after adjustment for age and BMI.Conclusions. Lower circulating levels of SPX in adults are modestly associated with components of MetS and are sex-specific. Further studies are necessary to determine whether SPX is associated with harder outcomes such as atherosclerosis and diabetes in the general population.

Download Full-text

Influence of Metabolic Syndrome on Factors Associated with Chronic Kidney Disease: A Cross-Sectional Study

Current Nutrition & Food Science ◽

10.2174/1573401317666210702103247 ◽

2021 ◽

Vol 17 ◽

Author(s):

Camila Santos Marreiros ◽

Thaís Rodrigues Nogueira ◽

Paulo Pedro do Nascimento ◽

Diana Stefany Cardoso de Araújo ◽

Nayara Vieira do Nascimento Monteiro ◽

...

Keyword(s):

Metabolic Syndrome ◽

Chronic Kidney Disease ◽

Kidney Disease ◽

Serum Levels ◽

Cross Sectional Study ◽

Serum Glucose ◽

Cross Sectional ◽

Significance Level ◽

Glucose Levels ◽

Progression Of Kidney Disease

Background: Metabolic Syndrome (MetS) is defined by the presence of three or more of the following components: inadequate fasting serum glucose levels and elevated waist circumference, hypertension and dyslipidemia, which represent a potential risk for the development and/or worsening of Chronic Kidney Disease. Objective: This research aimed to investigate the presence of MetS and its influence on associated factors in patients with Chronic Kidney Disease undergoing hemodialysis. Methods: This is an evaluation of a cross-sectional multicenter research project, carried out with 95 patients with Chronic Kidney Disease, seen at outpatient clinics in the state capital Piaui. Anthropometric, biochemical and hemodynamic parameters were determined. The data were analyzed using the Stata® v.12 software (Statacorp, College Station, Texas, USA), adopting a significance level of p < 0,05. The survey received ethical approval (nº 2.527.329). Results: It was observed that individuals with elevated BMI, WC, NC, SBP, DBP were more likely to develop MetS, with significant differences (p <0.001). In addition, it was found that serum levels of glucose, insulin, HOMA-IR, TC, LDL, TG and blood pressure were higher in the group with MetS. Conclusion: It was concluded that changes in the parameters analyzed in patients with CKD reinforce MetS as a predictive condition for worsening nutritional status and a factor for the progression of kidney disease.

Download Full-text

Increased Plasma Levels of Adenylate Cyclase 8 and cAMP Are Associated with Obesity and Type 2 Diabetes: Results from a Cross-Sectional Study

Biology ◽

10.3390/biology9090244 ◽

2020 ◽

Vol 9 (9) ◽

pp. 244

Author(s):

Samy M. Abdel-Halim ◽

Ashraf Al Madhoun ◽

Rasheeba Nizam ◽

Motasem Melhem ◽

Preethi Cherian ◽

...

Keyword(s):

Type 2 Diabetes ◽

Plasma Levels ◽

Energy Homeostasis ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Glucose Levels ◽

Camp Levels ◽

Circulating Levels

Adenylate cyclases (ADCYs) catalyze the conversion of ATP to cAMP, an important co-factor in energy homeostasis. Giving ADCYs role in obesity, diabetes and inflammation, we questioned whether calcium-stimulated ADCY isoforms may be variably detectable in human plasma. We report the results of a cross-sectional study assessing circulating levels of functional ADCY1, −3 and −8 in patients with T2D vs. non-diabetic (ND) controls in association with obesity. ADCY1 levels exhibited no significant change between ND and T2D groups. ADCY3 levels were lower in obese individuals, albeit not statistically significantly. In contrast, ADCY8 plasma levels were significantly higher in obese and T2D patients compared to controls (p = 0.001) and patients with T2D only (p = 0.039). ADCY8 levels correlated positively with body mass index and Hb1Ac levels. Parallel to the increased ADCY8 levels, significantly higher cAMP levels were observed in patients with T2D compared with ND controls, and further elevated in obese individuals, irrespective of T2D status. Additionally, cAMP levels positively correlated with fasting plasma glucose levels. In conclusion, the current cross-sectional study demonstrated elevated levels of circulating plasma ADCY8 and cAMP in obesity and T2D.

Download Full-text

A study of platelet to lymphocyte ratio in patients with metabolic syndrome

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20201607 ◽

2020 ◽

Vol 7 (5) ◽

pp. 737

Author(s):

Thyagaraj . ◽

Manjushree Mohan ◽

Sreedevi .

Keyword(s):

Metabolic Syndrome ◽

Complete Blood Count ◽

Cross Sectional Study ◽

Serum Glucose ◽

Outpatient Basis ◽

Cross Sectional ◽

Lymphocyte Ratio ◽

Inflammatory Index ◽

Glucose Levels ◽

The Metabolic Syndrome

Background: The prevalence of the metabolic syndrome varies around the world, in part reflecting the age and ethnicity of the populations studied and the diagnostic criteria applied. Numerous studies have shown an association of Metabolic Syndrome (MS) and insulin resistance (IR) with inflammation. Platelet-lymphocyte ratio (PLR) has recently emerged as a novel inflammatory index that may serve as an important predictor of inflammatory state and overall mortality. Aim of this study is to evaluate the PLR in patients with MS and to correlate the same with the severity of MS based on its categories.Methods: A cross sectional study was conducted on 210 subjects (105 subjects with Metabolic Syndrome and 105 age and gender matched control participants without Metabolic Syndrome) seen on outpatient basis at hospitals attached to Basaveshwara medical college and research institute, Chitradurga. Detailed history including history of risk factors if any, physical examinations and baseline investigations like complete blood counts, HbA1c levels, serum glucose levels, fasting lipid profile, electrocardiography and the data was analyzed using appropriate statistical methods.Results: PLR was 6% higher in males (PLR-144.77±34.6) when compared to females (PLR-136.57±30.4) in subjects with metabolic syndrome. There was 95.9% higher PLR in subjects with metabolic syndrome when compared to subjects without metabolic syndrome (p<0.05). Furthermore, PLR increased more as severity of metabolic syndrome increased (5/5 PLR-180.55±25.3,4/5 PLR-132.33±23.6, 3/5 PLR- 109.63±22.6 and non-metabolic syndrome (PLR- 77.45±19.5).Conclusions: In this study, PLR above 90 predicted significant inflammation. PLR is calculated from complete blood count with differential, is an inexpensive, easy to obtain, widely available marker of inflammation, which can aid in the risk stratification of patients with various cardiovascular diseases in addition to the traditionally used markers.

Download Full-text

Cigarette smoking and metabolic syndrome components: a cross-sectional study from Maracaibo City, Venezuela

F1000Research ◽

10.12688/f1000research.14571.3 ◽

2019 ◽

Vol 7 ◽

pp. 565 ◽

Cited By ~ 3

Author(s):

Valmore Bermudez ◽

Luis Carlos Olivar ◽

Wheeler Torres ◽

Carla Navarro ◽

Robys Gonzalez ◽

...

Keyword(s):

Metabolic Syndrome ◽

Cigarette Smoking ◽

Smoking Habit ◽

Cross Sectional Study ◽

Abdominal Circumference ◽

Related Factor ◽

Sectional Study ◽

Cross Sectional ◽

Former Smokers ◽

Metabolic Syndrome Components

Background: A growing body of evidence suggests that cigarette smoking can cause the onset of metabolic syndrome prior to cardiovascular diseases. Therefore, the objective of this study was to evaluate the relationship between smoking habit and metabolic syndrome components in an adult population from Maracaibo city, Venezuela. Methods: The Maracaibo City Metabolic Syndrome Prevalence Study is a descriptive, cross-sectional study with random and multi-stage sampling. In this sub-study, 2212 adults from both genders were selected. On the basis of their medical background, they were classified as smokers, non-smokers and former smokers. Metabolic syndrome was defined according to Harmonizing 2009 criteria, using population-specific abdominal circumference cut-off points. The association between risk factors was evaluated using a logistic regression model. Results: In the studied population, 14.8% were smokers, 15.4% were former smokers. In the multivariate analysis, the presence of metabolic syndrome (smokers: OR, 1.54; 95% CI, 1.11–2.14; p=0.010) and its components were related to cigarette smoking, with the exception of hyperglycemia. High blood pressure was inversely associated with current smoking status (smokers: OR, 0.70 (0.51–0.95); p=0.025). Conclusion: Cigarette smoking represents a related factor with metabolic syndrome, being associated with low high-density lipoprotein-cholesterol, increased abdominal circumference and elevated triacylglyceride levels. Former smokers did not present a greater risk for developing this metabolic disease when compared to non-smokers. The effect of avoiding this habit should be evaluated in future studies in our population.

Download Full-text

Are Vaspin and Omentin-1 Related to Insulin Resistance, Blood Pressure and Inflammation in NAFLD Patients?

Journal of Medical Biochemistry ◽

10.1515/jomb-2018-0006 ◽

2018 ◽

Vol 0 (0) ◽

Author(s):

Fereshteh Aliasghari ◽

Azimeh Izadi ◽

Masoumeh Jabbari ◽

Bahareh Imani ◽

Bahram Pourghassem Gargari ◽

...

Keyword(s):

Insulin Resistance ◽

Blood Pressure ◽

Cross Sectional Study ◽

Serum Glucose ◽

Abdominal Ultrasonography ◽

Cross Sectional ◽

Alcoholic Fatty Liver ◽

Glucose Levels ◽

Partial Correlations ◽

Hs Crp

Summary Background: Non-alcoholic fatty liver disease (NAFLD), the hepatic manifestation of insulin resistance, is the most common cause of chronic liver. The present study aimed to investigate the roles of Vaspin and omentin-1 in the NAFLD-related pathology including IR, inflammation and elevated blood pressure. Methods: This cross-sectional study was conducted among 83 NAFLD patients in Jahrom, Iran. Plasma levels of omentin-1, Vaspin, hs-CRP and IL-6 were measured. Anthropometric indices, lipid profiles, liver enzymes as well as abdominal ultrasonography were assessed. Results: Partial correlations controlling for age and sex showed significant positive correlation between Vaspin and fasting blood sugar (FBS), insulin, HOMA-IR, and hs-CRP. It has been observed that omentin negatively correlated with glucose levels. Moreover, a marginally significant association has been found between Omentin levels and systolic blood pressure (SBP). Conclusions: This study shows that Vaspin and Omentin-1 are associated with inflammation, insulin resistance and serum glucose levels in patients with NAFLD.

Download Full-text

Dietary inflammatory index and metabolic syndrome in Iranian population (Fasa Persian Cohort Study)

Scientific Reports ◽

10.1038/s41598-020-73844-0 ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Mohammad Ariya ◽

Hadi Raeisi Shahraki ◽

Mojtaba Farjam ◽

Elham Ehrampoush ◽

Ehsan Bahramali ◽

...

Keyword(s):

Metabolic Syndrome ◽

Logistic Regression ◽

Cohort Study ◽

Multinomial Logistic Regression ◽

Cross Sectional Study ◽

Fars Province ◽

Cross Sectional ◽

Inflammatory Index ◽

Present Cross Sectional Study ◽

Unit Increase

Abstract Metabolic syndrome (MetS) is one of the risk factors for all causes of mortality. Inflammation is an important risk factor for MetS. The present cross-sectional study aimed to investigate the relationship between MetS and pro-inflammatory diet by using the food inflammation index (DII). This study consists of 10,017 participants with an age range of 35 to 70 years. The Fasa Cohort Study (FACS) population (Fars Province, Iran) was used to collect data. The DII was estimated according to Shivappa et al. method using a validated 125-item FFQ. To determine the association between MetS components and DII Logistic regression was used (P > 0.05). The overall mean of DII was − 0.89 ± 1.74. However, adjusted multinomial logistic regression indicates each unit increase in waist circumference (WC) (OR 0.98, 95% CI 0.96–0.99) and HDL-C (OR 0.99, 95% CI 0.98–0.99) was associated with significantly decreased odds of being in the 4th DII quartile in men and all participations respectively, there is no statistically significant relationship between MetS and DII. Overall, although people in the highest quartile of inflammatory food consumption had more likely to develop MetS, this relationship was not statistically significant among males and females.

Download Full-text

Interaction between a variant of vitamin D receptor gene and a posteriori dietary patterns on metabolic syndrome and its components

Nutrition & Food Science ◽

10.1108/nfs-11-2017-0254 ◽

2018 ◽

Vol 48 (5) ◽

pp. 780-794 ◽

Cited By ~ 2

Author(s):

Fatemeh Shokrzadeh ◽

Zahra Aslani ◽

Abbas Rahimi-Foroushani ◽

Sakineh Shab-Bidar

Keyword(s):

Metabolic Syndrome ◽

Vitamin D ◽

Vitamin D Receptor ◽

Dietary Patterns ◽

Receptor Gene ◽

Cross Sectional Study ◽

Serum Glucose ◽

Vdr Gene ◽

Cross Sectional ◽

Content Type

Purpose This paper aims to investigate whether the interaction between vitamin D receptor (VDR) FokI polymorphism and dietary patterns is associated with metabolic syndrome (MetS) and its components. Design/methodology/approach In total, 304 Iranians were enrolled in this cross-sectional study. Dietary patterns were identified using factor analysis. Fasting serum glucose and lipid profile were also assessed. FokI polymorphism of the VDR gene was genotyped using the restriction fragment length polymorphism method. Findings Individuals in third tertile of “Unhealthy Patterns had greater odds for MetS (odds ratio: 2.9; 95 per cent CI: 1.3, 6.1; P for trend = 0.03) compared to those in first tertile. Significant results disappeared after controlling for covariates (p = 0.09). There was no significant relationship between adherence to ‘Healthy Pattern’ and odds of MetS (p = 0.55). There were not any interactions between FokI polymorphism and major dietary patterns associated with MetS. Originality/value No evidence found for the interaction between polymorphism FokI and major dietary patterns associated with MetS and its components in Iranian subjects. Genome-wide association techniques are needed to assess the direct effect of this polymorphism on MetS.

Download Full-text

Does metabolic health status affect the optimal starting age for colorectal cancer screening? A Korean nationwide cross-sectional study.

Journal of Clinical Oncology ◽

10.1200/jco.2018.36.4_suppl.573 ◽

2018 ◽

Vol 36 (4_suppl) ◽

pp. 573-573

Author(s):

Yoon Jin Choi ◽

Dong Ho Lee

Keyword(s):

Colorectal Cancer ◽

Metabolic Syndrome ◽

Total Population ◽

Age Groups ◽

Cross Sectional Study ◽

Youden Index ◽

Cross Sectional ◽

Crc Screening ◽

Younger Age ◽

Metabolic Syndrome Components

573 Background: The association between metabolic syndrome and colorectal cancer (CRC) has been suggested as one of causes for the increasing incidence of CRC, particularly in younger age groups. The present study examined whether the current age threshold (50 years) for colorectal cancer (CRC) screening in Korea requires modification when considering metabolic syndrome. Methods: We examined data from the National Health Insurance Corporation database, which covers ~97% of the population in Korea. CRC risk was analyzed with stratification based on age and the presence/absence of relevant metabolic syndrome components (diabetes, dyslipidemia, and hypertension). The incidence of CRC was determined for four, 2-year time periods. Results: A total of 51,612,316 subjects enrolled during 2014-2015 were analyzed. Among them, 19.3% had diabetes, hypertension, dyslipidemia, or some combination thereof. This population had a higher incidence of CRC than did those without these conditions and this was more prominent in subjects < 40 years of age. The optimal cut-off age for detecting CRC, based on the highest Youden index, was 45 years among individuals without diabetes, dyslipidemia, and hypertension, and 62 years among individuals with at least one of these components of metabolic syndrome. Resetting the cut-off age from 50 years to 45 years achieved a 6% increment in sensitivity for CRC detection among the total population. Conclusions: An earlier start of CRC screening, namely at 45 rather than at 50 years of age, may improve secondary prevention of CRC in Korea.

Download Full-text