Deubiquitinating Enzymes and Bone Remodeling
Keyword(s):
Bone remodeling, which is essential for bone homeostasis, is controlled by multiple factors and mechanisms. In the past few years, studies have emphasized the role of the ubiquitin-dependent proteolysis system in regulating bone remodeling. Deubiquitinases, which are grouped into five families, remove ubiquitin from target proteins and are involved in several cell functions. Importantly, a number of deubiquitinases mediate bone remodeling through regulating differentiation and/or function of osteoblast and osteoclasts. In this review, we review the functions and mechanisms of deubiquitinases in mediating bone remodeling.
2020 ◽
Vol 21
(12)
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pp. 4196
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Keyword(s):
2019 ◽
Vol 98
(8)
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pp. 930-938
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Keyword(s):
1982 ◽
Vol 40
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pp. 274-277
1992 ◽
Vol 50
(1)
◽
pp. 480-481
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