scholarly journals Correlation between Changes in Serum RBP4, hs-CRP, and IL-27 Levels and Rosuvastatin in the Treatment of Coronary Heart Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yali Wang ◽  
Changrui Zhou ◽  
Tianlian Yu ◽  
Feng Zhao
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Control Group ◽  
Spearman Correlation ◽  
Gensini Score ◽  
Routine Treatment ◽  
Positive Correlation ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Hs Crp

Objective. To investigate the correlation between changes in serum RBP4, hs-CRP, and IL-27 levels and rosuvastatin in the treatment of coronary heart disease (CHD). Methods. One hundred and twenty patients with CHD admitted in our hospital were selected as the research object, including 60 patients with acute coronary syndrome as the ACS group, and 60 patients with stable angina as the SA group. Another 60 patients without CHD who were examined in our hospital at the same time were included in the non-CHD group. The patients with CHD were further divided into the control group (CG) (n = 42, with routine treatment) and the study group (SG) (n = 78, with routine treatment and rosuvastatin) to measure serum RBP4, hs-CRP, and IL-27 levels and analyze the correlation between each index and rosuvastatin in the treatment of CHD. Results. After retrospective analysis, no significant difference was found among the ACS group, the SA group, and the non-CHD group ( P  > 0.05). As for serum RBP4, hs-CRP, and IL-27 levels, ACS group > SA group > non-CHD group, with obvious differences among groups ( P  < 0.05). After Spearman correlation analysis, a positive correlation was observed between Gensini score and serum RBP4, hs-CRP, and IL-27 levels in patients with CHD ( P  < 0.05). After treatment, serum RBP4, hs-CRP, and IL-27 levels were gradually reduced. At 4 weeks after treatment, serum RBP4, hs-CRP, and IL-27 levels of the CG and the SG were decreased conspicuously, and compared with the control, each index of the SG was obviously lower ( P  < 0.05). Conclusion. Serum RBP4, hs-CRP, and IL-27 play an important role in the occurrence and development of CHD, with a positive correlation to the Gensini score, which can indicate the severity of cardiovascular disease to a certain extent. Meanwhile, rosuvastatin can remarkably reduce serum RBP4, hs-CRP, and IL-27 levels, which is of significance for prognosis.

scholarly journals Study of the correlation between platelet parameters in the patients with coronary heart disease

2017 ◽  
Vol 5 (6) ◽  
pp. 2319
Author(s):  
Mohamed Abdirahman Abdinur ◽  
Xie Yong ◽  
Kong Lingcai ◽  
Farah Abdidahir Mohamud ◽  
Jamac Abdidahir Mohamud ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Angiography ◽  
Control Group ◽  
Interventional Treatment ◽  
Clinical Value ◽  
Distribution Width ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Group 2

Background: The incidence and development of coronary heart disease are ultimately associated with the size and function of platelet. Present study aimed to determine the clinical value of platelet distribution width as an indicator for prediction or risk stratification of coronary heart disease by retrospective analysis of particular population.Methods: This retrospective study covered a total of 150 patients that were included due to a variety of indications for coronary angiography. The control group N-CHD was the patients without coronary heart disease confirmed by coronary angiography examination. The S-CHD group was patients with Stable type coronary heart disease confirmed diagnosis by coronary angiography examination. Study group 2 defined as group ACS were the patients who suffering acute coronary syndrome episode at admission and received coronary angiography and interventional treatment thereafter.Results: The PDW of S-CHD and ACS were 13.85±2.68 and 13.89±1.16, respectively, and there was no significant difference, while the PDW of the N-CHD group was 12.58±2.11, and the values of the first two groups were significantly higher than those of the N-CHD group. In addition, the MPV and P-LCR of S-CHD were significantly higher than those of N-CHD group (11.14±1.17 versus 10.51±0.91 and 32.71±9.99 versus 28.41±7.69), respectively P<0.01; but there was no significant difference between S-CHD and ACS.Conclusions: PDW, MPV, and P-LCR are the platelet volume indicators that can reflex the variability of circulation platelets; their increase was highly and positively associated with Coronary heart disease.

scholarly journals Relationship Between gamma-Glutamyltransferase (gamma-GT) with High Sensitive C-Reactive Protein (hs-CRP), Oxidized (Ox-LDL) and Glutathione Peroxidase (GPx) on Coronary Heart Disease (CHD) Patient

2009 ◽  
Vol 1 (2) ◽  
pp. 51 ◽  
Author(s):  
Marissa Arifin ◽  
Marsetio Donosepoetro ◽  
Sutomo Kasiman
Keyword(s):  
Oxidative Stress ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Glutathione Peroxidase ◽  
Medical Center ◽  
Oxidized Ldl ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Significant Difference ◽  
Hs Crp

BACKGROUND: Recent clinical studies have suggested that γ-glutamyltransferase (γ-GT) can trigger oxidative stress within the plaque. This study aimed to investigate whether serum γ-GT might be as a risk factor of coronary heart disease (CHD), and measure the associations of serum γ-GT with high sensitive C-Reactive Protein (hs-CRP), Oxidized LDL (Ox-LDL) and Glutathione Peroxidase (GPx).METHODS: This study recruited 48 patients aged 30-70 year who underwent coronary angiography at Haji Adam Malik Medical Center at Medan between February and April 2008 and who presented at least one coronary stenosis of > 50% of the luminar diameter. The sample subjects were consecutively selected.RESULTS: γ-Glutamyltransferase was positively associated (r = 0.546) with hs-CRP as a marker of chronic inflammation after careful adjustment for other established risk factors in CHD patient. But, there was no significant difference between γ-GT in male and female patients. Further, there were no correlations between γ-GT and Ox-LDL and GPx. Ratio of γ-GT/GPx was measured as well, and it was associated with hs-CRP.CONCLUSIONS: Ratio of γ-GT/GPx was associated with inflammation process in coronary heart disease patients.KEYWORDS: γ-glutamyltransferase (γ-GT), inflammation, oxidative stress, coronary heart disease

scholarly journals Therapeutic effect of nifedipine combined with enalapril on elderly patients with coronary heart disease complicated with hypertension

2018 ◽  
Vol 2 (6) ◽  
Author(s):  
Xiaoye Wang
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elderly Patients ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Significant Difference ◽  
Pre Treatment ◽  
Experimental Group

【Abstract】Objective: Toanalyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.METHODS:Sixty-six elderly patients with coronary heart disease and hypertension were enrolled from December 2017 to November 2018. They were randomly divided into two groups, 33 patients in each group. Patients in the experimental group received nifedipine. In combination with enalapril, patients enrolled in the control group received nifedipine monotherapy.RESULTS:Compared with the control group, the total effective rate, Serum Nitric Oxide (Serum NO) after treatment, CRP after treatment, HCY after treatment, and blood pressure after treatment were significantly improved (P<0.05). Serum NO and treatment before treatment in the 2 groups. There was no significant difference in pre-CRP, pre-treatment HCY, pre-treatment blood pressure, and adverse reactions during treatment (P>0.05).Conclusion: Theelderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril.

The Association between hs-CRP Levels with GRACE Score in Acute Coronary Syndrome Patients in H. Adam Malik Medan Central General Hospital

2021 ◽  
Vol 8 (8) ◽  
pp. 220-226
Author(s):  
Putri Gaby Yosephine ◽  
Refli Hasan ◽  
Rahmad Isnanta
Keyword(s):  
Acute Coronary Syndrome ◽  
General Hospital ◽  
Spearman Correlation ◽  
Correlation Test ◽  
Coronary Syndrome ◽  
Wide Range ◽  
Significant Difference ◽  
Spearman Correlation Test ◽  
Hs Crp ◽  
Grace Score

Objective: Acute coronary syndrome (ACS) describes a wide range of myocardial ischemia, which is always associated with the rupture of atherosclerotic plaques in coronary arteries. CRP has been shown to be a risk predictor of ACS. GRACE score has been associated with predicting early and late death in ACS patients. Therefore, this study aim to investigate the association between high sensitivity C-reactive protein (hs-CRP) levels with GRACE score in ACS patients. Methods: This study was a retrospective analytic study. The study population was acute coronary syndrome patients in central general hospital of H. Adam Malik, Medan city and 51 patients who met the inclusion and exclusion criteria. Data analysis was calculated using univariate and bivariate analysis. A correlation test was carried out using Spearman correlation test to determine the association between hs-CRP levels with GRACE score in ACS patients. Results: There were 51 samples included in the study. There was a significant difference (p = 0.005) in the mean hs-CRP levels in UAP, NSTEMI, and STEMI subjects. In contrast, there was no significant difference in GRACE score among the three ACS diagnoses. For the association of hs-CRP levels with GRACE score in all subjects, the Spearman correlation test showed a significant correlation between hs-CRP levels with GRACE score (p < 0.001) with a correlation coefficient (r) of 0.588. Conclusion: There was a significant association between serum hs-CRP levels with GRACE score and the higher hs-CRP levels, followed by a higher GRACE score. Keywords: Acute coronary syndrome, GRACE score, hs-CRP.

Office-Based Cholesterol Testing: Impact on Process-of-Care in Patients with Hypercholesterolemia a Pilot Study

1997 ◽  
Vol 13 (2) ◽  
pp. 75-79 ◽  
Author(s):  
David M Ruffin ◽  
James M McKenney
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Statistical Significance ◽  
Intervention Group ◽  
Office Visit ◽  
Therapeutic Interventions ◽  
Control Group ◽  
Process Of Care ◽  
Physician Office ◽  
Significant Difference

Objective: To determine whether providing cholesterol results during a patient-physician office encounter would affect the process-of-care in patients with hypercholesterolemia. Methods: We used a randomized, parallel-group, control design to conduct the study. Thirty-five participants had a lipoprotein analysis performed using the L.D.X. cholesterol analyzer. Patients randomly assigned to the intervention group (n = 19) had their results provided to the physician during the office visit; the results of those in the control group (n = 16) were not made available to the physician. Each participant's medical record was reviewed to determine the physican's process-of-care with respect to cholesterol management. The indicators of the process-of-care for which we sought documentation included therapeutic interventions and the physician's assessment of risk for coronary heart disease. We used Fisher's exact test to determine statistical significance of the intervention. Descriptive analysis was also performed. Results: We were unable to detect a statistically significant difference in therapeutic interventions (p = 0.183). However, we did observe a statistically significant difference in the physician's assessment of risk for coronary heart disease (p = 0.0001). Conclusions: Our data suggest that providing a cholesterol test result during a patient-physician office encounter positively affects the process-of-care in patients with hypercholesterolemia. Future studies should include larger numbers of patients and longer follow-up periods.

scholarly journals Cardiac Biomarkers and Left Ventricular Hypertrophy in Asymptomatic Hemodialysis Patients

2015 ◽  
Vol 4 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Reneta Yovcheva Koycheva ◽  
Vasil Cholakov ◽  
Jivko Andreev ◽  
Margarit Penev ◽  
Rosen Iliev ◽  
...  
Keyword(s):  
Left Ventricular Hypertrophy ◽  
Ventricular Hypertrophy ◽  
High Sensitivity ◽  
Left Ventricular ◽  
Cardiac Biomarkers ◽  
Strong Positive Correlation ◽  
Positive Correlation ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Hs Crp

BACKGROUND: Cardiac biomarkers are often elevated in dialysis patients showing the presence of left ventricular dysfunction. The aim of the study is to establish the plasma levels of high-sensitivity cardiac troponin T (hs TnT), precursor of B-natriuretic peptide (NT-proBNP) and high sensitivity C-reactive protein (hs CRP) and their relation to the presence of left ventricular hypertrophy (LVH) in patients undergoing hemodialysis without signs of acute coronary syndrome or heart failure.MATERIAL AND METHODS: Were studied 48 patients - 26 men and 22 women. Pre and postdialysis levels of hs cTnT, NT-proBNP and hs CRP were measured at week interim procedure. Patients were divided in two groups according to the presence of echocardiographic evidence of LVH - gr A - 40 patients (with LVH), and gr B - 8 patients (without LVH).RESULTS: In the whole group of patients was found elevated predialysis levels of all three biomarkers with significant increase (p < 0.05) after dialysis with low-flux dialyzers. Predialysis values of NT-proBNP show moderate positive correlation with hs cTnT (r = 0.47) and weaker with hs CRP (r = 0.163). Such dependence is observed in postdialysis values of these biomarkers. There is a strong positive correlation between the pre and postdialysis levels: for hs cTnT (r = 0.966), for NT-proBNP (r = 0.918) and for hs CRP (r = 0.859). It was found a significant difference in the mean values of hs cTnT in gr. A and gr. B (0.07 ± 0.01 versus 0.03 ± 0.01 ng /mL, p < 0.05) and NT-proBNP (15,605.8 ± 2,072.5 versus 2,745.5 ± 533.55 pg /mL, p < 0.05). Not find a significant difference in hs CRP in both groups. CONCLUSIONS: The results indicate the relationship of the studied cardiac biomarkers with LVH in asymptomatic patients undergoing hemodialysis treatment.

scholarly journals New perspectives in immunological diagnostics of coronary heart disease

2012 ◽  
Vol 11 (1) ◽  
pp. 49-53
Author(s):  
S. I. Davydov ◽  
A. A. Tarasov ◽  
A. L. Emelyanova ◽  
M. A. Kiseleva ◽  
A. R. Babaeva
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Troponin I ◽  
Solid Phase ◽  
Diagnostic Methods ◽  
Control Group ◽  
Activity Measurement ◽  
Immunological Parameters ◽  
Coronary Syndrome ◽  
Clinical Variants

Aim. To assess the diagnostic value of immunological markers of endothelial dysfunction (ED) in various clinical variants of coronary heart disease (CHD). Material and methods. The study included 455 patients with various clinical variants of CHD. The control group (CG) included 70 individuals without clinical CHD symptoms. Solid-phase immunoenzymatic method was used for measuring the serum titres of Chlamydia pneumoniae (Cp), sulphated glycosamineglycanes (s-GAG), collagen (C), and hyaluronic acid (HA) antibodies. Results. In patients with acute coronary syndrome (ACS), mean titres of Cp, s-GAG, C, and HA antibodies were significantly higher than in patients with chronic CHD or CG participants. Among patients with myocardial infarction (MI), the levels of troponin I (TrI) and MB-creatine phosphokinase (MB-CK) significantly correlated with the titres of s-GAG and C antibodies, while the levels of C-reactive protein (CRP) were linked to the titres of C and HA antibodies. In ACS with ST segment elevation, the measurement of Cp, s-GAG, C, and HA antibodies was comparable to the measurement of CRP, TrI, or MB-CK activity, being significantly more sensitive than echocardiography (EchoCG). In non-ST ACS, immunological parameters were as sensitive as electrocardiography or CRP measurement, more reliable than MB-CK activity measurement or EchoCG, and slightly less reliable than TrI measurement. In unstable angina pectoris (UAP), immunological analysis was significantly more sensitive than the majority of the standard diagnostic methods. Conclusion. Pathogenetic mechanisms of ACS are closely related to the development of specific autoimmune reactions. The assessed immunological parameters could be used as objective markers of acute CHD variants.

scholarly journals Application of MAT Methodology in the Evaluation of Prescribing Adherence to Clinical Practice Guidelines for Secondary Prevention of Coronary Heart Disease in Post-Acute Coronary Syndrome Patients in Kuwait

2021 ◽  
Vol 12 ◽  
Author(s):  
Dalal Al-Taweel ◽  
Abdelmoneim Awad
Keyword(s):  
Health Care ◽  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Secondary Prevention ◽  
Assessment Tools ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
St Elevation ◽  
The Impact

Quantification of prescribers’ adherence to evidence-based guidelines can be used as an outcome measure to assess the impact of services on the quality of medication use. Additionally, it can help in reducing inappropriate interventions and ensure that high-quality care is provided to patients. This study aimed to evaluate prescribing practices for secondary prevention of coronary heart disease (CHD) in post-acute coronary syndromes (ST-elevation myocardial infarction [STEMI] or non-ST elevation acute coronary syndrome [NSTEACS]) patients using two medication assessment tools (MATs) at secondary and tertiary health-care settings in Kuwait. Both MATs were developed and validated based on the relevant guidelines issued by the European Society of Cardiology and the American College of Cardiology/American Heart Association. A quantitative cross-sectional multicenter study was conducted on 460 patients’ medical records collected randomly from six health-care facilities in Kuwait. Application of MATSTEMI on 232 patients’ medication records (with 85.9% applicability) resulted in intermediate overall adherence (69.8%; 95% CI: 67.6–72.0). Application of MATNSTEACS on 228 patients’ medication records (with applicability 83.2%) resulted in intermediate overall adherence (73.3%; 95% CI: 70.5–76.0). There was no significant difference between the percentages of overall adherence among patients managed post-NSTEACS compared to those managed post-STEMI (p = 0.05). Multivariable logistic regression analysis revealed that the overall adherence to the MATSTEMI criteria was significantly higher among the specialized cardiac centers than among the general hospitals (OR: 1.6; 95% CI: 1.1–2.3; p = 0.02). The overall adherence to the MATNSTEACS criteria was found to be significantly lower among non-Kuwaitis than among Kuwaitis (OR: 0.6; 95% CI: 0.5–0.9; p = 0.01) and patients with a serum LDL ≥1.8 mmol/L than those with a serum LDL-C &lt; 1.8 mmol/L (OR: 0.5; 95% CI: 0.4–0.7; p &lt; 0.001). The present findings revealed that both MATs were useful tools in identifying the standard of clinical performances and highlighting areas for improvement regarding secondary prevention of CHD in post-acute coronary syndrome patients.

scholarly journals Association of SRB1, ITGB2 gene polymorphisms with coronary heart disease in Chinese Han population

2018 ◽  
Author(s):  
Yuan Sun ◽  
Tian Long-Wang ◽  
Yong Zeng ◽  
Feng-Ying Gong ◽  
Hui-Juan Zhu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Recessive Model ◽  
Chinese Han Population ◽  
Control Group ◽  
Chinese Han ◽  
Han Population ◽  
Diabetes Status ◽  
Significant Difference ◽  
Equilibrium Test

AbstractBackgroundPrevious studies in mice and humans have implicated the lipoprotein receptor SRB1 in association with atherosclerosis and lipid levels. In our previous proteomics research, the expression of ITGB2 has differences between epicardial and subcutaneous adipose tissue. However, the association between the reported variants and risk of coronary heart disease (CHD) was not confirmed.MethodsWe conducted a case–control study consisted of 496 CHD patients and 367 controls. The two groups are adjusted for age, sex, body mass index, diabetes status and the proportion of dyslipidemia. The genotypes and allele frequency of variants rs838880,rs5888,rs5889 in SRB1 and rs235326,rs2070947,rs2070946 in ITGB2 were determined using Sequenom Mass-ARRAY technology.ResultsThe genotypes frequencies of all the six SNPs were consistent with Hardy-Weinberg Equilibrium test. For gene SRB1 rs838880, there was a significant difference in the alleles frequency(p=0.017), genotype frequency(p=0.0028), recessive model (p=0.000672) between CHD group and control group. For gene ITGB2 rs2070947, there was a significant difference in the recessive model (p=0.03). By comparing the clinical and serum metabolic indexes of SNP sites by genotype we find that among three genotypes of SRB1 rs5888,there were significant difference in the level of dyslipidemia history and serum LPA, among three genotypes of ITGB2 rs235236,there were significant difference in the levels of serum HDL,APOA1 and hypertension history, among three genotypes of ITGB2 rs2070947,there were significant difference in the level of serum APOA1,hsCRP.ConclusionsOur findings indicated that SNP rs838880 of gene SRB1 and rs2070947 of gene ITGB2 are associated with the risk of CHD in Chinese han population.

scholarly journals THE COMPARISON OF ARRHYTHMOGENICITY OF DIFFERENT SURGICAL APPROACHES TO ATRIAL FIBRILLATION IN PATIENTS WITH CORONARY HEART DISEASE

2014 ◽  
Vol 13 (2) ◽  
pp. 40-45
Author(s):  
A. M. Chernyavsky ◽  
Yu. E. Kareva ◽  
I. A. Pak ◽  
S. S. Rakhmonov ◽  
A. B. Romanov ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Mitral Valve ◽  
Atrial Flutter ◽  
Left Atrial ◽  
Pulmonary Veins ◽  
Maze Procedure ◽  
Control Group ◽  
Significant Difference

Aim. To estimate the prevalence of iatrogenic atrial flutter in patients with coronary heart disease (CHD) and atrial fibrillation (AF) after two types of surgical operations: radiofrequency pulmonary veins isolation and radiofrequency modified mini Maze procedure; and to compare the results with control group of patients undergone aortic-coronary bypass grafting (CABG).Material and methods. Totally 95 patients included with CHD and persistent AF. Subjects were randomized into three groups: 1st (n=31) — with simultaneous CABG and radiofrequency ablation of pulmonary veins ostiums; 2nd (n=30) — simultaneous CABG and mini Maze procedure; 3rd control (n=34) — CABG only. For prolonged ECG monitoring the implanted devices Reveal XT were used in 53 subjects.Results. The patients escaped from left-atrial flutter were 90% in the 1st group. In the 2nd there was 1 case of left-atrial flutter (according to electrophysiological investigation — the leap through the mitral valve line), meaning 96,9% patients free from it. However there was no significant difference between 1st and 2nd groups (p=0,6). In the 3rd group postprocedure flutter developed in one case too, due to the scar on the left atrium wall after mitral valve regurgitation correction; so 97% patients escaped from flutter, but the difference was still not significant (p=0,4).Conclusion. In patients with CHD and AF it is recommended to perform radiofrequency modified mini Maze procedure combined with CABG due to its lower proarrhythmogenic effect. The rate of iatrogenic flutter is 3,1% after mini Maze and 10% after pulmonary veins ostiums isolation.

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