scholarly journals Old and Recent Advances in Life Cycle, Pathogenesis, Diagnosis, Prevention, and Treatment of Malaria Including Perspectives in Ethiopia

2020 ◽  
Vol 2020 ◽  
pp. 1-17
Author(s):  
Dejen Nureye ◽  
Solomon Assefa
Keyword(s):  
Life Cycle ◽  
Anopheles Funestus ◽  
New Drugs ◽  
Complex Life Cycle ◽  
Malaria Vectors ◽  
Clear Understanding ◽  
Human Beings ◽  
High Prevalence ◽  
The World ◽  
Prevention And Treatment

Malaria, caused by apicomplexan parasite, is an old disease and continues to be a major public health threat in many countries. This article aims to present different aspects of malaria including causes, pathogenesis, prevention, and treatment in an articulate and comprehensive manner. Six Plasmodium species are recognized as the etiology of human malaria, of which Plasmodium falciparum is popular in East and Southern Africa. Malaria is transmitted mainly through Anopheles gambiae and Anopheles funestus, the two most effective malaria vectors in the world. Half of the world’s population is at risk for malaria infection. Globally, the morbidity and mortality rates of malaria have become decreased even though few reports in Ethiopia showed high prevalence of malaria. The malaria parasite has a complex life cycle that takes place both inside the mosquito and human beings. Generally, diagnosis of malaria is classified into clinical and parasitological diagnoses. Lack of clear understanding on the overall biology of Plasmodium has created a challenge in an effort to develop new drugs, vaccines, and preventive methods against malaria. However, three types of vaccines and a lot of novel compounds are under perclinical and clinical studies that are triggered by the occurrence of resistance among commonly used drugs and insecticides. Antiadhesion adjunctive therapies are also under investigation in the laboratory. In addition to previously known targets for diagnostic tool, vaccine and drug discovery scientists from all corner of the world are in search of new targets and chemical entities.

Ramularia leaf spot in barley

2021 ◽  
pp. 681-706
Author(s):  
Neil Havis ◽  
Keyword(s):  
Life Cycle ◽  
Leaf Spot ◽  
Fungicide Resistance ◽  
Complex Life Cycle ◽  
Rate Of Development ◽  
Major Disease ◽  
Ramularia Leaf Spot ◽  
The World ◽  
Causal Pathogen ◽  
And Control

Ramularia leaf spot is an emerging pathogen across barley growing regions of the world. It's rise from minor to major disease has been rapid over the last twenty years. The causal pathogen, Ramularia collo-cygni is poorly understood but it has been shown to have a complex life cycle and the ability to exist on many hosts in an endophytic state. The rate of development of fungicide resistance in the fungus is also extremely fast and many of the major single site fungicides are no longer effective in many countries. With multisite fungicides having their approval or reconsidered and no consistent varietal resistance available, control of the disease is increasing challenging. This chapter reviews the latest research into Ramularia biology and control and highlights the areas where recent advances have been made.

Depression Rises the Risk of Hypertension Incidence: Discussing the Link through the Ca2+/cAMP Signalling

2020 ◽  
Vol 16 (1) ◽  
pp. 73-78
Author(s):  
Leandro B. Bergantin
Keyword(s):  
Signalling Pathways ◽  
Cellular Mechanisms ◽  
Medical Problems ◽  
Camp Signalling ◽  
Data Support ◽  
High Prevalence ◽  
The World ◽  
Prevention And Treatment ◽  
Treatment Of Hypertension ◽  
Risk Issue

Background: Depression and hypertension are medical problems both with clearly restricted pharmacotherapies, along with a high prevalence around the world. In fact, an intensive discussion in the field is that a dysregulation of the intracellular Ca2+ homeostasis (e.g. excess of intracellular Ca2+) contributes to the pathogenesis of both hypertension and depression. Furthermore, depression rises the risk of hypertension incidence. Indeed, several data support the concept that depression is an independent risk issue for hypertension. Conclusion: Then, which are the possible cellular mechanisms involved in this link between depression and hypertension? Considering our previous reports about the Ca2+ and cAMP signalling pathways (Ca2+/cAMP signalling), in this review I have discussed the virtual involvement of the Ca2+/cAMP signalling in this link (between depression and hypertension). Then, it is important to consider depression into account during the process of prevention, and treatment, of hypertension.

scholarly journals Life cycle stages, specific organelles and invasion mechanisms of Eimeria species

Parasitology ◽  
2019 ◽  
Vol 147 (3) ◽  
pp. 263-278 ◽  
Author(s):  
Alana Burrell ◽  
Fiona M. Tomley ◽  
Sue Vaughan ◽  
Virginia Marugan-Hernandez
Keyword(s):  
Life Cycle ◽  
Cell Biology ◽  
Eimeria Species ◽  
Cellular Structures ◽  
Health And Wellbeing ◽  
Invasion Mechanisms ◽  
Financial Costs ◽  
Life Cycle Stages ◽  
High Prevalence ◽  
The World

AbstractApicomplexans, including species of Eimeria, pose a real threat to the health and wellbeing of animals and humans. Eimeria parasites do not infect humans but cause an important economic impact on livestock, in particular on the poultry industry. Despite its high prevalence and financial costs, little is known about the cell biology of these ‘cosmopolitan’ parasites found all over the world. In this review, we discuss different aspects of the life cycle and stages of Eimeria species, focusing on cellular structures and organelles typical of the coccidian family as well as genus-specific features, complementing some ‘unknowns’ with what is described in the closely related coccidian Toxoplasma gondii.

Human rights education and the plight of vulnerable groups with specific reference to people with albinism in Tanzania

2020 ◽  
Vol 20 (2-3) ◽  
pp. 137-155
Author(s):  
John Cantius Mubangizi ◽  
Ines Kajiru
Keyword(s):  
Human Rights ◽  
Legal Framework ◽  
Sub Saharan Africa ◽  
Vulnerable Groups ◽  
Human Rights Education ◽  
Specific Reference ◽  
Human Beings ◽  
High Prevalence ◽  
The World ◽  
Sub Saharan

Although all human beings are vulnerable, some are more vulnerable than others, for example, people with albinism. Similarly, although albinism occurs in all parts of the world, it is more prevalent in some societies than in others. For example, Tanzania, in common with other countries in sub-Saharan Africa, has a high prevalence of albinism. Apart from being subjected to blatant discrimination and abuse, people with albinism suffer atrocious attacks sometimes resulting in death. This paper explores the nature and extent of discrimination and human rights violations of people with albinism in Tanzania in the context of the relevant legal framework available for their protection. Using people with albinism in Tanzania as a proxy, the paper argues that there is a need for human rights education not only to empower vulnerable people to defend and protect their rights but also to sensitize societies to respect and not violate the rights of such people. The paper concludes with several recommendations that apply to people with albinism in Tanzania as much as they would apply to any vulnerable group anywhere else in the world.

Ahimsa (Non-violence) in the Indian Ethos

2002 ◽  
Vol 8 (1) ◽  
pp. 17-25 ◽  
Author(s):  
S.K. Chakraborty
Keyword(s):  
Physical Violence ◽  
Nuclear Proliferation ◽  
Modern Technology ◽  
Wisdom Literature ◽  
Clear Understanding ◽  
Human Beings ◽  
General Welfare ◽  
The World ◽  
The Times ◽  
Spiritual Consciousness

In a world fraught with violence in its macabre form, it is essential to have a broad and clear understanding of the principle of non-violence (ahimsa), its various nuances, its potential and limitations. Covering a span of wisdom literature on the Indian ethos from the times of the Upanishads to the works of modern seers like Gandhi, Tagore and Aurobindo, the author presents the notions of non-violence and violence along a finely graduated scale instead of going into sharp polarities. While making a clear distinction between gross physical violence and the subtle play of violence in words, thoughts and ideas, the paper goes on to offer a critique of modern technology and nuclear proliferation for perpetrating violence on nature and fellow human beings in the name of progress and development. While expressing his admiration for the Gandhian principle of non-violence, the author advocates practical idealism that admits violence with caution but without hatred for the purpose of general welfare (lokasamgraha), along the lines of the messages of Krishna in the Gita. This is of practical necessity till such time as the world has been awakened to a heightened level of spiritual consciousness.

scholarly journals A Silent Attacker SARS-CoV-2 - A Review

2020 ◽  
Vol 2 (3) ◽  
Author(s):  
Khoshnur Jannat ◽  
Nusratun Nahar ◽  
Md Shahadat Hossan ◽  
Tohmina Afroze Bondhon ◽  
Anamul Hasan ◽  
...  
Keyword(s):  
Social Isolation ◽  
New Drugs ◽  
Effective Drug ◽  
Human Beings ◽  
Economic Activities ◽  
Comprehensive View ◽  
Economic Recessions ◽  
The World ◽  
World Economic ◽  
To Come

The recent coronavirus (known as COVID-19 or SARS-CoV-2) has created a pandemic of unheard proportions affecting virtually every country and region of the world. As of April 15, 2020 the virus has resulted in over 2 million infections, and over 100,000 deaths and has brought world economic activities to a standstill, and has led to social isolation and massive unemployment with possible economic recessions on an unprecedented scale around the corner. Till now, the virus shows no signs of abatement. Also till now, scientists have not been able to come out with an effective drug or vaccine against the virus. This review attempts to give a comprehensive view of the origin of the virus, the mode of its entry and infecting human beings, and further discusses the possibility of new drugs and vaccines against the virus.

Ultrastructural analysis of “Sensory” surface nerve endings and “putative” neurotransmitter sites in Schistosoma mansoni Miracidia

1989 ◽  
Vol 47 ◽  
pp. 962-963
Author(s):  
Betty Ruth Jones ◽  
Steve Chi-Tang Pan
Keyword(s):  
Nervous System ◽  
Life Cycle ◽  
Schistosoma Mansoni ◽  
Snail Host ◽  
Complex Life Cycle ◽  
Rational Approach ◽  
Effective Control ◽  
The Social ◽  
Social And Economic Development ◽  
Basic Biology

INTRODUCTION: Schistosomiasis has been described as “one of the most devastating diseases of mankind, second only to malaria in its deleterious effects on the social and economic development of populations in many warm areas of the world.” The disease is worldwide and is probably spreading faster and becoming more intense than the overall research efforts designed to provide the basis for countering it. Moreover, there are indications that the development of water resources and the demands for increasing cultivation and food in developing countries may prevent adequate control of the disease and thus the number of infections are increasing.Our knowledge of the basic biology of the parasites causing the disease is far from adequate. Such knowledge is essential if we are to develop a rational approach to the effective control of human schistosomiasis. The miracidium is the first infective stage in the complex life cycle of schistosomes. The future of the entire life cycle depends on the capacity and ability of this organism to locate and enter a suitable snail host for further development, Little is known about the nervous system of the miracidium of Schistosoma mansoni and of other trematodes. Studies indicate that miracidia contain a well developed and complex nervous system that may aid the larvae in locating and entering a susceptible snail host (Wilson, 1970; Brooker, 1972; Chernin, 1974; Pan, 1980; Mehlhorn, 1988; and Jones, 1987-1988).

“Utopia First!” A Machiavellian Conception of Solidarity in More's Utopia

Moreana ◽  
2018 ◽  
Vol 55 (Number 209) (1) ◽  
pp. 79-93
Author(s):  
Marie-Claire Phélippeau
Keyword(s):  
At Risk ◽  
Human Beings ◽  
Farm Work ◽  
The World ◽  
Social Difficulties ◽  
The Republic ◽  
The Individual ◽  
Democratic Elections ◽  
Communal Organization

This paper shows how solidarity is one of the founding principles in Thomas More's Utopia (1516). In the fictional republic of Utopia described in Book II, solidarity has a political and a moral function. The principle is at the center of the communal organization of Utopian society, exemplified in a number of practices such as the sharing of farm work, the management of surplus crops, or the democratic elections of the governor and the priests. Not only does solidarity benefit the individual Utopian, but it is a prerequisite to ensure the prosperity of the island of Utopia and its moral preeminence over its neighboring countries. However, a limit to this principle is drawn when the republic of Utopia faces specific social difficulties, and also deals with the rest of the world. In order for the principle of solidarity to function perfectly, it is necessary to apply it exclusively within the island or the republic would be at risk. War is not out of the question then, and compassion does not apply to all human beings. This conception of solidarity, summed up as “Utopia first!,” could be dubbed a Machiavellian strategy, devised to ensure the durability of the republic. We will show how some of the recommendations of Realpolitik made by Machiavelli in The Prince (1532) correspond to the Utopian policy enforced to protect their commonwealth.

Jalan Kesempurnaan Menurut Jamaah Insan Al-Kamil di Cijati Desa Cikareo Selatan Sumedang

2020 ◽  
Vol 2 (1) ◽  
pp. 23-37
Author(s):  
Syarifudin Syarifudin
Keyword(s):  
Qualitative Method ◽  
Human Beings ◽  
The Core ◽  
The World ◽  
The Subject ◽  
Religious Sect ◽  
Descriptive Qualitative

Each religious sect has its own characteristics, whether fundamental, radical, or religious. One of them is Insan Al-Kamil Congregation, which is in Cijati, South Cikareo Village, Wado District, Sumedang Regency. This congregation is Sufism with the concept of self-purification as the subject of its teachings. So, the purpose of this study is to reveal how the origin of Insan Al-Kamil Congregation, the concept of its purification, and the procedures of achieving its purification. This research uses a descriptive qualitative method with a normative theological approach as the blade of analysis. In addition, the data generated is the result of observation, interviews, and document studies. From the collected data, Jamaah Insan Al-Kamil adheres to the core teachings of Islam and is the tenth regeneration of Islam Teachings, which refers to the Prophet Muhammad SAW. According to this congregation, self-perfection becomes an obligation that must be achieved by human beings in order to remember Allah when life is done. The process of self-purification is done when human beings still live in the world by knowing His God. Therefore, the peak of self-purification is called Insan Kamil. 

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