scholarly journals Study of the correlation between platelet parameters in the patients with coronary heart disease

2017 ◽  
Vol 5 (6) ◽  
pp. 2319
Author(s):  
Mohamed Abdirahman Abdinur ◽  
Xie Yong ◽  
Kong Lingcai ◽  
Farah Abdidahir Mohamud ◽  
Jamac Abdidahir Mohamud ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Coronary Angiography ◽  
Control Group ◽  
Interventional Treatment ◽  
Clinical Value ◽  
Distribution Width ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Group 2

Background: The incidence and development of coronary heart disease are ultimately associated with the size and function of platelet. Present study aimed to determine the clinical value of platelet distribution width as an indicator for prediction or risk stratification of coronary heart disease by retrospective analysis of particular population.Methods: This retrospective study covered a total of 150 patients that were included due to a variety of indications for coronary angiography. The control group N-CHD was the patients without coronary heart disease confirmed by coronary angiography examination. The S-CHD group was patients with Stable type coronary heart disease confirmed diagnosis by coronary angiography examination. Study group 2 defined as group ACS were the patients who suffering acute coronary syndrome episode at admission and received coronary angiography and interventional treatment thereafter.Results: The PDW of S-CHD and ACS were 13.85±2.68 and 13.89±1.16, respectively, and there was no significant difference, while the PDW of the N-CHD group was 12.58±2.11, and the values of the first two groups were significantly higher than those of the N-CHD group. In addition, the MPV and P-LCR of S-CHD were significantly higher than those of N-CHD group (11.14±1.17 versus 10.51±0.91 and 32.71±9.99 versus 28.41±7.69), respectively P<0.01; but there was no significant difference between S-CHD and ACS.Conclusions: PDW, MPV, and P-LCR are the platelet volume indicators that can reflex the variability of circulation platelets; their increase was highly and positively associated with Coronary heart disease.

scholarly journals Correlation between Changes in Serum RBP4, hs-CRP, and IL-27 Levels and Rosuvastatin in the Treatment of Coronary Heart Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Yali Wang ◽  
Changrui Zhou ◽  
Tianlian Yu ◽  
Feng Zhao
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Control Group ◽  
Spearman Correlation ◽  
Gensini Score ◽  
Routine Treatment ◽  
Positive Correlation ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
Hs Crp

Objective. To investigate the correlation between changes in serum RBP4, hs-CRP, and IL-27 levels and rosuvastatin in the treatment of coronary heart disease (CHD). Methods. One hundred and twenty patients with CHD admitted in our hospital were selected as the research object, including 60 patients with acute coronary syndrome as the ACS group, and 60 patients with stable angina as the SA group. Another 60 patients without CHD who were examined in our hospital at the same time were included in the non-CHD group. The patients with CHD were further divided into the control group (CG) (n = 42, with routine treatment) and the study group (SG) (n = 78, with routine treatment and rosuvastatin) to measure serum RBP4, hs-CRP, and IL-27 levels and analyze the correlation between each index and rosuvastatin in the treatment of CHD. Results. After retrospective analysis, no significant difference was found among the ACS group, the SA group, and the non-CHD group ( P  > 0.05). As for serum RBP4, hs-CRP, and IL-27 levels, ACS group > SA group > non-CHD group, with obvious differences among groups ( P  < 0.05). After Spearman correlation analysis, a positive correlation was observed between Gensini score and serum RBP4, hs-CRP, and IL-27 levels in patients with CHD ( P  < 0.05). After treatment, serum RBP4, hs-CRP, and IL-27 levels were gradually reduced. At 4 weeks after treatment, serum RBP4, hs-CRP, and IL-27 levels of the CG and the SG were decreased conspicuously, and compared with the control, each index of the SG was obviously lower ( P  < 0.05). Conclusion. Serum RBP4, hs-CRP, and IL-27 play an important role in the occurrence and development of CHD, with a positive correlation to the Gensini score, which can indicate the severity of cardiovascular disease to a certain extent. Meanwhile, rosuvastatin can remarkably reduce serum RBP4, hs-CRP, and IL-27 levels, which is of significance for prognosis.

scholarly journals Therapeutic effect of nifedipine combined with enalapril on elderly patients with coronary heart disease complicated with hypertension

2018 ◽  
Vol 2 (6) ◽  
Author(s):  
Xiaoye Wang
Keyword(s):  
Blood Pressure ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Elderly Patients ◽  
Adverse Reactions ◽  
Effective Rate ◽  
Control Group ◽  
Significant Difference ◽  
Pre Treatment ◽  
Experimental Group

【Abstract】Objective: Toanalyze the efficacy of combined drug therapy for elderly patients with coronary heart disease and hypertension.METHODS:Sixty-six elderly patients with coronary heart disease and hypertension were enrolled from December 2017 to November 2018. They were randomly divided into two groups, 33 patients in each group. Patients in the experimental group received nifedipine. In combination with enalapril, patients enrolled in the control group received nifedipine monotherapy.RESULTS:Compared with the control group, the total effective rate, Serum Nitric Oxide (Serum NO) after treatment, CRP after treatment, HCY after treatment, and blood pressure after treatment were significantly improved (P<0.05). Serum NO and treatment before treatment in the 2 groups. There was no significant difference in pre-CRP, pre-treatment HCY, pre-treatment blood pressure, and adverse reactions during treatment (P>0.05).Conclusion: Theelderly patients with coronary heart disease and hypertension are treated with nifedipine and enalapril.

Office-Based Cholesterol Testing: Impact on Process-of-Care in Patients with Hypercholesterolemia a Pilot Study

1997 ◽  
Vol 13 (2) ◽  
pp. 75-79 ◽  
Author(s):  
David M Ruffin ◽  
James M McKenney
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Statistical Significance ◽  
Intervention Group ◽  
Office Visit ◽  
Therapeutic Interventions ◽  
Control Group ◽  
Process Of Care ◽  
Physician Office ◽  
Significant Difference

Objective: To determine whether providing cholesterol results during a patient-physician office encounter would affect the process-of-care in patients with hypercholesterolemia. Methods: We used a randomized, parallel-group, control design to conduct the study. Thirty-five participants had a lipoprotein analysis performed using the L.D.X. cholesterol analyzer. Patients randomly assigned to the intervention group (n = 19) had their results provided to the physician during the office visit; the results of those in the control group (n = 16) were not made available to the physician. Each participant's medical record was reviewed to determine the physican's process-of-care with respect to cholesterol management. The indicators of the process-of-care for which we sought documentation included therapeutic interventions and the physician's assessment of risk for coronary heart disease. We used Fisher's exact test to determine statistical significance of the intervention. Descriptive analysis was also performed. Results: We were unable to detect a statistically significant difference in therapeutic interventions (p = 0.183). However, we did observe a statistically significant difference in the physician's assessment of risk for coronary heart disease (p = 0.0001). Conclusions: Our data suggest that providing a cholesterol test result during a patient-physician office encounter positively affects the process-of-care in patients with hypercholesterolemia. Future studies should include larger numbers of patients and longer follow-up periods.

scholarly journals The Difference of ACE and ACE2 Gene Expression in Patients With Acute Aortic Dissection and Coronary Heart Disease

2021 ◽  
Author(s):  
Yang Li ◽  
Long Mao ◽  
Zongwei Xiao ◽  
Sandeep Bhushan
Keyword(s):  
Gene Expression ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Arterial Wall ◽  
Acute Aortic Dissection ◽  
Venous Blood ◽  
Control Group ◽  
The Difference ◽  
Group 2 ◽  
Ace2 Gene

Abstract BackgroundTo explore whether there is a difference in the expression of ACE and ACE2 genes in patients with acute AD and CHD. MethodsBlood samples from 68 patients, including 34 cases of acute AD (including Stanford type A and B), 21 cases of CHD, and 13 cases of control group. 2 ml of venous blood is submitted for plasma ACE concentration. The arterial wall tissue was taken during the operation for mRNA detection. ResultsThe ACE concentration in the AD group was (17.9 ± 7. 9) U / L, in the CHD group was (33.5 ± 8.1) U / L, and the ACE concentration in the control group was (38.4) ±4.8) U/L, statistically significant (P<0.05). The expression of ACE gene in the AD group was (0.2265 ± 0.3783); the expression in the CHD group was (7.085 7 ± 7.692 9), with significant (P < 0. 05). The expression of ACE2 gene in the AD group was (0.766 2 ± 0.858 6); in the CHD group was (9.612 7 ± 11.542 6), and the difference was significant (P < 0. 05). The expression of the ratio of ACE / ACE2 in the AD group was (0.413 8 ± 0.448); the expression in the CHD group was (0.811 1 ± 0.256 3), the difference was statistically significant (P <0. 001). ConclusionPlasma ACE concentration, ACE and ACE2 gene expression are significantly reduced in acute AD. The imbalance of ACE and ACE2 expression may be involved in the pathogenesis of AD.

scholarly journals New perspectives in immunological diagnostics of coronary heart disease

2012 ◽  
Vol 11 (1) ◽  
pp. 49-53
Author(s):  
S. I. Davydov ◽  
A. A. Tarasov ◽  
A. L. Emelyanova ◽  
M. A. Kiseleva ◽  
A. R. Babaeva
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Troponin I ◽  
Solid Phase ◽  
Diagnostic Methods ◽  
Control Group ◽  
Activity Measurement ◽  
Immunological Parameters ◽  
Coronary Syndrome ◽  
Clinical Variants

Aim. To assess the diagnostic value of immunological markers of endothelial dysfunction (ED) in various clinical variants of coronary heart disease (CHD). Material and methods. The study included 455 patients with various clinical variants of CHD. The control group (CG) included 70 individuals without clinical CHD symptoms. Solid-phase immunoenzymatic method was used for measuring the serum titres of Chlamydia pneumoniae (Cp), sulphated glycosamineglycanes (s-GAG), collagen (C), and hyaluronic acid (HA) antibodies. Results. In patients with acute coronary syndrome (ACS), mean titres of Cp, s-GAG, C, and HA antibodies were significantly higher than in patients with chronic CHD or CG participants. Among patients with myocardial infarction (MI), the levels of troponin I (TrI) and MB-creatine phosphokinase (MB-CK) significantly correlated with the titres of s-GAG and C antibodies, while the levels of C-reactive protein (CRP) were linked to the titres of C and HA antibodies. In ACS with ST segment elevation, the measurement of Cp, s-GAG, C, and HA antibodies was comparable to the measurement of CRP, TrI, or MB-CK activity, being significantly more sensitive than echocardiography (EchoCG). In non-ST ACS, immunological parameters were as sensitive as electrocardiography or CRP measurement, more reliable than MB-CK activity measurement or EchoCG, and slightly less reliable than TrI measurement. In unstable angina pectoris (UAP), immunological analysis was significantly more sensitive than the majority of the standard diagnostic methods. Conclusion. Pathogenetic mechanisms of ACS are closely related to the development of specific autoimmune reactions. The assessed immunological parameters could be used as objective markers of acute CHD variants.

scholarly journals Application of MAT Methodology in the Evaluation of Prescribing Adherence to Clinical Practice Guidelines for Secondary Prevention of Coronary Heart Disease in Post-Acute Coronary Syndrome Patients in Kuwait

2021 ◽  
Vol 12 ◽  
Author(s):  
Dalal Al-Taweel ◽  
Abdelmoneim Awad
Keyword(s):  
Health Care ◽  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Secondary Prevention ◽  
Assessment Tools ◽  
Coronary Syndrome ◽  
Significant Difference ◽  
St Elevation ◽  
The Impact

Quantification of prescribers’ adherence to evidence-based guidelines can be used as an outcome measure to assess the impact of services on the quality of medication use. Additionally, it can help in reducing inappropriate interventions and ensure that high-quality care is provided to patients. This study aimed to evaluate prescribing practices for secondary prevention of coronary heart disease (CHD) in post-acute coronary syndromes (ST-elevation myocardial infarction [STEMI] or non-ST elevation acute coronary syndrome [NSTEACS]) patients using two medication assessment tools (MATs) at secondary and tertiary health-care settings in Kuwait. Both MATs were developed and validated based on the relevant guidelines issued by the European Society of Cardiology and the American College of Cardiology/American Heart Association. A quantitative cross-sectional multicenter study was conducted on 460 patients’ medical records collected randomly from six health-care facilities in Kuwait. Application of MATSTEMI on 232 patients’ medication records (with 85.9% applicability) resulted in intermediate overall adherence (69.8%; 95% CI: 67.6–72.0). Application of MATNSTEACS on 228 patients’ medication records (with applicability 83.2%) resulted in intermediate overall adherence (73.3%; 95% CI: 70.5–76.0). There was no significant difference between the percentages of overall adherence among patients managed post-NSTEACS compared to those managed post-STEMI (p = 0.05). Multivariable logistic regression analysis revealed that the overall adherence to the MATSTEMI criteria was significantly higher among the specialized cardiac centers than among the general hospitals (OR: 1.6; 95% CI: 1.1–2.3; p = 0.02). The overall adherence to the MATNSTEACS criteria was found to be significantly lower among non-Kuwaitis than among Kuwaitis (OR: 0.6; 95% CI: 0.5–0.9; p = 0.01) and patients with a serum LDL ≥1.8 mmol/L than those with a serum LDL-C &lt; 1.8 mmol/L (OR: 0.5; 95% CI: 0.4–0.7; p &lt; 0.001). The present findings revealed that both MATs were useful tools in identifying the standard of clinical performances and highlighting areas for improvement regarding secondary prevention of CHD in post-acute coronary syndrome patients.

scholarly journals Intervention Effect of Probiotics in Gastric Cancer Patients with Complications of Coronary Heart Disease and Heart Failure

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Hui Yu ◽  
Anqin Dong ◽  
Luosha Zhao ◽  
Ping Li ◽  
Qiujun Zhang ◽  
...  
Keyword(s):  
Heart Failure ◽  
Gastric Cancer ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Control Group ◽  
Observation Group ◽  
Group A ◽  
Group 2 ◽  
Gastric Cancer Patients ◽  
Group 1

Objective. To investigate the characteristics of intestinal flora in patients with gastric cancer complicated by coronary heart disease and heart failure and the guiding value of probiotics intervention for clinical treatment. Methods. (1) One hundred and sixty-eight gastric cancer patients with complications of coronary heart disease and heart failure from August 2017 to December 2020 were selected as the observation group. A total of 125 patients with coronary heart disease treated at the same time were selected as control group 1, and 89 healthy subjects were selected as control group 2. Fecal samples were retained to extract the total RNA, and high-throughput sequencing was applied to complete the analysis of microbial diversity and structure differences, so as to obtain the biological species information of the specimens. (2) Patients in the observation group were randomly divided into two equal groups of 84 patients, namely, group A and group B. Group A was treated with conventional methods, and group B was combined with probiotics intervention on the basis of group A; then, the differences in the intestinal mucosal barrier between the two groups were compared. Results. The Chao, ACE, and Simpson index in the observation group were lower than those in control group 1 ( P < 0.05 ), and the Shannon index was higher than that in control group 1 ( P < 0.05 ). The Chao, ACE, and Shannon index in control group 1 were lower than those in control group 2 ( P < 0.05 ), whereas the Simpson index was higher than in control group 2 ( P < 0.05 ). The abundance of Bacteroidetes in the observation group was lower than that in control group 1 and control group 2 ( P < 0.05 ). The abundance of Firmicutes was higher than that of control group 1 and control group 2 ( P < 0.05 ). Four weeks after treatment, the levels of ET, D-lactic acid, and PCT in the group B were (0.10 ± 0.01), (3.99 ± 0.32), and (0.41 ± 0.10), respectively, which were lower than those in group A (0.19 ± 0.03), (4.51 ± 0.46), and (0.81 0.13). Conclusion. Gastric cancer patients with complications of coronary heart disease and heart failure are associated with intestinal flora disorder, which may be involved in the occurrence and development of the disease. Probiotics intervention is helpful to repair the intestinal mucosal barrier in patients, which is worthy of popularization and application.

scholarly journals Association of SRB1, ITGB2 gene polymorphisms with coronary heart disease in Chinese Han population

2018 ◽  
Author(s):  
Yuan Sun ◽  
Tian Long-Wang ◽  
Yong Zeng ◽  
Feng-Ying Gong ◽  
Hui-Juan Zhu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Recessive Model ◽  
Chinese Han Population ◽  
Control Group ◽  
Chinese Han ◽  
Han Population ◽  
Diabetes Status ◽  
Significant Difference ◽  
Equilibrium Test

AbstractBackgroundPrevious studies in mice and humans have implicated the lipoprotein receptor SRB1 in association with atherosclerosis and lipid levels. In our previous proteomics research, the expression of ITGB2 has differences between epicardial and subcutaneous adipose tissue. However, the association between the reported variants and risk of coronary heart disease (CHD) was not confirmed.MethodsWe conducted a case–control study consisted of 496 CHD patients and 367 controls. The two groups are adjusted for age, sex, body mass index, diabetes status and the proportion of dyslipidemia. The genotypes and allele frequency of variants rs838880,rs5888,rs5889 in SRB1 and rs235326,rs2070947,rs2070946 in ITGB2 were determined using Sequenom Mass-ARRAY technology.ResultsThe genotypes frequencies of all the six SNPs were consistent with Hardy-Weinberg Equilibrium test. For gene SRB1 rs838880, there was a significant difference in the alleles frequency(p=0.017), genotype frequency(p=0.0028), recessive model (p=0.000672) between CHD group and control group. For gene ITGB2 rs2070947, there was a significant difference in the recessive model (p=0.03). By comparing the clinical and serum metabolic indexes of SNP sites by genotype we find that among three genotypes of SRB1 rs5888,there were significant difference in the level of dyslipidemia history and serum LPA, among three genotypes of ITGB2 rs235236,there were significant difference in the levels of serum HDL,APOA1 and hypertension history, among three genotypes of ITGB2 rs2070947,there were significant difference in the level of serum APOA1,hsCRP.ConclusionsOur findings indicated that SNP rs838880 of gene SRB1 and rs2070947 of gene ITGB2 are associated with the risk of CHD in Chinese han population.

scholarly journals THE COMPARISON OF ARRHYTHMOGENICITY OF DIFFERENT SURGICAL APPROACHES TO ATRIAL FIBRILLATION IN PATIENTS WITH CORONARY HEART DISEASE

2014 ◽  
Vol 13 (2) ◽  
pp. 40-45
Author(s):  
A. M. Chernyavsky ◽  
Yu. E. Kareva ◽  
I. A. Pak ◽  
S. S. Rakhmonov ◽  
A. B. Romanov ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Mitral Valve ◽  
Atrial Flutter ◽  
Left Atrial ◽  
Pulmonary Veins ◽  
Maze Procedure ◽  
Control Group ◽  
Significant Difference

Aim. To estimate the prevalence of iatrogenic atrial flutter in patients with coronary heart disease (CHD) and atrial fibrillation (AF) after two types of surgical operations: radiofrequency pulmonary veins isolation and radiofrequency modified mini Maze procedure; and to compare the results with control group of patients undergone aortic-coronary bypass grafting (CABG).Material and methods. Totally 95 patients included with CHD and persistent AF. Subjects were randomized into three groups: 1st (n=31) — with simultaneous CABG and radiofrequency ablation of pulmonary veins ostiums; 2nd (n=30) — simultaneous CABG and mini Maze procedure; 3rd control (n=34) — CABG only. For prolonged ECG monitoring the implanted devices Reveal XT were used in 53 subjects.Results. The patients escaped from left-atrial flutter were 90% in the 1st group. In the 2nd there was 1 case of left-atrial flutter (according to electrophysiological investigation — the leap through the mitral valve line), meaning 96,9% patients free from it. However there was no significant difference between 1st and 2nd groups (p=0,6). In the 3rd group postprocedure flutter developed in one case too, due to the scar on the left atrium wall after mitral valve regurgitation correction; so 97% patients escaped from flutter, but the difference was still not significant (p=0,4).Conclusion. In patients with CHD and AF it is recommended to perform radiofrequency modified mini Maze procedure combined with CABG due to its lower proarrhythmogenic effect. The rate of iatrogenic flutter is 3,1% after mini Maze and 10% after pulmonary veins ostiums isolation.

scholarly journals ROLE OF OXIDATIVE STRESS IN PATHOGENESIS AND PROGRESSION OF NON-ALCOHOLIC STEATOHEPATITIS IN PATIENTS WITH CONCOMITANT CORONARY HEART DISEASE

2018 ◽  
Vol 18 (4) ◽  
pp. 76-79 ◽  
Author(s):  
O.S. Khukhlina ◽  
O.B. Kuzminska ◽  
T.M. Danylyshyn ◽  
O.Ye. Grinyuk ◽  
V.V. Kropyva
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Pathological Process ◽  
Reduced Form ◽  
Control Group ◽  
Antioxidant Protection ◽  
Energy Potential ◽  
Diene Conjugates ◽  
Conjugated Trienes ◽  
Group 2

The aim of the study: to investigate the state of the system of oxidant-antioxidant homeostasis in patients with NASH and comorbid coronary heart disease. Material and methods. We examined 86 patients with NASH, including 30 patients with NASH and obesity of I-II degree (group 1) and 56 patients with NASH and comorbid coronary heart disease (stable angina pectoris I-II) (group 2). The control group consisted of 30 healthy individuals of the comparable age. The average age of patients was 56,6 ± 5,74 years. Results. An essential pathogenetic factor for the onset and progression of NASH in the presence of comorbid coronary heart disease is the intensification of the processes of free radical lipids oxidation that determines the degree of activity of the pathological process in the liver: the accumulation of intermediate (isolated double bonds, diene conjugates, ketodiens and conjugated trienes) and terminal (malonic aldehyde of plasma and erythrocytes) products of lipid peroxidation against the background of disintegration of the system of antioxidant protection (reduction of the content of glutathione reduced in erythrocytes, compensatory growth of catalase activity). Insufficiency and disintegration in the system of antioxidant protection is one of the main factors resulting in the increase in metabolic intoxication, while preserving of glutathione in a reduced form is necessary to prevent the inactivation of a number of enzymes, protecting the hepatocyte membranes from the effects of oxidants. The oxidation of reduced glutathione leads to decrease in the intensity of glycolysis, lowered synthesis of ATP and decline in the energy potential of hepatocytes and cardiomyocytes that is particularly undesirable for the comorbidity of NASH and coronary heart disease.

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