scholarly journals CT Image Feature under Intelligent Algorithm in the Evaluation of Continuous Blood Purification in the Treatment and Nursing of Pulmonary Infection-Caused Severe Sepsis

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Liping Liu ◽  
Yanyan Liu ◽  
Aimin Xing ◽  
Siyu Chen ◽  
Mingli Gu
Keyword(s):  
Severe Sepsis ◽  
Pulmonary Infection ◽  
Blood Purification ◽  
Control Group ◽  
Intelligent Algorithm ◽  
Tnf Α ◽  
Neural Network Algorithm ◽  
Hs Crp ◽  
Experimental Group ◽  
Continuous Blood Purification

This study was to explore the CT image features based on intelligent algorithm to evaluate continuous blood purification in the treatment of severe sepsis caused by pulmonary infection and nursing. 50 patients in the hospital were selected as the research objects. Convolutional neural network algorithm was used to segment CT images of severe sepsis caused by pulmonary infection. They were randomly divided into 25 cases of experimental group and 25 cases of control group. The experimental group was given continuous blood purification treatment, combined with comprehensive nursing. The control group was given routine treatment and basic nursing. Fasting plasma glucose (FPG) and fasting insulin (FIN), interleukin-6 (IL-6), tumor necrosis factor (TNF-α), high-sensitivity c-reactive protein (hs-CRP) levels, CD3+, CD4+, CD4+/CD8+ levels, ICU monitoring time, malnutrition inflammation score (MIS), and incidence of adverse events were compared between the two groups before and after treatment. There was no difference in FPG and FIN between the two groups before treatment. After treatment, the FPG and FIN of the experimental group were lower than those of the control group, and there was statistical significance ( P < 0.05 ). There was no difference in IL-6, TNF-α, and hs-CRP between the two groups before treatment. After treatment, IL-6, TNF-α, and hs-CRP in the experimental group were lower than those in the control group. There was no difference in the percentage of CD3+, CD4+, and CD4+/CD8+ between the two groups before treatment. After treatment, the CD3+, CD4+, and CD4+/CD8+ in the experimental group were higher than those in the control group. The ICU monitoring time, MIS, and incidence of adverse events in the experimental group were lower than those in the control group ( P > 0.05 ). Convolutional neural network algorithm can accurately identify and segment CT images of patients with severe sepsis, which has high clinical application value. Continuous blood purification therapy can effectively control blood glucose level, improve immune function, and reduce the content of inflammatory factors in patients with severe sepsis caused by pulmonary infection. Effective nursing measures can improve the therapeutic effect.

scholarly journals Therapeutic effect of Xuezhitong capsule on microvascular angina

2021 ◽  
Vol 20 (9) ◽  
pp. 1991-1997
Author(s):  
Xiaomei Ma ◽  
Dehui Yang ◽  
Weichun Shen ◽  
Wei Liang ◽  
Qian Lin
Keyword(s):  
Treatment Group ◽  
Therapeutic Effect ◽  
Conventional Treatment ◽  
Density Lipoprotein ◽  
Control Group ◽  
Vascular Endothelial ◽  
Beijing City ◽  
Microvascular Angina ◽  
Tnf Α ◽  
Hs Crp

Purpose: To determine the therapeutic effect of Xuezhitong capsule in patients with microvascular angina (MVA), and its impact on vascular endothelial function.Methods: In total, 172 MVA patients treated in Beijing City Fengtai District Nanyuan Hospital from September 2017 to September 2019 were selected and randomized into control group which received conventional treatment, and treatment group which received Xuezhitong capsules plus. There were 86 patients in each group. Therapeutic effect, levels of inflammatory factors, i.e., high-sensitivity C- reactive protein (hs-CRP), interleukin-(IL-6), tumor necrosis factor-α (TNF-α), and vascular endothelial factors such as nitric oxide (NO), thromboxane B2 (TXB2) and endothelin (ET), were determined.Results: Markedly higher total treatment effectiveness was observed in the treatment group than in the control group (89.53 % vs. 72.94 %; p < 0.05). In both groups, treatment reduced the levels of hs-CRP, IL-6, TNF-α, TXB2 and ET, but elevated NO, with better results for treatment group than the control group (p < 0.05). Better optimizations of total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein (HDL) were observed in the treatment group, relative to the control group (p < 0.05). Patients in the treatment group experienced fewer (8.14%) adverse reactions than those in control group (21.18 %, p < 0.05).Conclusion: Xuezhitong capsule, when combined with conventional treatment, exerts high therapeutic effectiveness and safety in MVA patients by inhibiting inflammatory reactions, optimizing endothelialfunction, reducing blood lipid levels, and decreasing the incidence of cardiovascular adverse events. Thus, the combination therapy is a potentially superior therapeutic strategy to the conventional approach for the management of MVA patients.

scholarly journals Effect of Entecavir Combined with Adefovir Dipivoxil on Clinical Efficacy and TNF-α and IL-6 Levels in Patients with Hepatitis B Cirrhosis

2021 ◽  
Vol 2021 ◽  
pp. 1-5
Author(s):  
Yonghuan Yu ◽  
Xinfeng Cui ◽  
Jingjing Zhao ◽  
Ting Jia ◽  
Baofeng Ren ◽  
...  
Keyword(s):  
Liver Fibrosis ◽  
Hepatitis B ◽  
Liver Function ◽  
Adefovir Dipivoxil ◽  
Adverse Reactions ◽  
Statistical Significance ◽  
Effective Rate ◽  
Control Group ◽  
Tnf Α ◽  
Experimental Group

Objective. The purpose of the study was to investigate the effect of entecavir combined with adefovir dipivoxil on clinical efficacy and TNF-α and IL-6 levels in patients with hepatitis B cirrhosis. Methods. A total of 100 patients with hepatitis B cirrhosis admitted to our hospital between January 2018 and June 2019 were randomly selected and divided into the control group (n = 50) and experimental group (n = 50) according to the order of admission. Among them, the control group patients were treated with entecavir, while the patients in the experimental group received entecavir combined with adefovir dipivoxil. After that, the effective rate of treatment, the incidence of adverse reactions, liver function indexes, liver fibrosis condition, and TNF-α and IL-6 expression levels were all compared between the two groups. Results. The effective rate of treatment in the experimental group was significantly higher than that in the control group, with statistical significance ( p < 0.001 ); the incidence of adverse reactions of the patients in the experimental group was significantly lower than that in the control group, with statistical significance ( p < 0.001 ); the liver function indexes in the experimental group were significantly better than those in the control group, with statistical significance ( p < 0.001 ); the number of patients with liver fibrosis in the experimental group was significantly less than that in the control group, with statistical significance ( p < 0.001 ); the TNF-α and IL-6 expression levels in the experimental group were significantly lower than those in the control group, with statistical significance ( p < 0.001 ). Conclusion. Entecavir combined with adefovir dipivoxil in the treatment of hepatitis B cirrhosis can effectively improve the therapeutic effect and reduce the serum inflammatory factor levels, with high safety, which is worthy of application and popularization.

scholarly journals Effect of Yoganidra on Blood Pressure, Hs-CRP, and Lipid Profile of Hypertensive Subjects: A Pilot Study

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
J. P. Devraj ◽  
B. Santosh Kumar ◽  
M. Raja Sriswan ◽  
B. Jagdish ◽  
B. S. Priya ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pilot Study ◽  
Lipid Profile ◽  
Intervention Group ◽  
Pharmacological Therapy ◽  
Control Group ◽  
Psychological Disturbances ◽  
Group A ◽  
Hs Crp ◽  
Experimental Group

Background. Yoganidra is a systematic method of promoting a state of complete physical, mental, and emotional relaxation. It is a safe, inexpensive, and very effective method of management of hypertension when used along with standard pharmacological therapy. This study aims to assess the effect of yoganidra on blood pressure (both systolic blood pressure (SBP) and diastolic blood pressure (DBP)), Hs-CRP, and lipid profile of hypertensive subjects at the time of enrollment (subjects that are hypertensive at the time of enrollment). Methods. Both treated and untreated subjects (n = 74) with hypertension (blood pressure ≥140/90 mmHg) and age between 35 and 70 years were included in this study after obtaining ICMR-NIN-IEC approval and written informed consent from all subjects. Subjects with critical illness and/or psychological disturbances were excluded from this study. The subjects in the experimental group (n = 31) practiced yoganidra for 45 minutes daily for 12 weeks under strict supervision. There was no intervention in the control group (n = 43). Weekly blood pressure was recorded in the experimental group, whereas it was performed at baseline and at endpoint for control groups. Hs-CRP and lipid profile were estimated at baseline and endpoint for both the groups. Results. A significant reduction in mean SBP from 142.9 mm Hg (SD ± 16.46) to 118.68 mm Hg (SD ± 9.21; p value 0.0001) and DBP from 89.84 mm Hg (SD ± 10.42) to 77.03 mm Hg (SD ± 6.47: p value 0.0001) was observed among the experimental group after 12 weeks of yoganidra practice when compared with the control group. A significant reduction in mean Hs-CRP (2.21 ± 1.49 to 1.06 ± 0.82 mg/L, p  < 0.001 ∗ ∗ ∗ ) was observed among the experimental group. There were no significant differences between triglycerides and total cholesterol levels, whereas LDL-C and HDL-C showed a trend of improvement in the experimental group after intervention. Conclusions. In this pilot study, we observed a significant reduction in blood pressure and Hs-CRP in the yoganidra group compared with the control group. There were no significant side effects observed in the intervention group during the study period.

scholarly journals Research Progress of Continuous Blood Purification in the Treatment of Severe Sepsis in Children

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Weikai Wang ◽  
Yun Du ◽  
Aiqin Cheng ◽  
Shunli Liu ◽  
Lin Wei ◽  
...  
Keyword(s):  
Severe Sepsis ◽  
Mortality Rate ◽  
Incidence Rate ◽  
Clinical Symptoms ◽  
Abdominal Cavity ◽  
Relevant Literature ◽  
Blood Purification ◽  
Research Progress ◽  
Common Disease ◽  
Continuous Blood Purification

Pediatric sepsis is the most common disease in pediatric critical illness, because the main reason for the disease is that children's immune level is not high or the immune system is not perfect, when children's lung, abdominal cavity and blood system are infected, it will cause systemic inflammation and immune dysfunction. Early clinical symptoms are mainly irregular and intermittent fever. When the disease develops to severe sepsis, the children will suffer from acute heart failure, oliguria, respiratory alkalosis and even multiple organ failure. The incidence of death is high. It is reported that the incidence rate of sepsis in children can reach 0.3%, and the mortality rate is 50%. High incidence rate, high mortality rate and high treatment cost are the biggest problems in the pediatric field. In the past, the clinical hope of clearing away heat and toxin, promoting blood circulation and removing stasis, strengthening inflammation and other methods in traditional Chinese medicine, but the treatment effect is not ideal. With the improvement of modern medical understanding of sepsis, continuous blood purification therapy is introduced into the treatment of children with severe sepsis. In order to further explore the effect of continuous blood purification in the treatment of children with severe sepsis, the author summarizes the clinical practice experience and relevant literature, hoping to provide reference for relevant medical staff.

scholarly journals Therapeutic Effect of Cervical Cerclage on Cervical Insufficiency during Pregnancy Analyzed by Magnetic Resonance Image under Neural Network Algorithm

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Yongjuan Liu ◽  
Yongpan Tan ◽  
Rongxia Liu ◽  
Xuekui Ye ◽  
Lina Wang ◽  
...  
Keyword(s):  
Neural Network ◽  
Magnetic Resonance ◽  
Control Group ◽  
Cervical Insufficiency ◽  
Cervical Cerclage ◽  
Normal Delivery ◽  
Bleeding Rate ◽  
Network Algorithm ◽  
Neural Network Algorithm ◽  
Experimental Group

Objective. This research was developed to investigate the effect of magnetic resonance imaging (MRI) analysis based on neural network algorithm for cervical ligation in the treatment of cervical insufficiency. Methods. 44 patients who were suspected to be pregnant with cervical insufficiency and needed cervical ligation were selected. MR imaging analysis was performed before cervical ligation. MR images were analyzed based on the back propagation neural network (BPNN) algorithm, and patients were randomly divided into experimental group and control group. Preoperative MRI analysis was performed in the experimental group, while simple transvaginal ultrasonography was used to diagnose cervical insufficiency in the control group. Then, postoperative fetal preservation time, vaginal bleeding rate, and infection rate within one week after surgery were compared between the two groups. Results. Based on experience and experimental testing, the relevant parameters were set as follows. The number of particles n = 50, the inertia weight ω = 0.9, and c1 = c2 = 2. The weight range of the output layer of the neural network was [−1, 1], the target error e = 10−5, and the maximum number of iteration steps was 3,000. Compared with the control group, the experimental group’s postoperative bleeding rate and infection probability were substantially reduced, while the normal delivery rate was substantially increased ( P < 0.05 ). Conclusion. MR image analysis based on neural network algorithm played an important role in cervical cerclage surgery. The image map showed the local anatomy clearly, increasing the success rate of the operation and improving the prognosis of the patient.

scholarly journals Detection and significance of TNF-α and hs-CRP in the pleural effusion of patients with diabetes and pulmonary tuberculosis

2019 ◽  
Vol 17 ◽  
pp. 205873921982862
Author(s):  
Xin Xue ◽  
Yi Qiu ◽  
Sizhe Cao ◽  
Ying Yue ◽  
Xiaofang Sun ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Pulmonary Tuberculosis ◽  
High Sensitivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Control Group ◽  
Study Group ◽  
Tnf Α ◽  
Patients With Diabetes ◽  
Hs Crp ◽  
Factor Α

It is postulated that high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor α (TNF-α) are diagnostic utilities for pleural effusion. This study was designed to explore the detection and significance of TNF-α and hs-CRP in the pleural effusion of patients with diabetes and pulmonary tuberculosis. A total of 60 patients with diabetes and pulmonary tuberculosis pleural effusion were selected as the study group, while 60 patients with pulmonary tuberculosis pleural effusion were considered as the control group. The expression of TNF-α and hs-CRP in the two groups was determined from pleural effusion by enzyme-linked immunosorbent assay (ELISA). The expression levels of TNF-α and hs-CRP in pleural effusion of the study group were significantly ( P < 0.05) higher than the control group, and the sensitivity and specificity of the combined detection were significantly ( P < 0.05) higher than those of the separate detection. The expression of TNF-α and hs-CRP in the pleural effusion of patients with diabetes and pulmonary tuberculosis increased remarkably, which plays an important role in the diagnosis and treatment helping with differential diagnosis and evaluation of severity and prognosis by related detection of changes of these indexes, especially the combined detections.

scholarly journals Effects of dexmedetomidine on renal function in patients with septic shock

2018 ◽  
Vol 16 ◽  
pp. 205873921879406
Author(s):  
Lvlin Chen ◽  
Ying Lan ◽  
Jun-Cheng Zhu ◽  
Yan He
Keyword(s):  
Septic Shock ◽  
Controlled Trial ◽  
Kidney Injury ◽  
Control Group ◽  
Randomized Controlled ◽  
Prospective Randomized Controlled Trial ◽  
Tnf Α ◽  
And Control ◽  
Experimental Group ◽  
Necrosis Factor

This study was to observe the effects of dexmedetomidine against acute kidney injury in patients with septic shock. A prospective randomized controlled trial (RCT) was conducted in which 80 patients with septic shock admitted in Department of Critical Care Medicine of the Affiliated Hospital of Chengdu University from June 2015 to January 2017 were divided into experimental group and control group. The patients in both groups received basic treatment for septic shock, and the patients in the experimental group were given intravenous injection of dexmedetomidine, maintained with 0.1–0.2 µg kg−1 h−1 for 5 days. In both groups, the changes in the levels of interleukin (IL)-6, tumor necrosis factor (TNF)-α, serum creatinine (SCr), cystatin C (Cys C), and β2-microglobulin (β2-MG) were determined before treatment and 1, 3, and 5 days after treatment. At 5 days after treatment, Cys C, β2-MG, and SCr were significantly decreased in both groups ( P < 0.05), and the degree of decrease in the experimental group was more obvious ( P < 0.05). At 1, 3, and 5 days after treatment, IL-6 and TNF-α were significantly decreased in both groups ( P < 0.05) and the degree of decrease in the experimental group was more obvious ( P < 0.05). Dexmedetomidine has certain renal protective effect in patients with septic shock, and its mechanism is possibly related to the regulation and improvement of uncontrolled inflammatory response.

scholarly journals Changes in inflammatory factors in the Brown Norway rat model of food allergy

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Qingling Zhu ◽  
Junli Wang ◽  
Jingqiu Ma ◽  
Xiaoyang Sheng ◽  
Feng Li
Keyword(s):  
Food Allergy ◽  
Intestinal Inflammation ◽  
Food Allergies ◽  
Inflammatory Factors ◽  
Brown Norway ◽  
Control Group ◽  
Related Factors ◽  
Norway Rat ◽  
Tnf Α ◽  
Experimental Group

Abstract Background The role of serum S100A8/A9 in intestinal inflammation has been confirmed, and its role in food allergy is currently being investigated. Objective To explore the levels of S100A8/A9 and inflammatory factors, including Toll-like receptors 4 (TLR4), Nuclear transcription factors (NF-κB) and Tumor necrosis factor α (TNF-α), in mild food allergies. Methods Eighty 3-week-old male Brown Norway rats were used. Forty rats were randomly assigned to the ovalbumin-sensitized experimental group, while 40 rats were assigned to the normal saline sham-sensitized control group. Body weight and length and the levels of serum ovalbumin-specific IgE (OVA-IgE), histamine, Th1-associated and Th2-associated factors, S100A8/A9 and inflammation-associated cytokines were compared. Results Through the evaluation of OVA-IgE level and Th1/Th2 balance in the experimental group, a successful IgE-mediated food allergy model was constructed. Compared with the control group, the experimental group had higher serum S100A8/A9 levels on days 21, 28, 35 and 42 (all P < 0.05); higher TLR4 levels on days 28, 35 and 42 (all P < 0.05); higher TNF-α levels on days 28, 35 and 42 (all P < 0.05); higher NF-κB levels on days 35 and 42 (all P < 0.05); and higher IL-1β and IL-6 levels on days 7 to 42 (all P < 0.05). Moreover, positive correlations were found between the serum levels of S100A8/A9 and inflammation-associated cytokines [TNF-α: r = 0.378, P = 0.039; IL-1β: r = 0.679, P = 0.000; IL-6: r = 0.590, P = 0.001]. Conclusion S100A8/A9 and inflammatory-related factors, including TLR4, NF-κB, TNF-α, IL-6 and IL-1β, is closely related to food allergies. Moreover, immune and inflammatory factors interact with each other in food allergies, which may provide insight into food allergy causes and treatments.

scholarly journals Inflammatory Cytokines, Adipocytokines, and Th17/Treg Balance in Patients with Nonalcoholic Fatty Liver Disease following Administration of Dahuang Zhechong Pills

2022 ◽  
Vol 2022 ◽  
pp. 1-5
Author(s):  
Xiaohua Duan ◽  
Jianlin Lv ◽  
Hebei Jiang ◽  
Kefei Zheng ◽  
Yulin Chen
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Inflammatory Cytokines ◽  
Fatty Liver Disease ◽  
Test Group ◽  
Control Group ◽  
Nonalcoholic Fatty Liver ◽  
Expression Levels ◽  
Tnf Α ◽  
Hs Crp

Objectives. The occurrence and development of nonalcoholic fatty liver disease (NAFLD) is related to lipid peroxidation, imbalance of inflammatory response factors, and immune function disorder. This study was conducted with the purpose of investigating the expression levels of inflammatory cytokines and adipocytokines and Th17/Treg balance in NAFLD patients treated with Dahuang Zhechong pills (DHZCPs). Methods. The study recruited 100 NAFLD patients who were then arranged into the test group and control group. Patients in the test group were treated with DHZCPs, while patients in the control group were untreated. Peripheral TH17 and Treg cells were detected by flow cytometry, and peripheral IL-17, IL-10, hs-CRP, and TNF-α expression levels were determined by enzyme-linked immunosorbent assay (ELISA) methods. The concentrations of ghrelin, leptin, and adiponectin were quantitatively examined. Results. The levels of TC, TG, ALT, and AST were declined but the level of HDL-C was increased in NAFLD patients treated with DHZCPs compared with untreated patients ( P < 0.05 ). The ratio of Th17/Treg in NAFLD patients treated with DHZCPs was (1.52 ± 0.21), which was significantly lower than (2.39 ± 0.45) of untreated patients ( P < 0.05 ). The levels of IL-17, hs-CRP, and TNF-α were lower, but the level of IL-10 was higher in NAFLD patients treated with DHZCPs than that in untreated patients ( P < 0.05 ). The expression levels of ghrelin and adiponectin in NAFLD patients treated with DHZCPs were evidently higher than those in untreated patients ( P < 0.01 ), and the expression level of leptin in NAFLD patients treated with DHZCPs was evidently lower than that in untreated patients ( P < 0.01 ). Conclusions. Administration of DHZCPs regulates the immune function of NAFLD patients by keeping Th17/Treg balance and affecting the levels of inflammatory cytokines and adipocytokines.

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