Resveratrol Treatment Is Associated with Lipid Regulation and Inhibition of Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) in Rabbits Fed a High-Fat Diet

The effects of resveratrol on various conditions have been widely studied previously. This paper aimed to investigate the influence of resveratrol on atherosclerosis (AS). Twenty-four New Zealand male rabbits were randomly and equally assigned to the normal diet group (NDG), fat diet group (FDG), and fat diet with resveratrol group (80 mg/kg/d, RFG). Biochemical indicators from blood samples were analyzed at baseline and 3 months to investigate the effects of resveratrol on blood lipid, lipoprotein-associated phospholipase A2 (Lp-PLA2), liver, and renal function. The indicators including alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine (CREA), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and Lp-PLA2. At 3 months, arteries were stained with hematoxylin and eosin to study the influence of resveratrol on the aortic intima, smooth muscle layer, and the intima/media ratio. Comparisons of weight, ALT, AST, CREA, TG, TC, HDL-C, LDL-C, and Lp-PLA2 among the three groups showed no significant difference at baseline. However, at the end of 3 months, significant differences were observed in AST, CREA, TC, HDL-C, LDL-C, and Lp-PLA2 between the three groups (P<0.05). In pairwise comparison, CREA, TC, LDL-C, and Lp-PLA2 had significant differences between any two groups (P<0.05). In addition, there were significant differences in the AST and HDL-C levels between RFG and NDG groups (P<0.05). Meanwhile, the HDL-C levels were also significantly different between the FDG and NDG groups (P<0.01). The histologic analysis also showed that the thickness of the aortic intima and the ratio of the intima and aortic tunica media (P<0.05) significantly decreased in RFG compared to FDG. Resveratrol may have an antiatherosclerosis effect on a rabbit model of AS.

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Low serum apolipoprotein A 1 is an indicator of severity in patients with coronavirus disease 2019

10.21203/rs.3.rs-33301/v1 ◽

2020 ◽

Author(s):

Yayun Yang ◽

Zhe Zhu ◽

Lingyan Fan ◽

Shuyuan Ye ◽

Kehong Lou ◽

...

Keyword(s):

Predictive Value ◽

Risk Model ◽

Laboratory Data ◽

Density Lipoprotein ◽

Blood Lipid ◽

Apolipoprotein A1 ◽

Lipoprotein Cholesterol ◽

Predictive Values ◽

Significant Difference ◽

Severe Group

Abstract Background: Recently, dyslipidaemia was observed in patients with coronavirus disease 2019 (COVID-19), especially in severe cases. This study aimed to explore the predictive value of blood lipid levels for COVID-19 severity.Methods: All patients with COVID-19 admitted to HwaMei Hospital, University of Chinese Academy of Sciences, from January 23 to April 20, 2020, were included in this retrospective study. General clinical characteristics and laboratory data (including blood lipid parameters) were obtained, and their predictive values for the severity were analysed.Results: In total, 142 consecutive patients with COVID-19 were included. The non-severe group included 125 cases, and 17 cases were included in the severe group. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and apolipoprotein A1 (ApoA1) at baseline were significantly lower in the severe group. ApoA1 and interleukin-6 (IL-6) were recognized as independent risk factors for COVID-19 severity. ApoA1 had the highest area under the receiver operator characteristic curve (AUC) among all the single markers (AUC: 0.896, 95% CI: 0.834-0.941). Moreover, the risk model established using ApoA1 and IL-6 enhanced the predictive value (AUC: 0.977, 95% CI: 0.932-0.995). On the other hand, ApoA1 levels were elevated in the severe group during treatment, and there was no significant difference between the severe and non-severe groups during the recovery stage of the disease.Conclusion: The blood lipid profile in severe COVID-19 patients is quite different from that in non-severe cases. Serum ApoA1 could severe as a good indictor to reflect the severity of COVID-19.

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Comparative Effects of Animal and Vegetable Fats on Lipid Profile and Patho-physiological Changes in Mice

Journal of Scientific Research ◽

10.3329/jsr.v5i2.11909 ◽

2013 ◽

Vol 5 (2) ◽

pp. 353-361

Author(s):

S. Akter ◽

A. Miah ◽

K. Islam ◽

A. H. Khan

Keyword(s):

Body Weight ◽

Blood Glucose ◽

Soybean Oil ◽

Lipid Profile ◽

Total Cholesterol ◽

Control Diet ◽

Density Lipoprotein ◽

Diet Group ◽

Normal Diet ◽

Lipoprotein Cholesterol

Dietary intake of high amounts of animal fats can cause hypercholesterolemia whereas plant fat like soybean oil reduces serum cholesterol and lipoproteins in mice. The effects of animal fat (butter) and plant fat (soybean oil) fortified diet on lipid profile (serum total cholesterol, low density lipoprotein-cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), and triglycerides), body weight, blood glucose and on tissue texture were investigated in mice. 30 Swiss albino mice were divided equally into three groups. Mice were fed a normal diet (untreated control), a high-fat diet (5% butter) (butter group) and an unsaturated fat diet (5% soybean oil) (soybean oil group) for 90 days. Mice of butter group showed significantly increased level of total cholesterol, LDL-C and triglycerides and decreased level of HDL-C in the serum but not found in mice of soybean fed diet group. Body weight and blood glucose were also markedly elevated in mice fed only butter enriched diet. Histological analysis of liver at the end of 90 days showed increased fat deposition in the mice fed with butter diet than those of control diet and plant fat diet group. Mice fed with butter showed an elevation of lipid levels and developed fatty changes in liver.Keywords: Butter; Soybean oil; Lipid profile; Fatty change; Mice.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i2.11909 J. Sci. Res. 5 (2), 353-361 (2013)

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Low serum level of apolipoprotein A1 is an indicator of severity in patients with coronavirus disease 2019

10.21203/rs.3.rs-31251/v1 ◽

2020 ◽

Author(s):

Yayun Yang ◽

Zhe Zhu ◽

Lingyan Fan ◽

Shuyuan Ye ◽

Kehong Lou ◽

...

Keyword(s):

Risk Model ◽

Characteristic Curve ◽

Laboratory Data ◽

Density Lipoprotein ◽

Blood Lipid ◽

Apolipoprotein A1 ◽

Lipoprotein Cholesterol ◽

Predictive Values ◽

Significant Difference ◽

Severe Group

Abstract Background: Recently, dyslipidemia was observed in the patients of coronavirus disease 2019 (COVID-19), especially in the severe cases. This study aimed to explore the predictive value of blood lipid for the severity of COVID-19.Methods: All patients with COVID-19 who admitted to HwaMei Hospital, University of Chinese Academy of Sciences from January 23 to April 20, 2020 were included in this retrospective study. General clinical characteristics and laboratory data (including blood lipid parameters) were obtained, and their predictive values for the severity were analyzed.Results: 142 consecutive patients with COVID-19 were included. There were 125 cases in the non-severe group and 17 cases in the severe group. Total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 (ApoA1) at baseline were significantly lower in the severe group. ApoA1 and interleukin-6 (IL-6) were recognized as independent risk factors for the severity of COVID-19. ApoA1 had the highest area under the receiver operator characteristic curve (AUROC) among all the single markers (AUROC: 0.896, 95% CI: 0.834-0.941). Moreover, the risk model established upon ApoA1 and IL-6 enhanced the predictability (AUROC: 0.977, 95% CI: 0.932-0.995). On the other hand, ApoA1 in the severe group elevated during the treatment, there was no significant difference between the severe and non-severe groups in the recovery stage of disease.Conclusion: The profile of blood lipid in the severe patients with COVID-19 is quite different from that in the non-severe cases. Serum ApoA1 could severe as a good marker to reflect the severity of COVID-19.

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Acute Stress-Induced Blood Lipid Reactivity in Hypertensive and Normotensive Men and Prospective Associations with Future Cardiovascular Risk

Journal of Clinical Medicine ◽

10.3390/jcm10153400 ◽

2021 ◽

Vol 10 (15) ◽

pp. 3400

Author(s):

Cathy Degroote ◽

Roland von Känel ◽

Livia Thomas ◽

Claudia Zuccarella-Hackl ◽

Jens C. Pruessner ◽

...

Keyword(s):

Essential Hypertension ◽

Cardiovascular Risk ◽

Stress Reactivity ◽

Density Lipoprotein ◽

Blood Lipid ◽

Lipoprotein Cholesterol ◽

Cvd Risk ◽

P Values ◽

D Dimer

Hyperreactivity to stress may be one explanation for the increased risk of cardiovascular disease (CVD) in individuals with essential hypertension. We investigated blood lipid reactivity to the Montreal Imaging Stress Task (MIST), a psychosocial stressor, in hypertensive and normotensive men and tested for prospective associations with biological risk factors. Fifty-six otherwise healthy and medication-free hypertensive and normotensive men underwent the MIST. We repeatedly measured cortisol and blood lipid profiles (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG)) immediately before and up to 1 h after stress. Lipid levels were corrected for stress hemoconcentration. Thirty-five participants completed follow-up assessment 2.9 ± 0.12 (SEM) years later. CVD risk was assessed by prospective changes in TC/HDL-C ratio, IL-6, D-dimer, and HbA1c from baseline to follow-up. The MIST induced significant changes in all parameters except TC (p-values ≤ 0.043). Compared with normotensives, hypertensives had higher TC/HDL-C-ratio and TG (p-values ≤ 0.049) stress responses. Blood lipid stress reactivity predicted future cardiovascular risk (p = 0.036) with increases in HbA1c (ß = 0.34, p = 0.046), IL-6 (ß = 0.31, p = 0.075), and D-dimer (ß = 0.33, p = 0.050). Our results suggest that the greater blood lipid reactivity to psychosocial stress in hypertensives, the greater their future biological CVD risk. This points to lipid stress reactivity as a potential mechanism through which stress might increase CVD risk in essential hypertension.

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Effects of diets rich in ghee or olive oil on cardiometabolic risk factors in healthy adults: A 2-period, crossover, randomized trial

British Journal Of Nutrition ◽

10.1017/s0007114521004645 ◽

2021 ◽

pp. 1-30

Author(s):

Susan Mohammadi Hosseinabadi ◽

Javad Nasrollahzadeh

Keyword(s):

Olive Oil ◽

Dietary Intervention ◽

Disease Risk ◽

Cardiovascular Disease Risk ◽

Density Lipoprotein ◽

Dietary Fats ◽

Lipoprotein Cholesterol ◽

Apo B ◽

Blood Samples ◽

Significant Difference

Abstract This study aimed to evaluate the cardiovascular health-related effects of consuming ghee in the usual diet. Thirty healthy men and women were studied in a free-living outpatient regimen. The participants were instructed for the isocaloric inclusion of ghee or olive oil in their diets for 4 weeks using a randomized crossover design. At the end of run-in (baseline), 2-week wash-out, and interventions, fasting blood samples were drawn. In addition, 2-h postprandial blood samples were collected after ingestion of a meal containing olive oil or ghee at week 4 of each dietary intervention. Body weight was not different between the two interventions. Compared to the olive oil, the diet with ghee increased fasting plasma apolipoprotein-B (apo B) (0.09, 95% CI 0.02 to 0.17 g/L, p= 0.018) and non-high-density lipoprotein cholesterol (non-HDL-C) (0.53, 95% CI 0.01 to 1.05 mmol/L, p= 0.046) and low-density lipoprotein cholesterol did not differ significantly between diet groups (0.29, 95% CI –0.05 to 0.63 mmol/L, p= 0.092), but had no significant effect on total cholesterol/HDL-C ratio (0.75, 95% CI −0.24 to 1.74 mmol/L, p= 0.118). No significant difference was observed in fasting as well as 2-h postprandial plasma triacylglycerol, glucose, insulin, and plasminogen activator inhibitor-1 concentrations. This study showed that ghee which is predominantly saturated fats had an increasing effect on plasma apo B and non-HDL-C compared to olive oil, adding further evidence to the existing recommendations to replace dietary fats high in SFA with dietary fats high in unsaturated fats to reduce cardiovascular disease risk.

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Abstract 13170: Endothelial Function is Impaired in Relation to Alcohol Consumption in Men in a Large General Population

Circulation ◽

10.1161/circ.132.suppl_3.13170 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

Nozomu Oda ◽

Yukihito Higashi ◽

Masato Kajikawa ◽

Tatsuya Maruhashi ◽

Akimichi Iwamoto ◽

...

Keyword(s):

Blood Pressure ◽

Alcohol Consumption ◽

General Population ◽

Endothelial Function ◽

Vascular Function ◽

Density Lipoprotein ◽

Self Report ◽

Lipoprotein Cholesterol ◽

Adjusted Risk ◽

Significant Difference

Introduction: Endothelial function is impaired in heavy or binge drinking. Heavy drinking should be a predictor of endothelial dysfunction. However, there is little information on the effects of dose-dependent alcohol consumption on endothelial function. Therefore, we evaluated the relationship between alcohol consumption and endothelial function in a large general population. Methods and Results: We measured flow-mediated vasodilation (FMD) in 2734 men who provided self-report about habitual alcohol intake. The subjects were divided into five groups by alcohol consumption: none (0 g/week), light (0 g/week< to ≤140 g/week), moderate (140 g/week< to ≤280 g/week), heavy (280 g/week< to ≤420 g/week), and excessive (420 g/week<). Age, systolic blood pressure, diastolic blood pressure, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, gamma glutamyl transpeptidase, uric acid, plasma glucose, hemoglobin A1c, and current smoking were significantly correlated with alcohol consumption. FMD showed a gradual decrease according to increased alcohol consumption (none, 6.6±3.4%; light, 6.2±3.0%; moderate, 6.0±3.0%; heavy, 5.5±2.9%; excessive, 5.3±3.0%; P<0.01). There was a significant difference in FMD between the non-drinker group and the light drinker group (P=0.018). After adjusted risk factors, we showed the significantly smaller FMD in the 4 drinker groups than in the non-drinker group: light drinker group (OR, 1.38; 95% CI, 1.10 to 1.75), moderate drinker group (OR, 1.36; 95% CI, 1.01 to 1.82), heavy drinker group (OR, 2.05; 95% CI, 1.46 to 2.87), excessive drinker group (OR, 2.04; 95% CI, 1.43 to 2.89). Conclusions: These findings suggest that even light alcohol consumption impair the endothelial function. Alcohol drinking may be harmful for vascular function.

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ANTI-HYPERLIPIDEMIC ACTIVITY OF METHANOLIC EXTRACT OF BOESENBERGIA PANDURATA (FINGER ROOT) IN EXPERIMENTAL INDUCED HYPERCHOLESTROLEMIC SPRAGUE DAWLEY RATS

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11s3.29962 ◽

2018 ◽

Vol 11 (15) ◽

pp. 8

Author(s):

Santosh Fattepur ◽

Kiran Chanabasappa Nilugal ◽

Ranya Rajendran ◽

Fadli Asmani ◽

Eddy Yusuf

Keyword(s):

Heart Diseases ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Positive Control ◽

Lipoprotein Cholesterol ◽

Current Therapy ◽

Histopathological Study ◽

Sprague Dawley ◽

Methanolic Extracts ◽

Significant Difference

Objective: Hyperlipidemia is one of the risk factors that contribute to the prevalence of coronary heart diseases and antihyperlipidemic agents, such as statin, was used to treat hyperlipidemia as a current therapy. Boesenbergia pandurata has not been exploited for antihyperlipidemic effect. Hence, this study aims to screen for the antihyperlipidemic activity of methanolic extracts of B. pandurata rhizomes (BPR extracts) in hypercholesterolemia-induced Sprague-Dawley rats.Methods: BPR extracts were prepared using the maceration method with 1500 ml of 80% methanol at room temperature for about 7 days. A toxicity study was carried out based on OECD guidelines. Hypercholesterolemia was induced by 6% lard oil, 2% of cheese, and egg yolks. Two different doses of BPR extracts, 200 and 400 mg/kg, were used to screen for antihyperlipidemic effect. Histopathological study was carried out in the liver. The results were evaluated for the statistically significant difference by using the one-way ANOVA followed by post hoc Dunnett test.Results: No mortality was witnessed even till 2 g/kg. Only 400 mg/kg of BPR extracts statistically reduced in total cholesterol (p<0.05), low-density lipoprotein-cholesterol (p<0.05) and an increase in high-density lipoprotein-cholesterol (p<0.05) when compared to the positive control. BPR extracts (400 mg/kg) showed less enlargement of lipid droplets as compared to positive control.Conclusion: BPR extracts can be a promising medicinal plant for treating hyperlipidemia in underdeveloped countries.

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Effect of Hydroxychloroquine on the Lipid Profile of Patients with Sjögren Syndrome

The Journal of Rheumatology ◽

10.3899/jrheum.131156 ◽

2014 ◽

Vol 41 (5) ◽

pp. 902-908 ◽

Cited By ~ 10

Author(s):

Michail P. Migkos ◽

Theodora E. Markatseli ◽

Chrisoula Iliou ◽

Paraskevi V. Voulgari ◽

Alexandros A. Drosos

Keyword(s):

Lipid Profile ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Sjögren Syndrome ◽

Lipoprotein Cholesterol ◽

Atherogenic Index ◽

Entire Group ◽

Sjogren Syndrome ◽

Significant Difference ◽

Changes Over Time

Objective.Many studies have highlighted the hypolipidemic action of hydroxychloroquine (HCQ). We investigated the effect of HCQ on the lipid profile of patients with Sjögren syndrome (SS).Methods.The present retrospective observational study included 71 female patients with SS treated with HCQ. The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol, triglycerides (TG), and atherogenic index (TC/HDL) were measured at baseline, after 6 months, and 1, 3, and 5 years after initiation of HCQ treatment. Analysis to investigate changes over time was performed in the entire patient group and in the separate subgroups: those receiving (21 patients) and those not receiving (50 patients) hypolipidemic treatment.Results.For the entire group of patients a statistically significant decrease in TC was noted (levels before treatment 220 ± 41 mg/dl, and at 5 yrs 206 ± 32 mg/dl, p = 0.006). A statistically significant difference was observed in the levels of HDL (57 ± 14 mg/dl vs 67 ± 17 mg/dl, p < 0.001) and in atherogenic index (4.0 ± 1.3 vs 3.3 ± 0.9, p < 0.001). Patients not receiving a hypolipidemic agent during the same period demonstrated a decrease in TC (214 ± 40 mg/dl vs 208 ± 34 mg/dl, p = 0.049), an increase in HDL levels (55 ± 15 mg/dl vs 67 ± 18 mg/dl, p < 0.001), and a decrease in atherogenic index (4.0 ± 1.4 vs 3.3 ± 0.9, p < 0.001). In the subgroup of patients receiving hypolipidemic treatment, the respective changes in their lipid profile were not significant in the first years but became significant in the long term.Conclusion.Use of HCQ in patients with SS was related to a statistically significant decrease in TC, an increase in HDL, and improvement in the atherogenic index.

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ASSOCIATION BETWEEN BLOOD LIPID PROFILE AND BLOOD GLUCOSE LEVELS IN MEN WITH CORONARY HEART DISEASE, METABOLIC SYNDROME, AND TYPE 2 DIABETES MELLITUS

CARDIOVASCULAR THERAPY AND PREVENTION ◽

10.15829/1728-8800-2013-5-29-33 ◽

2013 ◽

Vol 12 (5) ◽

pp. 29-33

Author(s):

S. A. Matveeva

Keyword(s):

Blood Glucose ◽

Lipid Profile ◽

Low Density Lipoprotein ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Blood Lipid ◽

Lipoprotein Cholesterol ◽

Blood Lipid Profile ◽

Glucose Levels ◽

Blood Glucose Levels

Aim.To study the associations between blood lipid profile and blood glucose levels in men with coronary heart disease (CHD), stable effort angina (SEA), metabolic syndrome (MS), and Type 2 diabetes mellitus (DM-2).Material and methods.The study included 82 men (mean age 50,5±0,9 years) with CHD, Functional Class I–III SEA, MS, and DM-2. The following lipid profile parameters were assessed: total cholesterol (TCH), triglycerides (TG), low-density lipoprotein cholesterol (LDL–CH), very low-density lipoprotein cholesterol (VLDL–CH), high-density lipoprotein cholesterol (HDL–CH), atherogenic index (AI), and triglyceride index (TGI), together with fasting blood glucose.Results.There were positive (direct) associations between higher levels (>90th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, HDL–CH, AI, TGI) and blood glucose, as well as between lower levels (≤10th percentile) of lipid profile parameters (TCH, TG, LDL–CH, VLDL– CH, AI, TGI) and blood glucose. At the same time, there were negative (inverse) associations between lower lipid levels (≤10th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and higher glucose levels (>90th percentile), as well as between higher lipid levels (>90th percentile of TCH, TG, LDL–CH, VLDL–CH, HDL–CH, AI, TGI) and lower glucose levels (≤10th percentile).Conclusion.Dyslipidemia and hyperglycemia demonstrate synergetic proatherogenic effects in patients with CHD, SEA, MS, and DM-2, as suggested by significant heterogeneous (direct and inverse) associations between lipid profile parameters and fasting blood glucose. The results obtained provide an opportunity for the assessment of risk levels, prognosis, and need for pharmacological prevention and treatment in patients with combined cardiovascular pathology.

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Effects of Quercetin Supplementation on Lipid and Protein Metabolism after Classic Boxing Training

Journal of Education and Training Studies ◽

10.11114/jets.v5i4.2193 ◽

2017 ◽

Vol 5 (4) ◽

pp. 74

Author(s):

Nevzat Demirci ◽

Mehmet Akif Ziyagil

Keyword(s):

Protein Metabolism ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Lipoprotein Cholesterol ◽

Control Group ◽

Physical Conditioning ◽

Control Groups ◽

Significant Difference ◽

And Control ◽

Metabolic Fitness

The metabolic fitness (MF) is a component of athletes’ physical conditioning. This study aims to investigate the effects of quercetin supplementation on Turkish Junior athletes’ lipid and protein metabolism relating to MF after one month classic boxing training. Totally 20 voluntary junior male athletes were separated into two equal groups as the experimental group (EG) and control group (CG). The participants were supplemented with 500 mg quercetin fifteen minutes before each workout in one month boxing training program. Blood samples during pre and post training were taken from athletes in order to determine metabolic fitness related parameters. Lipid profile contains low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), trigliserid (TG), total cholesterol (TC) variables while protein metabolism includes the albumin, total protein, direct bilirubin and total bilirubin parameters. The Mann Whitney U analyzes were used for comparison of the means between experimental and control groups during pre and posttest and between pre and post test results in experimental and control groups. This study showed that EG had a similar physical characteristic with CG. There were significant decrease in TC and LDL-C and an increase in HDL-C in EG while there was only significant increase in HDL-C of in controls. A significant difference of HDL-C was observed between EG and CG during pretest. In other side, TC and LDL-C and HDL-C were significantly differentiated between EG and CG during posttest. Conclusion: it can be concluded that quercetin plays an important role on lipid metabolism not protein.

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